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Gram H 's Articles

[30038218] Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.

Gomez Delphine , Baylis Richard A , Durgin Brittany G , Newman Alexandra A C , Alencar Gabriel F , Mahan Sidney , St Hilaire Cynthia , Müller Werner , Waisman Ari , Francis Sheila E , Pinteaux Emmanuel , Randolph Gwendalyn J , Gram Hermann , Owens Gary K ,

[29690837] Neutralization of Interleukin-1β following Diffuse Traumatic Brain Injury in the Mouse Attenuates the Loss of Mature Oligodendrocytes.

Flygt Johanna , Ruscher Karsten , Norberg Amanda , Mir Anis , Gram Hermann , Clausen Fredrik , Marklund Niklas ,

[29375547] An Activating Janus Kinase-3 Mutation Is Associated with Cytotoxic T Lymphocyte Antigen-4-Dependent Immune Dysregulation Syndrome.

Sic Heiko , Speletas Matthaios , Cornacchione Vanessa , Seidl Maximillian , Beibel Martin , Linghu Bolan , Yang Fan , Sevdali Eirini , Germenis Anastasios E , Oakeley Edward J , Vangrevelinghe Eric , Sailer Andreas W , Traggiai Elisabetta , Gram Hermann , Eibel Hermann ,

[28115015] Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy.

Brachat Arndt H , Grom Alexei A , Wulffraat Nico , Brunner Hermine I , Quartier Pierre , Brik Riva , McCann Liza , Ozdogan Huri , Rutkowska-Sak Lidia , Schneider Rayfel , Gerloni Valeria , Harel Liora , Terreri Maria , Houghton Kristin , Joos Rik , Kingsbury Daniel , Lopez-Benitez Jorge M , Bek Stephan , Schumacher Martin , Valentin Marie-Anne , Gram Hermann , Abrams Ken , Martini Alberto , Lovell Daniel J , Nirmala Nanguneri R , Ruperto Nicolino , ,

[27219859] Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis.

Weehuizen Tassili A F , Lankelma Jacqueline M , De Jong Hanna K , De Boer Onno J , Roelofs Joris J T H , Day Nicholas P , Gram Hermann , De Vos Alex F , Wiersinga W Joost ,

[27091435] Diffuse traumatic axonal injury in mice induces complex behavioural alterations that are normalized by neutralization of interleukin-1β.

Ekmark-Lewén Sara , Flygt Johanna , Fridgeirsdottir Gudrun A , Kiwanuka Olivia , Hånell Anders , Meyerson Bengt J , Mir Anis K , Gram Hermann , Lewén Anders , Clausen Fredrik , Hillered Lars , Marklund Niklas ,

[26720283] Preclinical characterization and clinical development of ILARIS(®) (canakinumab) for the treatment of autoinflammatory diseases.

Gram Hermann ,

[26668315] Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.

Korneeva Nadejda L , Song Anren , Gram Hermann , Edens Mary Ann , Rhoads Robert E ,

[26284424] The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β.

Rondeau Jean-Michel , Ramage Paul , Zurini Mauro , Gram Hermann ,

[25904765] Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia.

Awan Zuhier , Denis Maxime , Roubtsova Anna , Essalmani Rachid , Marcinkiewicz Jadwiga , Awan Amani , Gram Hermann , Seidah Nabil G , Genest Jacques ,

[25050926] Biomarkers in systemic juvenile idiopathic arthritis: a comparison with biomarkers in cryopyrin-associated periodic syndromes.

Nirmala Nanguneri , Grom Alexei , Gram Hermann ,

[24825858] Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R.

Parameswaran Reshmi , Lim Min , Fei Fei , Abdel-Azim Hisham , Arutyunyan Anna , Schiffer Isabelle , McLaughlin Margaret E , Gram Hermann , Huet Heather , Groffen John , Heisterkamp Nora ,

[24140353] Pharmacokinetics, biocompatibility and bioavailability of a controlled release monoclonal antibody formulation.

Schweizer Daniel , Vostiar Igor , Heier Annabelle , Serno Tim , Schoenhammer Karin , Jahn Michael , Jones Stewart , Piequet Aline , Beerli Christian , Gram Hermann , Goepferich Achim ,

[23130147] Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis.

Denes Adam , Drake Caroline , Stordy Jing , Chamberlain Janet , McColl Barry W , Gram Hermann , Crossman David , Francis Sheila , Allan Stuart M , Rothwell Nancy J ,

[22550964] Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody.

Chakraborty Abhijit , Tannenbaum Stacey , Rordorf Christiane , Lowe Philip J , Floch David , Gram Hermann , Roy Sandip ,

[22126489] Proteomics analysis and evaluation of biomarkers for detection of cholangiocarcinoma.

Sriwanitchrak Pramote , Viyanant Vithoon , Chaijaroenkul Wanna , Srivatanakul Petcharin , Gram Hans Rudi , Eursiddhichai Veerachai , Na-Bangchang Kesara ,

[21838425] Inhibitory effects of anti-IL-1β antibody in murine AA amyloidosis mode.

Murata S , Ueda M , Tanabe Y , Kurata N , Demura N , Gram H , Tasaki M , Su Y , Jono H , Shono M , Obayashi K , Ando Y ,

[21623956] Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice.

Clausen Fredrik , Hånell Anders , Israelsson Charlotte , Hedin Johanna , Ebendal Ted , Mir Anis K , Gram Hermann , Marklund Niklas ,

[21047768] Mnk mediates integrin α6β4-dependent eIF4E phosphorylation and translation of VEGF mRNA.

Korneeva Nadejda L , Soung Young Hwa , Kim Hong Im , Giordano Anthony , Rhoads Robert E , Gram Hermann , Chung Jun ,

[19614750] Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice.

Clausen Fredrik , Hånell Anders , Björk Maria , Hillered Lars , Mir Anis K , Gram Hermann , Marklund Niklas ,

[19479877] The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.

Koziczak-Holbro Magdalena , Littlewood-Evans Amanda , Pöllinger Bernadette , Kovarik Jiri , Dawson Janet , Zenke Gerhard , Burkhart Christoph , Müller Matthias , Gram Hermann ,

[18855149] Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance.

Osborn Olivia , Gram Hermann , Zorrilla Eric P , Conti Bruno , Bartfai Tamas ,

[18723371] Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity.

Osborn O , Brownell S E , Sanchez-Alavez M , Salomon D , Gram H , Bartfai T ,

[18694961] Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance.

Zhang Min , Fu Wuxia , Prabhu Sharmila , Moore James C , Ko Je , Kim Jung Woo , Druker Brian J , Trapp Valerie , Fruehauf John , Gram Hermann , Fan Hung Y , Ong S Tiong ,

[18534016] The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis.

Alten Rieke , Gram Hermann , Joosten Leo A , van den Berg Wim B , Sieper Joachim , Wassenberg Siegfrid , Burmester Gerd , van Riel Piet , Diaz-Lorente Maria , Bruin Gerardus J M , Woodworth Thasia G , Rordorf Christiane , Batard Yannik , Wright Andrew M , Jung Thomas ,

[18510099] Solving the IRAK-4 enigma: application of kinase-dead knock-in mice.

Koziczak-Holbro M , Joyce C , Glück A , Kinzel B , Müller M , Gram H ,

[18266302] IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes.

Koziczak-Holbro Magdalena , Glück Anton , Tschopp Claude , Mathison John C , Gram Hermann ,

[17337443] IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression.

Koziczak-Holbro Magdalena , Joyce Claire , Glück Anton , Kinzel Bernd , Müller Matthias , Tschopp Claude , Mathison John C , Davis Christopher N , Gram Hermann ,

[17130135] MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines.

Chrestensen Carol A , Shuman Jacquelyn K , Eschenroeder Andrew , Worthington Mark , Gram Hermann , Sturgill Thomas W ,

[16869001] A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis.

Haringman Jasper J , Gerlag Danielle M , Smeets Tom J M , Baeten Dominique , van den Bosch Filip , Bresnihan Barry , Breedveld Ferdinand C , Dinant Huib J , Legay Francois , Gram Hermann , Loetscher Pius , Schmouder Robert , Woodworth Thasia , Tak Paul P ,

[16249085] Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.

Revesz Laszlo , Blum Ernst , Di Padova Franco E , Buhl Thomas , Feifel Roland , Gram Hermann , Hiestand Peter , Manning Ute , Neumann Ulf , Rucklin Gerard ,

[15982477] Production of antibodies to canine IL-1beta and canine TNF to assess the role of proinflammatory cytokines.

Baggio Vannozza , Ott Fabienne , Fischer René W , Gram Hermann , Peele John , Spreng David , Schmökel Hugo , Jungi Thomas W ,

[15972960] Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

Koenders Marije I , Lubberts Erik , Oppers-Walgreen Birgitte , van den Bersselaar Liduine , Helsen Monique M , Di Padova Franco E , Boots Annemieke M H , Gram Hermann , Joosten Leo A B , van den Berg Wim B ,

[15766526] Involvement of microRNA in AU-rich element-mediated mRNA instability.

Jing Qing , Huang Shuang , Guth Sabine , Zarubin Tyler , Motoyama Andrea , Chen Jianming , Di Padova Franco , Lin Sheng-Cai , Gram Hermann , Han Jiahuai ,

[15177483] SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity.

Revesz Laszlo , Blum Ernst , Di Padova Franco E , Buhl Thomas , Feifel Roland , Gram Hermann , Hiestand Peter , Manning Ute , Rucklin Gerard ,

[15177482] Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.

Revesz Laszlo , Blum Ernst , Di Padova Franco E , Buhl Thomas , Feifel Roland , Gram Hermann , Hiestand Peter , Manning Ute , Rucklin Gerard ,

[15021835] Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation.

Schuler Walter , Bigaud Marc , Brinkmann Volker , Di Padova Franco , Geisse Sabine , Gram Hermann , Hungerford Valerie , Kleuser Beate , Kristofic Colette , Menninger Klaus , Tees Reet , Wieczorek Grazyna , Wilt Corinne , Wioland Catherine , Zurini Mauro ,

[12127515] SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.

Revesz Laszlo , Di Padova Franco E , Buhl Thomas , Feifel Roland , Gram Hermann , Hiestand Peter , Manning Ute , Wolf Romain , Zimmerlin Alfred G ,

[11847341] MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.

Ge Baoxue , Gram Hermann , Di Padova Franco , Huang Betty , New Liguo , Ulevitch Richard J , Luo Ying , Han Jiahuai ,

[11463832] Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.

Knauf U , Tschopp C , Gram H ,

[11435226] Gene suppression by tristetraprolin and release by the p38 pathway.

Zhu W , Brauchle M A , Di Padova F , Gram H , New L , Ono K , Downey J S , Han J ,

[10912795] Independent role of p38 and ERK1/2 mitogen-activated kinases in the upregulation of matrix metalloproteinase-1.

Brauchle M , Glück D , Di Padova F , Han J , Gram H ,

[10891393] Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies.

Tschopp C , Knauf U , Brauchle M , Zurini M , Ramage P , Glueck D , New L , Han J , Gram H ,

[10866395] SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.

Revesz L , Di Padova F E , Buhl T , Feifel R , Gram H , Hiestand P , Manning U , Zimmerlin A G ,

[10843689] Regulation of TNF expression by multiple mitogen-activated protein kinase pathways.

Zhu W , Downey J S , Gu J , Di Padova F , Gram H , Han J ,

[10811012] Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli.

Fearns C , Kline L , Gram H , Di Padova F , Zurini M , Han J , Ulevitch R J ,

[10420972] Phage display in proteolysis and signal transduction.

Gram H ,

[9873047] Cloning and characterization of RLPK, a novel RSK-related protein kinase.

New L , Zhao M , Li Y , Bassett W W , Feng Y , Ludwig S , Padova F D , Gram H , Han J ,

[9858528] Regulation of the MEF2 family of transcription factors by p38.

Zhao M , New L , Kravchenko V V , Kato Y , Gram H , di Padova F , Olson E N , Ulevitch R J , Han J ,

[9680640] Secretion of scFv antibody fragments.

Gram H , Schmitz R , Ridder R ,

 

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