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Nuciforo P 's Articles

[30377213] A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.

Castroviejo-Bermejo Marta , Cruz Cristina , Llop-Guevara Alba , Gutiérrez-Enríquez Sara , Ducy Mandy , Ibrahim Yasir Hussein , Gris-Oliver Albert , Pellegrino Benedetta , Bruna Alejandra , Guzmán Marta , Rodríguez Olga , Grueso Judit , Bonache Sandra , Moles-Fernández Alejandro , Villacampa Guillermo , Viaplana Cristina , Gómez Patricia , Vidal Marc , Peg Vicente , Serres-Créixams Xavier , Dellaire Graham , Simard Jacques , Nuciforo Paolo , Rubio Isabel T , Dientsmann Rodrigo , Barrett J Carl , Caldas Carlos , Baselga José , Saura Cristina , Cortés Javier , Déas Olivier , Jonkers Jos , Masson Jean-Yves , Cairo Stefano , Judde Jean-Gabriel , O'Connor Mark J , Díez Orland , Balmaña Judith , Serra Violeta ,

[30282693] p95HER2-T cell bispecific antibody for breast cancer treatment.

Rius Ruiz Irene , Vicario Rocio , Morancho Beatriz , Morales Cristina Bernadó , Arenas Enrique J , Herter Sylvia , Freimoser-Grundschober Anne , Somandin Jitka , Sam Johannes , Ast Oliver , Barriocanal Águeda Martinez , Luque Antonio , Escorihuela Marta , Varela Ismael , Cuartas Isabel , Nuciforo Paolo , Fasani Roberta , Peg Vicente , Rubio Isabel , Cortés Javier , Serra Violeta , Escriva-de-Romani Santiago , Sperinde Jeff , Chenna Ahmed , Huang Weidong , Winslow John , Albanell Joan , Seoane Joan , Scaltriti Maurizio , Baselga Jose , Tabernero Josep , Umana Pablo , Bacac Marina , Saura Cristina , Klein Christian , Arribas Joaquín ,

[30088816] Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy.

Allen W L , Dunne P D , McDade S , Scanlon E , Loughrey M , Coleman H , McCann C , McLaughlin K , Nemeth Z , Syed N , Jithesh P , Arthur K , Wilson R , Coyle V , McArt D , Murray G I , Samuel L , Nuciforo P , Jimenez J , Argiles G , Dienstmann R , Tabernero J , Messerini L , Nobili S , Mini E , Sheahan K , Ryan E , Johnston P G , Van Schaeybroeck S , Lawler M , Longley D B ,

[29944140] TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence.

Puig Isabel , Tenbaum Stephan P , Chicote Irene , Arqués Oriol , Martínez-Quintanilla Jordi , Cuesta-Borrás Estefania , Ramírez Lorena , Gonzalo Pilar , Soto Atenea , Aguilar Susana , Eguizabal Cristina , Caratù Ginevra , Prat Aleix , Argilés Guillem , Landolfi Stefania , Casanovas Oriol , Serra Violeta , Villanueva Alberto , Arroyo Alicia G , Terracciano Luigi , Nuciforo Paolo , Seoane Joan , Recio Juan A , Vivancos Ana , Dienstmann Rodrigo , Tabernero Josep , Palmer Héctor G ,

[29902299] Association of T-Cell Receptor Repertoire Use With Response to Combined Trastuzumab-Lapatinib Treatment of HER2-Positive Breast Cancer: Secondary Analysis of the NeoALTTO Randomized Clinical Trial.

Powles Ryan L , Redmond David , Sotiriou Christos , Loi Sherene , Fumagalli Debora , Nuciforo Paolo , Harbeck Nadia , de Azambuja Evandro , Sarp Severine , Di Cosimo Serena , Huober Jens , Baselga Jose , Piccart-Gebhart Martine , Elemento Olivier , Pusztai Lajos , Hatzis Christos ,

[29880484] Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies.

Saei Azad , Palafox Marta , Benoukraf Touati , Kumari Nishi , Jaynes Patrick William , Iyengar Prasanna Vasudevan , Muñoz-Couselo Eva , Nuciforo Paolo , Cortés Javier , Nötzel Christopher , Kumarakulasinghe Nesaretnam Barr , Richard John Lalith Charles , Bin Adam Isa Zul Fazreen , Pang Brendan , Guzman Marta , Siqin Zhou , Yang Henry , Tam Wai Leong , Serra Violeta , Eichhorn Pieter Johan Adam ,

[29755676] Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases.

De Mattos-Arruda Leticia , Ng Charlotte K Y , Piscuoglio Salvatore , Gonzalez-Cao Maria , Lim Raymond S , De Filippo Maria R , Fusco Nicola , Schultheis Anne M , Ortiz Carolina , Viteri Santiago , Arias Alexandra , Macedo Gabriel S , Oliveira Mafalda , Gomez Patricia , Teixidó Cristina , Nuciforo Paolo , Peg Vicente , Saura Cristina , Ramon Y Cajal Santiago , Casas Francesc Tresserra , Weigelt Britta , Cortes Javier , Seoane Joan , Reis-Filho Jorge S ,

[29718117] Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle.

Mattos-Arruda L De , Weigelt B , Cortes J , Won H H , Ng C K Y , Nuciforo P , Bidard F-C , Aura C , Saura C , Peg V , Piscuoglio S , Oliveira M , Smolders Y , Patel P , Norton L , Tabernero J , Berger M F , Seoane J , Reis-Filho J S ,

[29701764] Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial.

Shi W , Jiang T , Nuciforo P , Hatzis C , Holmes E , Harbeck N , Sotiriou C , Peña L , Loi S , Rosa D D , Chia S , Wardley A , Ueno T , Rossari J , Eidtmann H , Armour A , Piccart-Gebhart M , Rimm D L , Baselga J , Pusztai L ,

[29648575] Early evolutionary divergence between papillary and anaplastic thyroid cancers.

Capdevila J , Mayor R , Mancuso F M , Iglesias C , Caratù G , Matos I , Zafón C , Hernando J , Petit A , Nuciforo P , Cameselle-Teijeiro J M , Álvarez C , Recio J A , Tabernero J , Matias-Guiu X , Vivancos A , Seoane J ,

[29635390] RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.

Cruz C , Castroviejo-Bermejo M , Gutiérrez-Enríquez S , Llop-Guevara A , Ibrahim Y H , Gris-Oliver A , Bonache S , Morancho B , Bruna A , Rueda O M , Lai Z , Polanska U M , Jones G N , Kristel P , de Bustos L , Guzman M , Rodríguez O , Grueso J , Montalban G , Caratú G , Mancuso F , Fasani R , Jiménez J , Howat W J , Dougherty B , Vivancos A , Nuciforo P , Serres-Créixams X , Rubio I T , Oaknin A , Cadogan E , Barrett J C , Caldas C , Baselga J , Saura C , Cortés J , Arribas J , Jonkers J , Díez O , O'Connor M J , Balmaña J , Serra V ,

[29529211] Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation.

Cedrés Susana , Felip Enriqueta , Cruz Cristina , Martinez de Castro Ana , Pardo Nuria , Navarro Alejandro , Martinez-Marti Alex , Remon Jordin , Zeron-Medina Jorge , Balmaña Judith , Llop-Guevara Alba , Miquel Josep M , Sansano Irene , Nuciforo Paolo , Mancuso Francesco , Serra Violeta , Vivancos Ana ,

[29342137] Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

Zabala-Letona Amaia , Arruabarrena-Aristorena Amaia , Martín-Martín Natalia , Fernandez-Ruiz Sonia , Sutherland James D , Clasquin Michelle , Tomas-Cortazar Julen , Jimenez Jose , Torres Ines , Quang Phong , Ximenez-Embun Pilar , Bago Ruzica , Ugalde-Olano Aitziber , Loizaga-Iriarte Ana , Lacasa-Viscasillas Isabel , Unda Miguel , Torrano Verónica , Cabrera Diana , van Liempd Sebastiaan M , Cendon Ylenia , Castro Elena , Murray Stuart , Revandkar Ajinkya , Alimonti Andrea , Zhang Yinan , Barnett Amelia , Lein Gina , Pirman David , Cortazar Ana R , Arreal Leire , Prudkin Ludmila , Astobiza Ianire , Valcarcel-Jimenez Lorea , Zuñiga-García Patricia , Fernandez-Dominguez Itziar , Piva Marco , Caro-Maldonado Alfredo , Sánchez-Mosquera Pilar , Castillo-Martín Mireia , Serra Violeta , Beraza Naiara , Gentilella Antonio , Thomas George , Azkargorta Mikel , Elortza Felix , Farràs Rosa , Olmos David , Efeyan Alejo , Anguita Juan , Muñoz Javier , Falcón-Pérez Juan M , Barrio Rosa , Macarulla Teresa , Mato Jose M , Martinez-Chantar Maria L , Cordon-Cardo Carlos , Aransay Ana M , Marks Kevin , Baselga José , Tabernero Josep , Nuciforo Paolo , Manning Brendan D , Marjon Katya , Carracedo Arkaitz ,

[29170280] Analysis of persistence and antibiotic response in colorectal cancer.

Bullman Susan , Pedamallu Chandra S , Sicinska Ewa , Clancy Thomas E , Zhang Xiaoyang , Cai Diana , Neuberg Donna , Huang Katherine , Guevara Fatima , Nelson Timothy , Chipashvili Otari , Hagan Timothy , Walker Mark , Ramachandran Aruna , Diosdado Begoña , Serna Garazi , Mulet Nuria , Landolfi Stefania , Ramon Y Cajal Santiago , Fasani Roberta , Aguirre Andrew J , Ng Kimmie , Élez Elena , Ogino Shuji , Tabernero Josep , Fuchs Charles S , Hahn William C , Nuciforo Paolo , Meyerson Matthew ,

[29045543] A predictive model of pathologic response based on tumor cellularity and tumor-infiltrating lymphocytes (CelTIL) in HER2-positive breast cancer treated with chemo-free dual HER2 blockade.

Nuciforo P , Pascual T , Cortés J , Llombart-Cussac A , Fasani R , Paré L , Oliveira M , Galvan P , Martínez N , Bermejo B , Vidal M , Pernas S , López R , Muñoz M , Garau I , Manso L , Alarcón J , Martínez E , Rodrik-Outmezguine V , Brase J C , Villagrasa P , Prat A , Holgado E ,

[28961841] Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC).

Martinez-Marti A , Felip E , Matito J , Mereu E , Navarro A , Cedrés S , Pardo N , Martinez de Castro A , Remon J , Miquel J M , Guillaumet-Adkins A , Nadal E , Rodriguez-Esteban G , Arqués O , Fasani R , Nuciforo P , Heyn H , Villanueva A , Palmer H G , Vivancos A ,

[28777143] Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors.

Hendry Shona , Salgado Roberto , Gevaert Thomas , Russell Prudence A , John Tom , Thapa Bibhusal , Christie Michael , van de Vijver Koen , Estrada M V , Gonzalez-Ericsson Paula I , Sanders Melinda , Solomon Benjamin , Solinas Cinzia , Van den Eynden Gert G G M , Allory Yves , Preusser Matthias , Hainfellner Johannes , Pruneri Giancarlo , Vingiani Andrea , Demaria Sandra , Symmans Fraser , Nuciforo Paolo , Comerma Laura , Thompson E A , Lakhani Sunil , Kim Seong-Rim , Schnitt Stuart , Colpaert Cecile , Sotiriou Christos , Scherer Stefan J , Ignatiadis Michail , Badve Sunil , Pierce Robert H , Viale Giuseppe , Sirtaine Nicolas , Penault-Llorca Frederique , Sugie Tomohagu , Fineberg Susan , Paik Soonmyung , Srinivasan Ashok , Richardson Andrea , Wang Yihong , Chmielik Ewa , Brock Jane , Johnson Douglas B , Balko Justin , Wienert Stephan , Bossuyt Veerle , Michiels Stefan , Ternes Nils , Burchardi Nicole , Luen Stephen J , Savas Peter , Klauschen Frederick , Watson Peter H , Nelson Brad H , Criscitiello Carmen , O'Toole Sandra , Larsimont Denis , de Wind Roland , Curigliano Giuseppe , André Fabrice , Lacroix-Triki Magali , van de Vijver Mark , Rojo Federico , Floris Giuseppe , Bedri Shahinaz , Sparano Joseph , Rimm David , Nielsen Torsten , Kos Zuzana , Hewitt Stephen , Singh Baljit , Farshid Gelareh , Loibl Sibylle , Allison Kimberly H , Tung Nadine , Adams Sylvia , Willard-Gallo Karen , Horlings Hugo M , Gandhi Leena , Moreira Andre , Hirsch Fred , Dieci Maria V , Urbanowicz Maria , Brcic Iva , Korski Konstanty , Gaire Fabien , Koeppen Hartmut , Lo Amy , Giltnane Jennifer , Rebelatto Marlon C , Steele Keith E , Zha Jiping , Emancipator Kenneth , Juco Jonathan W , Denkert Carsten , Reis-Filho Jorge , Loi Sherene , Fox Stephen B ,

[28777142] Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research.

Hendry Shona , Salgado Roberto , Gevaert Thomas , Russell Prudence A , John Tom , Thapa Bibhusal , Christie Michael , van de Vijver Koen , Estrada M V , Gonzalez-Ericsson Paula I , Sanders Melinda , Solomon Benjamin , Solinas Cinzia , Van den Eynden Gert G G M , Allory Yves , Preusser Matthias , Hainfellner Johannes , Pruneri Giancarlo , Vingiani Andrea , Demaria Sandra , Symmans Fraser , Nuciforo Paolo , Comerma Laura , Thompson E A , Lakhani Sunil , Kim Seong-Rim , Schnitt Stuart , Colpaert Cecile , Sotiriou Christos , Scherer Stefan J , Ignatiadis Michail , Badve Sunil , Pierce Robert H , Viale Giuseppe , Sirtaine Nicolas , Penault-Llorca Frederique , Sugie Tomohagu , Fineberg Susan , Paik Soonmyung , Srinivasan Ashok , Richardson Andrea , Wang Yihong , Chmielik Ewa , Brock Jane , Johnson Douglas B , Balko Justin , Wienert Stephan , Bossuyt Veerle , Michiels Stefan , Ternes Nils , Burchardi Nicole , Luen Stephen J , Savas Peter , Klauschen Frederick , Watson Peter H , Nelson Brad H , Criscitiello Carmen , O'Toole Sandra , Larsimont Denis , de Wind Roland , Curigliano Giuseppe , André Fabrice , Lacroix-Triki Magali , van de Vijver Mark , Rojo Federico , Floris Giuseppe , Bedri Shahinaz , Sparano Joseph , Rimm David , Nielsen Torsten , Kos Zuzana , Hewitt Stephen , Singh Baljit , Farshid Gelareh , Loibl Sibylle , Allison Kimberly H , Tung Nadine , Adams Sylvia , Willard-Gallo Karen , Horlings Hugo M , Gandhi Leena , Moreira Andre , Hirsch Fred , Dieci Maria V , Urbanowicz Maria , Brcic Iva , Korski Konstanty , Gaire Fabien , Koeppen Hartmut , Lo Amy , Giltnane Jennifer , Rebelatto Marlon C , Steele Keith E , Zha Jiping , Emancipator Kenneth , Juco Jonathan W , Denkert Carsten , Reis-Filho Jorge , Loi Sherene , Fox Stephen B ,

[28658205] mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

Zabala-Letona Amaia , Arruabarrena-Aristorena Amaia , Martín-Martín Natalia , Fernandez-Ruiz Sonia , Sutherland James D , Clasquin Michelle , Tomas-Cortazar Julen , Jimenez Jose , Torres Ines , Quang Phong , Ximenez-Embun Pilar , Bago Ruzica , Ugalde-Olano Aitziber , Loizaga-Iriarte Ana , Lacasa-Viscasillas Isabel , Unda Miguel , Torrano Verónica , Cabrera Diana , van Liempd Sebastiaan M , Cendon Ylenia , Castro Elena , Murray Stuart , Revandkar Ajinkya , Alimonti Andrea , Zhang Yinan , Barnett Amelia , Lein Gina , Pirman David , Cortazar Ana R , Arreal Leire , Prudkin Ludmila , Astobiza Ianire , Valcarcel-Jimenez Lorea , Zuñiga-García Patricia , Fernandez-Dominguez Itziar , Piva Marco , Caro-Maldonado Alfredo , Sánchez-Mosquera Pilar , Castillo-Martín Mireia , Serra Violeta , Beraza Naiara , Gentilella Antonio , Thomas George , Azkargorta Mikel , Elortza Felix , Farràs Rosa , Olmos David , Efeyan Alejo , Anguita Juan , Muñoz Javier , Falcón-Pérez Juan M , Barrio Rosa , Macarulla Teresa , Mato Jose M , Martinez-Chantar Maria L , Cordon-Cardo Carlos , Aransay Ana M , Marks Kevin , Baselga José , Tabernero Josep , Nuciforo Paolo , Manning Brendan D , Marjon Katya , Carracedo Arkaitz ,

[28624695] First-in-human phase I study of oral S49076, a unique MET/AXL/FGFR inhibitor, in advanced solid tumours.

Rodon Jordi , Postel-Vinay Sophie , Hollebecque Antoine , Nuciforo Paolo , Azaro Analia , Cattan Valérie , Marfai Lucie , Sudey Isabelle , Brendel Karl , Delmas Audrey , Malasse Stéphanie , Soria Jean-Charles ,

[28618197] Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights.

Dienstmann Rodrigo , Elez Elena , Argiles Guillem , Matos Ignacio , Sanz-Garcia Enrique , Ortiz Carolina , Macarulla Teresa , Capdevila Jaume , Alsina Maria , Sauri Tamara , Verdaguer Helena , Vilaro Marta , Ruiz-Pace Fiorella , Viaplana Cristina , Garcia Ariadna , Landolfi Stefania , Palmer Hector G , Nuciforo Paolo , Rodon Jordi , Vivancos Ana , Tabernero Josep ,

[28487385] Immune-Related Gene Expression Profiling After PD-1 Blockade in Non-Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma.

Prat Aleix , Navarro Alejandro , Paré Laia , Reguart Noemí , Galván Patricia , Pascual Tomás , Martínez Alex , Nuciforo Paolo , Comerma Laura , Alos Llucia , Pardo Nuria , Cedrés Susana , Fan Cheng , Parker Joel S , Gaba Lydia , Victoria Iván , Viñolas Nuria , Vivancos Ana , Arance Ana , Felip Enriqueta ,

[28368441] Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer.

Grasselli J , Elez E , Caratù G , Matito J , Santos C , Macarulla T , Vidal J , Garcia M , Viéitez J M , Paéz D , Falcó E , Lopez Lopez C , Aranda E , Jones F , Sikri V , Nuciforo P , Fasani R , Tabernero J , Montagut C , Azuara D , Dienstmann R , Salazar R , Vivancos A ,

[28249905] Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer.

Cejalvo Juan M , Martínez de Dueñas Eduardo , Galván Patricia , García-Recio Susana , Burgués Gasión Octavio , Paré Laia , Antolín Silvia , Martinello Rosella , Blancas Isabel , Adamo Barbara , Guerrero-Zotano Ángel , Muñoz Montserrat , Nucíforo Paolo , Vidal María , Pérez Ramón M , Chacón López-Muniz José I , Caballero Rosalía , Peg Vicente , Carrasco Eva , Rojo Federico , Perou Charles M , Cortés Javier , Adamo Vincenzo , Albanell Joan , Gomis Roger R , Lluch Ana , Prat Aleix ,

[28238593] HER2-enriched subtype as a predictor of pathological complete response following trastuzumab and lapatinib without chemotherapy in early-stage HER2-positive breast cancer (PAMELA): an open-label, single-group, multicentre, phase 2 trial.

Llombart-Cussac Antonio , Cortés Javier , Paré Laia , Galván Patricia , Bermejo Begoña , Martínez Noelia , Vidal Maria , Pernas Sònia , López Rafael , Muñoz Montserrat , Nuciforo Paolo , Morales Serafín , Oliveira Mafalda , de la Peña Lorena , Peláez Alexandra , Prat Aleix ,

[28177469] The search for simplicity: is this compatible with precision medicine?

Nuciforo P G ,

[28177460] Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial.

Shi W , Jiang T , Nuciforo P , Hatzis C , Holmes E , Harbeck N , Sotiriou C , Peña L , Loi S , Rosa D D , Chia S , Wardley A , Ueno T , Rossari J , Eidtmann H , Armour A , Piccart-Gebhart M , Rimm D L , Baselga J , Pusztai L ,

[27684533] RNA Sequencing to Predict Response to Neoadjuvant Anti-HER2 Therapy: A Secondary Analysis of the NeoALTTO Randomized Clinical Trial.

Fumagalli Debora , Venet David , Ignatiadis Michail , Azim Hatem A , Maetens Marion , Rothé Françoise , Salgado Roberto , Bradbury Ian , Pusztai Lajos , Harbeck Nadia , Gomez Henry , Chang Tsai-Wang , Coccia-Portugal Maria Antonia , Di Cosimo Serena , de Azambuja Evandro , de la Peña Lorena , Nuciforo Paolo , Brase Jan C , Huober Jens , Baselga José , Piccart Martine , Loi Sherene , Sotiriou Christos ,

[27462779] Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer.

Hergueta-Redondo Marta , Sarrio David , Molina-Crespo Ángela , Vicario Rocío , Bernadó-Morales Cristina , Martínez Lidia , Rojo-Sebastián Alejandro , Serra-Musach Jordi , Mota Alba , Martínez-Ramírez Ángel , Castilla Mª Ángeles , González-Martin Antonio , Pernas Sonia , Cano Amparo , Cortes Javier , Nuciforo Paolo G , Peg Vicente , Palacios José , Pujana Miguel Ángel , Arribas Joaquín , Moreno-Bueno Gema ,

[27281556] Prognostic Value of Intrinsic Subtypes in Hormone Receptor-Positive Metastatic Breast Cancer Treated With Letrozole With or Without Lapatinib.

Prat Aleix , Cheang Maggie C U , Galván Patricia , Nuciforo Paolo , Paré Laia , Adamo Barbara , Muñoz Montserrat , Viladot Margarida , Press Michael F , Gagnon Robert , Ellis Catherine , Johnston Stephen ,

[26452030] MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients.

De Mattos-Arruda Leticia , Bottai Giulia , Nuciforo Paolo G , Di Tommaso Luca , Giovannetti Elisa , Peg Vicente , Losurdo Agnese , Pérez-Garcia José , Masci Giovanna , Corsi Fabio , Cortés Javier , Seoane Joan , Calin George A , Santarpia Libero ,

[26422389] High HER2 protein levels correlate with increased survival in breast cancer patients treated with anti-HER2 therapy.

Nuciforo Paolo , Thyparambil Sheeno , Aura Claudia , Garrido-Castro Ana , Vilaro Marta , Peg Vicente , Jimenez José , Vicario Rocio , Cecchi Fabiola , Hoos William , Burrows Jon , Hembrough Todd , Ferreres Juan Carles , Perez-Garcia José , Arribas Joaquin , Cortes Javier , Scaltriti Maurizio ,

[26272063] MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.

García-García Celina , Rivas Martín A , Ibrahim Yasir H , Calvo María Teresa , Gris-Oliver Albert , Rodríguez Olga , Grueso Judit , Antón Pilar , Guzmán Marta , Aura Claudia , Nuciforo Paolo , Jessen Katti , Argilés Guillem , Dienstmann Rodrigo , Bertotti Andrea , Trusolino Livio , Matito Judit , Vivancos Ana , Chicote Irene , Palmer Héctor G , Tabernero Josep , Scaltriti Maurizio , Baselga José , Serra Violeta ,

[26267534] Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes.

Herrero Ana , Pinto Adán , Colón-Bolea Paula , Casar Berta , Jones Mary , Agudo-Ibáñez Lorena , Vidal Rebeca , Tenbaum Stephan P , Nuciforo Paolo , Valdizán Elsa M , Horvath Zoltan , Orfi Laszlo , Pineda-Lucena Antonio , Bony Emilie , Keri Gyorgy , Rivas Germán , Pazos Angel , Gozalbes Rafael , Palmer Héctor G , Hurlstone Adam , Crespo Piero ,

[26224873] Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer.

Arqués Oriol , Chicote Irene , Puig Isabel , Tenbaum Stephan P , Argilés Guillem , Dienstmann Rodrigo , Fernández Natalia , Caratù Ginevra , Matito Judit , Silberschmidt Daniel , Rodon Jordi , Landolfi Stefania , Prat Aleix , Espín Eloy , Charco Ramón , Nuciforo Paolo , Vivancos Ana , Shao Wenlin , Tabernero Josep , Palmer Héctor G ,

[26181252] Tumor-Infiltrating Lymphocytes and Associations With Pathological Complete Response and Event-Free Survival in HER2-Positive Early-Stage Breast Cancer Treated With Lapatinib and Trastuzumab: A Secondary Analysis of the NeoALTTO Trial.

Salgado Roberto , Denkert Carsten , Campbell Christine , Savas Peter , Nuciforo Paolo , Nucifero Paolo , Aura Claudia , de Azambuja Evandro , Eidtmann Holger , Ellis Catherine E , Baselga Jose , Piccart-Gebhart Martine J , Michiels Stefan , Bradbury Ian , Sotiriou Christos , Loi Sherene ,

[26152740] Prediction of Response to Neoadjuvant Chemotherapy Using Core Needle Biopsy Samples with the Prosigna Assay.

Prat Aleix , Galván Patricia , Jimenez Begoña , Buckingham Wesley , Jeiranian H Arthur , Schaper Carl , Vidal Maria , Álvarez Martina , Díaz Sherley , Ellis Catherine , Nuciforo Paolo , Ferree Sean , Ribelles Nuria , Adamo Barbara , Ramón Y Cajal Santiago , Peg Vicente , Alba Emilio ,

[26075403] Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies.

Vicario Rocio , Peg Vicente , Morancho Beatriz , Zacarias-Fluck Mariano , Zhang Junjie , Martínez-Barriocanal Águeda , Navarro Jiménez Alexandra , Aura Claudia , Burgues Octavio , Lluch Ana , Cortés Javier , Nuciforo Paolo , Rubio Isabel T , Marangoni Elisabetta , Deeds James , Boehm Markus , Schlegel Robert , Tabernero Josep , Mosher Rebecca , Arribas Joaquín ,

[25887735] Quantification of HER family receptors in breast cancer.

Nuciforo Paolo , Radosevic-Robin Nina , Ng Tony , Scaltriti Maurizio ,

[25851628] Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) status.

Nuciforo P G , Aura C , Holmes E , Prudkin L , Jimenez J , Martinez P , Ameels H , de la Peña L , Ellis C , Eidtmann H , Piccart-Gebhart M J , Scaltriti M , Baselga J ,

[25670223] ERRATUM: Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity.

Prat Aleix , Adamo Barbara , Fan Cheng , Peg Vicente , Vidal Maria , Galván Patricia , Vivancos Ana , Nuciforo Paolo , Palmer Héctor G , Dawood Shaheenah , Rodón Jordi , Cajal Santiago Ramon Y , Campo Josep Maria Del , Felip Enriqueta , Tabernero Josep , Cortés Javier ,

[25649019] PTEN Loss Is Associated with Worse Outcome in HER2-Amplified Breast Cancer Patients but Is Not Associated with Trastuzumab Resistance.

Stern Howard M , Gardner Humphrey , Burzykowski Tomasz , Elatre Wafaa , O'Brien Carol , Lackner Mark R , Pestano Gary A , Santiago Angela , Villalobos Ivonne , Eiermann Wolfgang , Pienkowski Tadeusz , Martin Miguel , Robert Nicholas , Crown John , Nuciforo Paolo , Bee Valerie , Mackey John , Slamon Dennis J , Press Michael F ,

[25559818] PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer.

Majewski Ian J , Nuciforo Paolo , Mittempergher Lorenza , Bosma Astrid J , Eidtmann Holger , Holmes Eileen , Sotiriou Christos , Fumagalli Debora , Jimenez Jose , Aura Claudia , Prudkin Ludmila , Díaz-Delgado Maria Carmen , de la Peña Lorena , Loi Sherene , Ellis Catherine , Schultz Nikolaus , de Azambuja Evandro , Harbeck Nadia , Piccart-Gebhart Martine , Bernards René , Baselga José ,

[25467182] High HER2 expression correlates with response to the combination of lapatinib and trastuzumab.

Scaltriti Maurizio , Nuciforo Paolo , Bradbury Ian , Sperinde Jeff , Agbor-Tarh Dominique , Campbell Christine , Chenna Ahmed , Winslow John , Serra Violeta , Parra Josep Lluis , Prudkin Ludmila , Jimenez José , Aura Claudia , Harbeck Nadia , Pusztai Lajos , Ellis Catherine , Eidtmann Holger , Arribas Joaquin , Cortes Javier , de Azambuja Evandro , Piccart Martine , Baselga José ,

[25253614] Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy.

Parra-Palau Josep Lluís , Morancho Beatriz , Peg Vicente , Escorihuela Marta , Scaltriti Maurizio , Vicario Rocio , Zacarias-Fluck Mariano , Pedersen Kim , Pandiella Atanasio , Nuciforo Paolo , Serra Violeta , Cortés Javier , Baselga José , Perou Charles M , Prat Aleix , Rubio Isabel T , Arribas Joaquín ,

[25185990] Obstacles to precision oncology: confronting current factors affecting the successful introduction of biomarkers to the clinic.

Prudkin Ludmila , Nuciforo Paolo ,

[25009010] Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle.

De Mattos-Arruda L , Weigelt B , Cortes J , Won H H , Ng C K Y , Nuciforo P , Bidard F-C , Aura C , Saura C , Peg V , Piscuoglio S , Oliveira M , Smolders Y , Patel P , Norton L , Tabernero J , Berger M F , Seoane J , Reis-Filho J S ,

[24384914] Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity.

Prat Aleix , Adamo Barbara , Fan Cheng , Peg Vicente , Vidal Maria , Galván Patricia , Vivancos Ana , Nuciforo Paolo , Palmer Héctor G , Dawood Shaheenah , Rodón Jordi , Ramon y Cajal Santiago , Ramony Cajal Santiago , Del Campo Josep Maria , Felip Enriqueta , Tabernero Josep , Cortés Javier ,

[24265351] Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors.

Dienstmann R , Rodon J , Prat A , Perez-Garcia J , Adamo B , Felip E , Cortes J , Iafrate A J , Nuciforo P , Tabernero J ,

[24220311] Establishing the origin of metastatic deposits in the setting of multiple primary malignancies: the role of massively parallel sequencing.

De Mattos-Arruda Leticia , Bidard Francois-Clement , Won Helen H , Cortes Javier , Ng Charlotte K Y , Peg Vicente , Nuciforo Paolo , Jungbluth Achim A , Weigelt Britta , Berger Michael F , Seoane Joan , Reis-Filho Jorge S ,

 

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