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Pubmed ID :22488668
Publication Date : 2012/04/10

Optical fiber-based in vivo quantification of growth factor receptors.


Growth factor receptors such as epidermal growth factor receptor 1 and human epidermal growth receptor 2 (HER2) are overexpressed in certain cancer cells. Antibodies against these receptors (eg. cetuximab and transtuzumab [Herceptin]) have shown therapeutic value in cancer treatment. The existing methods for the quantification of these receptors in tumors involve immunohistochemistry or DNA quantification, both in extracted tissue samples. The goal of the study was to evaluate whether an optical fiber-based technique can be used to quantify the expression of multiple growth factor receptors simultaneously.

Authors : Thomas Thommey P, Chang Yu-Chung, Ye Jing Yong, Kotlyar Alina, Cao Zhengyi, Shukla Rameshwer, Qin Suyang, Norris Theodore B, Baker James R,

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