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[Thr6]-bradykinyl-Val,Asp (Bradykinin-related peptide RD-11) [Cleaved into: [Thr6]-bradykinin]

 BRKP1_PACDA             Reviewed;          61 AA.
L0PIN3;
15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
06-MAR-2013, sequence version 1.
22-NOV-2017, entry version 20.
RecName: Full=[Thr6]-bradykinyl-Val,Asp {ECO:0000303|PubMed:24394432};
AltName: Full=Bradykinin-related peptide RD-11 {ECO:0000303|PubMed:24394432};
Contains:
RecName: Full=[Thr6]-bradykinin {ECO:0000303|PubMed:24394432};
Flags: Precursor;
Pachymedusa dacnicolor (Giant mexican leaf frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae;
Phyllomedusinae; Pachymedusa.
NCBI_TaxID=75988 {ECO:0000312|EMBL:CCJ67650.1};
[1] {ECO:0000312|EMBL:CCJ67650.1}
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 51-61, FUNCTION,
SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY,
HYDROXYLATION AT PRO-53, AND IDENTIFICATION BY MASS SPECTROMETRY.
TISSUE=Skin {ECO:0000312|EMBL:CCJ67650.1}, and
Skin secretion {ECO:0000303|PubMed:24394432};
PubMed=24394432; DOI=10.1016/j.peptides.2013.12.013;
Jiang Y., Xi X., Ge L., Yang N., Hou X., Ma J., Ma C., Wu Y., Guo X.,
Li R., Zhou M., Wang L., Chen T., Shaw C.;
"Bradykinin-related peptides (BRPs) from skin secretions of three
genera of phyllomedusine leaf frogs and their comparative
pharmacological effects on mammalian smooth muscles.";
Peptides 52:122-133(2014).
-!- FUNCTION: [Thr6]-bradykinin: Induces relaxation of rat smooth
muscle from tail artery (EC(50)=16.8 nM) and contraction of that
from ileum (EC(50)=205 nM), urinary bladder (EC(50)=895 nM) and
uterus (EC(50)=60.3 nM). Binds to both bradykinin receptor B1
(BDKRB1) and B2 (BDKRB2). {ECO:0000269|PubMed:24394432}.
-!- FUNCTION: [Hyp3,Thr6]-bradykinin: Induces relaxation of rat smooth
muscle from tail artery (EC(50)=56.7 nM) and contraction of that
from ileum (EC(50)=588 nM), urinary bladder (EC(50)=4.6 uM) and
uterus (EC(50)=3.9 nM). Binds to both bradykinin receptor B1
(BDKRB1) and B2 (BDKRB2). In arterial smooth muscle, the effect
via BDKRB1 is stronger, in uterus, ileum and urinary bladder the
effect via BDKRB2. {ECO:0000269|PubMed:24394432}.
-!- FUNCTION: [Thr6]-bradykinyl-Val,Asp: Induces relaxation of rat
smooth muscle from tail artery (EC(50)=10.8 nM) and contraction of
that from ileum (EC(50)=645 nM), urinary bladder (EC(50)=1.1 uM)
and uterus (EC(50)=1.2 uM). Binds to both bradykinin receptor B1
(BDKRB1) and B2 (BDKRB2). Apart from uterus smooth muscle, the
effect via BDKRB2 is stronger. {ECO:0000269|PubMed:24394432}.
-!- FUNCTION: [Hyp3,Thr6]-bradykinyl-Val,Asp: Induces relaxation of
rat smooth muscle from tail artery (EC(50)=3.5 nM) and contraction
of that from ileum (EC(50)=223 nM), urinary bladder (EC(50)=1.5
uM) and uterus (EC(50)=356 nM). Binds to both bradykinin receptor
B1 (BDKRB1) and B2 (BDKRB2); the effects via BDKRB2 are stronger.
{ECO:0000269|PubMed:24394432}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000255|SAAS:SAAS00090082,
ECO:0000269|PubMed:24394432}.
-!- TISSUE SPECIFICITY: Expressed by the skin glands.
{ECO:0000305|PubMed:24394432}.
-!- MASS SPECTROMETRY: Mass=1303.55; Method=MALDI; Range=51-61;
Note=[Hyp3,Thr6]-bradykinyl-Val,Asp.;
Evidence={ECO:0000269|PubMed:24394432};
-!- MASS SPECTROMETRY: Mass=1287.90; Method=MALDI; Range=51-61;
Note=[Thr6]-bradykinyl-Val,Asp.;
Evidence={ECO:0000269|PubMed:24394432};
-!- MASS SPECTROMETRY: Mass=1089.70; Method=MALDI; Range=51-59;
Note=[Hyp3,Thr6]-bradykinin.;
Evidence={ECO:0000269|PubMed:24394432};
-!- MASS SPECTROMETRY: Mass=1073.45; Method=MALDI; Range=51-59;
Note=[Thr6]-bradykinin.; Evidence={ECO:0000269|PubMed:24394432};
-!- SIMILARITY: Belongs to the bradykinin-related peptide family.
{ECO:0000305}.
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EMBL; HE967329; CCJ67650.1; -; mRNA.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0031712; F:B1 bradykinin receptor binding; IDA:UniProtKB.
GO; GO:0031713; F:B2 bradykinin receptor binding; IDA:UniProtKB.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
GO; GO:1905655; P:negative regulation of artery smooth muscle contraction; IDA:UniProtKB.
GO; GO:1904349; P:positive regulation of small intestine smooth muscle contraction; IDA:UniProtKB.
GO; GO:1904320; P:positive regulation of smooth muscle contraction involved in micturition; IDA:UniProtKB.
GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; IDA:UniProtKB.
GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
InterPro; IPR004275; Frog_antimicrobial_propeptide.
Pfam; PF03032; FSAP_sig_propep; 1.
1: Evidence at protein level;
Amphibian defense peptide; Direct protein sequencing;
G-protein coupled receptor impairing toxin; Hydroxylation; Secreted;
Signal; Toxin; Vasoactive; Vasodilator.
SIGNAL 1 22 {ECO:0000255}.
PROPEP 23 50 {ECO:0000305|PubMed:24394432}.
/FTId=PRO_0000438933.
PEPTIDE 51 61 [Thr6]-bradykinyl-Val,Asp.
{ECO:0000269|PubMed:24394432}.
/FTId=PRO_0000438934.
PEPTIDE 51 59 [Thr6]-bradykinin.
{ECO:0000269|PubMed:24394432}.
/FTId=PRO_0000438935.
COMPBIAS 28 38 Poly-Glu. {ECO:0000255}.
MOD_RES 53 53 4-hydroxyproline; in form [Hyp3,Thr6]-
bradykinyl-Val,Asp and [Hyp3,Thr6]-
bradykinin.
{ECO:0000269|PubMed:24394432}.
SEQUENCE 61 AA; 7389 MW; AD0730EB02116862 CRC64;
MSFLKKSLFL VLFLGFVSFS ICEEEKREDE EEENEREENK ESEEKRNQEE RPPGFTPFRV
D


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