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12-alpha-hydroxysteroid dehydrogenase (EC 1.1.1.176) (Fragment)

 12AH_CLOS4              Reviewed;          29 AA.
P21215;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-AUG-1991, sequence version 1.
28-FEB-2018, entry version 48.
RecName: Full=12-alpha-hydroxysteroid dehydrogenase;
EC=1.1.1.176;
Flags: Fragment;
Clostridium sp. (strain ATCC 29733 / VPI C48-50).
Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
Clostridium.
NCBI_TaxID=1507;
[1]
PROTEIN SEQUENCE.
PubMed=2007406; DOI=10.1111/j.1432-1033.1991.tb15835.x;
Braun M., Luensdorf H., Bueckmann A.F.;
"12 alpha-hydroxysteroid dehydrogenase from Clostridium group P,
strain C 48-50. Production, purification and characterization.";
Eur. J. Biochem. 196:439-450(1991).
-!- FUNCTION: Catalyzes the oxidation of the 12-alpha-hydroxyl group
of bile acids, both in their free and conjugated form. Also acts
on bile alcohols.
-!- CATALYTIC ACTIVITY: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-
cholanate + NADP(+) = 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-
cholanate + NADPH.
-!- SUBUNIT: Homotetramer.
-!- MISCELLANEOUS: The thermostability of the enzyme is greatly
increased due to NADP binding.
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PIR; S14099; S14099.
SMR; P21215; -.
BioCyc; MetaCyc:MONOMER-15705; -.
GO; GO:0047013; F:cholate 12-alpha dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0030573; P:bile acid catabolic process; IEA:UniProtKB-KW.
GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
SUPFAM; SSF51735; SSF51735; 1.
1: Evidence at protein level;
Bile acid catabolism; Direct protein sequencing; Lipid degradation;
Lipid metabolism; NADP; Oxidoreductase; Steroid metabolism.
CHAIN 1 >29 12-alpha-hydroxysteroid dehydrogenase.
/FTId=PRO_0000064347.
NON_TER 29 29
SEQUENCE 29 AA; 2900 MW; A827DB34DB6C8812 CRC64;
MIFDGKVAII TGGGKAKSIG YGIAVAYAK


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