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13S globulin seed storage protein 3 (Legumin-like protein 3) (allergen Fag e 1) [Cleaved into: 13S globulin seed storage protein 3 acidic chain; 13S globulin seed storage protein 3 basic chain]

 13S3_FAGES              Reviewed;         538 AA.
Q9XFM4; Q9M641;
11-APR-2003, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
28-FEB-2018, entry version 69.
RecName: Full=13S globulin seed storage protein 3;
AltName: Full=Legumin-like protein 3;
AltName: Allergen=Fag e 1;
Contains:
RecName: Full=13S globulin seed storage protein 3 acidic chain;
Contains:
RecName: Full=13S globulin seed storage protein 3 basic chain;
Flags: Precursor;
Name=FAGAG1;
Fagopyrum esculentum (Common buckwheat) (Polygonum fagopyrum).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; Caryophyllales; Polygonaceae; Polygonoideae; Fagopyreae;
Fagopyrum.
NCBI_TaxID=3617;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Miyazaki zairai;
Nair A., Ohmoto T., Woo S.H., Adachi T.;
"A molecular-genetic approach for hypoallergenic buckwheat.";
Fagopyrum 16:29-36(1999).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 348-538.
PubMed=12806007; DOI=10.1100/tsw.2002.157;
Nair A., Adachi T.;
"Screening and selection of hypoallergenic buckwheat species.";
ScientificWorldJournal 2:818-826(2002).
-!- FUNCTION: Seed storage protein.
-!- SUBUNIT: Hexamer; each subunit is composed of an acidic and a
basic chain derived from a single precursor and linked by a
disulfide bond. {ECO:0000250}.
-!- ALLERGEN: Causes an allergic reaction in human.
-!- SIMILARITY: Belongs to the 11S seed storage protein (globulins)
family. {ECO:0000305}.
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EMBL; AF152003; AAD32713.1; -; mRNA.
EMBL; AF216801; AAF34635.1; -; Genomic_DNA.
ProteinModelPortal; Q9XFM4; -.
SMR; Q9XFM4; -.
Allergome; 698; Fag e 1.
PRIDE; Q9XFM4; -.
GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
Gene3D; 2.60.120.10; -; 3.
InterPro; IPR006044; 11S_seedstore_pln.
InterPro; IPR006045; Cupin_1.
InterPro; IPR014710; RmlC-like_jellyroll.
InterPro; IPR011051; RmlC_Cupin_sf.
Pfam; PF00190; Cupin_1; 2.
PRINTS; PR00439; 11SGLOBULIN.
SMART; SM00835; Cupin_1; 2.
SUPFAM; SSF51182; SSF51182; 3.
1: Evidence at protein level;
Allergen; Disulfide bond; Seed storage protein; Signal;
Storage protein.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 347 13S globulin seed storage protein 3
acidic chain. {ECO:0000250}.
/FTId=PRO_0000032007.
CHAIN 348 538 13S globulin seed storage protein 3 basic
chain. {ECO:0000250}.
/FTId=PRO_0000032008.
DISULFID 44 77 {ECO:0000250}.
DISULFID 120 354 Interchain (between acidic and basic
chains). {ECO:0000255}.
SEQUENCE 538 AA; 61164 MW; 41D6BA55220CFDAC CRC64;
MSTKLILSFS LCLMVLSCSA QLLPWQKGQR SRPHHGHQQF QHQCDIQRLT ASEPSRRVRS
EAGVTEIWDH DTPEFRCAGF VAVRVVIQPG GLLLPSYSNA PYITFVEQGR GVQGVVVPGC
PETFQSGSEF EYPRSQRDQR SRQSESGESS RGDQRSRQSE SEESSRGDQR SRQSESEEFS
RGDQHQKIFR IRDGDVIPSP AGVVQWTHNN GDNDLISITL YDANSFQNQL DENVRNFFLA
GQSKQSREDR RSQRQTREEG SDRQSRESQD DEALLEANIL SGFEDEILQE IFRNVDQETI
SKLRGENDQR GFIVQARDLK LRVPEEYEEE LQRERGDRKR GGSGRSNGLE QAFCNLKFRQ
NVNRPSRADV FNPRAGRINT VDSNNLPILE FIQLSAQHVV LYKNAILGPR WNLNAHSALY
VTRGEGRVQV VGDEGRSVFD DNVQRGQILV VPQGFAVVLK AGREGLEWVE LKNDDNAITS
PIAGKTSVLR AIPVEVLANS YDISTKEAFR LKNGRQEVEV FRPFQSRDEK ERERFSIV


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