Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)]

 3BHS1_RAT               Reviewed;         373 AA.
P22071; Q19P43;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
23-MAY-2018, entry version 142.
RecName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1;
AltName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I;
Short=3-beta-HSD I;
Includes:
RecName: Full=3-beta-hydroxy-Delta(5)-steroid dehydrogenase;
EC=1.1.1.145;
AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase;
AltName: Full=Progesterone reductase;
Includes:
RecName: Full=Steroid Delta-isomerase;
EC=5.3.3.1;
AltName: Full=Delta-5-3-ketosteroid isomerase;
Name=Hsd3b1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1985917;
Zhao H.-F., Labrie C., Simard J., de Launoit Y., Trudel C., Martel C.,
Rheaume E., Dupont E., Luu-The V., Pelletier G., Labrie F.;
"Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-
delta 4 isomerase cDNAs and differential tissue-specific expression of
the corresponding mRNAs in steroidogenic and peripheral tissues.";
J. Biol. Chem. 266:583-593(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
PubMed=1955079; DOI=10.1016/0303-7207(91)90139-J;
Lorence M.C., Naville D., Graham-Lorence S.E., Mack S.O., Murry B.A.,
Trant J.M., Mason J.I.;
"3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase expression
in rat and characterization of the testis isoform.";
Mol. Cell. Endocrinol. 80:21-31(1991).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 227-358.
STRAIN=Wistar;
Si J.L., Li J., Xu X.Q.;
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: 3-beta-HSD is a bifunctional enzyme, that catalyzes the
oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and
the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic
system plays a crucial role in the biosynthesis of all classes of
hormonal steroids.
-!- CATALYTIC ACTIVITY: A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a
3-oxo-Delta(5)-steroid + NADH.
-!- CATALYTIC ACTIVITY: A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-
steroid.
-!- PATHWAY: Lipid metabolism; steroid biosynthesis.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
membrane protein. Mitochondrion membrane; Single-pass membrane
protein.
-!- TISSUE SPECIFICITY: Adrenal glands, testes and ovaries.
-!- SIMILARITY: Belongs to the 3-beta-HSD family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M38178; AAA63474.1; -; mRNA.
EMBL; BC086578; AAH86578.1; -; mRNA.
EMBL; DQ515797; ABF70960.1; -; mRNA.
PIR; A39051; DERTH1.
RefSeq; NP_001007720.3; NM_001007719.3.
UniGene; Rn.128814; -.
ProteinModelPortal; P22071; -.
GeneID; 360348; -.
KEGG; rno:360348; -.
UCSC; RGD:1308676; rat.
CTD; 3283; -.
RGD; 1308676; Hsd3b1.
HOGENOM; HOG000167989; -.
HOVERGEN; HBG000014; -.
InParanoid; P22071; -.
KO; K00070; -.
PhylomeDB; P22071; -.
BRENDA; 1.1.1.145; 5301.
BRENDA; 5.3.3.1; 5301.
UniPathway; UPA00062; -.
PRO; PR:P22071; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
GO; GO:0030061; C:mitochondrial crista; IDA:RGD.
GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IDA:RGD.
GO; GO:0102294; F:cholesterol dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0035410; F:dihydrotestosterone 17-beta-dehydrogenase activity; IDA:RGD.
GO; GO:0051287; F:NAD binding; IDA:RGD.
GO; GO:0005496; F:steroid binding; IPI:RGD.
GO; GO:0004769; F:steroid delta-isomerase activity; IDA:RGD.
GO; GO:0030325; P:adrenal gland development; IEP:RGD.
GO; GO:0018879; P:biphenyl metabolic process; IEP:RGD.
GO; GO:0008207; P:C21-steroid hormone metabolic process; IDA:RGD.
GO; GO:0071236; P:cellular response to antibiotic; IEP:RGD.
GO; GO:0071320; P:cellular response to cAMP; IEP:RGD.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEP:RGD.
GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEP:RGD.
GO; GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
GO; GO:0071371; P:cellular response to gonadotropin stimulus; IEP:RGD.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
GO; GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IEP:RGD.
GO; GO:0071288; P:cellular response to mercury ion; IEP:RGD.
GO; GO:0071406; P:cellular response to methylmercury; IEP:RGD.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
GO; GO:0018894; P:dibenzo-p-dioxin metabolic process; IEP:RGD.
GO; GO:0016101; P:diterpenoid metabolic process; IEP:RGD.
GO; GO:0008585; P:female gonad development; IEP:RGD.
GO; GO:0030851; P:granulocyte differentiation; IEP:RGD.
GO; GO:0021766; P:hippocampus development; IEP:RGD.
GO; GO:0017143; P:insecticide metabolic process; IEP:RGD.
GO; GO:0033327; P:Leydig cell differentiation; IEP:RGD.
GO; GO:0008584; P:male gonad development; IEP:RGD.
GO; GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD.
GO; GO:0006082; P:organic acid metabolic process; IEP:RGD.
GO; GO:0030728; P:ovulation; IEP:RGD.
GO; GO:0018958; P:phenol-containing compound metabolic process; IEP:RGD.
GO; GO:0046470; P:phosphatidylcholine metabolic process; IEP:RGD.
GO; GO:0006701; P:progesterone biosynthetic process; IDA:RGD.
GO; GO:0014823; P:response to activity; IEP:RGD.
GO; GO:0043279; P:response to alkaloid; IEP:RGD.
GO; GO:0046685; P:response to arsenic-containing substance; IEP:RGD.
GO; GO:0046686; P:response to cadmium ion; IEP:RGD.
GO; GO:0051592; P:response to calcium ion; IEP:RGD.
GO; GO:0051412; P:response to corticosterone; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0045471; P:response to ethanol; IEP:RGD.
GO; GO:0070542; P:response to fatty acid; IEP:RGD.
GO; GO:0060992; P:response to fungicide; IEP:RGD.
GO; GO:0009635; P:response to herbicide; IEP:RGD.
GO; GO:0033591; P:response to L-ascorbic acid; IEP:RGD.
GO; GO:0010288; P:response to lead ion; IEP:RGD.
GO; GO:0010226; P:response to lithium ion; IEP:RGD.
GO; GO:0010038; P:response to metal ion; IEP:RGD.
GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0010033; P:response to organic substance; IEP:RGD.
GO; GO:0033197; P:response to vitamin E; IEP:RGD.
GO; GO:0008202; P:steroid metabolic process; IDA:RGD.
GO; GO:0061370; P:testosterone biosynthetic process; IEP:RGD.
GO; GO:0018970; P:toluene metabolic process; IEP:RGD.
InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF01073; 3Beta_HSD; 1.
SUPFAM; SSF51735; SSF51735; 2.
2: Evidence at transcript level;
Complete proteome; Endoplasmic reticulum; Isomerase; Membrane;
Mitochondrion; Multifunctional enzyme; NAD; Oxidoreductase;
Reference proteome; Steroidogenesis; Transmembrane;
Transmembrane helix.
CHAIN 1 373 3 beta-hydroxysteroid dehydrogenase/Delta
5-->4-isomerase type 1.
/FTId=PRO_0000087787.
TRANSMEM 288 308 Helical. {ECO:0000255}.
ACT_SITE 155 155 Proton acceptor. {ECO:0000250}.
BINDING 159 159 NAD. {ECO:0000250}.
SEQUENCE 373 AA; 42037 MW; 1BB058B5171C2F24 CRC64;
MPGWSCLVTG AGGFVGQRII RMLVQEKELQ EVRALDKVFR PETKEEFSKL QTKAKVTMLE
GDILDAQYLR RACQGISVVI HTAAVIDVSH VLPRQTILDV NLKGTQNILE ACVEASVPAF
IYCSTVDVAG PNSYKKIILN GHEEEHHEST WSDAYPYSKR MAEKAVLAAN GSILKNGGTL
HTCALRPMYI YGERSPFLSV MILAALKNKG ILNVTGKFSI ANPVYVGNVA WAHILAARGL
RDPKKSQNVQ GQFYYISDDT PHQSYDDLNC TLSKEWGLRL DSSWSLPLPL LYWLAFLLET
VSFLLRPFYN YRPPFNCHLV TLSNSKFTFS YKKAQRDLGY VPLVSWEEAK QKTSEWIGTL
VEQHRETLDT KSQ


Related products :

Catalog number Product name Quantity
CSB-EL010781RA Rat hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (HSD3B1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL010783RA Rat hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 (HSD3B7) ELISA kit, Species Rat, Sample Type serum, plasma 96T
GS-1013a hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 primary antibody, Host: Rabbit 200ul
HSDL2 HSD3B7 Gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
201-20-2638 HSD3B2{hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2}rabbit.pAb 0.2ml
201-20-2639 HSD3B7{hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7}rabbit.pAb 0.2ml
HSD3B7 HSD3B1 Gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSDL1 HSD3B2 Gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
CSB-EL010782HU Human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL010782MO Mouse hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL010781MO Mouse hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (HSD3B1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL010781RH Monkey hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (HSD3B1) ELISA kit, Species Monkey, Sample Type serum, plasma 96T
CSB-EL010781HU Human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (HSD3B1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL010783HU Human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 (HSD3B7) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL010783MO Mouse hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 (HSD3B7) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-PA010782GA01HU Rabbit anti-human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 polyclonal Antibody Primary antibody Host:Rabbit IgG 50ul
CSB-PA010783GA01HU Rabbit anti-human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 polyclonal Antibody Primary antibody Host:Rabbit IgG 150ul
CSB-PA010783GA01HU Rabbit anti-human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 polyclonal Antibody Primary antibody Host:Rabbit IgG 50ul
CSB-PA010782GA01HU Rabbit anti-human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 polyclonal Antibody Primary antibody Host:Rabbit IgG 150ul
EIAAB12331 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase,Cholestenol Delta-isomerase,D8-D7 sterol isomerase,Delta(8)-Delta(7) sterol isomerase,EBP,Emopamil-binding protein,Homo sapiens,Human
EIAAB12332 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase,Cholestenol Delta-isomerase,D8-D7 sterol isomerase,Delta(8)-Delta(7) sterol isomerase,Ebp,Emopamil-binding protein,Mouse,Msi,Mus musculus
EIAAB12333 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase,Cholestenol Delta-isomerase,D8-D7 sterol isomerase,Delta(8)-Delta(7) sterol isomerase,Ebp,Emopamil-binding protein,Rat,Rattus norvegicus,Rsi,Sterol 8-
EH2238 3 beta-hydroxysteroid dehydrogenase per Delta 5-->4-isomerase type 1 Elisa Kit 96T
ER665 3 beta-hydroxysteroid dehydrogenase per Delta 5-->4-isomerase type 1 Elisa Kit 96T
3BHS2_MOUSE Mouse ELISA Kit FOR 3 beta-hydroxysteroid dehydrogenase per Delta 5-->4-isomerase type 2 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur