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3 beta-hydroxysteroid dehydrogenase type 4 (3 beta-hydroxysteroid dehydrogenase type IV) (3-beta-HSD IV) (3-beta-hydroxy-5-ene steroid dehydrogenase) (NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.-) (Progesterone reductase)

 3BHS4_MOUSE             Reviewed;         373 AA.
Q61767;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
12-SEP-2018, entry version 162.
RecName: Full=3 beta-hydroxysteroid dehydrogenase type 4;
AltName: Full=3 beta-hydroxysteroid dehydrogenase type IV;
Short=3-beta-HSD IV;
AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase;
AltName: Full=NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase;
EC=1.1.1.-;
AltName: Full=Progesterone reductase;
Name=Hsd3b4;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=ICR (CD-1); TISSUE=Kidney;
PubMed=8145763; DOI=10.1210/mend.7.12.8145763;
Clarke T.R., Bain P.A., Greco T.L., Payne A.H.;
"A novel mouse kidney 3 beta-hydroxysteroid dehydrogenase
complementary DNA encodes a 3-ketosteroid reductase instead of a 3
beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase.";
Mol. Endocrinol. 7:1569-1578(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: The 3-beta-HSD enzymatic system plays a crucial role in
the biosynthesis of all classes of hormonal steroids. HSD IV can
only catalyze the conversion of dihydrotestosterone to 5 alpha-
androstanediol in the presence of the cofactor NADPH. Does not
function as a isomerase.
-!- CATALYTIC ACTIVITY: 3-beta-hydroxy-Delta(5)-steroid + NADP(+) = 3-
oxo-Delta(5)-steroid + NADPH.
-!- PATHWAY: Lipid metabolism; steroid biosynthesis.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
membrane protein. Mitochondrion membrane; Single-pass membrane
protein.
-!- TISSUE SPECIFICITY: Kidney; found only in the cortex, appears to
be associated with the proximal tubules; and a minor expression in
testis.
-!- DEVELOPMENTAL STAGE: Expression between 15-20 days post-
implantation occurs only in the kidney of the male fetus and not
in the female, whereas a similar expression is found in adult male
and female kidneys.
-!- SIMILARITY: Belongs to the 3-beta-HSD family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L16919; AAA39374.1; -; mRNA.
EMBL; BC013449; AAH13449.1; -; mRNA.
CCDS; CCDS17665.1; -.
PIR; A49573; A49573.
RefSeq; NP_001104806.1; NM_001111336.1.
RefSeq; NP_001257358.1; NM_001270429.1.
RefSeq; NP_032320.1; NM_008294.2.
RefSeq; XP_017174900.1; XM_017319411.1.
RefSeq; XP_017174957.1; XM_017319468.1.
UniGene; Mm.14309; -.
UniGene; Mm.475664; -.
ProteinModelPortal; Q61767; -.
SMR; Q61767; -.
IntAct; Q61767; 730.
MINT; Q61767; -.
STRING; 10090.ENSMUSP00000136588; -.
iPTMnet; Q61767; -.
PhosphoSitePlus; Q61767; -.
MaxQB; Q61767; -.
PaxDb; Q61767; -.
PRIDE; Q61767; -.
Ensembl; ENSMUST00000058728; ENSMUSP00000055886; ENSMUSG00000095388.
Ensembl; ENSMUST00000178221; ENSMUSP00000136749; ENSMUSG00000095388.
Ensembl; ENSMUST00000179429; ENSMUSP00000136588; ENSMUSG00000095143.
Ensembl; ENSMUST00000186215; ENSMUSP00000140584; ENSMUSG00000095388.
Ensembl; ENSMUST00000196861; ENSMUSP00000142522; ENSMUSG00000095143.
GeneID; 100043456; -.
GeneID; 15495; -.
KEGG; mmu:100043456; -.
KEGG; mmu:15495; -.
UCSC; uc008qpw.3; mouse.
CTD; 15495; -.
MGI; MGI:96236; Hsd3b4.
eggNOG; KOG1430; Eukaryota.
eggNOG; COG0451; LUCA.
GeneTree; ENSGT00550000074557; -.
HOGENOM; HOG000167989; -.
HOVERGEN; HBG000014; -.
InParanoid; Q61767; -.
KO; K00070; -.
OMA; HECISTD; -.
OrthoDB; EOG091G0KJE; -.
PhylomeDB; Q61767; -.
TreeFam; TF343138; -.
Reactome; R-MMU-193048; Androgen biosynthesis.
Reactome; R-MMU-193993; Mineralocorticoid biosynthesis.
Reactome; R-MMU-194002; Glucocorticoid biosynthesis.
UniPathway; UPA00062; -.
PRO; PR:Q61767; -.
Proteomes; UP000000589; Chromosome 3.
Bgee; ENSMUSG00000095143; Expressed in 40 organ(s), highest expression level in adult mammalian kidney.
ExpressionAtlas; Q61767; baseline and differential.
Genevisible; Q61767; MM.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
GO; GO:0005743; C:mitochondrial inner membrane; HDA:MGI.
GO; GO:0005739; C:mitochondrion; HDA:MGI.
GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; ISO:MGI.
GO; GO:0051287; F:NAD binding; ISO:MGI.
GO; GO:0005496; F:steroid binding; ISO:MGI.
GO; GO:0035634; P:response to stilbenoid; IEP:UniProtKB.
GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-UniPathway.
InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF01073; 3Beta_HSD; 1.
SUPFAM; SSF51735; SSF51735; 2.
2: Evidence at transcript level;
Acetylation; Complete proteome; Endoplasmic reticulum; Membrane;
Mitochondrion; NADP; Oxidoreductase; Reference proteome;
Steroidogenesis; Transmembrane; Transmembrane helix.
CHAIN 1 373 3 beta-hydroxysteroid dehydrogenase type
4.
/FTId=PRO_0000087783.
TRANSMEM 288 308 Helical. {ECO:0000255}.
ACT_SITE 155 155 Proton acceptor. {ECO:0000250}.
BINDING 159 159 NAD. {ECO:0000250}.
MOD_RES 350 350 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q61694}.
SEQUENCE 373 AA; 41766 MW; 303E56BF9A8FAF1A CRC64;
MPGWSCLVTG AGGFLGQRIV RMLVQEEELQ EIRALFRTFG RKQEEELSKL QTKTKVTVLK
GDILDAQCLK RACQGMSAVI HTAAAIDPLG AASRQTILDV NLKGTQLLLD ACVEANVPTF
IYSSSVLVAG PNSYKEIILN AHEEEHHEST WSNPYPYSKK MAEKAVLAAN GSILKNGGTL
HTCALRLSFI YGEECQVTST TVKTALKNNS IIKKNATFSI ANPVYVGNAA WAHILAARSL
QDPKKSPSIQ GQFYYITDDT PHQSYDDLKC TLSKEWGLRL DTSWSLPLPL LYWLAFLLET
VSFLLRPVYN YRPPFNRLLI TVLNSVFTFS YKKAQRDLGY EPLVSWEEAK QKTSEWIGTL
VMQHREIGNK KSQ


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