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3-deoxy-D-manno-octulosonic acid transferase (Kdo transferase) (EC 2.4.99.12) (EC 2.4.99.13) (EC 2.4.99.14) (Kdo(2)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase) (Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase) (Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase) (Trifunctional Kdo transferase)

 KDTA_CHLPN              Reviewed;         437 AA.
Q46222; Q46224; Q9JS00; Q9S6B4;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 3.
27-SEP-2017, entry version 124.
RecName: Full=3-deoxy-D-manno-octulosonic acid transferase;
Short=Kdo transferase;
EC=2.4.99.12 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:8748024};
EC=2.4.99.13 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:8748024};
EC=2.4.99.14 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:8748024};
AltName: Full=Kdo(2)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase;
AltName: Full=Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase;
AltName: Full=Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase;
AltName: Full=Trifunctional Kdo transferase;
Name=waaA; Synonyms=gseA, kdtA;
OrderedLocusNames=CPn_0154, CP_0617, CpB0155;
Chlamydia pneumoniae (Chlamydophila pneumoniae).
Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
Chlamydia/Chlamydophila group; Chlamydia.
NCBI_TaxID=83558;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, AND
TRIFUNCTIONALITY.
STRAIN=TW-183;
PubMed=8748024; DOI=10.1111/j.1365-2958.1995.mmi_18030391.x;
Loebau S., Mamat U., Brabetz W., Brade H.;
"Molecular cloning, sequence analysis, and functional characterization
of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-
alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae
strain TW-183.";
Mol. Microbiol. 18:391-399(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CWL029;
PubMed=10192388; DOI=10.1038/7716;
Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
"Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
Nat. Genet. 21:385-389(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AR39;
PubMed=10684935; DOI=10.1093/nar/28.6.1397;
Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
pneumoniae AR39.";
Nucleic Acids Res. 28:1397-1406(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=J138;
PubMed=10871362; DOI=10.1093/nar/28.12.2311;
Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
"Comparison of whole genome sequences of Chlamydia pneumoniae J138
from Japan and CWL029 from USA.";
Nucleic Acids Res. 28:2311-2314(2000).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TW-183;
Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
"The genome sequence of Chlamydia pneumoniae TW183 and comparison with
other Chlamydia strains based on whole genome sequence analysis.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Koala type I;
PubMed=9765820; DOI=10.1016/S0923-2508(97)83872-7;
Girjes A., Carrick F.N., Lavin M.F.;
"Lipopolysaccharide biosynthesis genes in koala type I Chlamydia:
cloning and characterization.";
Res. Microbiol. 148:413-425(1997).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-329.
STRAIN=AR3883;
Kaltenboeck B., Gao D.;
"PCR amplification and sequencing of the partial coding region of the
Kdo transferase of Chlamydia.";
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
[8]
FUNCTION, CATALYTIC ACTIVITY, AND TRIFUNCTIONALITY.
STRAIN=TW-183;
PubMed=10951204; DOI=10.1046/j.1432-1327.2000.01619.x;
Brabetz W., Lindner B., Brade H.;
"Comparative analyses of secondary gene products of 3-deoxy-D-manno-
oct-2-ulosonic acid transferases from Chlamydiaceae in Escherichia
coli K-12.";
Eur. J. Biochem. 267:5458-5465(2000).
-!- FUNCTION: Involved in lipopolysaccharide (LPS) biosynthesis.
Catalyzes the transfer of three 3-deoxy-D-manno-octulosonate (Kdo)
residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-
1,4'-bisphosphate precursor of lipid A. Thus generates the genus-
specific LPS epitope of Chlamydia, composed of the trisaccharide
alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo.
{ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:8748024}.
-!- CATALYTIC ACTIVITY: Lipid IV(A) + CMP-beta-Kdo = alpha-Kdo-(2->6)-
lipid IV(A) + CMP. {ECO:0000269|PubMed:10951204,
ECO:0000269|PubMed:8748024}.
-!- CATALYTIC ACTIVITY: Alpha-Kdo-(2->6)-lipid IV(A) + CMP-beta-Kdo =
alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IV(A) + CMP.
{ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:8748024}.
-!- CATALYTIC ACTIVITY: Alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IV(A)
+ CMP-beta-Kdo = alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-
(2->6)-lipid IV(A) + CMP. {ECO:0000269|PubMed:10951204,
ECO:0000269|PubMed:8748024}.
-!- PATHWAY: Bacterial outer membrane biogenesis; LPS core
biosynthesis.
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-
pass membrane protein {ECO:0000250}; Cytoplasmic side
{ECO:0000250}.
-!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
Glycosyltransferase 30 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Z31593; CAA83470.1; -; Genomic_DNA.
EMBL; AE001363; AAD18307.1; -; Genomic_DNA.
EMBL; AE002161; AAF38432.1; -; Genomic_DNA.
EMBL; BA000008; BAA98364.1; -; Genomic_DNA.
EMBL; AE009440; AAP98088.1; -; Genomic_DNA.
EMBL; X80061; CAA56368.1; -; Genomic_DNA.
EMBL; AF111204; AAD20340.1; -; Genomic_DNA.
PIR; B86510; B86510.
PIR; E81557; E81557.
PIR; S70546; S70546.
RefSeq; NP_224362.1; NC_000922.1.
RefSeq; WP_010882804.1; NZ_LN847257.1.
RefSeq; WP_010892118.1; NZ_LN846995.1.
ProteinModelPortal; Q46222; -.
STRING; 182082.CpB0155; -.
CAZy; GT30; Glycosyltransferase Family 30.
EnsemblBacteria; AAD18307; AAD18307; CPn_0154.
EnsemblBacteria; AAF38432; AAF38432; CP_0617.
EnsemblBacteria; AAP98088; AAP98088; CpB0155.
EnsemblBacteria; BAA98364; BAA98364; BAA98364.
GeneID; 894969; -.
KEGG; cpa:CP_0617; -.
KEGG; cpj:gseA; -.
KEGG; cpn:CPn0154; -.
KEGG; cpt:CpB0155; -.
PATRIC; fig|115713.3.peg.176; -.
eggNOG; ENOG4105D8A; Bacteria.
eggNOG; COG1519; LUCA.
HOGENOM; HOG000035072; -.
KO; K02527; -.
OrthoDB; POG091H01YQ; -.
BioCyc; MetaCyc:MONOMER-15504; -.
BRENDA; 2.4.99.12; 1311.
BRENDA; 2.4.99.13; 1311.
BRENDA; 2.4.99.14; 1311.
UniPathway; UPA00958; -.
Proteomes; UP000000583; Chromosome.
Proteomes; UP000000801; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway.
InterPro; IPR007507; Glycos_transf_N.
Pfam; PF04413; Glycos_transf_N; 1.
1: Evidence at protein level;
Cell inner membrane; Cell membrane; Complete proteome;
Lipopolysaccharide biosynthesis; Membrane; Signal-anchor; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1 437 3-deoxy-D-manno-octulosonic acid
transferase.
/FTId=PRO_0000080283.
TRANSMEM 16 36 Helical; Signal-anchor. {ECO:0000255}.
REGION 279 280 CMP-Kdo binding. {ECO:0000250}.
REGION 319 321 CMP-Kdo binding. {ECO:0000250}.
REGION 346 349 CMP-Kdo binding. {ECO:0000250}.
ACT_SITE 70 70 Proton acceptor. {ECO:0000250}.
SITE 141 141 Transition state stabilizer.
{ECO:0000250}.
SITE 219 219 Transition state stabilizer.
{ECO:0000250}.
VARIANT 6 6 V -> I (in strain: Koala type I).
VARIANT 183 183 N -> T (in strain: Koala type I).
VARIANT 201 201 R -> P (in strain: Koala type I).
VARIANT 234 234 T -> A (in strain: Koala type I).
VARIANT 249 249 I -> V (in strain: Koala type I).
VARIANT 311 312 VP -> TS (in strain: Koala type I).
VARIANT 368 369 EL -> DV (in strain: Koala type I).
VARIANT 401 401 V -> M (in strain: Koala type I).
VARIANT 413 413 V -> L (in strain: Koala type I).
CONFLICT 137 137 V -> A (in Ref. 3 and 4). {ECO:0000305}.
CONFLICT 154 164 RIGATTLVING -> TYRCNYSRHQW (in Ref. 6;
CAA56368). {ECO:0000305}.
CONFLICT 295 307 LHIPYGLWSRGAN -> CTFLMGCGAVVHQ (in Ref.
6). {ECO:0000305}.
CONFLICT 319 321 IGL -> NWLV (in Ref. 6; CAA56368).
{ECO:0000305}.
SEQUENCE 437 AA; 49187 MW; 99BF3083E4858250 CRC64;
MMLRGVHRIF KCFYDVVLVC AFVIALPKLL YKMLVYGKYK KSLAVRFGLK KPHVPGEGPL
VWFHGASVGE VRLLLPVLEK FCEEFPGWRC LVTSCTELGV QVASQVFIPM GATVSILPLD
FSIIIKSVVA KLRPSLVVFS EGDCWLNFIE EAKRIGATTL VINGRISIDS SKRFKFLKRL
GKNYFSPVDG FLLQDEVQKQ RFLSLGIPEH KLQVTGNIKT YVAAQTALHL ERETWRDRLR
LPTDSKLVIL GSMHRSDAGK WLPVVQKLIK EGVSVLWVPR HVEKTKDVEE SLHRLHIPYG
LWSRGANFSY VPVVVVDEIG LLKQLYVAGD LAFVGGTFDP KIGGHNLLEP LQCEVPLIFG
PHITSQSELA QRLLLSGAGL CLDEIEPIID TVSFLLNNQE VREAYVQKGK VFVKAETASF
DRTWRALKSY IPLYKNS


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