Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1 1 1 35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1 1 1 51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1 1 1 178) (3-hydroxyacyl-CoA dehydrogenase type II) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Type II HADH)

 HCD2_BOVIN              Reviewed;         261 AA.
O02691; Q2TBG6;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
12-SEP-2018, entry version 135.
RecName: Full=3-hydroxyacyl-CoA dehydrogenase type-2;
EC=1.1.1.35 {ECO:0000250|UniProtKB:Q99714};
AltName: Full=17-beta-hydroxysteroid dehydrogenase 10;
Short=17-beta-HSD 10;
EC=1.1.1.51 {ECO:0000250|UniProtKB:Q99714};
AltName: Full=3-hydroxy-2-methylbutyryl-CoA dehydrogenase;
EC=1.1.1.178 {ECO:0000250|UniProtKB:Q99714};
AltName: Full=3-hydroxyacyl-CoA dehydrogenase type II;
AltName: Full=Mitochondrial ribonuclease P protein 2;
Short=Mitochondrial RNase P protein 2;
AltName: Full=Type II HADH;
Name=HSD17B10; Synonyms=HADH2;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Liver;
PubMed=9061028; DOI=10.1016/S0167-4781(96)00171-6;
Furuta S., Kobayashi A., Miyazawa S., Hashimoto T.;
"Cloning and expression of cDNA for a newly identified isozyme of
bovine liver 3-hydroxyacyl-CoA dehydrogenase and its import into
mitochondria.";
Biochim. Biophys. Acta 1350:317-324(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Liver;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Mitochondrial dehydrogenase that catalyzes the beta-
oxidation at position 17 of androgens and estrogens and has 3-
alpha-hydroxysteroid dehydrogenase activity with androsterone.
Catalyzes the third step in the beta-oxidation of fatty acids.
Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile
acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities
with C21 steroids. By interacting with intracellular amyloid-beta,
it may contribute to the neuronal dysfunction associated with
Alzheimer disease (AD). Essential for structural and functional
integrity of mitochondria. {ECO:0000250|UniProtKB:Q99714}.
-!- FUNCTION: In addition to mitochondrial dehydrogenase activity,
moonlights as a component of mitochondrial ribonuclease P, a
complex that cleaves tRNA molecules in their 5'-ends. Together
with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial
ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays
functions that are independent of the ribonuclease P activity. The
MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-
methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9,
respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic
subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation
platform: following 5'-end cleavage by the mitochondrial
ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the
efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA
product after ELAC2 processing and presents the nascent tRNA to
the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme.
{ECO:0000250|UniProtKB:Q99714}.
-!- CATALYTIC ACTIVITY: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA +
NAD(+) = 2-methylacetoacetyl-CoA + NADH.
{ECO:0000250|UniProtKB:Q99714}.
-!- CATALYTIC ACTIVITY: Testosterone + NAD(P)(+) = androst-4-ene-3,17-
dione + NAD(P)H. {ECO:0000250|UniProtKB:Q99714}.
-!- CATALYTIC ACTIVITY: (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA
+ NADH. {ECO:0000250|UniProtKB:Q99714}.
-!- SUBUNIT: Homotetramer. Component of mitochondrial ribonuclease P,
a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP31.
Interacts with TRMT10C/MRPP1; forming the MRPP1-MRPP2 subcomplex
of the mitochondrial ribonuclease P complex.
{ECO:0000250|UniProtKB:Q99714}.
-!- SUBCELLULAR LOCATION: Mitochondrion
{ECO:0000250|UniProtKB:Q99714}.
-!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
(SDR) family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AB002156; BAA19510.1; -; mRNA.
EMBL; BC110264; AAI10265.1; -; mRNA.
RefSeq; NP_776759.1; NM_174334.3.
UniGene; Bt.5231; -.
ProteinModelPortal; O02691; -.
SMR; O02691; -.
IntAct; O02691; 1.
STRING; 9913.ENSBTAP00000023642; -.
PaxDb; O02691; -.
PeptideAtlas; O02691; -.
PRIDE; O02691; -.
Ensembl; ENSBTAT00000023642; ENSBTAP00000023642; ENSBTAG00000017779.
GeneID; 281809; -.
KEGG; bta:281809; -.
CTD; 3028; -.
VGNC; VGNC:29969; HSD17B10.
eggNOG; KOG1199; Eukaryota.
eggNOG; ENOG410XNNW; LUCA.
GeneTree; ENSGT00920000148965; -.
HOVERGEN; HBG002145; -.
InParanoid; O02691; -.
KO; K08683; -.
OMA; LMGLVNC; -.
OrthoDB; EOG091G0G9O; -.
TreeFam; TF354307; -.
BRENDA; 1.1.1.135; 908.
Reactome; R-BTA-70895; Branched-chain amino acid catabolism.
Proteomes; UP000009136; Chromosome X.
Bgee; ENSBTAG00000017779; Expressed in 9 organ(s), highest expression level in liver.
GO; GO:0030678; C:mitochondrial ribonuclease P complex; ISS:UniProtKB.
GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO; GO:0047015; F:3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; ISS:UniProtKB.
GO; GO:0030283; F:testosterone dehydrogenase [NAD(P)] activity; ISS:UniProtKB.
GO; GO:0000049; F:tRNA binding; ISS:UniProtKB.
GO; GO:1990180; P:mitochondrial tRNA 3'-end processing; ISS:UniProtKB.
GO; GO:0097745; P:mitochondrial tRNA 5'-end processing; ISS:UniProtKB.
GO; GO:0070901; P:mitochondrial tRNA methylation; ISS:UniProtKB.
GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR020904; Sc_DH/Rdtase_CS.
InterPro; IPR002347; SDR_fam.
Pfam; PF00106; adh_short; 1.
PRINTS; PR00081; GDHRDH.
PRINTS; PR00080; SDRFAMILY.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00061; ADH_SHORT; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; Direct protein sequencing;
Mitochondrion; NAD; Oxidoreductase; Reference proteome;
tRNA processing.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q99714}.
CHAIN 2 261 3-hydroxyacyl-CoA dehydrogenase type-2.
/FTId=PRO_0000054809.
NP_BIND 12 37 NAD. {ECO:0000250|UniProtKB:Q99714}.
ACT_SITE 168 168 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU10001}.
BINDING 155 155 Substrate.
{ECO:0000250|UniProtKB:Q99714}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:Q99714}.
MOD_RES 53 53 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:O08756}.
MOD_RES 53 53 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:O08756}.
MOD_RES 69 69 N6-acetyllysine.
{ECO:0000250|UniProtKB:O08756}.
MOD_RES 99 99 N6-acetyllysine.
{ECO:0000250|UniProtKB:O08756}.
MOD_RES 105 105 N6-acetyllysine.
{ECO:0000250|UniProtKB:O08756}.
MOD_RES 212 212 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:O08756}.
MOD_RES 212 212 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:O08756}.
SEQUENCE 261 AA; 27140 MW; 8C7572B6A9A49780 CRC64;
MAAACRSVKG LVALITGGAS GLGLATAERL VGQGATAVLL DLPNSDGETQ AKKLGKSCAF
APADVTSEKD VQAALTLARE KFGRVDVAVN CAGIAVASKT YNLKKSQAHT LEDFQRVINV
NLIGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL
PIARDLAPMG IRVMTIAPGL FGTPLLTTLP DKVRNFLASQ VPFPSRLGDP AEYAHLVQAI
IENSFLNGEV IRLDGAIRMQ P


Related products :

Catalog number Product name Quantity
20-272-190169 ERAB - Mitochondrial Marker - Mouse monoclonal [10D12] to ERAB - Mitochondrial Marker; EC 1.1.1.35; 3-hydroxyacyl-CoA dehydrogenase type II; Type II HADH; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 0.1 ml
20-272-190170 ERAB - Mitochondrial Marker - Mouse monoclonal [5F3] to ERAB - Mitochondrial Marker; EC 1.1.1.35; 3-hydroxyacyl-CoA dehydrogenase type II; Type II HADH; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; EC 0.1 ml
EIAAB11152 11-beta-HSD2,11-beta-hydroxysteroid dehydrogenase type 2,11-DH2,Corticosteroid 11-beta-dehydrogenase isozyme 2,Homo sapiens,HSD11B2,HSD11K,Human,NAD-dependent 11-beta-hydroxysteroid dehydrogenase
EIAAB11148 11-beta-HSD2,11-beta-hydroxysteroid dehydrogenase type 2,11-DH2,Corticosteroid 11-beta-dehydrogenase isozyme 2,Hsd11b2,Hsd11k,NAD-dependent 11-beta-hydroxysteroid dehydrogenase,Rat,Rattus norvegicus
EIAAB11149 11-beta-HSD2,11-beta-hydroxysteroid dehydrogenase type 2,11-DH2,Corticosteroid 11-beta-dehydrogenase isozyme 2,HSD11B2,NAD-dependent 11-beta-hydroxysteroid dehydrogenase,Oryctolagus cuniculus,Rabbit
EIAAB11151 11-beta-HSD2,11-beta-hydroxysteroid dehydrogenase type 2,11-DH2,Corticosteroid 11-beta-dehydrogenase isozyme 2,Hsd11b2,Hsd11k,Mouse,Mus musculus,NAD-dependent 11-beta-hydroxysteroid dehydrogenase
EIAAB11106 17-beta-HSD 3,17-beta-hydroxysteroid dehydrogenase type 3,EDH17B3,Homo sapiens,HSD17B3,Human,Testicular 17-beta-hydroxysteroid dehydrogenase,Testosterone 17-beta-dehydrogenase 3
EIAAB11150 11-beta-HSD2,11-beta-hydroxysteroid dehydrogenase type 2,11-DH2,Bos taurus,Bovine,Corticosteroid 11-beta-dehydrogenase isozyme 2,HSD11B2,NAD-dependent 11-beta-hydroxysteroid dehydrogenase
EIAAB11108 17-beta-HSD 3,17-beta-hydroxysteroid dehydrogenase type 3,Edh17b3,Hsd17b3,Rat,Rattus norvegicus,Testicular 17-beta-hydroxysteroid dehydrogenase,Testosterone 17-beta-dehydrogenase 3
EIAAB11107 17-beta-HSD 3,17-beta-hydroxysteroid dehydrogenase type 3,Edh17b3,Hsd17b3,Mouse,Mus musculus,Testicular 17-beta-hydroxysteroid dehydrogenase,Testosterone 17-beta-dehydrogenase 3
15-288-22852 Corticosteroid 11-beta-dehydrogenase isozyme 2 - EC 1.1.1.-; 11-DH2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-HSD2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase Polyclonal 0.05 mg
15-288-22852 Corticosteroid 11-beta-dehydrogenase isozyme 2 - EC 1.1.1.-; 11-DH2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-HSD2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase Polyclonal 0.1 mg
EIAAB11104 17-beta-HSD 2,17-beta-hydroxysteroid dehydrogenase type 2,Edh17b2,Estradiol 17-beta-dehydrogenase 2,Hsd17b2,Mouse,Mus musculus,Testosterone 17-beta-dehydrogenase
EIAAB11103 17-beta-HSD 2,17-beta-hydroxysteroid dehydrogenase type 2,Edh17b2,Estradiol 17-beta-dehydrogenase 2,Hsd17b2,Rat,Rattus norvegicus,Testosterone 17-beta-dehydrogenase
EIAAB11092 17-beta-HSD 1,17-beta-hydroxysteroid dehydrogenase type 1,20 alpha-hydroxysteroid dehydrogenase,20-alpha-HSD,E17KSR,E2DH,EDH17B1,EDH17B2,EDHB17,Estradiol 17-beta-dehydrogenase 1,Homo sapiens,HSD17B1,H
EIAAB11105 17-beta-HSD 2,17-beta-hydroxysteroid dehydrogenase type 2,20 alpha-hydroxysteroid dehydrogenase,20-alpha-HSD,E2DH,EDH17B2,Estradiol 17-beta-dehydrogenase 2,Homo sapiens,HSD17B2,Human,Microsomal 17-bet
EIAAB11146 11-beta-HSD3,11-beta-hydroxysteroid dehydrogenase type 3,11-DH3,Homo sapiens,HSD11B1L,HSD3,Human,Hydroxysteroid 11-beta-dehydrogenase 1-like protein,SCDR10,Short-chain dehydrogenase_reductase 10
CSB-EL010117RA Rat Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial(HADH) ELISA kit 96T
EIAAB11117 17-beta-HSD 8,17-beta-hydroxysteroid dehydrogenase 8,3-oxoacyl-[acyl-carrier-protein] reductase,Estradiol 17-beta-dehydrogenase 8,Hsd17b8,Rat,Rattus norvegicus,Testosterone 17-beta-dehydrogenase 8
15-288-22261 Short chain 3-hydroxyacyl-CoA dehydrogenase. mitochondrial - EC 1.1.1.35; HCDH; Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase Polyclonal 0.05 mg
15-288-22261 Short chain 3-hydroxyacyl-CoA dehydrogenase. mitochondrial - EC 1.1.1.35; HCDH; Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase Polyclonal 0.1 mg
CSB-EL010117PI Pig Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial(HADH) ELISA kit SpeciesPig 96T
CSB-EL010117HU Human Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial(HADH) ELISA kit 96T
CSB-EL010117MO Mouse Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial(HADH) ELISA kit 96T
CSB-EL010117RA Rat Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial(HADH) ELISA kit SpeciesRat 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur