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3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.-) (EC 1.1.1.30) (Dehydrogenase/reductase SDR family member 6) (R-beta-hydroxybutyrate dehydrogenase)

 BDH2_MOUSE              Reviewed;         245 AA.
Q8JZV9;
11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
12-SEP-2018, entry version 118.
RecName: Full=3-hydroxybutyrate dehydrogenase type 2;
EC=1.1.1.-;
EC=1.1.1.30;
AltName: Full=Dehydrogenase/reductase SDR family member 6;
AltName: Full=R-beta-hydroxybutyrate dehydrogenase;
Name=Bdh2; Synonyms=Dhrs6;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
FUNCTION, PATHWAY, TISSUE SPECIFICITY, AND MUTAGENESIS OF TYR-147.
PubMed=20550936; DOI=10.1016/j.cell.2010.04.040;
Devireddy L.R., Hart D.O., Goetz D.H., Green M.R.;
"A mammalian siderophore synthesized by an enzyme with a bacterial
homolog involved in enterobactin production.";
Cell 141:1006-1017(2010).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Dehydrogenase that mediates the formation of 2,5-
dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares
structural similarities with bacterial enterobactin and associates
with LCN2, thereby playing a key role in iron homeostasis and
transport. Also acts as a 3-hydroxybutyrate dehydrogenase.
{ECO:0000269|PubMed:20550936}.
-!- CATALYTIC ACTIVITY: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate
+ NADH.
-!- PATHWAY: Siderophore biosynthesis. {ECO:0000269|PubMed:20550936}.
-!- SUBUNIT: Homotetramer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- TISSUE SPECIFICITY: Widely expressed.
{ECO:0000269|PubMed:20550936}.
-!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
(SDR) family. {ECO:0000305}.
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EMBL; BC036998; AAH36998.1; -; mRNA.
CCDS; CCDS17853.1; -.
RefSeq; NP_081484.1; NM_027208.2.
UniGene; Mm.45121; -.
ProteinModelPortal; Q8JZV9; -.
SMR; Q8JZV9; -.
STRING; 10090.ENSMUSP00000131111; -.
iPTMnet; Q8JZV9; -.
PhosphoSitePlus; Q8JZV9; -.
MaxQB; Q8JZV9; -.
PaxDb; Q8JZV9; -.
PRIDE; Q8JZV9; -.
Ensembl; ENSMUST00000029817; ENSMUSP00000029817; ENSMUSG00000028167.
GeneID; 69772; -.
KEGG; mmu:69772; -.
UCSC; uc008rla.2; mouse.
CTD; 56898; -.
MGI; MGI:1917022; Bdh2.
eggNOG; KOG0725; Eukaryota.
eggNOG; COG1028; LUCA.
GeneTree; ENSGT00920000148965; -.
HOVERGEN; HBG002145; -.
InParanoid; Q8JZV9; -.
KO; K00019; -.
PhylomeDB; Q8JZV9; -.
TreeFam; TF328795; -.
Reactome; R-MMU-77111; Synthesis of Ketone Bodies.
PRO; PR:Q8JZV9; -.
Proteomes; UP000000589; Chromosome 3.
Bgee; ENSMUSG00000028167; Expressed in 169 organ(s), highest expression level in utricle of membranous labyrinth.
CleanEx; MM_BDH2; -.
ExpressionAtlas; Q8JZV9; baseline and differential.
Genevisible; Q8JZV9; MM.
GO; GO:0005737; C:cytoplasm; ISS:HGNC.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0003858; F:3-hydroxybutyrate dehydrogenase activity; ISS:HGNC.
GO; GO:0051287; F:NAD binding; ISS:HGNC.
GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IMP:UniProtKB.
GO; GO:0030855; P:epithelial cell differentiation; ISO:MGI.
GO; GO:0006635; P:fatty acid beta-oxidation; ISS:HGNC.
GO; GO:0042168; P:heme metabolic process; ISS:UniProtKB.
GO; GO:0055072; P:iron ion homeostasis; IMP:UniProtKB.
GO; GO:0019290; P:siderophore biosynthetic process; IMP:UniProtKB.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR020904; Sc_DH/Rdtase_CS.
InterPro; IPR002347; SDR_fam.
PRINTS; PR00081; GDHRDH.
PRINTS; PR00080; SDRFAMILY.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00061; ADH_SHORT; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome.
CHAIN 1 245 3-hydroxybutyrate dehydrogenase type 2.
/FTId=PRO_0000042581.
NP_BIND 10 37 NAD. {ECO:0000250}.
NP_BIND 180 184 NAD. {ECO:0000250}.
ACT_SITE 147 147 Proton acceptor.
BINDING 58 58 NAD. {ECO:0000250}.
BINDING 144 144 Substrate. {ECO:0000250}.
BINDING 151 151 NAD. {ECO:0000250}.
BINDING 188 188 Substrate. {ECO:0000250}.
BINDING 205 205 Substrate. {ECO:0000250}.
MUTAGEN 147 147 Y->F: Loss of function.
{ECO:0000269|PubMed:20550936}.
SEQUENCE 245 AA; 26753 MW; 343A25B1F56B9CCF CRC64;
MGRLDGKVIV LTAAAQGIGR ASALAFAREG AKVIATDINE SKLQELESYR GIQTRVLDVT
KKRQIDQFAS EIERIDVLFN VAGFVHHGTI LDCEEKDWDF SMNLNVRSMF LMIKAFLPKM
LAQKSGNIIN MSSVASSIKG VENRCVYSAT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV
DTPSLQERIQ ARDNPKEALK TFLNRQKTGR FASAEEVALL CVYLASDESA YVTGNPVIID
GGWSL


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