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3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 3 (At3BETAHSD/D3) (EC 1.1.1.170) (4alpha-carboxysterol-C3-dehydrogenase/C4-decarboxylase isoform 1-3) (Reticulon-like protein B20) (AtRTNLB20) (Sterol-4-alpha-carboxylate 3-dehydrogenase 3, decarboxylating)

 HSDD3_ARATH             Reviewed;         561 AA.
A9X4U2; O22856; Q94AR9;
05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
05-MAY-2009, sequence version 2.
25-OCT-2017, entry version 75.
RecName: Full=3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 3;
Short=At3BETAHSD/D3;
EC=1.1.1.170;
AltName: Full=4alpha-carboxysterol-C3-dehydrogenase/C4-decarboxylase isoform 1-3;
AltName: Full=Reticulon-like protein B20;
Short=AtRTNLB20;
AltName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase 3, decarboxylating;
Name=3BETAHSD/D3; Synonyms=RTNLB20; OrderedLocusNames=At2g43420;
ORFNames=T1O24.16;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=16835224; DOI=10.1074/jbc.M604431200;
Rahier A., Darnet S., Bouvier F., Camara B., Bard M.;
"Molecular and enzymatic characterizations of novel bifunctional
3beta-hydroxysteroid dehydrogenases/C-4 decarboxylases from
Arabidopsis thaliana.";
J. Biol. Chem. 281:27264-27277(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=11910074; DOI=10.1126/science.1071006;
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
Shibata K., Shinagawa A., Shinozaki K.;
"Functional annotation of a full-length Arabidopsis cDNA collection.";
Science 296:141-145(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[6]
GENE FAMILY, AND NOMENCLATURE.
PubMed=17604024; DOI=10.1016/j.febslet.2007.06.032;
Nziengui H., Bouhidel K., Pillon D., Der C., Marty F., Schoefs B.;
"Reticulon-like proteins in Arabidopsis thaliana: structural
organization and ER localization.";
FEBS Lett. 581:3356-3362(2007).
-!- CATALYTIC ACTIVITY: A 3-beta-hydroxysteroid-4-alpha-carboxylate +
NAD(P)(+) = a 3-oxosteroid + CO(2) + NAD(P)H.
-!- PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol
from lanosterol: step 4/6.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the 3-beta-HSD family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; DQ415280; ABD76542.1; -; mRNA.
EMBL; AC002335; AAB64337.2; -; Genomic_DNA.
EMBL; CP002685; AEC10266.1; -; Genomic_DNA.
EMBL; AK117930; BAC42568.1; -; mRNA.
EMBL; AY045841; AAK76515.1; -; mRNA.
PIR; H84865; H84865.
RefSeq; NP_565998.1; NM_129903.3.
UniGene; At.12188; -.
UniGene; At.59216; -.
ProteinModelPortal; A9X4U2; -.
SMR; A9X4U2; -.
BioGrid; 4279; 66.
STRING; 3702.AT2G43420.1; -.
PaxDb; A9X4U2; -.
EnsemblPlants; AT2G43420.1; AT2G43420.1; AT2G43420.
GeneID; 818943; -.
Gramene; AT2G43420.1; AT2G43420.1; AT2G43420.
KEGG; ath:AT2G43420; -.
Araport; AT2G43420; -.
TAIR; locus:2058223; AT2G43420.
eggNOG; KOG1430; Eukaryota.
eggNOG; COG0451; LUCA.
HOGENOM; HOG000167989; -.
InParanoid; A9X4U2; -.
KO; K07748; -.
OMA; DFTYSEN; -.
OrthoDB; EOG093609X1; -.
PhylomeDB; A9X4U2; -.
BioCyc; ARA:AT2G43420-MONOMER; -.
Reactome; R-ATH-191273; Cholesterol biosynthesis.
UniPathway; UPA00770; UER00757.
PRO; PR:A9X4U2; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; A9X4U2; baseline and differential.
Genevisible; A9X4U2; AT.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:TAIR.
GO; GO:0009506; C:plasmodesma; IDA:TAIR.
GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
GO; GO:0103066; F:4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity; IEA:UniProtKB-EC.
GO; GO:0103067; F:4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
GO; GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR003388; Reticulon.
Pfam; PF01073; 3Beta_HSD; 1.
Pfam; PF02453; Reticulon; 1.
SUPFAM; SSF51735; SSF51735; 2.
PROSITE; PS50845; RETICULON; 1.
2: Evidence at transcript level;
Complete proteome; Endoplasmic reticulum; Lipid biosynthesis;
Lipid metabolism; Membrane; NAD; Oxidoreductase; Reference proteome;
Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis;
Sterol metabolism; Transmembrane; Transmembrane helix.
CHAIN 1 561 3beta-hydroxysteroid-
dehydrogenase/decarboxylase isoform 3.
/FTId=PRO_0000371281.
TRANSMEM 392 412 Helical. {ECO:0000255}.
TRANSMEM 420 440 Helical. {ECO:0000255}.
TRANSMEM 504 524 Helical. {ECO:0000255}.
DOMAIN 379 561 Reticulon. {ECO:0000255|PROSITE-
ProRule:PRU00170}.
BINDING 166 166 NAD. {ECO:0000250}.
CONFLICT 2 2 D -> G (in Ref. 1; ABD76542).
{ECO:0000305}.
SEQUENCE 561 AA; 63033 MW; 484C8E9BB423F891 CRC64;
MDEDSVHGDS HLKTCVVLGG RGFIGRSLVS RLLRLGNWTV RVADSGHTLH LDESDSLLED
ALSSGRASYH CVDVRDKPQI VKVTEGSYVV FYMGATDLRS HDYFDCYKVI VQGTRNVISA
CRESGVRKLI YNSTADVVFD GSQPIRDGDE SLRRPLKFQS MLTDFKAQAE ALIKLANNRD
GLLTCALRSS IVFGPGDTEF VPFLVNLAKS GYAKFILGSG ENISDFTYSE NVSHAHICAV
KALDSQMEFV AGKEFFITNL KPVRFWDFVS HIVEGLGYPR PSIKLPVRLV LYVFSLLKWT
HEKEGLGSNY DTAHQYALLA SSTRTFNCNA AKKHLGYTPV VTLEDGIAST LQWFSRDLEK
SDDTIIQSTA DQLLGCGKVA DILLWRNEKK TFVSFLVLNL FYYWFFFSGN TFTSSAAQLL
FIFAVALYGV SFVPSKIFGF QVNKIPPWRF EISESAVRDL SSDIVVVWNQ GVRSFKSLSS
GGDWIKFFKI AGSLYLLKLI VSRSLAAFLF TVMSFSFTGF FIYEQYELEL YHLARIFVEC
LTFIKRMVIP VSDASSKPMF M


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