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40S ribosomal protein S19-B (RP55B) (S16a) (Small ribosomal subunit protein eS19-B) (YS16B)

 RS19B_YEAST             Reviewed;         144 AA.
P07281; D6W0P2;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
18-JUL-2018, entry version 153.
RecName: Full=40S ribosomal protein S19-B {ECO:0000303|PubMed:9559554};
AltName: Full=RP55B;
AltName: Full=S16a;
AltName: Full=Small ribosomal subunit protein eS19-B {ECO:0000303|PubMed:24524803};
AltName: Full=YS16B;
Name=RPS19B {ECO:0000303|PubMed:9559554}; Synonyms=RP55B, RPS16AB;
OrderedLocusNames=YNL302C; ORFNames=N0422;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6387623; DOI=10.1093/nar/12.19.7345;
Molenaar C.M.T., Woudt L.P., Jansen A.E.M., Mager W.H., Planta R.J.,
Donovan D.M., Pearson N.J.;
"Structure and organization of two linked ribosomal protein genes in
yeast.";
Nucleic Acids Res. 12:7345-7358(1984).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=8553702; DOI=10.1002/yea.320111311;
Maurer K.C.T., Urbanus J.H.M., Planta R.J.;
"Sequence analysis of a 30 kb DNA segment from yeast chromosome XIV
carrying a ribosomal protein gene cluster, the genes encoding a plasma
membrane protein and a subunit of replication factor C, and a novel
putative serine/threonine protein kinase gene.";
Yeast 11:1303-1310(1995).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169873;
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F.,
Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M.,
Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N.,
Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D.,
Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A.,
Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A.,
Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C.,
Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M.,
Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J.,
Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L.,
Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M.,
Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P.,
Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A.,
Wambutt R., Wedler H., Zollner A., Hani J.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV
and its evolutionary implications.";
Nature 387:93-98(1997).
[4]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[5]
PROTEIN SEQUENCE OF 2-50.
PubMed=6814480; DOI=10.1021/bi00262a005;
Otaka E., Higo K., Osawa S.;
"Isolation of seventeen proteins and amino-terminal amino acid
sequences of eight proteins from cytoplasmic ribosomes of yeast.";
Biochemistry 21:4545-4550(1982).
[6]
NOMENCLATURE, AND SUBUNIT.
PubMed=9559554;
DOI=10.1002/(SICI)1097-0061(19980330)14:5<471::AID-YEA241>3.0.CO;2-U;
Planta R.J., Mager W.H.;
"The list of cytoplasmic ribosomal proteins of Saccharomyces
cerevisiae.";
Yeast 14:471-477(1998).
[7]
CLEAVAGE OF INITIATOR METHIONINE.
PubMed=10601260; DOI=10.1074/jbc.274.52.37035;
Arnold R.J., Polevoda B., Reilly J.P., Sherman F.;
"The action of N-terminal acetyltransferases on yeast ribosomal
proteins.";
J. Biol. Chem. 274:37035-37040(1999).
[8]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[9]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[10]
FUNCTION IN RIBOSOME SYNTHESIS, AND DISRUPTION PHENOTYPE.
PubMed=16159874; DOI=10.1074/jbc.M506916200;
Leger-Silvestre I., Caffrey J.M., Dawaliby R., Alvarez-Arias D.A.,
Gas N., Bertolone S.J., Gleizes P.E., Ellis S.R.;
"Specific role for yeast homologs of the Diamond Blackfan anemia-
associated Rps19 protein in ribosome synthesis.";
J. Biol. Chem. 280:38177-38185(2005).
[11]
SUBUNIT, AND SUBCELLULAR LOCATION.
PubMed=22096102; DOI=10.1126/science.1212642;
Ben-Shem A., Garreau de Loubresse N., Melnikov S., Jenner L.,
Yusupova G., Yusupov M.;
"The structure of the eukaryotic ribosome at 3.0 A resolution.";
Science 334:1524-1529(2011).
[12]
NOMENCLATURE.
PubMed=24524803; DOI=10.1016/j.sbi.2014.01.002;
Ban N., Beckmann R., Cate J.H.D., Dinman J.D., Dragon F., Ellis S.R.,
Lafontaine D.L.J., Lindahl L., Liljas A., Lipton J.M., McAlear M.A.,
Moore P.B., Noller H.F., Ortega J., Panse V.G., Ramakrishnan V.,
Spahn C.M.T., Steitz T.A., Tchorzewski M., Tollervey D., Warren A.J.,
Williamson J.R., Wilson D., Yonath A., Yusupov M.;
"A new system for naming ribosomal proteins.";
Curr. Opin. Struct. Biol. 24:165-169(2014).
-!- FUNCTION: Component of the ribosome, a large ribonucleoprotein
complex responsible for the synthesis of proteins in the cell. The
small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and
translates the encoded message by selecting cognate aminoacyl-
transfer RNA (tRNA) molecules. The large subunit (LSU) contains
the ribosomal catalytic site termed the peptidyl transferase
center (PTC), which catalyzes the formation of peptide bonds,
thereby polymerizing the amino acids delivered by tRNAs into a
polypeptide chain. The nascent polypeptides leave the ribosome
through a tunnel in the LSU and interact with protein factors that
function in enzymatic processing, targeting, and the membrane
insertion of nascent chains at the exit of the ribosomal tunnel
(PubMed:22096102). eS19 is required for proper maturation of the
small (40S) ribosomal subunit. Binds to 40S pre-ribosomal
particles, probably required after association of NOC4 but before
association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA
(PubMed:16159874). {ECO:0000269|PubMed:16159874,
ECO:0000305|PubMed:22096102}.
-!- FUNCTION: Required for proper maturation of the small (40S)
ribosomal subunit. Binds to 40s pre-ribosomal particles, probably
required after association of NOC4 but before association of ENP1,
TSR1 and RIO2 with 20/21S pre-rRNA. {ECO:0000269|PubMed:16159874}.
-!- SUBUNIT: Component of the small ribosomal subunit (SSU). Mature
yeast ribosomes consist of a small (40S) and a large (60S)
subunit. The 40S small subunit contains 1 molecule of ribosomal
RNA (18S rRNA) and 33 different proteins (encoded by 57 genes).
The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S
rRNA) and 46 different proteins (encoded by 81 genes)
(PubMed:9559554, PubMed:22096102). {ECO:0000269|PubMed:22096102,
ECO:0000305|PubMed:9559554}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095,
ECO:0000269|PubMed:22096102}.
-!- DISRUPTION PHENOTYPE: Disruption of a single RPS19 gene reduces
cell growth; a double disruption is lethal. Depletion experiments
show the proteins are required for correct maturation of precursor
rRNA to generate the 18S small rRNA. A specific site between the
18S and 5.8S precursors (site A2 in ETS1) is not cleaved in
disruption mutants. Partially assembled ribosomes are retained in
the nucleolus rather than being exported to the cytoplasm. All
effects are exacerbated in the double disruption. Increases
association of NOC4 with 20/21S pre-rRNA, decreases association of
ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.
{ECO:0000269|PubMed:16159874}.
-!- MISCELLANEOUS: Present with 3440 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- MISCELLANEOUS: There are 2 genes for eS19 in yeast. {ECO:0000305}.
-!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS19
family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; X01100; CAA25575.1; -; Genomic_DNA.
EMBL; U23084; AAC49096.1; -; Genomic_DNA.
EMBL; Z71578; CAA96220.1; -; Genomic_DNA.
EMBL; BK006947; DAA10258.1; -; Genomic_DNA.
PIR; S60398; S60398.
RefSeq; NP_014097.1; NM_001183140.1.
ProteinModelPortal; P07281; -.
BioGrid; 35536; 199.
IntAct; P07281; 8.
MINT; P07281; -.
STRING; 4932.YNL302C; -.
CarbonylDB; P07281; -.
iPTMnet; P07281; -.
MaxQB; P07281; -.
PaxDb; P07281; -.
PRIDE; P07281; -.
TopDownProteomics; P07281; -.
EnsemblFungi; YNL302C; YNL302C; YNL302C.
GeneID; 855414; -.
KEGG; sce:YNL302C; -.
EuPathDB; FungiDB:YNL302C; -.
SGD; S000005246; RPS19B.
GeneTree; ENSGT00390000013102; -.
HOGENOM; HOG000230649; -.
InParanoid; P07281; -.
KO; K02966; -.
OMA; RMVEKHP; -.
OrthoDB; EOG092C5NFY; -.
BioCyc; YEAST:G3O-33290-MONOMER; -.
Reactome; R-SCE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
Reactome; R-SCE-1799339; SRP-dependent cotranslational protein targeting to membrane.
Reactome; R-SCE-72689; Formation of a pool of free 40S subunits.
Reactome; R-SCE-72695; Formation of the ternary complex, and subsequently, the 43S complex.
Reactome; R-SCE-72702; Ribosomal scanning and start codon recognition.
Reactome; R-SCE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
Reactome; R-SCE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
Reactome; R-SCE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
PRO; PR:P07281; -.
Proteomes; UP000002311; Chromosome XIV.
GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:SGD.
GO; GO:0003735; F:structural constituent of ribosome; IDA:SGD.
GO; GO:0002181; P:cytoplasmic translation; IC:SGD.
GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
GO; GO:0042274; P:ribosomal small subunit biogenesis; IMP:SGD.
GO; GO:0006407; P:rRNA export from nucleus; IMP:SGD.
Gene3D; 1.10.10.2700; -; 1.
InterPro; IPR001266; Ribosomal_S19e.
InterPro; IPR018277; Ribosomal_S19e_CS.
InterPro; IPR038111; Ribosomal_S19e_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR11710; PTHR11710; 1.
Pfam; PF01090; Ribosomal_S19e; 1.
ProDom; PD003854; Ribosomal_S19e; 1.
SMART; SM01413; Ribosomal_S19e; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00628; RIBOSOMAL_S19E; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Direct protein sequencing;
Reference proteome; Ribonucleoprotein; Ribosomal protein;
Ribosome biogenesis.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:10601260,
ECO:0000269|PubMed:6814480}.
CHAIN 2 144 40S ribosomal protein S19-B.
/FTId=PRO_0000153836.
SEQUENCE 144 AA; 15891 MW; A36AA94B855768CB CRC64;
MAGVSVRDVA AQDFINAYAS FLQRQGKLEV PGYVDIVKTS SGNEMPPQDA EGWFYKRAAS
VARHIYMRKQ VGVGKLNKLY GGAKSRGVRP YKHIDASGSI NRKVLQALEK IGIVEISPKG
GRRISENGQR DLDRIAAQTL EEDE


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