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5' exonuclease Apollo (EC 3.1.-.-) (DNA cross-link repair 1B protein) (SNM1 homolog B)

 DCR1B_RAT               Reviewed;         541 AA.
Q4KLY6;
05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
05-OCT-2010, sequence version 2.
07-NOV-2018, entry version 71.
RecName: Full=5' exonuclease Apollo;
EC=3.1.-.-;
AltName: Full=DNA cross-link repair 1B protein;
AltName: Full=SNM1 homolog B;
Name=Dclre1b; Synonyms=Snm1b;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: 5'-3' exonuclease that plays a central role in telomere
maintenance and protection during S-phase. Participates in the
protection of telomeres against non-homologous end-joining (NHEJ)-
mediated repair, thereby ensuring that telomeres do not fuse.
Plays a key role in telomeric loop (T loop) formation by being
recruited by TERF2 at the leading end telomeres and by processing
leading-end telomeres immediately after their replication via its
exonuclease activity: generates 3' single-stranded overhang at the
leading end telomeres avoiding blunt leading-end telomeres that
are vulnerable to end-joining reactions and expose the telomere
end in a manner that activates the DNA repair pathways. Together
with TERF2, required to protect telomeres from replicative damage
during replication by controlling the amount of DNA topoisomerase
(TOP1, TOP2A and TOP2B) needed for telomere replication during
fork passage and prevent aberrant telomere topology. Also involved
in response to DNA damage: plays a role in response to DNA
interstrand cross-links (ICLs) by facilitating double-strand break
formation. In case of spindle stress, involved in prophase
checkpoint (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with TERF2; the interaction is direct.
Interacts with MUS81, MRE11 and FANCD2. Interacts with HSPA2,
HSPA8 and HSPA14. Interacts with SPAG5 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000250}. Nucleus
{ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing
center, centrosome {ECO:0000250}. Note=Mainly localizes to
telomeres, recruited via its interaction with TERF2. During
mitosis, localizes to the centrosome (By similarity).
{ECO:0000250}.
-!- DOMAIN: The TBM domain mediates interaction with TERF2.
{ECO:0000250}.
-!- PTM: Ubiquitinated, leading to its degradation. Interaction with
TERF2 protects it from ubiquitination (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase
(DRMBL) family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH98939.1; Type=Frameshift; Positions=306; Evidence={ECO:0000305};
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EMBL; BC098939; AAH98939.1; ALT_FRAME; mRNA.
RefSeq; NP_001020858.1; NM_001025687.1.
UniGene; Rn.39355; -.
SMR; Q4KLY6; -.
STRING; 10116.ENSRNOP00000026213; -.
PhosphoSitePlus; Q4KLY6; -.
PaxDb; Q4KLY6; -.
PRIDE; Q4KLY6; -.
GeneID; 310745; -.
KEGG; rno:310745; -.
UCSC; RGD:1310343; rat.
CTD; 64858; -.
RGD; 1310343; Dclre1b.
eggNOG; KOG1361; Eukaryota.
eggNOG; COG1236; LUCA.
HOGENOM; HOG000043118; -.
HOVERGEN; HBG081419; -.
InParanoid; Q4KLY6; -.
KO; K15341; -.
PhylomeDB; Q4KLY6; -.
PRO; PR:Q4KLY6; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005813; C:centrosome; ISS:UniProtKB.
GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0000784; C:nuclear chromosome, telomeric region; IBA:GO_Central.
GO; GO:0035312; F:5'-3' exodeoxyribonuclease activity; IBA:GO_Central.
GO; GO:0008409; F:5'-3' exonuclease activity; ISS:UniProtKB.
GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IBA:GO_Central.
GO; GO:0036297; P:interstrand cross-link repair; IBA:GO_Central.
GO; GO:0007093; P:mitotic cell cycle checkpoint; ISS:UniProtKB.
GO; GO:0031848; P:protection from non-homologous end joining at telomere; ISS:UniProtKB.
GO; GO:0000723; P:telomere maintenance; ISS:UniProtKB.
GO; GO:0031860; P:telomeric 3' overhang formation; ISS:UniProtKB.
GO; GO:0031627; P:telomeric loop formation; ISS:UniProtKB.
Gene3D; 3.60.15.10; -; 1.
InterPro; IPR011084; DRMBL.
InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
Pfam; PF07522; DRMBL; 1.
SUPFAM; SSF56281; SSF56281; 1.
1: Evidence at protein level;
Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; DNA damage;
DNA repair; Exonuclease; Hydrolase; Isopeptide bond; Nuclease;
Nucleus; Reference proteome; Telomere; Ubl conjugation.
CHAIN 1 541 5' exonuclease Apollo.
/FTId=PRO_0000398626.
MOTIF 492 507 TBM.
CROSSLNK 334 334 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q9H816}.
SEQUENCE 541 AA; 60924 MW; C194022A218F9D2C CRC64;
MNGVVIPQTP IAVDFWSLRR AGTARLFFLS HMHCDHTVGL SSTWARPLYC SPITAHLLHR
RLQVSKQWIR ALEIGESHVL LLDEIGQETM TVTLIDANHC PGSVMFLFEG YFGTILYTGD
FRYTPSMLKE PALTLGKQIH TLYLDNTNCN PALVLPSRQE ATQQIIQLIR QFPQHNIKIG
LYSLGKESLL EQLALEFQTW VVLSPQRLEL VQLLGLADVF TVEEEAGRIH AVDHMEICHS
AMLQWNQTHP TIAIFPTSRK IRSPHPSIYS IPYSDHSSYS ELRAFVAALR PCQVVPIVRE
QPCGEFFQDS LSPRLSMPLI PHSVQQYMSS SSRKTNVFWQ LERRLKRPRT QGVVFESPEE
KADQVKVDRD SKKHKKESLS PWAGCLSRLC PHPLQARKQL FPDFCRKEGD EPVLFCDSNK
MATVLTAPLE LSVQLQPVDE FPFPETREEI GLGSPLWSGG GSGSPTRGKQ SNGMGCGSPP
THISRTTHLT PESGGLALKY LLTPVDFLQA GFSSRNFDQQ VEKHQRVQCN NPAVMNTVDD
V


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