Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)

 AAKB2_RAT               Reviewed;         271 AA.
Q9QZH4;
01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
22-NOV-2017, entry version 113.
RecName: Full=5'-AMP-activated protein kinase subunit beta-2;
Short=AMPK subunit beta-2;
Name=Prkab2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PHOSPHORYLATION AT SER-183.
STRAIN=Sprague-Dawley; TISSUE=Skeletal muscle;
PubMed=10544261; DOI=10.1016/S0014-5793(99)01371-X;
Chen Z., Heierhorst J., Mann R.J., Mitchelhill K.I., Michell B.J.,
Witters L.A., Lynch G.S., Kemp B.E., Stapleton D.;
"Expression of the AMP-activated protein kinase beta1 and beta2
subunits in skeletal muscle.";
FEBS Lett. 460:343-348(1999).
[2]
PHOSPHORYLATION BY ULK1 AND ULK2, AND PHOSPHORYLATION AT SER-38;
THR-39; SER-68 AND SER-173.
PubMed=21460634; DOI=10.4161/auto.7.7.15451;
Loffler A.S., Alers S., Dieterle A.M., Keppeler H., Franz-Wachtel M.,
Kundu M., Campbell D.G., Wesselborg S., Alessi D.R., Stork B.;
"Ulk1-mediated phosphorylation of AMPK constitutes a negative
regulatory feedback loop.";
Autophagy 7:696-706(2011).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Non-catalytic subunit of AMP-activated protein kinase
(AMPK), an energy sensor protein kinase that plays a key role in
regulating cellular energy metabolism. In response to reduction of
intracellular ATP levels, AMPK activates energy-producing pathways
and inhibits energy-consuming processes: inhibits protein,
carbohydrate and lipid biosynthesis, as well as cell growth and
proliferation. AMPK acts via direct phosphorylation of metabolic
enzymes, and by longer-term effects via phosphorylation of
transcription regulators. Also acts as a regulator of cellular
polarity by remodeling the actin cytoskeleton; probably by
indirectly activating myosin. Beta non-catalytic subunit acts as a
scaffold on which the AMPK complex assembles, via its C-terminus
that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1,
PRKAG2 or PRKAG3) (By similarity). {ECO:0000250}.
-!- SUBUNIT: AMPK is a heterotrimer of an alpha catalytic subunit
(PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-
catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). {ECO:0000250}.
-!- PTM: Phosphorylated when associated with the catalytic subunit
(PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to
negatively regulate AMPK activity and suggesting the existence of
a regulatory feedback loop between ULK1, ULK2 and AMPK.
{ECO:0000269|PubMed:10544261, ECO:0000269|PubMed:21460634}.
-!- SIMILARITY: Belongs to the 5'-AMP-activated protein kinase beta
subunit family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF182717; AAF01293.1; -; mRNA.
RefSeq; NP_072149.1; NM_022627.2.
UniGene; Rn.207202; -.
PDB; 2LU3; NMR; -; A=67-163.
PDB; 2LU4; NMR; -; A=67-163.
PDB; 4Y0G; X-ray; 1.60 A; A/B=74-155.
PDB; 4YEE; X-ray; 2.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=74-155.
PDBsum; 2LU3; -.
PDBsum; 2LU4; -.
PDBsum; 4Y0G; -.
PDBsum; 4YEE; -.
ProteinModelPortal; Q9QZH4; -.
SMR; Q9QZH4; -.
STRING; 10116.ENSRNOP00000062137; -.
CAZy; CBM48; Carbohydrate-Binding Module Family 48.
iPTMnet; Q9QZH4; -.
PhosphoSitePlus; Q9QZH4; -.
PaxDb; Q9QZH4; -.
PRIDE; Q9QZH4; -.
DNASU; 64562; -.
GeneID; 64562; -.
KEGG; rno:64562; -.
CTD; 5565; -.
RGD; 620905; Prkab2.
eggNOG; KOG1616; Eukaryota.
eggNOG; ENOG410XRB3; LUCA.
HOGENOM; HOG000230597; -.
HOVERGEN; HBG050430; -.
InParanoid; Q9QZH4; -.
KO; K07199; -.
PhylomeDB; Q9QZH4; -.
PRO; PR:Q9QZH4; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
GO; GO:0005952; C:cAMP-dependent protein kinase complex; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0031588; C:nucleotide-activated protein kinase complex; IDA:RGD.
GO; GO:0019899; F:enzyme binding; IPI:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0019901; F:protein kinase binding; IPI:RGD.
GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0006468; P:protein phosphorylation; IEA:GOC.
GO; GO:0042304; P:regulation of fatty acid biosynthetic process; TAS:Reactome.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR032640; AMPK1_CBM.
InterPro; IPR006828; ASC_dom.
InterPro; IPR037256; ASC_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
Pfam; PF16561; AMPK1_CBM; 1.
Pfam; PF04739; AMPKBI; 1.
SMART; SM01010; AMPKBI; 1.
SUPFAM; SSF160219; SSF160219; 1.
SUPFAM; SSF81296; SSF81296; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Fatty acid biosynthesis;
Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism;
Phosphoprotein; Reference proteome.
CHAIN 1 271 5'-AMP-activated protein kinase subunit
beta-2.
/FTId=PRO_0000204370.
MOD_RES 38 38 Phosphoserine; by ULK1.
{ECO:0000244|PubMed:22673903,
ECO:0000269|PubMed:21460634}.
MOD_RES 39 39 Phosphothreonine; by ULK1.
{ECO:0000269|PubMed:21460634}.
MOD_RES 68 68 Phosphoserine; by ULK1.
{ECO:0000269|PubMed:21460634}.
MOD_RES 94 94 Phosphoserine.
{ECO:0000250|UniProtKB:O43741}.
MOD_RES 107 107 Phosphoserine.
{ECO:0000250|UniProtKB:O43741}.
MOD_RES 147 147 Phosphothreonine.
{ECO:0000250|UniProtKB:O43741}.
MOD_RES 157 157 Phosphoserine.
{ECO:0000250|UniProtKB:O43741}.
MOD_RES 169 169 Phosphoserine.
{ECO:0000250|UniProtKB:O43741}.
MOD_RES 173 173 Phosphoserine; by ULK1.
{ECO:0000269|PubMed:21460634}.
MOD_RES 183 183 Phosphoserine.
{ECO:0000269|PubMed:10544261}.
STRAND 73 75 {ECO:0000244|PDB:2LU4}.
STRAND 76 82 {ECO:0000244|PDB:4Y0G}.
STRAND 89 93 {ECO:0000244|PDB:4Y0G}.
HELIX 94 96 {ECO:0000244|PDB:4Y0G}.
STRAND 105 107 {ECO:0000244|PDB:4Y0G}.
STRAND 110 117 {ECO:0000244|PDB:4Y0G}.
STRAND 119 128 {ECO:0000244|PDB:4Y0G}.
STRAND 131 133 {ECO:0000244|PDB:4Y0G}.
STRAND 136 138 {ECO:0000244|PDB:2LU3}.
STRAND 140 142 {ECO:0000244|PDB:4Y0G}.
STRAND 148 154 {ECO:0000244|PDB:4Y0G}.
STRAND 157 160 {ECO:0000244|PDB:2LU3}.
SEQUENCE 271 AA; 30227 MW; D881451A03287BEA CRC64;
MGNTTSERVS GERHGAKAAR AEGGGHGPGK EHKIMVGSTD DPSVFSLPDS KLPGDKEFVP
WQQDLDDSVK PTQQARPTVI RWSEGGKEVF ISGSFNNWST KIPLIKSHND FVAILDLPEG
EHQYKFFVDG QWVHDPSEPV VTSQLGTINN LIHVKKSDFE VFDALKLDSM ESSETSCRDL
SSSPPGPYGQ EMYVFRSEER FKSPPILPPH LLQVILNKDT NISCDPALLP EPNHVMLNHL
YALSTKDSVM VLSATHRYKK KYVTTLLYKP I


Related products :

Catalog number Product name Quantity
EIAAB29520 C2-PI3K,Homo sapiens,Human,Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta,Phosphoinositide 3-kinase-C2-beta,PI3K-C2-beta,PIK3C2B,PtdIns-3-kinase C2 subunit beta
30-953 PRKAA1 belongs to the ser_thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells 0.05 mg
E1761h ELISA Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
U1761h CLIA Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
E1761h ELISA kit Homo sapiens,Human,IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,OSMR,OSMRB 96T
15-288-21448A AP-3 complex subunit beta-2 - Adapter-related protein complex 3 beta-2 subunit; Beta3B-adaptin; Adaptor protein complex AP-3 beta-2 subunit; AP-3 complex beta-2 subunit; Clathrin assembly protein comp 0.05 mg
15-288-21448A AP-3 complex subunit beta-2 - Adapter-related protein complex 3 beta-2 subunit; Beta3B-adaptin; Adaptor protein complex AP-3 beta-2 subunit; AP-3 complex beta-2 subunit; Clathrin assembly protein comp 0.1 mg
U1761m CLIA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Mouse,Mus musculus,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb 96T
U1761r CLIA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb,Rat,Rattus norvegicus 96T
E1761r ELISA kit IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb,Rat,Rattus norvegicus 96T
E1761r ELISA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb,Rat,Rattus norvegicus 96T
E1761m ELISA kit IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Mouse,Mus musculus,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb 96T
E1761m ELISA IL-31 receptor subunit beta,IL-31R subunit beta,IL-31RB,IL-31R-beta,Interleukin-31 receptor subunit beta,Mouse,Mus musculus,Oncostatin-M-specific receptor subunit beta,Osmr,Osmrb 96T
EIAAB29606 Homo sapiens,Human,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta,Phosphatidylinositol 3-kinase regulatory subunit beta,PI3K regulatory subunit beta,PI3-kinase regulatory subunit beta,PI
EIAAB29611 Homo sapiens,Human,PAF acetylhydrolase 30 kDa subunit,PAF-AH 30 kDa subunit,PAFAH subunit beta,PAF-AH subunit beta,PAFAH1B2,PAFAHB,Platelet-activating factor acetylhydrolase IB subunit beta
EIAAB29614 Bos taurus,Bovine,PAF acetylhydrolase 30 kDa subunit,PAF-AH 30 kDa subunit,PAFAH subunit beta,PAF-AH subunit beta,PAFAH1B2,PAFAHB,Platelet-activating factor acetylhydrolase IB subunit beta
EIAAB29612 Mouse,Mus musculus,PAF acetylhydrolase 30 kDa subunit,PAF-AH 30 kDa subunit,PAFAH subunit beta,PAF-AH subunit beta,Pafah1b2,Pafahb,Platelet-activating factor acetylhydrolase IB subunit beta
EIAAB30507 Cbfb,CBF-beta,Core-binding factor subunit beta,Mouse,Mus musculus,PEA2-beta,Pebp2b,PEBP2-beta,Pebpb2,Polyomavirus enhancer-binding protein 2 beta subunit,SL3_AKV core-binding factor beta subunit,SL3-3
18-003-44199 Guanine nucleotide-binding protein subunit beta-2-like 1 - Guanine nucleotide-binding protein subunit beta-like protein 12.3; Receptor of activated protein kinase C 1; RACK1; Receptor for activated C 0.05 mg Aff Pur
EIAAB40065 Homo sapiens,HSD25,Human,Signal sequence receptor subunit beta,SSR2,SSR-beta,Translocon-associated protein subunit beta,TRAPB,TRAP-beta
EIAAB40066 Bos taurus,Bovine,Signal sequence receptor subunit beta,SSR2,SSR-beta,Translocon-associated protein subunit beta,TRAP-beta
EIAAB40067 Mouse,Mus musculus,Signal sequence receptor subunit beta,Ssr2,SSR-beta,Translocon-associated protein subunit beta,TRAP-beta
EH1881 5'-AMP-activated protein kinase subunit beta-1 Elisa Kit 96T
ER580 5'-AMP-activated protein kinase subunit beta-1 Elisa Kit 96T
EIAAB29605 Bos taurus,Bovine,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta,Phosphatidylinositol 3-kinase regulatory subunit beta,PI3K regulatory subunit beta,PI3-kinase regulatory subunit beta,PI3


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur