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5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) (GRP94-neighboring nucleotidase)

 NT5D3_HUMAN             Reviewed;         548 AA.
Q86UY8; Q9NUM7; Q9P2T2; Q9P2T3;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
23-MAY-2018, entry version 120.
RecName: Full=5'-nucleotidase domain-containing protein 3;
EC=3.1.3.-;
AltName: Full=GRP94-neighboring nucleotidase;
Name=NT5DC3; Synonyms=GNN, TU12B1-TY;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
[MRNA] OF 51-548 (ISOFORM 1), AND TISSUE SPECIFICITY.
PubMed=15547748;
Yatsuoka T., Furukawa T., Sunamura M., Matsuno S., Horii A.;
"TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently
deleted in pancreatic cancer, shows reduced expression in pancreatic
cancer cells.";
Oncol. Rep. 12:1263-1268(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 428-548 (ISOFORM 1).
TISSUE=Placenta;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q86UY8-1; Sequence=Displayed;
Name=2;
IsoId=Q86UY8-2; Sequence=VSP_032643, VSP_032644;
-!- TISSUE SPECIFICITY: Expressed in brain, placenta, skeletal muscle,
pancreas, testis, uterus, and small intestine. Reduced expression
in pancreatic cancer cells. {ECO:0000269|PubMed:15547748}.
-!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAA92095.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAA93053.1; Type=Frameshift; Positions=62; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AB032773; BAA93053.1; ALT_FRAME; mRNA.
EMBL; AB032786; BAA93086.1; -; Genomic_DNA.
EMBL; CH471054; EAW97716.1; -; Genomic_DNA.
EMBL; BC052293; AAH52293.1; -; mRNA.
EMBL; AK002128; BAA92095.1; ALT_INIT; mRNA.
CCDS; CCDS41824.1; -. [Q86UY8-1]
RefSeq; NP_001026871.1; NM_001031701.2. [Q86UY8-1]
UniGene; Hs.48428; -.
ProteinModelPortal; Q86UY8; -.
SMR; Q86UY8; -.
BioGrid; 119609; 6.
IntAct; Q86UY8; 9.
STRING; 9606.ENSP00000376615; -.
DEPOD; Q86UY8; -.
iPTMnet; Q86UY8; -.
PhosphoSitePlus; Q86UY8; -.
BioMuta; NT5DC3; -.
DMDM; 74727508; -.
EPD; Q86UY8; -.
MaxQB; Q86UY8; -.
PaxDb; Q86UY8; -.
PeptideAtlas; Q86UY8; -.
PRIDE; Q86UY8; -.
Ensembl; ENST00000392876; ENSP00000376615; ENSG00000111696. [Q86UY8-1]
GeneID; 51559; -.
KEGG; hsa:51559; -.
UCSC; uc010swe.2; human. [Q86UY8-1]
CTD; 51559; -.
DisGeNET; 51559; -.
EuPathDB; HostDB:ENSG00000111696.11; -.
GeneCards; NT5DC3; -.
HGNC; HGNC:30826; NT5DC3.
HPA; HPA041634; -.
MIM; 611076; gene.
neXtProt; NX_Q86UY8; -.
OpenTargets; ENSG00000111696; -.
PharmGKB; PA143485562; -.
eggNOG; KOG2470; Eukaryota.
eggNOG; ENOG410XT8W; LUCA.
GeneTree; ENSGT00550000074539; -.
HOGENOM; HOG000230610; -.
HOVERGEN; HBG053334; -.
OMA; HTMKQFM; -.
OrthoDB; EOG091G048T; -.
PhylomeDB; Q86UY8; -.
TreeFam; TF323990; -.
ChiTaRS; NT5DC3; human.
GenomeRNAi; 51559; -.
PRO; PR:Q86UY8; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000111696; -.
CleanEx; HS_NT5DC3; -.
ExpressionAtlas; Q86UY8; baseline and differential.
Genevisible; Q86UY8; HS.
GO; GO:0043235; C:receptor complex; IDA:MGI.
GO; GO:0008253; F:5'-nucleotidase activity; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
Gene3D; 3.40.50.1000; -; 1.
InterPro; IPR036412; HAD-like_sf.
InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl.
InterPro; IPR023214; HAD_sf.
InterPro; IPR016695; Pur_nucleotidase.
PANTHER; PTHR12103; PTHR12103; 1.
Pfam; PF05761; 5_nucleotid; 1.
PIRSF; PIRSF017434; Purine_5'-nucleotidase; 1.
SUPFAM; SSF56784; SSF56784; 1.
TIGRFAMs; TIGR02244; HAD-IG-Ncltidse; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Hydrolase; Magnesium;
Metal-binding; Polymorphism; Reference proteome.
CHAIN 1 548 5'-nucleotidase domain-containing protein
3.
/FTId=PRO_0000326247.
REGION 251 259 Substrate binding. {ECO:0000255}.
COMPBIAS 4 7 Poly-Ala.
ACT_SITE 102 102 Nucleophile. {ECO:0000250}.
ACT_SITE 104 104 Proton donor. {ECO:0000250}.
METAL 102 102 Magnesium. {ECO:0000250}.
METAL 104 104 Magnesium; via carbonyl oxygen.
{ECO:0000250}.
METAL 389 389 Magnesium. {ECO:0000250}.
VAR_SEQ 1 75 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_032643.
VAR_SEQ 466 474 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_032644.
VARIANT 266 266 A -> E (in dbSNP:rs12184494).
/FTId=VAR_040043.
SEQUENCE 548 AA; 63420 MW; 93B1C8CD7C2E0434 CRC64;
MTMAAAAVVA RGAGARAATA AALRGGCGTA ARGRPCAGPA RPLCTAPGTA PDMKRYLWER
YREAKRSTEE LVPSIMSNLL NPDAIFSNNE MSLSDIEIYG FDYDYTLVFY SKHLHTLIFN
AARDLLINEH RYPAEIRKYE YDPNFAIRGL HYDVQRAVLM KIDAFHYIQL GTVYRGLSVV
PDEEVIEMYE GSHVPLEQMS DFYGKSSHGN TMKQFMDIFS LPEMTLLSCV NEYFLKNNID
YEPVHLYKDV KDSIRDVHIK GIMYRAIEAD IEKYICYAEQ TRAVLAKLAD HGKKMFLITN
SPSSFVDKGM SYIVGKDWRD LFDVVIVQAE KPNFFNDKRR PFRKMNEKGV LLWDKIHKLQ
KGQIYKQGNL YEFLKLTGWR GSRVLYFGDH IYSDLADLTL KHGWRTGAII PELRSELKIM
NTEQYIQTMT WLQTLTGLLE QMQVHRDAES QLVLQEWKKE RKEMREMTKS FFNAQFGSLF
RTDQNPTYFL RRLSRFADIY MASLSCLLNY DVSHTFYPRR TPLQHELPAW SERPPTFGTP
LLQEAQAK


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