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5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (Serotonin receptor 1A)

 5HT1A_VULVU             Reviewed;         423 AA.
Q6XXY0;
12-APR-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
25-OCT-2017, entry version 70.
RecName: Full=5-hydroxytryptamine receptor 1A;
Short=5-HT-1A;
Short=5-HT1A;
AltName: Full=Serotonin receptor 1A;
Name=HTR1A;
Vulpes vulpes (Red fox).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Vulpes.
NCBI_TaxID=9627;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Silver;
PubMed=15220384; DOI=10.1093/jhered/esh033;
Kukekova A.V., Trut L.N., Oskina I.N., Kharlamova A.V.,
Shikhevich S.G., Kirkness E.F., Aguirre G.D., Acland G.M.;
"A marker set for construction of a genetic map of the silver fox
(Vulpes vulpes).";
J. Hered. 95:185-194(2004).
-!- FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine
(serotonin). Also functions as a receptor for various drugs and
psychoactive substances. Ligand binding causes a conformation
change that triggers signaling via guanine nucleotide-binding
proteins (G proteins) and modulates the activity of down-stream
effectors, such as adenylate cyclase. Beta-arrestin family members
inhibit signaling via G proteins and mediate activation of
alternative signaling pathways. Signaling inhibits adenylate
cyclase activity and activates a phosphatidylinositol-calcium
second messenger system that regulates the release of Ca(2+) ions
from intracellular stores. Plays a role in the regulation of 5-
hydroxytryptamine release and in the regulation of dopamine and 5-
hydroxytryptamine metabolism. Plays a role in the regulation of
dopamine and 5-hydroxytryptamine levels in the brain, and thereby
affects neural activity, mood and behavior. Plays a role in the
response to anxiogenic stimuli (By similarity). {ECO:0000250}.
-!- SUBUNIT: Heterodimer; heterodimerizes with GPER1. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. 5-
hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; AY204569; AAP12466.1; -; Genomic_DNA.
ProteinModelPortal; Q6XXY0; -.
HOVERGEN; HBG106962; -.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0004993; F:G-protein coupled serotonin receptor activity; ISS:UniProtKB.
GO; GO:0007198; P:adenylate cyclase-inhibiting serotonin receptor signaling pathway; ISS:UniProtKB.
GO; GO:0001662; P:behavioral fear response; ISS:UniProtKB.
GO; GO:0008283; P:cell proliferation; IEA:InterPro.
GO; GO:0035640; P:exploration behavior; ISS:UniProtKB.
GO; GO:0050795; P:regulation of behavior; IEA:InterPro.
GO; GO:0042053; P:regulation of dopamine metabolic process; ISS:UniProtKB.
GO; GO:0046883; P:regulation of hormone secretion; IEA:InterPro.
GO; GO:0014062; P:regulation of serotonin secretion; ISS:UniProtKB.
GO; GO:0042428; P:serotonin metabolic process; ISS:UniProtKB.
GO; GO:0007210; P:serotonin receptor signaling pathway; ISS:UniProtKB.
GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
CDD; cd15330; 7tmA_5-HT1A_vertebrates; 1.
InterPro; IPR000610; 5HT1A_rcpt.
InterPro; IPR002231; 5HT_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
PANTHER; PTHR24247:SF20; PTHR24247:SF20; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00512; 5HT1ARECEPTR.
PRINTS; PR01101; 5HTRECEPTOR.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
Behavior; Cell membrane; Disulfide bond; G-protein coupled receptor;
Glycoprotein; Membrane; Receptor; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 423 5-hydroxytryptamine receptor 1A.
/FTId=PRO_0000068908.
TOPO_DOM 1 36 Extracellular. {ECO:0000250}.
TRANSMEM 37 62 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 63 73 Cytoplasmic. {ECO:0000250}.
TRANSMEM 74 98 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 99 110 Extracellular. {ECO:0000250}.
TRANSMEM 111 132 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 133 152 Cytoplasmic. {ECO:0000250}.
TRANSMEM 153 178 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 179 191 Extracellular. {ECO:0000250}.
TRANSMEM 192 217 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 218 345 Cytoplasmic. {ECO:0000250}.
TRANSMEM 346 367 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 368 378 Extracellular. {ECO:0000250}.
TRANSMEM 379 403 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 404 423 Cytoplasmic. {ECO:0000250}.
REGION 112 121 Agonist binding. {ECO:0000250}.
REGION 358 362 Agonist binding. {ECO:0000250}.
MOTIF 133 135 DRY motif; important for ligand-induced
conformation changes. {ECO:0000250}.
MOTIF 396 400 NPxxY motif; important for ligand-induced
conformation changes and signaling.
{ECO:0000250}.
CARBOHYD 10 10 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 11 11 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 24 24 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 109 187 {ECO:0000255|PROSITE-ProRule:PRU00521}.
SEQUENCE 423 AA; 46284 MW; FBA56507BD8CF0FF CRC64;
MEGLSPGQGN NTTSSEGPFG TRGNATGISD VTFSYQVITS LLLGTLIFCA VLGNACVVAA
IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC
TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED
RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKAERKGADA
RSGVSPAPQP RKSVNGEPGG REWRQGPGSK AGGPLCTNGA VRRGDDGAAL EVIEVHRVGS
SKEHLPLPSE AGAIPCAPAS FEKKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP
FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIVRCKFC
RRR


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