Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (Serotonin receptor 2C)

 5HT2C_CANLF             Reviewed;         458 AA.
Q60F97;
26-APR-2005, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 1.
25-OCT-2017, entry version 83.
RecName: Full=5-hydroxytryptamine receptor 2C;
Short=5-HT-2C;
Short=5-HT2C;
Short=5-HTR2C;
AltName: Full=Serotonin receptor 2C;
Flags: Precursor;
Name=HTR2C;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle;
PubMed=15353848; DOI=10.1292/jvms.66.965;
Masuda K., Hashizume C., Ogata N., Kikusui T., Takeuchi Y., Mori Y.;
"Sequencing of canine 5-hydroxytriptamine receptor (5-HTR) 1B, 2A, 2C
genes and identification of polymorphisms in the 5-HTR1B gene.";
J. Vet. Med. Sci. 66:965-972(2004).
-!- FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine
(serotonin). Also functions as a receptor for various drugs and
psychoactive substances, including ergot alkaloid derivatives, 1-
2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid
diethylamide (LSD). Ligand binding causes a conformation change
that triggers signaling via guanine nucleotide-binding proteins (G
proteins) and modulates the activity of down-stream effectors.
Beta-arrestin family members inhibit signaling via G proteins and
mediate activation of alternative signaling pathways. Signaling
activates a phosphatidylinositol-calcium second messenger system
that modulates the activity of phosphatidylinositol 3-kinase and
down-stream signaling cascades and promotes the release of Ca(2+)
ions from intracellular stores. Regulates neuronal activity via
the activation of short transient receptor potential calcium
channels in the brain, and thereby modulates the activation of
pro-opiomelacortin neurons and the release of CRH that then
regulates the release of corticosterone. Plays a role in the
regulation of appetite and feeding behavior, responses to
anxiogenic stimuli and stress. Plays a role in insulin sensitivity
and glucose homeostasis (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with MPDZ. Interacts with ARRB2 (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- DOMAIN: The PDZ domain-binding motif is involved in the
interaction with MPDZ. {ECO:0000250}.
-!- PTM: N-glycosylated. {ECO:0000250}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB193091; BAD60921.1; -; mRNA.
RefSeq; NP_001006649.1; NM_001006648.1.
UniGene; Cfa.16240; -.
ProteinModelPortal; Q60F97; -.
SMR; Q60F97; -.
STRING; 9615.ENSCAFP00000043222; -.
BindingDB; Q60F97; -.
ChEMBL; CHEMBL1770041; -.
PaxDb; Q60F97; -.
GeneID; 450240; -.
KEGG; cfa:450240; -.
CTD; 3358; -.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
HOGENOM; HOG000240378; -.
HOVERGEN; HBG107487; -.
InParanoid; Q60F97; -.
KO; K04157; -.
PRO; PR:Q60F97; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0004993; F:G-protein coupled serotonin receptor activity; IBA:GO_Central.
GO; GO:0001587; F:Gq/11-coupled serotonin receptor activity; ISS:UniProtKB.
GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
GO; GO:0001662; P:behavioral fear response; ISS:UniProtKB.
GO; GO:0007631; P:feeding behavior; ISS:UniProtKB.
GO; GO:0007626; P:locomotory behavior; IEA:InterPro.
GO; GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007208; P:phospholipase C-activating serotonin receptor signaling pathway; ISS:UniProtKB.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; ISS:UniProtKB.
GO; GO:0032098; P:regulation of appetite; ISS:UniProtKB.
GO; GO:0043397; P:regulation of corticotropin-releasing hormone secretion; ISS:UniProtKB.
GO; GO:0031644; P:regulation of neurological system process; ISS:UniProtKB.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
GO; GO:0042493; P:response to drug; IBA:GO_Central.
InterPro; IPR000377; 5HT2C_rcpt.
InterPro; IPR002231; 5HT_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
PANTHER; PTHR24247:SF32; PTHR24247:SF32; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00517; 5HT2CRECEPTR.
PRINTS; PR01101; 5HTRECEPTOR.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Behavior; Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
Reference proteome; Signal; Transducer; Transmembrane;
Transmembrane helix.
SIGNAL 1 32 {ECO:0000250}.
CHAIN 33 458 5-hydroxytryptamine receptor 2C.
/FTId=PRO_0000068957.
TOPO_DOM 33 52 Extracellular. {ECO:0000250}.
TRANSMEM 53 78 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 79 89 Cytoplasmic. {ECO:0000250}.
TRANSMEM 90 110 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 111 127 Extracellular. {ECO:0000250}.
TRANSMEM 128 150 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 151 170 Cytoplasmic. {ECO:0000250}.
TRANSMEM 171 193 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 194 213 Extracellular. {ECO:0000250}.
TRANSMEM 214 235 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 236 311 Cytoplasmic. {ECO:0000250}.
TRANSMEM 312 333 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 334 348 Extracellular. {ECO:0000250}.
TRANSMEM 349 371 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 372 458 Cytoplasmic. {ECO:0000250}.
REGION 134 139 Agonist binding. {ECO:0000250}.
REGION 324 328 Agonist binding. {ECO:0000250}.
MOTIF 151 153 DRY motif; important for ligand-induced
conformation changes. {ECO:0000250}.
MOTIF 364 368 NPxxY motif; important for ligand-induced
conformation changes and signaling.
{ECO:0000250}.
MOTIF 456 458 PDZ-binding.
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 203 203 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 204 204 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 127 207 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 337 341 {ECO:0000255|PROSITE-ProRule:PRU00521}.
SEQUENCE 458 AA; 51836 MW; 5A03245262B6C7BB CRC64;
MVNLRKAVHS FLVHLIGLLV WQCDISVSPV AALVTDIFNT SDGGRFKFPD GVQNWPALSI
VIIIILTIGG NILVIMAVSL EKKLHNATNY FLMSLAIADM LVGLLVMPLS LLAILYDYVW
PLPRYLCPVW ISLDVLFSTA SIMHLCAISL DRYVAIRNPV EHSRFNSRTK AIMKIAIVWA
ISIGVSVPIP VIGLRDEEKV FVNNTTCVLN DPNFVLIGSF VAFFIPLTIM VITYCLTIHV
LRRQALMLLH GHVEEPPRIN LDFLKCCRRN GTEEENSANP NQDSNPRRRK KKERRPRGTM
QAINNERKAS KVLGIVFFVF LVMWCPFFIT NILSVLCGKA CNQKLMEKLL NVFVWIGYVC
SGINPLVYTL FNKIYRRAFS NYLRCNYKPE KKPPVRQMPR VAATALSGRE LNVNIYRHTN
EPVLKKANDK EPGIEMQVEN LELPVNPSSV VSERISSV


Related products :

Catalog number Product name Quantity
18-461-10656 5-hydroxytryptamine 2C receptor - 5-HT-2C; Serotonin receptor 2C; 5-HT2C; 5-HTR2C; 5HT-1C Polyclonal 0.05 ml
18-461-10658 5-hydroxytryptamine 2C receptor - 5-HT-2C; Serotonin receptor 2C; 5-HT2C; 5-HTR2C; 5HT-1C Polyclonal 0.05 ml
18-461-10657 5-hydroxytryptamine 2C receptor - 5-HT-2C; Serotonin receptor 2C; 5-HT2C; 5-HTR2C; 5HT-1C Polyclonal 0.05 ml
18-003-42961 5-hydroxytryptamine 2C receptor - 5-HT-2C; Serotonin receptor 2C; 5-HT2C; 5-HTR2C; 5HT-1C Polyclonal 0.1 mg Protein A
201-20-2669 HTR2C{5-hydroxytryptamine (serotonin) receptor 2C}rabbit.pAb 0.2ml
HTR2C HTR2A Gene 5-hydroxytryptamine (serotonin) receptor 2A
HTR3B HTR2C Gene 5-hydroxytryptamine (serotonin) receptor 2C
GWB-6AF54D Anti- HTR2C (5-hydroxytryptamine (serotonin) receptor 2C) Antibody
GS47 BV-HTR2C. Recombinant baculovirus expressing 5-hydroxytryptamine (serotonin) receptor 2C. 1 ml
CSB-EL010889DO Dog 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C) ELISA kit, Species Dog, Sample Type serum, plasma 96T
CSB-EL010889RA Rat 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C) ELISA kit, Species Rat, Sample Type serum, plasma 96T
GS47 BV-HTR2C. Recombinant baculovirus expressing 5-hydroxytryptamine (serotonin) receptor 2C. , Host: Spodoptera frugiperda, Trichoplusia ni 1 ml
CSB-EL010889HU Human 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL010889MO Mouse 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
31-114 The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] int 0.1 mg
DL-HTR2C-Ra Rat 5-Hydroxytryptamine Receptor 2C (HTR2C) ELISA Kit 96T
18-003-42960 5-hydroxytryptamine 1B receptor - 5-HT-1B; Serotonin receptor 1B; 5-HT1B; 5-HT-1D-beta; Serotonin 1D beta receptor; S12 Polyclonal 0.1 mg Protein A
CSB-EL010889RA Rat 5-hydroxytryptamine receptor 2C(HTR2C) ELISA kit 96T
E93488Ra ELISA Kit for 5-Hydroxytryptamine Receptor 2C (HTR2C) 96T/Kit
UB-E10080 Rat 5-Hydroxytryptamine Receptor 2C(HTR2C)ELISA Kit 96T
CSB-EL010889DO Dog 5-hydroxytryptamine receptor 2C(HTR2C) ELISA kit 96T
201-11-1566 Rat 5-Hydroxytryptamine Receptor 2C(HTR2C)ELISA Kit 96T
QY-E10080 Rat 5-Hydroxytryptamine Receptor 2C(HTR2C)ELISA Kit 96T
18-003-42962 5-hydroxytryptamine 3 receptor - 5-HT-3; Serotonin-gated ion channel receptor; 5-HT3R Polyclonal 0.05 mg Aff Pur
18-003-42963 5-hydroxytryptamine 3 receptor - 5-HT-3; Serotonin-gated ion channel receptor; 5-HT3R Polyclonal 0.05 mg Aff Pur


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur