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5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)

 5HT3A_RAT               Reviewed;         483 AA.
P35563;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 2.
23-MAY-2018, entry version 147.
RecName: Full=5-hydroxytryptamine receptor 3A;
Short=5-HT3-A;
Short=5-HT3A;
AltName: Full=5-hydroxytryptamine receptor 3;
Short=5-HT-3;
Short=5-HT3R;
AltName: Full=Serotonin receptor 3A;
AltName: Full=Serotonin-gated ion channel receptor;
Flags: Precursor;
Name=Htr3a; Synonyms=5ht3, Htr3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Miyake A., Mochizuki S., Akuzawa S., Kon G.;
Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 22-483.
PubMed=7509203;
Isenberg K.E., Ukhun I.A., Holstad S.G., Jafri S., Uchida U.,
Zorumski C.F., Yang J.;
"Partial cDNA cloning and NGF regulation of a rat 5-HT3 receptor
subunit.";
NeuroReport 5:121-124(1993).
[3]
SUBUNIT, AND INDUCTION.
PubMed=10854267; DOI=10.1046/j.1471-4159.2000.0750240.x;
Hanna M.C., Davies P.A., Hales T.G., Kirkness E.F.;
"Evidence for expression of heteromeric serotonin 5-HT(3) receptors in
rodents.";
J. Neurochem. 75:240-247(2000).
[4]
SUBUNIT, AND TISSUE SPECIFICITY.
PubMed=12151552;
Morales M., Wang S.-D.;
"Differential composition of 5-hydroxytryptamine3 receptors
synthesized in the rat CNS and peripheral nervous system.";
J. Neurosci. 22:6732-6741(2002).
[5]
FUNCTION, AND REGION.
PubMed=12867984; DOI=10.1038/nature01788;
Kelley S.P., Dunlop J.I., Kirkness E.F., Lambert J.J., Peters J.A.;
"A cytoplasmic region determines single-channel conductance in 5-HT3
receptors.";
Nature 424:321-324(2003).
-!- FUNCTION: This is one of the several different receptors for 5-
hydroxytryptamine (serotonin), a biogenic hormone that functions
as a neurotransmitter, a hormone, and a mitogen. This receptor is
a ligand-gated ion channel, which when activated causes fast,
depolarizing responses in neurons. It is a cation-specific, but
otherwise relatively nonselective, ion channel.
{ECO:0000269|PubMed:12867984}.
-!- SUBUNIT: Interacts with RIC3 (By similarity). Forms pentahomomeric
complex as well as pentaheteromeric complex with HTR3B; homomeric
complex is functional but exhibits low conductance with modified
voltage dependence and antagonist affinity. {ECO:0000250,
ECO:0000269|PubMed:10854267, ECO:0000269|PubMed:12151552}.
-!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
membrane protein.
-!- TISSUE SPECIFICITY: Expressed in central and peripheral neurons.
{ECO:0000269|PubMed:12151552}.
-!- INDUCTION: By nerve growth factor in PC12 cells.
{ECO:0000269|PubMed:10854267}.
-!- MISCELLANEOUS: The HA-stretch region of HTR3A seems to be
responsible for the low conductance of HTR3A homomers compared to
that of HTR3A/HTR3B heteromers.
-!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A
sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; D49395; BAA08388.1; -; mRNA.
EMBL; U01227; AAA52182.1; -; mRNA.
PIR; I58179; I58179.
RefSeq; NP_077370.2; NM_024394.2.
UniGene; Rn.55109; -.
ProteinModelPortal; P35563; -.
SMR; P35563; -.
STRING; 10116.ENSRNOP00000008965; -.
BindingDB; P35563; -.
ChEMBL; CHEMBL2411; -.
GuidetoPHARMACOLOGY; 373; -.
TCDB; 1.A.9.2.2; the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.
PhosphoSitePlus; P35563; -.
PaxDb; P35563; -.
Ensembl; ENSRNOT00000008965; ENSRNOP00000008965; ENSRNOG00000006595.
GeneID; 79246; -.
KEGG; rno:79246; -.
UCSC; RGD:61818; rat.
CTD; 3359; -.
RGD; 61818; Htr3a.
eggNOG; KOG3645; Eukaryota.
eggNOG; ENOG410XQGR; LUCA.
GeneTree; ENSGT00910000144023; -.
HOGENOM; HOG000241519; -.
HOVERGEN; HBG106638; -.
InParanoid; P35563; -.
KO; K04819; -.
OMA; LWSIWQY; -.
OrthoDB; EOG091G06Q8; -.
PhylomeDB; P35563; -.
TreeFam; TF315605; -.
Reactome; R-RNO-112314; Neurotransmitter receptors and postsynaptic signal transmission.
PRO; PR:P35563; -.
Proteomes; UP000002494; Chromosome 8.
Bgee; ENSRNOG00000006595; -.
Genevisible; P35563; RN.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0032154; C:cleavage furrow; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; TAS:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:1904602; C:serotonin-activated cation-selective channel complex; IEA:Ensembl.
GO; GO:0051378; F:serotonin binding; IEA:Ensembl.
GO; GO:0022850; F:serotonin-gated cation-selective channel activity; IDA:RGD.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.
GO; GO:0007268; P:chemical synaptic transmission; TAS:RGD.
GO; GO:0032414; P:positive regulation of ion transmembrane transporter activity; IDA:RGD.
GO; GO:0042220; P:response to cocaine; IEP:RGD.
GO; GO:0045471; P:response to ethanol; IEP:RGD.
Gene3D; 2.70.170.10; -; 1.
InterPro; IPR008132; 5HT3_rcpt.
InterPro; IPR008133; 5HT3_rcpt_A.
InterPro; IPR006202; Neur_chan_lig-bd.
InterPro; IPR036734; Neur_chan_lig-bd_sf.
InterPro; IPR006201; Neur_channel.
InterPro; IPR036719; Neuro-gated_channel_TM_sf.
InterPro; IPR006029; Neurotrans-gated_channel_TM.
InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
PANTHER; PTHR18945; PTHR18945; 1.
Pfam; PF02931; Neur_chan_LBD; 1.
Pfam; PF02932; Neur_chan_memb; 1.
PRINTS; PR01709; 5HT3ARECEPTR.
PRINTS; PR01708; 5HT3RECEPTOR.
PRINTS; PR00252; NRIONCHANNEL.
SUPFAM; SSF63712; SSF63712; 1.
SUPFAM; SSF90112; SSF90112; 1.
TIGRFAMs; TIGR00860; LIC; 1.
PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
1: Evidence at protein level;
Cell junction; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
Membrane; Postsynaptic cell membrane; Receptor; Reference proteome;
Signal; Synapse; Transmembrane; Transmembrane helix; Transport.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 483 5-hydroxytryptamine receptor 3A.
/FTId=PRO_0000000410.
TOPO_DOM 24 246 Extracellular. {ECO:0000255}.
TRANSMEM 247 273 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 274 278 Cytoplasmic. {ECO:0000255}.
TRANSMEM 279 297 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 298 307 Extracellular. {ECO:0000255}.
TRANSMEM 308 326 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 327 460 Cytoplasmic. {ECO:0000255}.
TRANSMEM 461 480 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 481 483 Extracellular. {ECO:0000255}.
REGION 419 455 HA-stretch.
CARBOHYD 109 109 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 175 175 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 191 191 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 162 176 {ECO:0000250}.
CONFLICT 22 22 E -> K (in Ref. 2; AAA52182).
{ECO:0000305}.
CONFLICT 306 306 G -> R (in Ref. 2; AAA52182).
{ECO:0000305}.
SEQUENCE 483 AA; 55428 MW; ED85257BBCCF28A4 CRC64;
MPLCIPQVLL ALFLSVLIAQ GEGSRRRATQ AHSTTQPALL RLSDHLLANY KKGVRPVRDW
RKPTLVSIDV IMYAILNVDE KNQVLTTYIW YRQFWTDEFL QWTPEDFDNV TKLSIPTDSI
WVPDILINEF VDVGKSPSIP YVYVHHQGEV QNYKPLQLVT ACSLDIYNFP FDVQNCSLTF
TSWLHTIQDI NISLWRTPEE VRSDKSIFIN QGEWELLGVF TKFQEFSIET SNSYAEMKFY
VVIRRRPLFY AVSLLLPSIF LMVVDIVGFC LPPDSGERVS FKITLLLGYS VFLIIVSDTL
PATAIGTPLI GVYFVVCMAL LVISLAETIF IVQLVHKQDL QRPVPDWLRH LVLDRIAWLL
CLGEQPMAHR PPATFQANKT DDCSAMGNHC SHVGSPQDLE KTSRSRDSPL PPPREASLAV
RGLLQELSSI RHSLEKRDEM REVARDWLRV GYVLDRLLFR IYLLAVLAYS ITLVTLWSIW
HYS


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