Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)

 5HT3A_HUMAN             Reviewed;         478 AA.
P46098; B4DSY6; G5E986; O60854; Q7KZM7; Q99918; Q9BSZ9;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
22-NOV-2017, entry version 181.
RecName: Full=5-hydroxytryptamine receptor 3A;
Short=5-HT3-A;
Short=5-HT3A;
AltName: Full=5-hydroxytryptamine receptor 3;
Short=5-HT-3;
Short=5-HT3R;
AltName: Full=Serotonin receptor 3A;
AltName: Full=Serotonin-gated ion channel receptor;
Flags: Precursor;
Name=HTR3A; Synonyms=5HT3R, HTR3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Hippocampus;
PubMed=7565620;
Miyake A., Mochizuki S., Takemoto Y., Akuzawa S.;
"Molecular cloning of human 5-hydroxytryptamine3 receptor:
heterogeneity in distribution and function among species.";
Mol. Pharmacol. 48:407-416(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Amygdala;
PubMed=8848005;
Belelli D., Balcarek J.M., Hope A.G., Peters J.A., Lambert J.J.,
Blackburn T.P.;
"Cloning and functional expression of a human 5-hydroxytryptamine type
3AS receptor subunit.";
Mol. Pharmacol. 48:1054-1062(1995).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Amygdala, and Hippocampus;
PubMed=9928262; DOI=10.1111/j.1749-6632.1998.tb10196.x;
Bruess M., Goethert M., Hayer M., Bonisch H.;
"Molecular cloning of alternatively spliced human 5HT3 receptor
cDNAs.";
Ann. N. Y. Acad. Sci. 861:234-235(1998).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Blood;
PubMed=10670426; DOI=10.1016/S0028-3908(99)00116-1;
Bruess M., Eucker T., Goethert M., Bonisch H.;
"Exon-intron organization of the human 5-HT3A receptor gene.";
Neuropharmacology 39:308-315(2000).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
"cDNA clones of human proteins involved in signal transduction
sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
PubMed=15028279; DOI=10.1016/j.ygeno.2003.09.023;
Jin P., Fu G.K., Wilson A.D., Yang J., Chien D., Hawkins P.R.,
Au-Young J., Stuve L.L.;
"PCR isolation and cloning of novel splice variant mRNAs from known
drug target genes.";
Genomics 83:566-571(2004).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16554811; DOI=10.1038/nature04632;
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene
identification.";
Nature 440:497-500(2006).
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[12]
FUNCTION, AND SUBUNIT.
PubMed=9950429; DOI=10.1038/16941;
Davies P.A., Pistis M., Hanna M.C., Peters J.A., Lambert J.J.,
Hales T.G., Kirkness E.F.;
"The 5-HT3B subunit is a major determinant of serotonin-receptor
function.";
Nature 397:359-363(1999).
[13]
SUBUNIT, AND TISSUE SPECIFICITY.
TISSUE=Small intestine;
PubMed=10521471; DOI=10.1074/jbc.274.43.30799;
Dubin A.E., Huvar R., D'Andrea M.R., Pyati J., Zhu J.Y., Joy K.C.,
Wilson S.J., Galindo J.E., Glass C.A., Luo L., Jackson M.R.,
Lovenberg T.W., Erlander M.G.;
"The pharmacological and functional characteristics of the serotonin
5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor
subunit.";
J. Biol. Chem. 274:30799-30810(1999).
[14]
FUNCTION, REGION, AND MUTAGENESIS OF ARG-432; ARG-436 AND ARG-440.
PubMed=12867984; DOI=10.1038/nature01788;
Kelley S.P., Dunlop J.I., Kirkness E.F., Lambert J.J., Peters J.A.;
"A cytoplasmic region determines single-channel conductance in 5-HT3
receptors.";
Nature 424:321-324(2003).
[15]
INTERACTION WITH RIC3.
PubMed=15809299; DOI=10.1074/jbc.M414341200;
Cheng A., McDonald N.A., Connolly C.N.;
"Cell surface expression of 5-hydroxytryptamine type 3 receptors is
promoted by RIC-3.";
J. Biol. Chem. 280:22502-22507(2005).
[16]
SUBUNIT, AND MUTAGENESIS OF TRP-178.
PubMed=17392525; DOI=10.1124/mol.106.032144;
Niesler B., Walstab J., Combrink S., Moeller D., Kapeller J.,
Rietdorf J., Boenisch H., Goethert M., Rappold G., Bruess M.;
"Characterization of the novel human serotonin receptor subunits 5-
HT3C, 5-HT3D, and 5-HT3E.";
Mol. Pharmacol. 72:8-17(2007).
[17]
VARIANT THR-33.
PubMed=15293096; DOI=10.1007/s10067-004-0927-2;
Frank B., Niesler B., Bondy B., Spaeth M., Pongratz D.E.,
Ackenheil M., Fischer C., Rappold G.;
"Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in
fibromyalgia patients.";
Clin. Rheumatol. 23:338-344(2004).
[18]
VARIANTS HIS-344; ARG-391 AND GLN-409.
PubMed=16487942; DOI=10.1016/j.biopsych.2005.11.008;
Yamada K., Hattori E., Iwayama Y., Ohnishi T., Ohba H., Toyota T.,
Takao H., Minabe Y., Nakatani N., Higuchi T., Detera-Wadleigh S.D.,
Yoshikawa T.;
"Distinguishable haplotype blocks in the HTR3A and HTR3B region in the
Japanese reveal evidence of association of HTR3B with female major
depression.";
Biol. Psychiatry 60:192-201(2006).
-!- FUNCTION: This is one of the several different receptors for 5-
hydroxytryptamine (serotonin), a biogenic hormone that functions
as a neurotransmitter, a hormone, and a mitogen. This receptor is
a ligand-gated ion channel, which when activated causes fast,
depolarizing responses in neurons. It is a cation-specific, but
otherwise relatively nonselective, ion channel.
{ECO:0000269|PubMed:12867984, ECO:0000269|PubMed:9950429}.
-!- SUBUNIT: Forms pentahomomeric complex as well as pentaheteromeric
complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex
is functional but exhibits low conductance with modified voltage
dependence, and decreased agonist and antagonist affinity.
Interacts with RIC3. {ECO:0000269|PubMed:10521471,
ECO:0000269|PubMed:15809299, ECO:0000269|PubMed:17392525,
ECO:0000269|PubMed:9950429}.
-!- INTERACTION:
Q8WXA8:HTR3C; NbExp=5; IntAct=EBI-9008743, EBI-9008753;
Q70Z44:HTR3D; NbExp=5; IntAct=EBI-9008743, EBI-9008717;
A5X5Y0-1:HTR3E; NbExp=5; IntAct=EBI-9008743, EBI-11174612;
A5X5Y0-3:HTR3E; NbExp=3; IntAct=EBI-9008743, EBI-11163690;
-!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=5;
Name=1; Synonyms=5-HT3R-AS;
IsoId=P46098-1; Sequence=Displayed;
Name=2; Synonyms=5-HT3R-AL;
IsoId=P46098-2; Sequence=VSP_000078;
Name=3;
IsoId=P46098-3; Sequence=VSP_042214;
Name=4;
IsoId=P46098-4; Sequence=VSP_043484;
Note=No experimental confirmation available.;
Name=5;
IsoId=P46098-5; Sequence=VSP_043484, VSP_000078;
Note=No experimental confirmation available. Ref.7 (CD014118)
sequence is in conflict in position: 342:C->W. {ECO:0000305};
-!- TISSUE SPECIFICITY: Expressed in cerebral cortex, amygdala,
hippocampus, and testis. Detected in monocytes of the spleen and
tonsil, in small and large intestine, uterus, prostate, ovary and
placenta. {ECO:0000269|PubMed:10521471}.
-!- MISCELLANEOUS: The HA-stretch region of HTR3A seems to be
responsible for the low conductance of HTR3A homomers compared to
that of HTR3A/HTR3B heteromers.
-!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A
sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; D49394; BAA08387.1; -; mRNA.
EMBL; S82612; AAB37533.2; -; mRNA.
EMBL; AJ003078; CAA05851.1; -; mRNA.
EMBL; AJ003079; CAA05852.1; -; mRNA.
EMBL; AJ005205; CAA06442.3; -; Genomic_DNA.
EMBL; AF498984; AAM21131.1; -; mRNA.
EMBL; BT007204; AAP35868.1; -; mRNA.
EMBL; CD014118; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AK299973; BAG61798.1; -; mRNA.
EMBL; AP000908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471065; EAW67238.1; -; Genomic_DNA.
EMBL; CH471065; EAW67240.1; -; Genomic_DNA.
EMBL; BC002354; AAH02354.1; -; mRNA.
EMBL; BC004453; AAH04453.2; -; mRNA.
CCDS; CCDS53710.1; -. [P46098-3]
CCDS; CCDS8365.2; -. [P46098-4]
CCDS; CCDS8366.2; -. [P46098-5]
RefSeq; NP_000860.2; NM_000869.5. [P46098-4]
RefSeq; NP_001155244.1; NM_001161772.2. [P46098-3]
RefSeq; NP_998786.2; NM_213621.3. [P46098-5]
UniGene; Hs.413899; -.
ProteinModelPortal; P46098; -.
SMR; P46098; -.
BioGrid; 109591; 112.
IntAct; P46098; 4.
BindingDB; P46098; -.
ChEMBL; CHEMBL1899; -.
DrugBank; DB00969; Alosetron.
DrugBank; DB00543; Amoxapine.
DrugBank; DB01238; Aripiprazole.
DrugBank; DB01161; Chloroprocaine.
DrugBank; DB04885; Cilansetron.
DrugBank; DB00604; Cisapride.
DrugBank; DB00363; Clozapine.
DrugBank; DB05049; DDP733.
DrugBank; DB00757; Dolasetron.
DrugBank; DB01049; Ergoloid mesylate.
DrugBank; DB00898; Ethanol.
DrugBank; DB00889; Granisetron.
DrugBank; DB00408; Loxapine.
DrugBank; DB01043; Memantine.
DrugBank; DB00333; Methadone.
DrugBank; DB01233; Metoclopramide.
DrugBank; DB00370; Mirtazapine.
DrugBank; DB00334; Olanzapine.
DrugBank; DB00904; Ondansetron.
DrugBank; DB00377; Palonosetron.
DrugBank; DB00721; Procaine.
DrugBank; DB01224; Quetiapine.
DrugBank; DB04917; Renzapride.
DrugBank; DB00728; Rocuronium.
DrugBank; DB06204; Tapentadol.
DrugBank; DB13025; Tiapride.
DrugBank; DB00726; Trimipramine.
DrugBank; DB11699; Tropisetron.
DrugBank; DB01199; Tubocurarine.
DrugBank; DB09068; Vortioxetine.
DrugBank; DB00246; Ziprasidone.
GuidetoPHARMACOLOGY; 373; -.
TCDB; 1.A.9.2.1; the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.
iPTMnet; P46098; -.
PhosphoSitePlus; P46098; -.
BioMuta; HTR3A; -.
DMDM; 1168222; -.
PRIDE; P46098; -.
DNASU; 3359; -.
Ensembl; ENST00000299961; ENSP00000299961; ENSG00000166736. [P46098-3]
Ensembl; ENST00000355556; ENSP00000347754; ENSG00000166736. [P46098-5]
Ensembl; ENST00000375498; ENSP00000364648; ENSG00000166736. [P46098-4]
Ensembl; ENST00000504030; ENSP00000424189; ENSG00000166736. [P46098-1]
Ensembl; ENST00000506841; ENSP00000424776; ENSG00000166736. [P46098-2]
GeneID; 3359; -.
KEGG; hsa:3359; -.
UCSC; uc010rxa.3; human. [P46098-1]
CTD; 3359; -.
DisGeNET; 3359; -.
EuPathDB; HostDB:ENSG00000166736.11; -.
GeneCards; HTR3A; -.
HGNC; HGNC:5297; HTR3A.
MIM; 182139; gene.
neXtProt; NX_P46098; -.
OpenTargets; ENSG00000166736; -.
PharmGKB; PA29555; -.
GeneTree; ENSGT00790000122957; -.
HOGENOM; HOG000241519; -.
HOVERGEN; HBG106638; -.
InParanoid; P46098; -.
KO; K04819; -.
OMA; EWLQVGY; -.
OrthoDB; EOG091G06Q8; -.
PhylomeDB; P46098; -.
TreeFam; TF315605; -.
Reactome; R-HSA-112314; Neurotransmitter receptors and postsynaptic signal transmission.
GeneWiki; HTR3A; -.
GenomeRNAi; 3359; -.
PRO; PR:P46098; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000166736; -.
CleanEx; HS_HTR3A; -.
ExpressionAtlas; P46098; baseline and differential.
Genevisible; P46098; HS.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0032154; C:cleavage furrow; IDA:HGNC.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:1904602; C:serotonin-activated cation-selective channel complex; IDA:GO_Central.
GO; GO:0051378; F:serotonin binding; IDA:MGI.
GO; GO:0022850; F:serotonin-gated cation-selective channel activity; IDA:GO_Central.
GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO; GO:0034220; P:ion transmembrane transport; TAS:Reactome.
GO; GO:0032414; P:positive regulation of ion transmembrane transporter activity; IEA:Ensembl.
GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
Gene3D; 1.20.58.390; -; 1.
Gene3D; 2.70.170.10; -; 1.
InterPro; IPR008132; 5HT3_rcpt.
InterPro; IPR008133; 5HT3_rcpt_A.
InterPro; IPR006202; Neur_chan_lig-bd.
InterPro; IPR036734; Neur_chan_lig-bd_sf.
InterPro; IPR006201; Neur_channel.
InterPro; IPR036719; Neuro-gated_channel_TM_sf.
InterPro; IPR006029; Neurotrans-gated_channel_TM.
InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
PANTHER; PTHR18945; PTHR18945; 1.
Pfam; PF02931; Neur_chan_LBD; 1.
Pfam; PF02932; Neur_chan_memb; 1.
PRINTS; PR01709; 5HT3ARECEPTR.
PRINTS; PR01708; 5HT3RECEPTOR.
PRINTS; PR00252; NRIONCHANNEL.
SUPFAM; SSF63712; SSF63712; 1.
SUPFAM; SSF90112; SSF90112; 1.
TIGRFAMs; TIGR00860; LIC; 1.
PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
1: Evidence at protein level;
Alternative splicing; Cell junction; Cell membrane; Complete proteome;
Disulfide bond; Glycoprotein; Ion channel; Ion transport;
Ligand-gated ion channel; Membrane; Polymorphism;
Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
Synapse; Transmembrane; Transmembrane helix; Transport.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 478 5-hydroxytryptamine receptor 3A.
/FTId=PRO_0000000408.
TOPO_DOM 24 241 Extracellular. {ECO:0000255}.
TRANSMEM 242 268 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 269 273 Cytoplasmic. {ECO:0000255}.
TRANSMEM 274 292 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 293 302 Extracellular. {ECO:0000255}.
TRANSMEM 303 321 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 322 455 Cytoplasmic. {ECO:0000255}.
TRANSMEM 456 475 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 476 478 Extracellular. {ECO:0000255}.
REGION 414 450 HA-stretch.
CARBOHYD 28 28 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 104 104 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 170 170 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 186 186 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 157 171 {ECO:0000250}.
VAR_SEQ 1 22 MLLWVQQALLALLLPTLLAQGE -> MHRSFLQ (in
isoform 3).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_042214.
VAR_SEQ 1 1 M -> MLGKLAM (in isoform 4 and isoform
5). {ECO:0000303|PubMed:15028279,
ECO:0000303|Ref.6}.
/FTId=VSP_043484.
VAR_SEQ 306 306 G -> GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG
(in isoform 2 and isoform 5).
{ECO:0000303|PubMed:15028279,
ECO:0000303|PubMed:9928262}.
/FTId=VSP_000078.
VARIANT 33 33 A -> T (in dbSNP:rs117793058).
{ECO:0000269|PubMed:15293096}.
/FTId=VAR_037398.
VARIANT 253 253 S -> N (in dbSNP:rs4938063).
/FTId=VAR_037399.
VARIANT 344 344 R -> H (in dbSNP:rs35815285).
{ECO:0000269|PubMed:16487942}.
/FTId=VAR_037400.
VARIANT 391 391 P -> R. {ECO:0000269|PubMed:16487942}.
/FTId=VAR_037401.
VARIANT 409 409 R -> Q (in dbSNP:rs183698487).
{ECO:0000269|PubMed:16487942}.
/FTId=VAR_037402.
MUTAGEN 178 178 W->S: Abolished ligand binding to the
heteromeric receptor.
{ECO:0000269|PubMed:17392525}.
MUTAGEN 432 432 R->Q: Little effect on conductance.
Massive increase of conductance; when
associated with D-436 and A-440.
{ECO:0000269|PubMed:12867984}.
MUTAGEN 436 436 R->D: Increased conductance. Massive
increase of conductance; when associated
with Q-432 and A-440.
{ECO:0000269|PubMed:12867984}.
MUTAGEN 440 440 R->A: Increased conductance. Massive
increase of conductance; when associated
with Q-432 and D-436.
{ECO:0000269|PubMed:12867984}.
CONFLICT 46 46 R -> T (in Ref. 2; AAB37533).
{ECO:0000305}.
CONFLICT 125 125 F -> L (in Ref. 2; AAB37533).
{ECO:0000305}.
CONFLICT 321 321 A -> T (in Ref. 2; AAB37533).
{ECO:0000305}.
CONFLICT 386 386 S -> T (in Ref. 2; AAB37533).
{ECO:0000305}.
SEQUENCE 478 AA; 55280 MW; 24CA9A232286FBC9 CRC64;
MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR PVRDWRKPTT
VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE DFDNITKLSI PTDSIWVPDI
LINEFVDVGK SPNIPYVYIR HQGEVQNYKP LQVVTACSLD IYNFPFDVQN CSLTFTSWLH
TIQDINISLW RLPEKVKSDR SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR
RPLFYVVSLL LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI
GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER IAWLLCLREQ
STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD RCSPPPPPRE ASLAVCGLLQ
ELSSIRQFLE KRDEIREVAR DWLRVGSVLD KLLFHIYLLA VLAYSITLVM LWSIWQYA


Related products :

Catalog number Product name Quantity
18-003-42963 5-hydroxytryptamine 3 receptor - 5-HT-3; Serotonin-gated ion channel receptor; 5-HT3R Polyclonal 0.05 mg Aff Pur
18-003-42963 5-hydroxytryptamine 3 receptor - 5-HT-3; Serotonin-gated ion channel receptor; 5-HT3R Polyclonal 0.1 mg Protein A
18-003-42962 5-hydroxytryptamine 3 receptor - 5-HT-3; Serotonin-gated ion channel receptor; 5-HT3R Polyclonal 0.05 mg Aff Pur
18-003-42962 5-hydroxytryptamine 3 receptor - 5-HT-3; Serotonin-gated ion channel receptor; 5-HT3R Polyclonal 0.1 mg Protein A
31-116 HTR3A belongs to the ligand-gated ion channel receptor superfamily. It is the subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmit 0.05 mg
25-268 HTR3E belongs to the ligand-gated ion channel receptor superfamily. HTR3E is a subunit E of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmi 0.05 mg
28-253 The product of HTR3B belongs to the ligand-gated ion channel receptor superfamily. HTR3B encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions 0.05 mg
31-114 The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] int 0.1 mg
18-003-42960 5-hydroxytryptamine 1B receptor - 5-HT-1B; Serotonin receptor 1B; 5-HT1B; 5-HT-1D-beta; Serotonin 1D beta receptor; S12 Polyclonal 0.1 mg Protein A
18-461-10658 5-hydroxytryptamine 2C receptor - 5-HT-2C; Serotonin receptor 2C; 5-HT2C; 5-HTR2C; 5HT-1C Polyclonal 0.05 ml
18-461-10656 5-hydroxytryptamine 2C receptor - 5-HT-2C; Serotonin receptor 2C; 5-HT2C; 5-HTR2C; 5HT-1C Polyclonal 0.05 ml
18-461-10657 5-hydroxytryptamine 2C receptor - 5-HT-2C; Serotonin receptor 2C; 5-HT2C; 5-HTR2C; 5HT-1C Polyclonal 0.05 ml
18-003-42961 5-hydroxytryptamine 2C receptor - 5-HT-2C; Serotonin receptor 2C; 5-HT2C; 5-HTR2C; 5HT-1C Polyclonal 0.1 mg Protein A
CSB-E14956r Rat Serotonin Receptor 2A_5-hydroxytryptamine Receptor 2A(5-HT-2A)ELISA Kit SpeciesRat 96T
18-461-10809 5-hydroxytryptamine 7 receptor - 5-HT-7; Serotonin receptor 7; 5-HT-X; 5HT7 Polyclonal 0.05 ml
18-003-42964 5-hydroxytryptamine 7 receptor - 5-HT-7; Serotonin receptor 7; 5-HT-X; 5HT7 Polyclonal 0.05 mg Aff Pur
18-003-42964 5-hydroxytryptamine 7 receptor - 5-HT-7; Serotonin receptor 7; 5-HT-X; 5HT7 Polyclonal 0.1 mg Protein A
18-003-43298 5-hydroxytryptamine 7 receptor - 5-HT-7; Serotonin receptor 7; 5-HT-X; 5HT7 Polyclonal 0.1 mg Protein A
18-461-10229 5-hydroxytryptamine 7 receptor - 5-HT-7; Serotonin receptor 7; 5-HT-X; 5HT7 Polyclonal 0.05 ml
18-461-10230 5-hydroxytryptamine 7 receptor - 5-HT-7; Serotonin receptor 7; 5-HT-X; 5HT7 Polyclonal 0.05 ml
18-461-10796 5-hydroxytryptamine 1D receptor - 5-HT-1D; Serotonin receptor 1D; 5-HT-1D-alpha Polyclonal 0.05 ml
18-461-10797 5-hydroxytryptamine 1D receptor - 5-HT-1D; Serotonin receptor 1D; 5-HT-1D-alpha Polyclonal 0.05 ml
18-461-10798 5-hydroxytryptamine 1D receptor - 5-HT-1D; Serotonin receptor 1D; 5-HT-1D-alpha Polyclonal 0.05 ml
18-003-42959 5-hydroxytryptamine 1A receptor - 5-HT-1A; Serotonin receptor 1A; 5-HT1A; G-21 Polyclonal 0.1 mg Protein A
18-461-10795 5-hydroxytryptamine 1D receptor - 5-HT-1D; Serotonin receptor 1D; 5-HT-1D-alpha Polyclonal 0.05 ml


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur