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5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (ST-B17) (Serotonin receptor 6)

 5HT6R_RAT               Reviewed;         436 AA.
P31388;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 2.
12-SEP-2018, entry version 130.
RecName: Full=5-hydroxytryptamine receptor 6;
Short=5-HT-6;
Short=5-HT6;
AltName: Full=ST-B17;
AltName: Full=Serotonin receptor 6;
Name=Htr6;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
STRAIN=Sprague-Dawley; TISSUE=Corpus striatum;
PubMed=7680751;
Monsma F.J. Jr., Shen Y., Ward R.P., Hamblin M.W., Sibley D.R.;
"Cloning and expression of a novel serotonin receptor with high
affinity for tricyclic psychotropic drugs.";
Mol. Pharmacol. 43:320-327(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8389146; DOI=10.1006/bbrc.1993.1619;
Ruat M., Traiffort E., Arrang J.-M., Tardivel-Lacombe J., Diaz J.,
Leurs R., Schwartz J.-C.;
"A novel rat serotonin (5-HT6) receptor: molecular cloning,
localization and stimulation of cAMP accumulation.";
Biochem. Biophys. Res. Commun. 193:268-276(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar;
Martial R.;
"A novel rat serotonin (5HT6) receptor.";
Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases.
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=16641100; DOI=10.1073/pnas.0600895103;
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
regulation of aquaporin-2 phosphorylation at two sites.";
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
-!- FUNCTION: This is one of the several different receptors for 5-
hydroxytryptamine (serotonin), a biogenic hormone that functions
as a neurotransmitter, a hormone, and a mitogen. The activity of
this receptor is mediated by G proteins that stimulate adenylate
cyclase. It has a high affinity for tricyclic psychotropic drugs
(PubMed:7680751). Controls pyramidal neurons migration during
corticogenesis, through the regulation of CDK5 activity (By
similarity). Is an activator of TOR signaling (By similarity).
{ECO:0000250|UniProtKB:P50406, ECO:0000250|UniProtKB:Q9R1C8,
ECO:0000269|PubMed:7680751}.
-!- SUBUNIT: Interacts with MTOR, RPTOR and NF1 (By similarity).
Interacts with CDK5 (By similarity).
{ECO:0000250|UniProtKB:P50406, ECO:0000250|UniProtKB:Q9R1C8}.
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Localized exclusively in the central nervous
system, predominantly in the corpus striatum but also in various
limbic and cortical regions.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; L03202; AAA40618.1; -; mRNA.
EMBL; S62043; AAB26908.1; -; mRNA.
EMBL; L19656; AAA40611.1; -; mRNA.
PIR; I57942; I57942.
PIR; JN0591; JN0591.
UniGene; Rn.10552; -.
ProteinModelPortal; P31388; -.
BioGrid; 249039; 1.
STRING; 10116.ENSRNOP00000064366; -.
BindingDB; P31388; -.
ChEMBL; CHEMBL3372; -.
GuidetoPHARMACOLOGY; 11; -.
iPTMnet; P31388; -.
PhosphoSitePlus; P31388; -.
PaxDb; P31388; -.
PRIDE; P31388; -.
Ensembl; ENSRNOT00000070865; ENSRNOP00000064366; ENSRNOG00000049761.
RGD; 62044; Htr6.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00890000139331; -.
HOVERGEN; HBG106962; -.
InParanoid; P31388; -.
Reactome; R-RNO-390666; Serotonin receptors.
PRO; PR:P31388; -.
Proteomes; UP000002494; Chromosome 5.
Bgee; ENSRNOG00000049761; Expressed in 1 organ(s), highest expression level in brain.
ExpressionAtlas; P31388; baseline and differential.
Genevisible; P31388; RN.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0004993; F:G-protein coupled serotonin receptor activity; IDA:RGD.
GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
GO; GO:0007420; P:brain development; IEP:RGD.
GO; GO:0021795; P:cerebral cortex cell migration; ISS:UniProtKB.
GO; GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IMP:RGD.
GO; GO:0007612; P:learning; IDA:RGD.
GO; GO:0060291; P:long-term synaptic potentiation; IMP:RGD.
GO; GO:0014058; P:negative regulation of acetylcholine secretion, neurotransmission; IMP:RGD.
GO; GO:0014053; P:negative regulation of gamma-aminobutyric acid secretion; IMP:RGD.
GO; GO:0014050; P:negative regulation of glutamate secretion; IMP:RGD.
GO; GO:0033603; P:positive regulation of dopamine secretion; IMP:RGD.
GO; GO:0014054; P:positive regulation of gamma-aminobutyric acid secretion; IMP:RGD.
GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
CDD; cd15054; 7tmA_5-HT6; 1.
InterPro; IPR002232; 5HT6_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
Reference proteome; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 436 5-hydroxytryptamine receptor 6.
/FTId=PRO_0000068977.
TOPO_DOM 1 34 Extracellular. {ECO:0000250}.
TRANSMEM 35 57 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 58 64 Cytoplasmic. {ECO:0000250}.
TRANSMEM 65 85 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 86 100 Extracellular. {ECO:0000250}.
TRANSMEM 101 122 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 123 144 Cytoplasmic. {ECO:0000250}.
TRANSMEM 145 166 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 167 184 Extracellular. {ECO:0000250}.
TRANSMEM 185 208 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 209 265 Cytoplasmic. {ECO:0000250}.
TRANSMEM 266 290 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 291 295 Extracellular. {ECO:0000250}.
TRANSMEM 296 320 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 321 436 Cytoplasmic. {ECO:0000250}.
CARBOHYD 9 9 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 99 180 {ECO:0000255|PROSITE-ProRule:PRU00521}.
CONFLICT 57 57 L -> V (in Ref. 1; AAA40618).
{ECO:0000305}.
CONFLICT 336 436 PCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQ
TQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWST
SLSQTLWSLRYGRIHSVPP -> HASTVPRSTGQPCLPLHV
DLSQRCQTRPQLQQVLALPLPPNSDSDSASGGTSGLQLTAQ
LLLPGEATRDPPPPTRATTVVNFFVTDSVEPEIRPHPLSSP
VN (in Ref. 1; AAA40618). {ECO:0000305}.
SEQUENCE 436 AA; 46923 MW; 6BC00F6A3CBA5FB4 CRC64;
MVPEPGPVNS STPAWGPGPP PAPGGSGWVA AALCVVIVLT AAANSLLIVL ICTQPALRNT
SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI
SLDRYLLILS PLRYKLRMTA PRALALILGA WSLAALASFL PLLLGWHELG KARTPAPGQC
RLLASLPFVL VASGVTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGTA GQALETLQVP
RTPRPGMESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIA QAVCDCISPG
LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCVHC PPEHRPALPP PPCGPLTAVP
DQASACSRCC LCLCRQTQIQ TPLQGAPRAC SSQPSFCCLE RPPGTPRHPP GPPLWSTSLS
QTLWSLRYGR IHSVPP


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