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A kinase (PRKA) anchor protein 1, isoform CRA_a (A-kinase anchor protein 1, mitochondrial)

 F1LMK0_RAT              Unreviewed;       544 AA.
F1LMK0;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
03-APR-2013, sequence version 2.
05-DEC-2018, entry version 54.
SubName: Full=A kinase (PRKA) anchor protein 1, isoform CRA_a {ECO:0000313|EMBL:EDM05642.1};
SubName: Full=A-kinase anchor protein 1, mitochondrial {ECO:0000313|Ensembl:ENSRNOP00000003251};
Name=Akap1 {ECO:0000313|EMBL:EDM05642.1,
ECO:0000313|Ensembl:ENSRNOP00000003251, ECO:0000313|RGD:620826};
ORFNames=rCG_33812 {ECO:0000313|EMBL:EDM05642.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000003251, ECO:0000313|Proteomes:UP000002494};
[1] {ECO:0000313|Ensembl:ENSRNOP00000003251, ECO:0000313|Proteomes:UP000002494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003251,
ECO:0000313|Proteomes:UP000002494};
PubMed=15057822; DOI=10.1038/nature02426;
Rat Genome Sequencing Project Consortium;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2] {ECO:0000313|EMBL:EDM05642.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDM05642.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[3] {ECO:0000313|EMBL:EDM05642.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDM05642.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSRNOP00000003251}
IDENTIFICATION.
STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003251};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[5] {ECO:0000213|PubMed:22673903}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
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EMBL; AABR07030205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH473948; EDM05642.1; -; Genomic_DNA.
UniGene; Rn.163146; -.
Ensembl; ENSRNOT00000003251; ENSRNOP00000003251; ENSRNOG00000002373.
RGD; 620826; Akap1.
eggNOG; KOG2279; Eukaryota.
eggNOG; ENOG410Z0DP; LUCA.
GeneTree; ENSGT00390000001360; -.
TreeFam; TF105401; -.
Reactome; R-RNO-983231; Factors involved in megakaryocyte development and platelet production.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000002373; Expressed in 10 organ(s), highest expression level in testis.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005739; C:mitochondrion; IEA:InterPro.
GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:InterPro.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0010738; P:regulation of protein kinase A signaling; IEA:InterPro.
InterPro; IPR033104; Akap1.
InterPro; IPR018459; RII_binding_1.
PANTHER; PTHR22948:SF18; PTHR22948:SF18; 1.
Pfam; PF10522; RII_binding_1; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000002494};
Kinase {ECO:0000313|EMBL:EDM05642.1};
Membrane {ECO:0000256|SAM:Phobius};
Proteomics identification {ECO:0000213|PeptideAtlas:F1LMK0};
Reference proteome {ECO:0000313|Proteomes:UP000002494};
Transferase {ECO:0000313|EMBL:EDM05642.1};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 7 26 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 301 319 RII_binding_1.
{ECO:0000259|Pfam:PF10522}.
SEQUENCE 544 AA; 57651 MW; CF24E0869E50A203 CRC64;
MAIQFRSLFP LALPGMLALL GWWWFFSRKK DRLSSNGKQV GTLKVGPAIE DRLPTEEACP
GVLSVTPSVT QPPGKEEQRS MDRPLTDPPA LPRTRQVRRR SESSGNLPSI VDTRLQAGQC
RDENSKVVLS LMGDEAKSIP LGRPLFPKDL SFPYEAVEGC KQESALGRTP GRGWLSQCAA
SGENARETGG AEGTGDAVLG ESVLEEGLLP QECVSEVEKS EFPILAPGGG GGEKVRSGPP
QVDELLKKEE YIVGKLPSSF VGPVHSELVK DEGALVPQVK GSQDRSLARE LDKDKTLPEK
DQIEQTAFQI ISQVILEATE EIRATTVGKT VAQVHPTPGT QPQGQEESCV PASQETSLGQ
EIPDPASTRT GATASPSAGA PPPKTYVSCL SSPLSGPTKD QKPKNSAHHI SLAPCPPPVT
PQRQSLDGAS NPRGDDTFVT CTSNNSQSVL SVTSLGLCSD PVSTSRLEDS CTETISSSGD
KAVTPPLPDS TEPFSNGVLK EELSDLGTED GWTMDTEADH SGVAAPPQER GHFGNGGCAG
FFEC


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