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A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 150 kDa) (AKAP 150) (P150) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein)

 AKAP5_MOUSE             Reviewed;         745 AA.
D3YVF0; D3Z5C9;
25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
05-APR-2011, sequence version 2.
05-DEC-2018, entry version 61.
RecName: Full=A-kinase anchor protein 5;
Short=AKAP-5;
AltName: Full=A-kinase anchor protein 150 kDa;
Short=AKAP 150;
Short=P150;
AltName: Full=cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein;
Name=Akap5; Synonyms=Akap150;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-22, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, and Lung;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: May anchor the PKA kinase to cytoskeletal and/or
organelle-associated proteins, targeting the signal carried by
cAMP to specific intracellular effectors. {ECO:0000250}.
-!- SUBUNIT: Interacts with ADCY8, and enhances its phosphorylation at
lipid rafts. Binds dimer of the RII-beta regulatory subunit of
cAMP-dependent protein kinase (By similarity). {ECO:0000250}.
-!- INTERACTION:
P97438:Kcnk2; NbExp=4; IntAct=EBI-7091108, EBI-7091062;
P48453:Ppp3cb; NbExp=3; IntAct=EBI-7091108, EBI-642618;
P12367:Prkar2a; NbExp=2; IntAct=EBI-7091108, EBI-645747;
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor
{ECO:0000250}. Note=Associates with lipid rafts. {ECO:0000250}.
-!- DOMAIN: The N-terminal region, which is highly basic, is required
for interaction with calmodulin. {ECO:0000250}.
-!- PTM: Palmitoylation at Cys-36 and Cys-123 plays a key role in
targeting to lipid rafts. {ECO:0000250}.
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EMBL; AC120002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS49092.1; -.
RefSeq; NP_001094941.1; NM_001101471.1.
UniGene; Mm.311452; -.
ProteinModelPortal; D3YVF0; -.
SMR; D3YVF0; -.
BioGrid; 231964; 3.
ComplexPortal; CPX-1006; Calcineurin-Calmodulin-AKAP5 complex, beta-R1 variant.
ComplexPortal; CPX-1113; Calcineurin-Calmodulin-AKAP5 complex, gamma-R1 variant.
ComplexPortal; CPX-1115; Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant.
ComplexPortal; CPX-1117; Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant.
ComplexPortal; CPX-1119; Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant.
ComplexPortal; CPX-881; Calcineurin-Calmodulin-AKAP5 complex, alpha-R1 variant.
IntAct; D3YVF0; 3.
MINT; D3YVF0; -.
STRING; 10090.ENSMUSP00000114495; -.
iPTMnet; D3YVF0; -.
PhosphoSitePlus; D3YVF0; -.
SwissPalm; D3YVF0; -.
MaxQB; D3YVF0; -.
PaxDb; D3YVF0; -.
PeptideAtlas; D3YVF0; -.
PRIDE; D3YVF0; -.
Ensembl; ENSMUST00000154078; ENSMUSP00000114495; ENSMUSG00000021057.
GeneID; 238276; -.
KEGG; mmu:238276; -.
UCSC; uc007nya.2; mouse.
CTD; 9495; -.
MGI; MGI:2685104; Akap5.
eggNOG; ENOG410IIWH; Eukaryota.
eggNOG; ENOG4111833; LUCA.
GeneTree; ENSGT00390000019941; -.
HOGENOM; HOG000168350; -.
InParanoid; D3YVF0; -.
KO; K16522; -.
OMA; SICEGRP; -.
PhylomeDB; D3YVF0; -.
Reactome; R-MMU-399719; Trafficking of AMPA receptors.
Reactome; R-MMU-9010642; ROBO receptors bind AKAP5.
PRO; PR:D3YVF0; -.
Proteomes; UP000000589; Chromosome 12.
Bgee; ENSMUSG00000021057; Expressed in 200 organ(s), highest expression level in lung.
ExpressionAtlas; D3YVF0; baseline and differential.
Genevisible; D3YVF0; MM.
GO; GO:0032279; C:asymmetric synapse; ISO:MGI.
GO; GO:0016323; C:basolateral plasma membrane; ISO:MGI.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; ISO:MGI.
GO; GO:0005856; C:cytoskeleton; IDA:MGI.
GO; GO:0030425; C:dendrite; ISO:MGI.
GO; GO:0032590; C:dendrite membrane; ISO:MGI.
GO; GO:0043198; C:dendritic shaft; ISO:MGI.
GO; GO:0043197; C:dendritic spine; ISO:MGI.
GO; GO:0032591; C:dendritic spine membrane; ISO:MGI.
GO; GO:0060076; C:excitatory synapse; ISO:MGI.
GO; GO:0031527; C:filopodium membrane; ISO:MGI.
GO; GO:0098978; C:glutamatergic synapse; ISO:MGI.
GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
GO; GO:0043025; C:neuronal cell body; ISO:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0014069; C:postsynaptic density; ISO:MGI.
GO; GO:0099092; C:postsynaptic density, intracellular component; ISO:MGI.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0003779; F:actin binding; ISO:MGI.
GO; GO:0008179; F:adenylate cyclase binding; IPI:MGI.
GO; GO:0031698; F:beta-2 adrenergic receptor binding; ISO:MGI.
GO; GO:0045296; F:cadherin binding; ISO:MGI.
GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
GO; GO:0050811; F:GABA receptor binding; ISO:MGI.
GO; GO:0035254; F:glutamate receptor binding; ISO:MGI.
GO; GO:0019900; F:kinase binding; ISO:MGI.
GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
GO; GO:0034237; F:protein kinase A regulatory subunit binding; ISO:MGI.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0030346; F:protein phosphatase 2B binding; ISO:MGI.
GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
GO; GO:0032947; F:protein-containing complex scaffold activity; ISO:MGI.
GO; GO:0097110; F:scaffold protein binding; ISO:MGI.
GO; GO:0017124; F:SH3 domain binding; ISO:MGI.
GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; ISO:MGI.
GO; GO:0036394; P:amylase secretion; IMP:MGI.
GO; GO:0043624; P:cellular protein complex disassembly; ISO:MGI.
GO; GO:0007194; P:negative regulation of adenylate cyclase activity; ISS:UniProtKB.
GO; GO:0043271; P:negative regulation of ion transport; ISO:MGI.
GO; GO:0043267; P:negative regulation of potassium ion transport; ISO:MGI.
GO; GO:0045762; P:positive regulation of adenylate cyclase activity; ISO:MGI.
GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; ISO:MGI.
GO; GO:0010524; P:positive regulation of calcium ion transport into cytosol; ISO:MGI.
GO; GO:0050775; P:positive regulation of dendrite morphogenesis; ISO:MGI.
GO; GO:0042307; P:positive regulation of protein import into nucleus; ISO:MGI.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISO:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
GO; GO:0006605; P:protein targeting; IEA:InterPro.
GO; GO:0099149; P:regulation of postsynaptic neurotransmitter receptor internalization; ISO:MGI.
GO; GO:0010738; P:regulation of protein kinase A signaling; ISO:MGI.
InterPro; IPR001573; Pkinase-A_anch_WSK-motif.
Pfam; PF03832; WSK; 1.
1: Evidence at protein level;
Calmodulin-binding; Complete proteome; Lipoprotein; Membrane;
Palmitate; Phosphoprotein; Reference proteome; Repeat.
CHAIN 1 745 A-kinase anchor protein 5.
/FTId=PRO_0000414750.
DOMAIN 71 100 AKAP.
REPEAT 304 312 1; approximate.
REPEAT 320 327 2; approximate.
REPEAT 328 335 3; approximate.
REPEAT 348 355 4; approximate.
REPEAT 356 363 5; approximate.
REPEAT 364 395 6; approximate.
REPEAT 420 436 7; approximate.
REPEAT 445 452 8; approximate.
REPEAT 461 468 9.
REPEAT 469 476 10.
REPEAT 477 484 11.
REPEAT 485 492 12.
REPEAT 493 500 13.
REPEAT 501 508 14; approximate.
REPEAT 517 524 15; approximate.
REPEAT 525 532 16.
REPEAT 533 540 17.
REPEAT 541 548 18.
REPEAT 549 556 19.
REPEAT 557 564 20; approximate.
REPEAT 565 572 21.
REPEAT 573 580 22; approximate.
REPEAT 581 588 23; approximate.
REPEAT 589 596 24; approximate.
REPEAT 597 604 25.
REPEAT 605 612 26; approximate.
REPEAT 613 620 27; approximate.
REPEAT 621 628 28; approximate.
REGION 1 164 Essential to the intracellular anchoring
function. {ECO:0000250}.
REGION 304 628 28 X 8 AA repeats of V-G-Q-A-E-E-A-T.
REGION 706 727 RII-beta subunit binding domain.
{ECO:0000250}.
COMPBIAS 332 654 Glu-rich.
MOD_RES 4 4 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 22 22 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
LIPID 36 36 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 123 123 S-palmitoyl cysteine. {ECO:0000250}.
SEQUENCE 745 AA; 79397 MW; B0A2949CC0F52569 CRC64;
METSVSEIQV ETKDEKGPVA ASPQKERQER KTATLCFKRR KKANKTKPKA GSRTAEETKK
HTPEAGGSGQ RQPAGAWASI KGLVTHRKRS EPAKKQKPPE AEVQPEDGAL PKKKAKSRLK
FPCLRFSRGA KRSRHSKLTE DSGYVRVQGE ADDLEIKAQT QPDDQAIQAG STQGLQEGVL
VRDGKKSQES HISNSVTSGE NVIAIELELE NKSSAIQMGT PELEKETKVI TEKPSVQTQR
ASLLESSAAG SPRSVTSAAP PSPATTHQHS LEEPSNGIRE SAPSGKDDRR KTAAEEKKSG
ETALGQAEEA AVGQADKRAL SQAGEATAGH PEEATVIQAE SQAKEGKLSQ AEETTVAQAK
ETVLSQAKEG ELSQAKKATV GQAEEATIDH TEKVTVDQAE ETTVGQAEEA TVGQAGEAIL
SQAKEATVVG QAEEATVDRA EEATVGQAEE ATVGHTEKVT VDQAEEATVG QAEEATVGQA
EEATVDWAEK PTVGQAEEAT VGQAEEATVG HTEKVTVDQA EEATVGQAEE ATVGHTEKVT
VDHAEEATVG QAEEATVGQA EKVTVDHAEE ATVGQAEEAT VGQAEKVTVD HAEEATVGQA
EEATVGQAEK VTVDQAEEPT VDQAEEAISS HAPDLKENGI DTEKPRSEES KRMEPIAIII
TDTEISEFDV KKSKNVPKQF LISMENEQVG VFANDSDFEG RTSEQYETLL IETASSLVKN
AIELSVEQLV NEMVSEDNQI NTLFQ


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