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AAEL000395-PA (Ultra spiracleisoform A nuclear receptor)

 Q0IGE0_AEDAE            Unreviewed;       484 AA.
Q0IGE0;
03-OCT-2006, integrated into UniProtKB/TrEMBL.
03-OCT-2006, sequence version 1.
22-NOV-2017, entry version 97.
SubName: Full=AAEL000395-PA {ECO:0000313|EMBL:EAT48598.1};
SubName: Full=Ultra spiracleisoform A nuclear receptor {ECO:0000313|VectorBase:AAEL000395-PA};
Name=USP {ECO:0000313|EMBL:EAT48598.1};
Synonyms=5576337 {ECO:0000313|VectorBase:AAEL000395-PA};
ORFNames=AAEL000395 {ECO:0000313|EMBL:EAT48598.1};
Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
Culicidae; Culicinae; Aedini; Aedes; Stegomyia.
NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT48598.1, ECO:0000313|Proteomes:UP000008820};
[1] {ECO:0000313|EMBL:EAT48598.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Liverpool {ECO:0000313|EMBL:EAT48598.1};
Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G.,
Utterback T., Rogers Y.-H., Kravitz S., Fraser C.M.;
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:EAT48598.1, ECO:0000313|Proteomes:UP000008820, ECO:0000313|VectorBase:AAEL000395-PA}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Liverpool {ECO:0000313|EMBL:EAT48598.1}, and
Liverpool/LVPib12 {ECO:0000313|Proteomes:UP000008820,
ECO:0000313|VectorBase:AAEL000395-PA};
PubMed=17510324; DOI=10.1126/science.1138878;
Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M.,
Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J.,
Sinkins S.P., Hogenkamp D.G., Amedeo P., Arensburger P.,
Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V.,
Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B.,
DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M.,
Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H.,
Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S.,
Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D.,
Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A.,
Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D.,
White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A.,
Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J.,
Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B.,
Fraser-Liggett C.M., Severson D.W.;
"Genome sequence of Aedes aegypti, a major arbovirus vector.";
Science 316:1718-1723(2007).
[3] {ECO:0000313|EMBL:EAT48598.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Liverpool {ECO:0000313|EMBL:EAT48598.1};
VectorBase;
Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|VectorBase:AAEL000395-PA}
IDENTIFICATION.
STRAIN=Liverpool/LVPib12 {ECO:0000313|VectorBase:AAEL000395-PA};
VectorBase;
Submitted (FEB-2017) to UniProtKB.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
ProRule:PRU00407, ECO:0000256|RuleBase:RU004334,
ECO:0000256|SAAS:SAAS00586772}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family.
{ECO:0000256|RuleBase:RU004334, ECO:0000256|SAAS:SAAS00595733}.
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EMBL; CH477192; EAT48598.1; -; Genomic_DNA.
RefSeq; XP_001656078.1; XM_001656028.2.
UniGene; Aae.19301; -.
ProteinModelPortal; Q0IGE0; -.
STRING; 7159.AAEL000395-PA; -.
EnsemblMetazoa; AAEL000395-RA; AAEL000395-PA; AAEL000395.
GeneID; 5576337; -.
KEGG; aag:AaeL_AAEL000395; -.
VectorBase; AAEL000395-RA; AAEL000395-PA; AAEL000395.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
HOGENOM; HOG000260821; -.
InParanoid; Q0IGE0; -.
KO; K14030; -.
OMA; LTCGMKR; -.
OrthoDB; EOG091G0YX6; -.
PhylomeDB; Q0IGE0; -.
Proteomes; UP000008820; Unassembled WGS sequence.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR000003; Retinoid-X_rcpt/HNF4.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR00545; RETINOIDXR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000008820};
DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|RuleBase:RU004334, ECO:0000256|SAAS:SAAS00517091};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|RuleBase:RU004334, ECO:0000256|SAAS:SAAS00517125};
Nucleus {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|RuleBase:RU004334, ECO:0000256|SAAS:SAAS00517080};
Receptor {ECO:0000256|RuleBase:RU004334};
Reference proteome {ECO:0000313|Proteomes:UP000008820};
Transcription {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|RuleBase:RU004334, ECO:0000256|SAAS:SAAS00517167};
Transcription regulation {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|RuleBase:RU004334, ECO:0000256|SAAS:SAAS00517167};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|RuleBase:RU004334, ECO:0000256|SAAS:SAAS00517125};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|RuleBase:RU004334, ECO:0000256|SAAS:SAAS00517125}.
DOMAIN 135 210 Nuclear receptor.
{ECO:0000259|PROSITE:PS51030}.
DNA_BIND 135 210 Nuclear receptor. {ECO:0000256|PROSITE-
ProRule:PRU00407}.
SEQUENCE 484 AA; 53983 MW; 9B0BFC895D56201E CRC64;
MLKKEKPMLS VAAIIQAQGR WDRTLPLAGL AGFDAALVGH MGPLSPQDMK PDLKPDISLL
NGSVGPFSPG NNCGPASPGA FNQQVAAALQ QQQQNVNSLN SQQSGGGGGG GGGTPTTPTN
MSQQYPPNHP LSGSKHLCSI CGDRASGKHY GVYSCEGCKG FFKRTVRKDL SYACREDKNC
TIDKRQRNRC QYCRYQKCLA CGMKREAVQE ERQRSSKFSI KSEEINSTSS VRDVTIERIH
EAEQLSEQKS GDNAIPYLRV GSNSMIPPEY KGAVSHLCQM VNKQIYQLID FARRVPHFIN
LPRDDQVMLL RCGWNEMLIA AVAWRSMEYI ETERSSDGSR ITVRQPQLMC LGPNFTLHRN
SAQQAGVDTL FDRILCELGI KMKRLDVTRA ELGVLKAIIL FNPDIRGLKC QKEIDGMREK
IYACLDEHCK QQHPSEDGRF AQLLLRLPAL RSISLKCLDH LNFIRLLSDK HLDSFIVEML
DMPI


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