GENTAUR Molecular Products.

 AB9C_ARATH              Reviewed;        1506 AA.
 Q9M1C7; F4JAM7;
 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
 25-JAN-2012, sequence version 2.
 23-MAY-2018, entry version 124.
 RecName: Full=ABC transporter C family member 9;
          Short=ABC transporter ABCC.9;
          Short=AtABCC9;
          EC=3.6.3.44;
 AltName: Full=ATP-energized glutathione S-conjugate pump 9;
 AltName: Full=Glutathione S-conjugate-transporting ATPase 9;
 AltName: Full=Multidrug resistance-associated protein 9;
 Name=ABCC9; Synonyms=MRP9; OrderedLocusNames=At3g60160;
 ORFNames=T2O9.140;
 Arabidopsis thaliana (Mouse-ear cress).
 Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
 Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
 Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
 Arabidopsis.
 NCBI_TaxID=3702;
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=cv. Columbia;
 PubMed=11130713; DOI=10.1038/35048706;
 Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M.,
 Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B.,
 Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P.,
 De Simone V., Choisne N., Artiguenave F., Robert C., Brottier P.,
 Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F.,
 Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V.,
 Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S.,
 Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G.,
 Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B.,
 Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G.,
 Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J.,
 Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D.,
 Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
 de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
 Monfort A., Argiriou A., Flores M., Liguori R., Vitale D.,
 Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W.,
 Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J.,
 Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P.,
 Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S.,
 Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V.,
 Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C.,
 Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E.,
 Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y.,
 Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
 Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
 Watanabe A., Yamada M., Yasuda M., Tabata S.;
 "Sequence and analysis of chromosome 3 of the plant Arabidopsis
 thaliana.";
 Nature 408:820-822(2000).
 [2]
 GENOME REANNOTATION.
 STRAIN=cv. Columbia;
 PubMed=27862469; DOI=10.1111/tpj.13415;
 Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
 Town C.D.;
 "Araport11: a complete reannotation of the Arabidopsis thaliana
 reference genome.";
 Plant J. 89:789-804(2017).
 [3]
 GENE FAMILY, AND NOMENCLATURE.
 PubMed=11346655; DOI=10.1074/jbc.M103104200;
 Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
 "The Arabidopsis thaliana ABC protein superfamily, a complete
 inventory.";
 J. Biol. Chem. 276:30231-30244(2001).
 [4]
 GENE FAMILY.
 PubMed=11855639; DOI=10.1007/s004250100661;
 Martinoia E., Klein M., Geisler M., Bovet L., Forestier C.,
 Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.;
 "Multifunctionality of plant ABC transporters -- more than just
 detoxifiers.";
 Planta 214:345-355(2002).
 [5]
 TISSUE SPECIFICITY.
 PubMed=12430019; DOI=10.1007/s00425-002-0890-6;
 Kolukisaoglu U.H., Bovet L., Klein M., Eggmann T., Geisler M.,
 Wanke D., Martinoia E., Schulz B.;
 "Family business: the multidrug-resistance related protein (MRP) ABC
 transporter genes in Arabidopsis thaliana.";
 Planta 216:107-119(2002).
 [6]
 GENE FAMILY, AND NOMENCLATURE.
 PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
 Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
 Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A.,
 Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K.,
 Theodoulou F.L.;
 "Plant ABC proteins - a unified nomenclature and updated inventory.";
 Trends Plant Sci. 13:151-159(2008).
 -!- FUNCTION: Pump for glutathione S-conjugates. {ECO:0000250}.
 -!- CATALYTIC ACTIVITY: ATP + H(2)O + xenobiotic(In) = ADP + phosphate
     + xenobiotic(Out).
 -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-
     ProRule:PRU00441}; Multi-pass membrane protein
     {ECO:0000255|PROSITE-ProRule:PRU00441}.
 -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12430019}.
 -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC
     family. Conjugate transporter (TC 3.A.1.208) subfamily.
     {ECO:0000305}.
 -!- SEQUENCE CAUTION:
     Sequence=CAB75931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
 -----------------------------------------------------------------------
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 EMBL; AL138658; CAB75931.1; ALT_SEQ; Genomic_DNA.
 EMBL; CP002686; AEE80019.1; -; Genomic_DNA.
 PIR; T47840; T47840.
 RefSeq; NP_191575.2; NM_115879.7.
 UniGene; At.34346; -.
 ProteinModelPortal; Q9M1C7; -.
 SMR; Q9M1C7; -.
 STRING; 3702.AT3G60160.1; -.
 iPTMnet; Q9M1C7; -.
 PaxDb; Q9M1C7; -.
 PRIDE; Q9M1C7; -.
 EnsemblPlants; AT3G60160.1; AT3G60160.1; AT3G60160.
 GeneID; 825186; -.
 Gramene; AT3G60160.1; AT3G60160.1; AT3G60160.
 KEGG; ath:AT3G60160; -.
 Araport; AT3G60160; -.
 TAIR; locus:2101452; AT3G60160.
 eggNOG; KOG0054; Eukaryota.
 eggNOG; COG1132; LUCA.
 InParanoid; Q9M1C7; -.
 OMA; FERENHI; -.
 OrthoDB; EOG093600HI; -.
 BioCyc; ARA:AT3G60160-MONOMER; -.
 Reactome; R-ATH-382556; ABC-family proteins mediated transport.
 PRO; PR:Q9M1C7; -.
 Proteomes; UP000006548; Chromosome 3.
 ExpressionAtlas; Q9M1C7; baseline and differential.
 Genevisible; Q9M1C7; AT.
 GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
 GO; GO:0000325; C:plant-type vacuole; IBA:GO_Central.
 GO; GO:0009506; C:plasmodesma; IDA:TAIR.
 GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
 GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; ISS:TAIR.
 GO; GO:0008559; F:xenobiotic transmembrane transporting ATPase activity; IEA:UniProtKB-EC.
 GO; GO:0009624; P:response to nematode; IEP:TAIR.
 GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
 Gene3D; 1.20.1560.10; -; 2.
 InterPro; IPR003593; AAA+_ATPase.
 InterPro; IPR011527; ABC1_TM_dom.
 InterPro; IPR036640; ABC1_TM_sf.
 InterPro; IPR003439; ABC_transporter-like.
 InterPro; IPR017871; ABC_transporter_CS.
 InterPro; IPR027417; P-loop_NTPase.
 Pfam; PF00664; ABC_membrane; 2.
 Pfam; PF00005; ABC_tran; 2.
 SMART; SM00382; AAA; 2.
 SUPFAM; SSF52540; SSF52540; 2.
 SUPFAM; SSF90123; SSF90123; 2.
 PROSITE; PS50929; ABC_TM1F; 2.
 PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
 PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
 2: Evidence at transcript level;
 ATP-binding; Complete proteome; Hydrolase; Membrane;
 Nucleotide-binding; Reference proteome; Repeat; Transmembrane;
 Transmembrane helix; Transport.
 CHAIN         1   1506       ABC transporter C family member 9.
                              /FTId=PRO_0000226080.
 TRANSMEM     37     57       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM     84    104       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    116    136       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    150    170       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    179    199       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    315    335       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    350    370       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    427    447       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    452    472       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    541    561       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    567    587       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    934    956       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM    976    996       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM   1048   1068       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM   1167   1187       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 TRANSMEM   1191   1211       Helical. {ECO:0000255|PROSITE-
                              ProRule:PRU00441}.
 DOMAIN      314    596       ABC transmembrane type-1 1.
                              {ECO:0000255|PROSITE-ProRule:PRU00441}.
 DOMAIN      630    853       ABC transporter 1. {ECO:0000255|PROSITE-
                              ProRule:PRU00434}.
 DOMAIN      936   1218       ABC transmembrane type-1 2.
                              {ECO:0000255|PROSITE-ProRule:PRU00441}.
 DOMAIN     1257   1489       ABC transporter 2. {ECO:0000255|PROSITE-
                              ProRule:PRU00434}.
 NP_BIND     665    672       ATP 1. {ECO:0000255|PROSITE-
                              ProRule:PRU00434}.
 NP_BIND    1289   1296       ATP 2. {ECO:0000255|PROSITE-
                              ProRule:PRU00434}.
 SEQUENCE   1506 AA;  168210 MW;  704CBD1D9EB97DBD CRC64;
 MFKPFGFAAE TGSHLLTTQW LQLGNSLCLK ERISIAMQVT FLAFFLIHLA LKWFGVVRNR
 GSNDVEEDLK KQSITVKQSF SYNISLLCSV SILGTHCFIL LLLFRDSVVS RCDSSVSVFS
 AEVSQSFSWL FVSVVVVKIR ERRLVKFPWM LRSWWLCSFI LSFSFDAHFI TAKHEPLEFQ
 DYADLTGLLA SLFLLAVSIR GKTGFHLLES SGNTEPLLLG DQTEQNKKDS YSSSSPYGNA
 TLFQRITFSW INPLFSLGYK RPLEKDDVPD IDVKDSARFC SHAFDQKLKT TKEKEGPGNA
 FFYNSVLRYV WRKAAINAVF AVVNASTAYI GPYLINDFVE FLSEKQSQSL NHGYLLALGF
 LTAKIVETVT QRQWIFGARQ LGLRLRAALI SHIYQKGLVL SSQSRQSHTS GEIINYMSVD
 VQRITDFIWY VNNIWMLPIQ IFSAIYILQK HLGLGALAAL VTTLMVMACN YPLTRLQRNY
 QSDIMNAKDD RMKATSEILK NMKILKLQAW DNQFLNKVKT LRKKEYDCLW KSLRLQAFTT
 FILWGAPSLI SVVTFVTCML MGVKLTAGAV LSALATFQML QSPIFGLPDL LSALVQSKVS
 ADRIASYLQQ SETQKDAVEY CSKDHTELSV EIENGAFSWE PESSRPTLDD IELKVKSGMK
 VAVCGAVGSG KSSLLSSILG EIQKLKGTVR VSGKQAYVPQ SPWILSGTIR DNILFGSMYE
 SEKYERTVKA CALIKDFELF SNGDLTEIGE RGINMSGGQK QRIQIARAVY QNADIYLLDD
 PFSAVDAHTG RELFEDCLMG ILKDKTVLYV THQVEFLPAA DLILVMQNGR VMQAGKFEEL
 LKQNIGFEVL VGAHNEALDS ILSIEKSSRN FKEGSKDDTA SIAESLQTHC DSEHNISTEN
 KKKEAKLVQD EETEKGVIGK EVYLAYLTTV KGGLLVPFII LAQSCFQMLQ IASNYWMAWT
 APPTAESIPK LGMGRILLVY ALLAAGSSLC VLARTILVAI GGLSTAETFF SRMLCSIFRA
 PMSFFDSTPT GRILNRASTD QSVLDLEMAV KLGWCAFSII QIVGTIFVMS QVAWQVCVIF
 IPVAVACVFY QRYYTPTARE LSRMSGVERA PILHHFAESL AGATTIRAFD QRDRFISSNL
 VLIDSHSRPW FHVASAMEWL SFRLNLLSHF VFAFSLVLLV TLPEGVINPS IAGLGVTYGL
 SLNVLQATVI WNICNAENKM ISVERILQYS KIPSEAPLVI DGHRPLDNWP NVGSIVFRDL
 QVRYAEHFPA VLKNITCEFP GGKKIGVVGR TGSGKSTLIQ ALFRIVEPSQ GTIVIDNVDI
 TKIGLHDLRS RLGIIPQDPA LFDGTIRLNL DPLAQYTDHE IWEAIDKCQL GDVIRAKDER
 LDATVVENGE NWSVGQRQLV CLGRVLLKKS NILVLDEATA SVDSATDGVI QKIINQEFKD
 RTVVTIAHRI HTVIESDLVL VLSDGRIAEF DSPAKLLQRE DSFFSKLIKE YSLRSNHFAG
 SNDLLS

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