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ABI gene family member 3 (New molecule including SH3) (Nesh)

 ABI3_HUMAN              Reviewed;         366 AA.
Q9P2A4; C9IZN8; Q9H0P6;
19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
18-MAY-2010, sequence version 2.
25-OCT-2017, entry version 139.
RecName: Full=ABI gene family member 3;
AltName: Full=New molecule including SH3;
Short=Nesh;
Name=ABI3; Synonyms=NESH;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
VARIANT SER-209.
TISSUE=Placenta;
PubMed=10978530; DOI=10.1016/S0167-4781(00)00158-5;
Miyazaki K., Matsuda S., Ichigotani Y., Takenouchi Y., Hayashi K.,
Fukuda Y., Nimura Y., Hamaguchi M.;
"Isolation and characterization of a novel human gene (NESH) which
encodes a putative signaling molecule similar to e3B1 protein.";
Biochim. Biophys. Acta 1493:237-241(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
GLN-44 AND SER-209.
TISSUE=Kidney;
PubMed=11230166; DOI=10.1101/gr.GR1547R;
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
Wambutt R., Korn B., Klein M., Poustka A.;
"Towards a catalog of human genes and proteins: sequencing and
analysis of 500 novel complete protein coding human cDNAs.";
Genome Res. 11:422-435(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
SER-209.
TISSUE=B-cell;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, PHOSPHORYLATION, AND SUBCELLULAR LOCATION.
PubMed=11956071;
Ichigotani Y., Yokozaki S., Fukuda Y., Hamaguchi M., Matsuda S.;
"Forced expression of NESH suppresses motility and metastatic
dissemination of malignant cells.";
Cancer Res. 62:2215-2219(2002).
[6]
INTERACTION WITH TARSH.
PubMed=11501947; DOI=10.1007/s100380170049;
Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N.,
Yamaki K., Hayakawa T., Hamaguchi M.;
"Cloning and sequencing of a novel human gene that encodes a putative
target protein of Nesh-SH3.";
J. Hum. Genet. 46:483-486(2001).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-216 AND
SER-342, VARIANT [LARGE SCALE ANALYSIS] SER-209, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
-!- FUNCTION: May inhibit tumor metastasis (By similarity). In vitro,
reduces cell motility. {ECO:0000250, ECO:0000269|PubMed:11956071}.
-!- SUBUNIT: May interact with PAK1 and PAK2. Probably interacts with
TARSH. {ECO:0000269|PubMed:11501947}.
-!- INTERACTION:
Self; NbExp=3; IntAct=EBI-742038, EBI-742038;
B2R8Y4:-; NbExp=3; IntAct=EBI-742038, EBI-10175581;
Q9H6L4:ARMC7; NbExp=3; IntAct=EBI-742038, EBI-742909;
Q13515:BFSP2; NbExp=4; IntAct=EBI-742038, EBI-10229433;
Q96L14:CEP170P1; NbExp=3; IntAct=EBI-742038, EBI-743488;
Q9C0F1:CEP44; NbExp=6; IntAct=EBI-742038, EBI-744115;
O60941:DTNB; NbExp=3; IntAct=EBI-742038, EBI-740402;
O15372:EIF3H; NbExp=5; IntAct=EBI-742038, EBI-709735;
Q6IB98:EIF3S3; NbExp=3; IntAct=EBI-742038, EBI-10184995;
Q9UI08:EVL; NbExp=3; IntAct=EBI-742038, EBI-346653;
Q9Y285:FARSA; NbExp=3; IntAct=EBI-742038, EBI-725361;
Q8TES7-6:FBF1; NbExp=3; IntAct=EBI-742038, EBI-10244131;
P62993:GRB2; NbExp=3; IntAct=EBI-742038, EBI-401755;
Q86YM7:HOMER1; NbExp=5; IntAct=EBI-742038, EBI-746815;
Q9NSB8-2:HOMER2; NbExp=4; IntAct=EBI-742038, EBI-12017090;
Q9NSC5:HOMER3; NbExp=4; IntAct=EBI-742038, EBI-748420;
Q63ZY3:KANK2; NbExp=5; IntAct=EBI-742038, EBI-2556193;
Q6ZU52:KIAA0408; NbExp=3; IntAct=EBI-742038, EBI-739493;
Q6P597:KLC3; NbExp=3; IntAct=EBI-742038, EBI-1643885;
Q9NSK0:KLC4; NbExp=3; IntAct=EBI-742038, EBI-949319;
A1A4E9:KRT13; NbExp=3; IntAct=EBI-742038, EBI-10171552;
Q15323:KRT31; NbExp=4; IntAct=EBI-742038, EBI-948001;
P43365:MAGEA12; NbExp=3; IntAct=EBI-742038, EBI-749530;
Q9Y605:MRFAP1; NbExp=4; IntAct=EBI-742038, EBI-995714;
Q96HT8:MRFAP1L1; NbExp=3; IntAct=EBI-742038, EBI-748896;
O43639:NCK2; NbExp=5; IntAct=EBI-742038, EBI-713635;
Q9BVL2:NUP58; NbExp=6; IntAct=EBI-742038, EBI-2811583;
P25786:PSMA1; NbExp=3; IntAct=EBI-742038, EBI-359352;
Q06455-4:RUNX1T1; NbExp=3; IntAct=EBI-742038, EBI-10224192;
P50552:VASP; NbExp=5; IntAct=EBI-742038, EBI-748201;
P42768:WAS; NbExp=4; IntAct=EBI-742038, EBI-346375;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11956071}.
Note=Colocalizes with PAK2 at leading edge of cells.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9P2A4-1; Sequence=Displayed;
Name=2;
IsoId=Q9P2A4-2; Sequence=VSP_041467;
-!- TISSUE SPECIFICITY: Expressed in heart, lung, liver, pancreas,
kidney, placenta and at low levels in brain and skeletal muscle.
{ECO:0000269|PubMed:10978530}.
-!- SIMILARITY: Belongs to the ABI family. {ECO:0000305}.
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EMBL; AB037886; BAA90667.1; -; mRNA.
EMBL; AL136709; CAB66644.1; -; mRNA.
EMBL; AC004797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC069454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC007780; AAH07780.1; -; mRNA.
CCDS; CCDS11546.1; -. [Q9P2A4-1]
CCDS; CCDS45725.1; -. [Q9P2A4-2]
RefSeq; NP_001128658.1; NM_001135186.1.
RefSeq; NP_057512.1; NM_016428.2.
UniGene; Hs.130719; -.
ProteinModelPortal; Q9P2A4; -.
SMR; Q9P2A4; -.
BioGrid; 119389; 35.
IntAct; Q9P2A4; 67.
MINT; MINT-235637; -.
STRING; 9606.ENSP00000225941; -.
iPTMnet; Q9P2A4; -.
PhosphoSitePlus; Q9P2A4; -.
BioMuta; ABI3; -.
DMDM; 296434384; -.
EPD; Q9P2A4; -.
MaxQB; Q9P2A4; -.
PaxDb; Q9P2A4; -.
PeptideAtlas; Q9P2A4; -.
PRIDE; Q9P2A4; -.
DNASU; 51225; -.
Ensembl; ENST00000225941; ENSP00000225941; ENSG00000108798. [Q9P2A4-1]
Ensembl; ENST00000419580; ENSP00000406651; ENSG00000108798. [Q9P2A4-2]
GeneID; 51225; -.
KEGG; hsa:51225; -.
UCSC; uc002iop.1; human. [Q9P2A4-1]
CTD; 51225; -.
DisGeNET; 51225; -.
EuPathDB; HostDB:ENSG00000108798.8; -.
GeneCards; ABI3; -.
HGNC; HGNC:29859; ABI3.
HPA; HPA017345; -.
MIM; 606363; gene.
neXtProt; NX_Q9P2A4; -.
OpenTargets; ENSG00000108798; -.
PharmGKB; PA134951642; -.
eggNOG; KOG2546; Eukaryota.
eggNOG; ENOG410Y0MH; LUCA.
GeneTree; ENSGT00390000003756; -.
HOGENOM; HOG000293213; -.
HOVERGEN; HBG050446; -.
InParanoid; Q9P2A4; -.
OMA; CEDNYVQ; -.
OrthoDB; EOG091G0AN8; -.
PhylomeDB; Q9P2A4; -.
TreeFam; TF314303; -.
GeneWiki; ABI3; -.
GenomeRNAi; 51225; -.
PRO; PR:Q9P2A4; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000108798; -.
CleanEx; HS_ABI3; -.
ExpressionAtlas; Q9P2A4; baseline and differential.
Genevisible; Q9P2A4; HS.
GO; GO:0005737; C:cytoplasm; IDA:LIFEdb.
GO; GO:0005622; C:intracellular; IDA:MGI.
GO; GO:0030027; C:lamellipodium; IDA:MGI.
GO; GO:0016020; C:membrane; IDA:UniProtKB.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0006928; P:movement of cell or subcellular component; NAS:UniProtKB.
GO; GO:0030334; P:regulation of cell migration; IDA:MGI.
InterPro; IPR028457; ABI.
InterPro; IPR028455; ABI3.
InterPro; IPR012849; Abl-interactor_HHR_dom.
InterPro; IPR036028; SH3-like_dom.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR10460; PTHR10460; 1.
PANTHER; PTHR10460:SF7; PTHR10460:SF7; 1.
Pfam; PF07815; Abi_HHR; 1.
Pfam; PF14604; SH3_9; 1.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00326; SH3; 1.
SUPFAM; SSF50044; SSF50044; 1.
PROSITE; PS50002; SH3; 1.
1: Evidence at protein level;
Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
Phosphoprotein; Polymorphism; Reference proteome; SH3 domain.
CHAIN 1 366 ABI gene family member 3.
/FTId=PRO_0000191792.
DOMAIN 308 366 SH3. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
COILED 33 61 {ECO:0000255}.
COMPBIAS 224 306 Pro-rich.
MOD_RES 213 213 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 216 216 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 342 342 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
VAR_SEQ 90 95 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_041467.
VARIANT 44 44 R -> Q (in dbSNP:rs2233369).
{ECO:0000269|PubMed:11230166}.
/FTId=VAR_022030.
VARIANT 203 203 S -> F (in dbSNP:rs616338).
/FTId=VAR_060243.
VARIANT 209 209 F -> S (in dbSNP:rs616338).
{ECO:0000244|PubMed:24275569,
ECO:0000269|PubMed:10978530,
ECO:0000269|PubMed:11230166,
ECO:0000269|PubMed:15489334}.
/FTId=VAR_060993.
SEQUENCE 366 AA; 39035 MW; 23EC3838E41D8ECD CRC64;
MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET MAFTTQALAS
VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH MEKVARREIG TLATVQRLPP
GQKVIAPENL PPLTPYCRRP LNFGCLDDIG HGIKDLSTQL SRTGTLSRKS IKAPATPASA
TLGRPPRIPE PVHLPVVPDG RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS
LDPPPPPAAV EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD
EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS SEGTGFFPGN
YVEPSC


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