Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

ADP-ribosylating toxin CARDS (EC 2.4.2.-) (ADP-ribosyltransferase CARDS) (CARDX TX)

 CARDS_MYCPN             Reviewed;         591 AA.
P75409; Q1PD42; Q1PD43; Q1PD44; Q1PD45; Q1PD46;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
07-JUN-2017, entry version 83.
RecName: Full=ADP-ribosylating toxin CARDS;
EC=2.4.2.-;
AltName: Full=ADP-ribosyltransferase CARDS;
AltName: Full=CARDX TX;
OrderedLocusNames=MPN_372; ORFNames=MP464;
Mycoplasma pneumoniae (strain ATCC 29342 / M129).
Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
NCBI_TaxID=272634;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
MUTAGENESIS OF GLU-132.
STRAIN=ATCC 29342 / M129, JL, L2, RJL1, and S1;
PubMed=16617115; DOI=10.1073/pnas.0510644103;
Kannan T.R., Baseman J.B.;
"ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae
represents unique virulence determinant among bacterial pathogens.";
Proc. Natl. Acad. Sci. U.S.A. 103:6724-6729(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29342 / M129;
PubMed=8948633; DOI=10.1093/nar/24.22.4420;
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C.,
Herrmann R.;
"Complete sequence analysis of the genome of the bacterium Mycoplasma
pneumoniae.";
Nucleic Acids Res. 24:4420-4449(1996).
[3]
IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH HUMAN SFTPA.
STRAIN=B9, and S1;
PubMed=15845487; DOI=10.1128/IAI.73.5.2828-2834.2005;
Kannan T.R., Provenzano D., Wright J.R., Baseman J.B.;
"Identification and characterization of human surfactant protein A
binding protein of Mycoplasma pneumoniae.";
Infect. Immun. 73:2828-2834(2005).
-!- FUNCTION: Acts as an ADP-ribosylating toxin, which may transfer
the ADP-ribosyl group from NAD(+) to specific amino acids in
target proteins. Elicits cytopathic effects in mammalian cells,
such as disorganization and disruption of respiratory epithelial
integrity in tracheal epithelium and vacuolization in the
cytoplasm of CHO and HeLa cells. {ECO:0000269|PubMed:16617115}.
-!- SUBUNIT: Binds to the pulmonary surfactant-associated protein A
(SFTPA/SP-A), the major mammalian protein component of pulmonary
surfactant.
-!- INTERACTION:
P07355:ANXA2 (xeno); NbExp=6; IntAct=EBI-2259548, EBI-352622;
Q8IWL2:SFTPA1 (xeno); NbExp=2; IntAct=EBI-2259548, EBI-11316418;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16617115};
Peripheral membrane protein {ECO:0000269|PubMed:16617115};
Extracellular side {ECO:0000269|PubMed:16617115}. Note=Surface-
associated protein.
-!- SIMILARITY: Belongs to the bacterial exotoxin subunit A family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; DQ447746; ABE27142.1; -; Genomic_DNA.
EMBL; DQ447747; ABE27143.1; -; Genomic_DNA.
EMBL; DQ447748; ABE27144.1; -; Genomic_DNA.
EMBL; DQ447749; ABE27145.1; -; Genomic_DNA.
EMBL; DQ447750; ABE27146.1; -; Genomic_DNA.
EMBL; U00089; AAB96112.1; -; Genomic_DNA.
PIR; S73790; S73790.
RefSeq; NP_110060.1; NC_000912.1.
RefSeq; WP_010874728.1; NC_000912.1.
PDB; 4TLV; X-ray; 1.90 A; A/B/C/D/E/F=1-591.
PDB; 4TLW; X-ray; 2.55 A; A=1-591.
PDBsum; 4TLV; -.
PDBsum; 4TLW; -.
ProteinModelPortal; P75409; -.
SMR; P75409; -.
IntAct; P75409; 2.
EnsemblBacteria; AAB96112; AAB96112; MPN_372.
GeneID; 877260; -.
KEGG; mpn:MPN372; -.
PATRIC; fig|272634.6.peg.403; -.
OMA; DECTTHA; -.
Proteomes; UP000000808; Chromosome.
GO; GO:0009986; C:cell surface; IDA:AgBase.
GO; GO:0005576; C:extracellular region; IEA:InterPro.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
GO; GO:0044075; P:modulation by symbiont of host vacuole organization; IMP:AgBase.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
InterPro; IPR003898; Borpert_toxA.
Pfam; PF02917; Pertussis_S1; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome; Glycosyltransferase;
Membrane; Reference proteome; Toxin; Transferase; Virulence.
CHAIN 1 591 ADP-ribosylating toxin CARDS.
/FTId=PRO_0000210665.
VARIANT 38 38 L -> P (in strain: S1).
VARIANT 245 245 D -> G (in strain: L2).
VARIANT 308 308 S -> P (in strain: S1).
VARIANT 371 371 I -> S (in strain: S1, L2, RJL1 and JL).
VARIANT 391 391 F -> S (in strain: S1).
VARIANT 392 392 W -> R (in strain: RJL1).
MUTAGEN 132 132 E->A: Reduces ADP-ribosylation activity.
Unable to elicit vacuolization in CHO
cells at 5 ug/ml.
{ECO:0000269|PubMed:16617115}.
STRAND 7 14 {ECO:0000244|PDB:4TLV}.
HELIX 16 22 {ECO:0000244|PDB:4TLV}.
HELIX 33 38 {ECO:0000244|PDB:4TLV}.
TURN 39 41 {ECO:0000244|PDB:4TLV}.
STRAND 45 53 {ECO:0000244|PDB:4TLV}.
HELIX 54 58 {ECO:0000244|PDB:4TLV}.
HELIX 59 62 {ECO:0000244|PDB:4TLV}.
STRAND 65 68 {ECO:0000244|PDB:4TLV}.
STRAND 74 82 {ECO:0000244|PDB:4TLV}.
STRAND 87 89 {ECO:0000244|PDB:4TLV}.
HELIX 90 102 {ECO:0000244|PDB:4TLV}.
STRAND 106 111 {ECO:0000244|PDB:4TLV}.
HELIX 113 124 {ECO:0000244|PDB:4TLV}.
TURN 125 127 {ECO:0000244|PDB:4TLV}.
HELIX 128 130 {ECO:0000244|PDB:4TLV}.
STRAND 132 137 {ECO:0000244|PDB:4TLV}.
HELIX 141 143 {ECO:0000244|PDB:4TLV}.
STRAND 144 156 {ECO:0000244|PDB:4TLV}.
TURN 157 159 {ECO:0000244|PDB:4TLV}.
HELIX 163 165 {ECO:0000244|PDB:4TLV}.
STRAND 169 173 {ECO:0000244|PDB:4TLV}.
STRAND 197 200 {ECO:0000244|PDB:4TLV}.
STRAND 204 208 {ECO:0000244|PDB:4TLV}.
STRAND 211 217 {ECO:0000244|PDB:4TLV}.
HELIX 226 229 {ECO:0000244|PDB:4TLV}.
HELIX 243 246 {ECO:0000244|PDB:4TLV}.
STRAND 249 256 {ECO:0000244|PDB:4TLV}.
HELIX 257 259 {ECO:0000244|PDB:4TLV}.
HELIX 265 269 {ECO:0000244|PDB:4TLV}.
STRAND 276 279 {ECO:0000244|PDB:4TLV}.
TURN 280 282 {ECO:0000244|PDB:4TLV}.
STRAND 285 290 {ECO:0000244|PDB:4TLV}.
TURN 292 294 {ECO:0000244|PDB:4TLV}.
STRAND 296 301 {ECO:0000244|PDB:4TLV}.
STRAND 315 318 {ECO:0000244|PDB:4TLV}.
STRAND 323 327 {ECO:0000244|PDB:4TLV}.
STRAND 335 340 {ECO:0000244|PDB:4TLV}.
STRAND 348 354 {ECO:0000244|PDB:4TLV}.
HELIX 360 362 {ECO:0000244|PDB:4TLV}.
STRAND 364 368 {ECO:0000244|PDB:4TLV}.
STRAND 375 380 {ECO:0000244|PDB:4TLV}.
HELIX 381 383 {ECO:0000244|PDB:4TLV}.
STRAND 388 393 {ECO:0000244|PDB:4TLV}.
STRAND 398 401 {ECO:0000244|PDB:4TLW}.
STRAND 404 410 {ECO:0000244|PDB:4TLV}.
STRAND 415 423 {ECO:0000244|PDB:4TLV}.
HELIX 429 432 {ECO:0000244|PDB:4TLV}.
STRAND 441 443 {ECO:0000244|PDB:4TLV}.
STRAND 447 450 {ECO:0000244|PDB:4TLV}.
STRAND 453 457 {ECO:0000244|PDB:4TLV}.
STRAND 463 466 {ECO:0000244|PDB:4TLV}.
STRAND 472 476 {ECO:0000244|PDB:4TLV}.
TURN 477 479 {ECO:0000244|PDB:4TLV}.
STRAND 481 487 {ECO:0000244|PDB:4TLV}.
STRAND 490 495 {ECO:0000244|PDB:4TLV}.
STRAND 502 508 {ECO:0000244|PDB:4TLV}.
STRAND 510 512 {ECO:0000244|PDB:4TLV}.
HELIX 522 524 {ECO:0000244|PDB:4TLV}.
STRAND 525 529 {ECO:0000244|PDB:4TLV}.
STRAND 543 548 {ECO:0000244|PDB:4TLV}.
TURN 549 551 {ECO:0000244|PDB:4TLV}.
STRAND 554 558 {ECO:0000244|PDB:4TLV}.
TURN 562 565 {ECO:0000244|PDB:4TLV}.
STRAND 567 571 {ECO:0000244|PDB:4TLV}.
STRAND 576 579 {ECO:0000244|PDB:4TLV}.
TURN 586 589 {ECO:0000244|PDB:4TLV}.
SEQUENCE 591 AA; 68057 MW; B958C85C9EE29E90 CRC64;
MPNPVRFVYR VDLRSPEEIF EHGFSTLGDV RNFFEHILST NFGRSYFIST SETPTAAIRF
FGSWLREYVP EHPRRAYLYE IRADQHFYNA RATGENLLDL MRQRQVVFDS GDREMAQMGI
RALRTSFAYQ REWFTDGPIA AANVRSAWLV DAVPVEPGHA HHPAGRVVET TRINEPEMHN
PHYQELQTQA NDQPWLPTPG IATPVHLSIP QAASVADVSE GTSASLSFAC PDWSPPSSNG
ENPLDKCIAE KIDNYNLQSL PQYASSVKEL EDTPVYLRGI KTQKTFMLQA DPQNNNVFLV
EVNPKQKSSF PQTIFFWDVY QRICLKDLTG AQISLSLTAF TTQYAGQLKV HLSVSAVNAV
NQKWKMTPQD IAITQFRVSS ELLGQTENGL FWNTKSGGSQ HDLYVCPLKN PPSDLEELQI
IVDECTTHAQ FVTMRAASTF FVDVQLGWYW RGYYYTPQLS GWSYQMKTPD GQIFYDLKTS
KIFFVQDNQN VFFLHNKLNK QTGYSWDWVE WLKHDMNEDK DENFKWYFSR DDLTIPSVEG
LNFRHIRCYA DNQQLKVIIS GSRWGGWYST YDKVESNVED KILVKDGFDR F


Related products :

Catalog number Product name Quantity
AS-10010-00 ID-Centrifuge for Gel Card, TD2-24, 24 Gel cards
CP1423 CRP (Complete Kit with Disposible Cards) LATEX SLIDE TEST 100T
LO1476 ASO (Complete Kit with Disposable Cards) LATEX SLIDE TEST 100T
2047 TIP ESP10 S3 CLR ESP RELOAD _ NON-FILTERED _ NON-STERILE _ LOW RETENTION 20 cards of 96 _ pack 4 packs / case
2167 TIP ESP1000 ESP RELOAD _ NON-FILTERED _ NON-STERILE _ STANDARD 16 cards of 60 _ pack 4 packs / case
RF1436 RHEUMATOID FACTOR (Complete Kit with Disposable Cards) LATEX SLIDE TEST 100T
TA598 G6PD Deficiency Qualitative Kit, 250 Test (with Filter Cards), Clinical Chemistry Kits
TA603 G6PD Deficiency Quantitative Kit, 75 Test (with Filter Cards), Clinical Chemistry Kits 5
TA604 G6PD Deficiency Quantitative Kit, 150 Test (with Filter Cards), Clinical Chemistry Kits
TA599 G6PD Deficiency Qualitative Kit, 500 Test (with Filter Cards), Clinical Chemistry Kits
TA600 G6PD Deficiency Qualitative Kit, 750 Test (With Filter Cards), Clinical Chemistry Kits
BS-010208-VK R-24GC, Rotor for 24 gel-cards power supply 230VAC 50 60Hz Euro plug
SSIPneumotest-LatexKit Pneumococcal Latex Test Kit, containes 14 pool sera + 50 reaction cards kit
BS-010208-VK R-24GC, Rotor for 24 gel-cards power supply 230VAC 50_60Hz Euro plug
2047.S TIP ESP10 STERILE ESP RELOAD _ NON-FILTERED _ STERILE _ LOW RETENTION 20 cards of 96 _ pack 4 packs / case
2167.S TIP ESP1000 STERILE ESP RELOAD _ NON-FILTERED _ STERILE _ STANDARD 16 cards of 60 _ pack 4 packs / case
SSI54991 Streptococcus Group B Latex Kit, incl 9 types (Ia_VIII) + 25 reaction cards; latex agglutination kit
BS-010116-AK Bio PP-4, Flat platform with non-slip rubber mat for Petri dishes, culture flasks, agglutination cards power supply 230VAC 50_60Hz Euro plug
BS-010116-AK Bio PP-4, Flat platform with non-slip rubber mat for Petri dishes, culture flasks, agglutination cards power supply 230VAC 50 60Hz Euro plug
30-999 In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1, NOD1, and NOD2. These proteins have 0.05 mg
SSIW53285 Pneumococcal Latex Reaction Cards, for Pneumococcal Latex Test Kit box
26-898 ARF6 is a member of the human ARF family, which is part of the RAS superfamily. They are small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin a 0.05 mg
EIAAB26381 ART5,Bos taurus,Bovine,Ecto-ADP-ribosyltransferase 5,Mono(ADP-ribosyl)transferase 5,NAD(P)(+)--arginine ADP-ribosyltransferase 5
EIAAB26380 Art5,Ecto-ADP-ribosyltransferase 5,Mono(ADP-ribosyl)transferase 5,Mouse,Mus musculus,NAD(P)(+)--arginine ADP-ribosyltransferase 5,YAC-2
EIAAB26378 Art3,Ecto-ADP-ribosyltransferase 3,Mono(ADP-ribosyl)transferase 3,Mouse,Mus musculus,NAD(P)(+)--arginine ADP-ribosyltransferase 3


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur