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AGR2 isoform 1 (Anterior gradient 2, protein disulphide isomerase family member)

 H2QU78_PANTR            Unreviewed;       175 AA.
H2QU78; A0A2J8MEK4;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
12-SEP-2018, entry version 36.
SubName: Full=AGR2 isoform 1 {ECO:0000313|EMBL:PNI57947.1};
SubName: Full=Anterior gradient 2, protein disulphide isomerase family member {ECO:0000313|Ensembl:ENSPTRP00000032379};
Name=AGR2 {ECO:0000313|Ensembl:ENSPTRP00000032379,
ECO:0000313|VGNC:VGNC:7208};
ORFNames=CK820_G0021321 {ECO:0000313|EMBL:PNI57947.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000032379, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000032379, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000032379}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:PNI57947.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI57947.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI57947.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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EMBL; AC192720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; NBAG03000259; PNI57947.1; -; Genomic_DNA.
RefSeq; XP_003318380.1; XM_003318332.3.
RefSeq; XP_003318381.1; XM_003318333.3.
PaxDb; H2QU78; -.
Ensembl; ENSPTRT00000035035; ENSPTRP00000032379; ENSPTRG00000018953.
GeneID; 463277; -.
KEGG; ptr:463277; -.
CTD; 10551; -.
VGNC; VGNC:7208; AGR2.
eggNOG; ENOG410IVR8; Eukaryota.
eggNOG; ENOG4111K70; LUCA.
GeneTree; ENSGT00530000063273; -.
InParanoid; H2QU78; -.
KO; K20356; -.
OMA; YSNMQKA; -.
OrthoDB; EOG091G0RHV; -.
TreeFam; TF321449; -.
Proteomes; UP000002277; Chromosome 7.
Bgee; ENSPTRG00000018953; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0002162; F:dystroglycan binding; IBA:GO_Central.
GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0048546; P:digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0060480; P:lung goblet cell differentiation; IEA:Ensembl.
GO; GO:0070254; P:mucus secretion; IEA:Ensembl.
GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl.
GO; GO:0048639; P:positive regulation of developmental growth; IEA:Ensembl.
GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:1903896; P:positive regulation of IRE1-mediated unfolded protein response; IEA:Ensembl.
GO; GO:1903899; P:positive regulation of PERK-mediated unfolded protein response; IEA:Ensembl.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
InterPro; IPR036249; Thioredoxin-like_sf.
SUPFAM; SSF52833; SSF52833; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 175 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5015093099.
SEQUENCE 175 AA; 19969 MW; F03ADDB10603B12E CRC64;
MEKISVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD QLIWTQTYEE
ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL AEQFVLLNLV YETTDKHLSP
DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY AYEPADTALL LDNMKKALKL LKTEL


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