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AP-2 complex subunit mu (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) (Protein dumpy-23)

 AP2M_CAEEL              Reviewed;         441 AA.
P35603; Q8MXF2; Q9TZC9;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
15-AUG-2003, sequence version 2.
27-SEP-2017, entry version 132.
RecName: Full=AP-2 complex subunit mu;
AltName: Full=Clathrin assembly protein complex 2 mu medium chain;
AltName: Full=Clathrin coat assembly protein AP50;
AltName: Full=Clathrin coat-associated protein AP50;
AltName: Full=Mu2-adaptin;
AltName: Full=Plasma membrane adaptor AP-2 50 kDa protein;
AltName: Full=Protein dumpy-23;
Name=dpy-23; Synonyms=ap50; ORFNames=R160.1;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
STRAIN=Bristol N2;
PubMed=8288128; DOI=10.1101/gad.8.1.60;
Lee J., Jongeward G.D., Sternberg P.W.;
"unc-101, a gene required for many aspects of Caenorhabditis elegans
development and behavior, encodes a clathrin-associated protein.";
Genes Dev. 8:60-73(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
SPLICING.
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=18160346; DOI=10.1016/j.devcel.2007.12.001;
Pan C.L., Baum P.D., Gu M., Jorgensen E.M., Clark S.G., Garriga G.;
"C. elegans AP-2 and retromer control Wnt signaling by regulating mig-
14/Wntless.";
Dev. Cell 14:132-139(2008).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=18160347; DOI=10.1016/j.devcel.2007.12.004;
Yang P.T., Lorenowicz M.J., Silhankova M., Coudreuse D.Y.,
Betist M.C., Korswagen H.C.;
"Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless
in Wnt-producing cells.";
Dev. Cell 14:140-147(2008).
-!- FUNCTION: Component of the adaptor complexes which link clathrin
to receptors in coated vesicles (By similarity). Clathrin-
associated protein complexes are believed to interact with the
cytoplasmic tails of membrane proteins, leading to their selection
and concentration (By similarity). AP50 is a subunit of the plasma
membrane adaptor (By similarity). Essential wnt/egl-20 signaling
protein that functions in wnt/egl-20-producing cells
(PubMed:18160346, PubMed:18160347). Required for the AP-2 complex-
mediated endocytosis of membrane proteins including wntless
homolog mig-14 in egl-20-producing cells (PubMed:18160346,
PubMed:18160347). During development, regulates the migration of
HSN neurons and the left and right Q neuroblasts (QL and QR,
respectively) and their descendants, possibly through hox gene and
wnt/egl-20 gene target mab-5, and plays a role in establishing ALM
and PLM neuronal cell polarity (PubMed:18160346). Required for the
asymmetric divisions of V5 cells (PubMed:18160346).
{ECO:0000250|UniProtKB:Q09718, ECO:0000250|UniProtKB:Q99186,
ECO:0000269|PubMed:18160346, ECO:0000269|PubMed:18160347}.
-!- SUBUNIT: Adaptor protein complex 2 (AP-2) is a heterotetramer
composed of two large adaptins (alpha-type subunit and beta-type
subunits), a medium adaptin (mu-type subunit AP50) and a small
adaptin (sigma-type subunit AP17).
-!- SUBCELLULAR LOCATION: Cell membrane. Membrane, coated pit;
Peripheral membrane protein; Cytoplasmic side. Note=Component of
the coat surrounding the cytoplasmic face of coated vesicles in
the plasma membrane.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=a;
IsoId=P35603-1; Sequence=Displayed;
Name=b;
IsoId=P35603-2; Sequence=VSP_008037;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Brain, heart, lung, liver, testis and spleen.
-!- DISRUPTION PHENOTYPE: Mutants display a squat body statue referred
to as a dumpy phenotype and have defective HSN neuronal cell
migration (PubMed:18160346). RNAi-mediated knockdown results in
impaired function of the AP-2 complex and accumulation of the
wntless homolog mig-14 at the cell membrane (PubMed:18160347).
{ECO:0000269|PubMed:18160346, ECO:0000269|PubMed:18160347}.
-!- SIMILARITY: Belongs to the adaptor complexes medium subunit
family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; L26290; AAA27981.1; -; mRNA.
EMBL; FO081006; CCD68418.1; -; Genomic_DNA.
EMBL; FO081006; CCD68419.1; -; Genomic_DNA.
PIR; B49837; B49837.
RefSeq; NP_001024865.1; NM_001029694.3. [P35603-2]
RefSeq; NP_741770.1; NM_171670.4. [P35603-1]
UniGene; Cel.6847; -.
ProteinModelPortal; P35603; -.
SMR; P35603; -.
BioGrid; 45648; 2.
STRING; 6239.R160.1a; -.
EPD; P35603; -.
PaxDb; P35603; -.
PeptideAtlas; P35603; -.
PRIDE; P35603; -.
EnsemblMetazoa; R160.1a; R160.1a; WBGene00001082. [P35603-1]
GeneID; 180713; -.
KEGG; cel:CELE_R160.1; -.
UCSC; R160.1b; c. elegans. [P35603-1]
CTD; 180713; -.
WormBase; R160.1a; CE33813; WBGene00001082; dpy-23. [P35603-1]
WormBase; R160.1b; CE33814; WBGene00001082; dpy-23. [P35603-2]
eggNOG; KOG0937; Eukaryota.
eggNOG; ENOG410XPFS; LUCA.
GeneTree; ENSGT00530000062779; -.
HOGENOM; HOG000173246; -.
InParanoid; P35603; -.
KO; K11826; -.
OMA; SWRKADV; -.
OrthoDB; EOG091G06XI; -.
PhylomeDB; P35603; -.
Reactome; R-CEL-437239; Recycling pathway of L1.
Reactome; R-CEL-5099900; WNT5A-dependent internalization of FZD4.
Reactome; R-CEL-5140745; WNT5A-dependent internalization of FZD2, FZD5 and ROR2.
Reactome; R-CEL-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
SignaLink; P35603; -.
PRO; PR:P35603; -.
Proteomes; UP000001940; Chromosome X.
Bgee; WBGene00001082; -.
GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
GO; GO:1990075; C:periciliary membrane compartment; IDA:WormBase.
GO; GO:0045202; C:synapse; IDA:WormBase.
GO; GO:0008021; C:synaptic vesicle; IDA:WormBase.
GO; GO:0010171; P:body morphogenesis; IMP:WormBase.
GO; GO:0072583; P:clathrin-dependent endocytosis; IMP:WormBase.
GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO; GO:0010940; P:positive regulation of necrotic cell death; IGI:WormBase.
GO; GO:0061357; P:positive regulation of Wnt protein secretion; IMP:WormBase.
GO; GO:0097499; P:protein localization to non-motile cilium; IMP:WormBase.
GO; GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.
InterPro; IPR022775; AP_mu_sigma_su.
InterPro; IPR001392; Clathrin_mu.
InterPro; IPR018240; Clathrin_mu_CS.
InterPro; IPR011012; Longin-like_dom.
InterPro; IPR028565; MHD.
Pfam; PF00928; Adap_comp_sub; 1.
Pfam; PF01217; Clat_adaptor_s; 1.
PIRSF; PIRSF005992; Clathrin_mu; 1.
PRINTS; PR00314; CLATHRINADPT.
SUPFAM; SSF49447; SSF49447; 1.
SUPFAM; SSF64356; SSF64356; 1.
PROSITE; PS00990; CLAT_ADAPTOR_M_1; 1.
PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
PROSITE; PS51072; MHD; 1.
2: Evidence at transcript level;
Alternative splicing; Cell membrane; Coated pit; Complete proteome;
Endocytosis; Membrane; Protein transport; Reference proteome;
Transport.
CHAIN 1 441 AP-2 complex subunit mu.
/FTId=PRO_0000193791.
DOMAIN 174 440 MHD. {ECO:0000255|PROSITE-
ProRule:PRU00404}.
VAR_SEQ 142 147 Missing (in isoform b). {ECO:0000305}.
/FTId=VSP_008037.
CONFLICT 80 80 E -> A (in Ref. 1; AAA27981).
{ECO:0000305}.
SEQUENCE 441 AA; 50300 MW; D8F8B7760CAB164F CRC64;
MIGGLFVYNH KGEVLISRIY RDDVTRNAVD AFRVNVIHAR QQVRSPVTNM ARTSFFHVKR
GNVWICAVTR QNVNAAMVFE FLKRFADTMQ SYFGKLNEEN VKNNFVLIYE LLDEILDFGY
PQNTDPGVLK TFITQQGVRT ADAPVPVTKE EQSQITSQVT GQIGWRREGI KYRRNELFLD
VIEYVNLLMN QQGQVLSAHV AGKVAMKSYL SGMPECKFGI NDKITIEGKS KPGSDDPNKA
SRAAVAIDDC QFHQCVKLTK FETEHAISFI PPDGEYELMR YRTTKDIQLP FRVIPLVREV
SRNKMEVKVV VKSNFKPSLL AQKLEVRIPT PPNTSGVQLI CMKGKAKYKA GENAIVWKIK
RMAGMKESQI SAEIDLLSTG NVEKKKWNRP PVSMNFEVPF APSGLKVRYL KVFEPKLNYS
DHDVIKWVRY IGRSGLYETR C


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