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AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (BLVPCP1) (Bovine leukemia virus cell receptor) (BLV-R) (Delta-adaptin)

 AP3D1_BOVIN             Reviewed;        1207 AA.
Q865S1; Q03368; Q28876;
24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
24-JAN-2006, sequence version 2.
25-OCT-2017, entry version 106.
RecName: Full=AP-3 complex subunit delta-1;
AltName: Full=AP-3 complex subunit delta;
AltName: Full=Adaptor-related protein complex 3 subunit delta-1;
AltName: Full=BLVPCP1;
AltName: Full=Bovine leukemia virus cell receptor;
Short=BLV-R;
AltName: Full=Delta-adaptin;
Name=AP3D1; Synonyms=BLVR;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, IDENTIFICATION IN
THE AP-3 COMPLEX, AND LACK OF FUNCTION AS RECEPTOR FOR BOVINE LEUKEMIA
VIRUS.
TISSUE=Brain;
PubMed=12692298; DOI=10.1099/vir.0.18763-0;
Suzuki T., Matsubara Y., Kitani H., Ikeda H.;
"Evaluation of the delta subunit of bovine adaptor protein complex 3
as a receptor for bovine leukaemia virus.";
J. Gen. Virol. 84:1309-1316(2003).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 493-845.
TISSUE=Kidney;
PubMed=7998843; DOI=10.1007/BF01379141;
Ban J., Truong A.T., Horion B., Altaner C., Burny A., Portetelle D.,
Kettmann R.;
"Isolation of the missing 5'-end of the encoding region of the bovine
leukemia virus cell receptor gene.";
Arch. Virol. 138:379-383(1994).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 758-1207.
TISSUE=Kidney;
PubMed=8380453;
Ban J., Portetelle D., Altaner C., Horion B., Milan D., Krchnak V.,
Burny A., Kettmann R.;
"Isolation and characterization of a 2.3-kilobase-pair cDNA fragment
encoding the binding domain of the bovine leukemia virus cell
receptor.";
J. Virol. 67:1050-1057(1993).
-!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex
which is not clathrin-associated. The complex is associated with
the Golgi region as well as more peripheral structures. It
facilitates the budding of vesicles from the Golgi membrane and
may be directly involved in trafficking to lysosomes. Involved in
process of CD8+ T-cell and NK cell degranulation. In concert with
the BLOC-1 complex, AP-3 is required to target cargos into
vesicles assembled at cell bodies for delivery into neurites and
nerve terminals. {ECO:0000250|UniProtKB:O14617,
ECO:0000250|UniProtKB:O54774}.
-!- SUBUNIT: AP-3 associates with the BLOC-1 complex (By similarity).
Adaptor protein complex 3 (AP-3) is a heterotetramer composed of
two large adaptins (delta-type subunit AP3D1 and beta-type subunit
AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2)
and a small adaptin (sigma-type subunit APS1 or AP3S2)
(PubMed:12692298). Interacts with SLC30A2 (By similarity).
{ECO:0000250|UniProtKB:O14617, ECO:0000269|PubMed:12692298}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12692298}.
Golgi apparatus membrane {ECO:0000250}; Peripheral membrane
protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
-!- MISCELLANEOUS: Was originally thought to be a bovine leukemia
virus receptor. {ECO:0000305|PubMed:7998843}.
-!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA30633.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAA30633.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Sequence=AAB32770.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=BAA36591.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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EMBL; AB015979; BAA36591.1; ALT_INIT; mRNA.
EMBL; S75828; AAB32770.2; ALT_SEQ; Genomic_DNA.
EMBL; M98430; AAA30633.1; ALT_SEQ; mRNA.
RefSeq; NP_776423.3; NM_173998.4.
UniGene; Bt.8223; -.
ProteinModelPortal; Q865S1; -.
STRING; 9913.ENSBTAP00000011906; -.
PaxDb; Q865S1; -.
PeptideAtlas; Q865S1; -.
PRIDE; Q865S1; -.
Ensembl; ENSBTAT00000011906; ENSBTAP00000011906; ENSBTAG00000009034.
GeneID; 281023; -.
KEGG; bta:281023; -.
CTD; 8943; -.
eggNOG; KOG1059; Eukaryota.
eggNOG; ENOG410XQFB; LUCA.
GeneTree; ENSGT00550000075067; -.
HOGENOM; HOG000000981; -.
HOVERGEN; HBG004853; -.
InParanoid; Q865S1; -.
KO; K12396; -.
OMA; AWINEPL; -.
OrthoDB; EOG091G04IL; -.
TreeFam; TF105666; -.
Proteomes; UP000009136; Chromosome 7.
Bgee; ENSBTAG00000009034; -.
GO; GO:0030123; C:AP-3 adaptor complex; IEA:InterPro.
GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:GOC.
GO; GO:0098830; C:presynaptic endosome; IEA:Ensembl.
GO; GO:0043195; C:terminal bouton; IEA:Ensembl.
GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
GO; GO:0048007; P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib; IEA:Ensembl.
GO; GO:0035646; P:endosome to melanosome transport; IEA:Ensembl.
GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IEA:Ensembl.
GO; GO:0051138; P:positive regulation of NK T cell differentiation; IEA:Ensembl.
GO; GO:0072657; P:protein localization to membrane; IEA:Ensembl.
GO; GO:0061088; P:regulation of sequestering of zinc ion; IEA:Ensembl.
GO; GO:0048499; P:synaptic vesicle membrane organization; IEA:Ensembl.
Gene3D; 1.25.10.10; -; 2.
InterPro; IPR017105; AP3_complex_dsu.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
PANTHER; PTHR22781; PTHR22781; 3.
Pfam; PF01602; Adaptin_N; 1.
SUPFAM; SSF48371; SSF48371; 1.
1: Evidence at protein level;
Acetylation; Coiled coil; Complete proteome; Cytoplasm;
Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
Reference proteome; Repeat; Transport.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:O14617}.
CHAIN 2 1207 AP-3 complex subunit delta-1.
/FTId=PRO_0000193765.
REPEAT 34 71 HEAT 1.
REPEAT 142 179 HEAT 2.
REPEAT 180 216 HEAT 3.
REPEAT 218 254 HEAT 4.
REPEAT 257 296 HEAT 5.
REPEAT 298 336 HEAT 6.
REPEAT 337 373 HEAT 7.
REPEAT 375 409 HEAT 8.
REPEAT 521 558 HEAT 9.
COILED 659 679 {ECO:0000255}.
COILED 725 752 {ECO:0000255}.
COILED 846 870 {ECO:0000255}.
COMPBIAS 840 948 Lys-rich.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 632 632 Phosphoserine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 634 634 Phosphoserine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 636 636 Phosphoserine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 688 688 Phosphoserine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 758 758 Phosphoserine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 759 759 Phosphoserine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 762 762 Phosphothreonine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 764 764 Phosphoserine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 788 788 Phosphoserine.
{ECO:0000250|UniProtKB:O14617}.
MOD_RES 829 829 Phosphoserine.
{ECO:0000250|UniProtKB:O14617}.
CONFLICT 758 758 S -> R (in Ref. 2; AAB32770 and 3;
AAA30633). {ECO:0000305}.
SEQUENCE 1207 AA; 136390 MW; 8E07DD39B33E529A CRC64;
MALKMVKGSI DRMFDKNLQD LVRGIRNHKE DEAKYISQCI DEIKQELKQD NIAVKANAVC
KLTYLQMLGY DISWAAFNII EVMSASKFTF KRIGYLAASQ CFHEGTDVIM LTTNQIRKDL
SSPSQYDTGV ALTGLSCFVT PDLARDLAND IMTLMSHTKP YIRKKAVLIM YKVFLKYPES
LRPAFPRLKE KLEDPDPGVQ SAAVNVICEL ARRNPKNYLS LAPLFFKLMT SSTNNWVLIK
IIKLFGALTP LEPRLGKKLI EPLTNLIHST SAMSLLYECV NTVIAVLISL SSGMPNHSAS
IQLCVQKLRI LIEDSDQNLK YLGLLAMSKI LRTHPKSVQA HKDLVLQCLD DKDESIRLRA
LDLLYGMVSK KNLMEIVKKL MTHVDKAEGT TYRDELLTKI IDICSQSNYQ HITNFEWYIS
ILVELTRLEG TRHGHLIAAQ MLDVAIRVKA IRRFAVAQMS ALLDSAHLVA SSPQRSGICE
VLYAAAWICG EFSEHLQEPQ QTLEAMLRPK VTTLPGHIQA VYVQNVVKLY AAILQQKEQA
ADTSAAQEVT QLLVERLPQF VQSADLEVQE RASCILQLVK HVQKLQAKDV PVAEEVSALF
AGELNPVAPK AQKKVPVPEG LDLDAWINEP LSDSESEDEK PKAMFQDEEQ RHTKPRAPEA
DEQELARRRE ARRQEQANNP FYIKSSPSPQ KRYQDAPGVE HIPVVQIDLS VPLKVPGMPL
SDQYVKLEEE RRHRQRLEKD KRKKKKRERE RRGTRRHSSL HTESDEDIAP AQRVDIVTEE
MPENALPSDE DDKDPNDPYR ALDIDLDKPL ADSEKLPVQK HRNAETSKSP EKEDVPLVEK
KSKKPKKKEK KHKEKEREKK KKEVEKGEDL DFWLSTTPPA ATPALEELEV NTTVTVLKEG
QEEPRGEEQD AEEDREQDLE KKPSKHKKKK HKKDKEERPK DKRKSKKKVP PADEEAAEPV
ENGTLEEEPL PPMSSYILLA ENSYIKMTYD VQGSLQKDSQ VTVSVVLENQ SDSFLKSMEL
NVLDSLNARL ARPEGSSVHD GVPVPFQLPP GISNEAQFVF TIQSIVMAQK LKGTLSFIAK
NDEGSTHEKL DFKLHFTCTS YLVTTPCYSD AFAKLLESGD LSMSSIKVDG ISMSFHNLLA
KICFHHRFSV VERVDSCASM YSRSIQGHHV CLLVKKGEKS VSVDGKCSDP TLLSNLLEEM
KETLATC


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