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AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)

 AP4M1_MOUSE             Reviewed;         449 AA.
Q9JKC7;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
28-FEB-2018, entry version 125.
RecName: Full=AP-4 complex subunit mu-1 {ECO:0000305};
AltName: Full=AP-4 adaptor complex mu subunit;
AltName: Full=Adaptor-related protein complex 4 subunit mu-1;
AltName: Full=Mu subunit of AP-4;
AltName: Full=Mu-adaptin-related protein 2;
Short=mu-ARP2;
AltName: Full=Mu4-adaptin;
Short=mu4;
Name=Ap4m1 {ECO:0000312|MGI:MGI:1337063};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Werner H., Nave K.-A.;
"Mus musculus adaptor-related protein complex AP-4 mu4 subunit.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION, AND INTERACTION WITH CACNG3; GRIA1 AND GRIA2.
PubMed=18341993; DOI=10.1016/j.neuron.2008.02.012;
Matsuda S., Miura E., Matsuda K., Kakegawa W., Kohda K., Watanabe M.,
Yuzaki M.;
"Accumulation of AMPA receptors in autophagosomes in neuronal axons
lacking adaptor protein AP-4.";
Neuron 57:730-745(2008).
-!- FUNCTION: Component of the adaptor protein complex 4 (AP-4).
Adaptor protein complexes are vesicle coat components involved
both in vesicle formation and cargo selection. They control the
vesicular transport of proteins in different trafficking pathways.
AP-4 forms a non clathrin-associated coat on vesicles departing
the trans-Golgi network (TGN) and may be involved in the targeting
of proteins from the trans-Golgi network (TGN) to the endosomal-
lysosomal system (By similarity). It is also involved in protein
sorting to the basolateral membrane in epithelial cells and the
proper asymmetric localization of somatodendritic proteins in
neurons (PubMed:18341993). Within AP-4, the mu-type subunit AP4M1
is directly involved in the recognition and binding of tyrosine-
based sorting signals found in the cytoplasmic part of cargos. The
adaptor protein complex 4 (AP-4) may also recognize other types of
sorting signal (By similarity). {ECO:0000250|UniProtKB:O00189,
ECO:0000269|PubMed:18341993}.
-!- SUBUNIT: Adaptor protein complex 4 (AP-4) is a heterotetramer
composed of two large adaptins (epsilon-type subunit AP4E1 and
beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1)
and a small adaptin (sigma-type AP4S1). Interacts with tyrosine-
based sorting signals on the cytoplasmic tail of cargo proteins
such as APP, LAMP2 and NAGPA. Interacts with the C-terminal domain
of GRID2 (By similarity). Interacts with GRIA1 and GRIA2; the
interaction is indirect via CACNG3 (PubMed:18341993). Interacts
with CACNG3; CACNG3 associates GRIA1 and GRIA2 with the adaptor
protein complex 4 (AP-4) to target them to the somatodendritic
compartment of neurons (PubMed:18341993).
{ECO:0000250|UniProtKB:O00189, ECO:0000269|PubMed:18341993}.
-!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
membrane {ECO:0000250|UniProtKB:O00189}; Peripheral membrane
protein {ECO:0000250|UniProtKB:O00189}. Early endosome
{ECO:0000250|UniProtKB:O00189}. Note=Found in soma and dendritic
shafts of neuronal cells. {ECO:0000250|UniProtKB:Q2PWT8}.
-!- SIMILARITY: Belongs to the adaptor complexes medium subunit
family. {ECO:0000305}.
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EMBL; AF242858; AAF63513.1; -; mRNA.
EMBL; BC011174; AAH11174.1; -; mRNA.
CCDS; CCDS19794.1; -.
RefSeq; NP_067367.3; NM_021392.4.
UniGene; Mm.113205; -.
UniGene; Mm.477097; -.
ProteinModelPortal; Q9JKC7; -.
SMR; Q9JKC7; -.
STRING; 10090.ENSMUSP00000019662; -.
iPTMnet; Q9JKC7; -.
PhosphoSitePlus; Q9JKC7; -.
MaxQB; Q9JKC7; -.
PaxDb; Q9JKC7; -.
PRIDE; Q9JKC7; -.
Ensembl; ENSMUST00000019662; ENSMUSP00000019662; ENSMUSG00000019518.
GeneID; 11781; -.
KEGG; mmu:11781; -.
UCSC; uc009aev.2; mouse.
CTD; 9179; -.
MGI; MGI:1337063; Ap4m1.
eggNOG; KOG0937; Eukaryota.
eggNOG; ENOG410XPFS; LUCA.
GeneTree; ENSGT00530000062779; -.
HOGENOM; HOG000173245; -.
HOVERGEN; HBG102734; -.
InParanoid; Q9JKC7; -.
KO; K12402; -.
OMA; IHIRHSG; -.
OrthoDB; EOG091G0ISV; -.
PhylomeDB; Q9JKC7; -.
TreeFam; TF329745; -.
Reactome; R-MMU-432720; Lysosome Vesicle Biogenesis.
PRO; PR:Q9JKC7; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000019518; -.
CleanEx; MM_AP4M1; -.
ExpressionAtlas; Q9JKC7; baseline and differential.
Genevisible; Q9JKC7; MM.
GO; GO:0030124; C:AP-4 adaptor complex; ISS:UniProtKB.
GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
GO; GO:0005829; C:cytosol; IEA:GOC.
GO; GO:0005769; C:early endosome; ISS:UniProtKB.
GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
GO; GO:0006895; P:Golgi to endosome transport; ISS:UniProtKB.
GO; GO:0090160; P:Golgi to lysosome transport; ISS:UniProtKB.
GO; GO:0006886; P:intracellular protein transport; ISS:UniProtKB.
GO; GO:0008104; P:protein localization; IMP:UniProtKB.
GO; GO:1903361; P:protein localization to basolateral plasma membrane; ISS:UniProtKB.
GO; GO:0006605; P:protein targeting; IMP:UniProtKB.
GO; GO:0006622; P:protein targeting to lysosome; ISO:MGI.
GO; GO:0016192; P:vesicle-mediated transport; TAS:MGI.
InterPro; IPR036168; AP2_Mu_C_sf.
InterPro; IPR001392; Clathrin_mu.
InterPro; IPR018240; Clathrin_mu_CS.
InterPro; IPR011012; Longin-like_dom_sf.
InterPro; IPR028565; MHD.
Pfam; PF00928; Adap_comp_sub; 1.
PIRSF; PIRSF005992; Clathrin_mu; 1.
PRINTS; PR00314; CLATHRINADPT.
SUPFAM; SSF49447; SSF49447; 1.
SUPFAM; SSF64356; SSF64356; 1.
PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
PROSITE; PS51072; MHD; 1.
1: Evidence at protein level;
Complete proteome; Endosome; Golgi apparatus; Membrane;
Protein transport; Reference proteome; Transport.
CHAIN 1 449 AP-4 complex subunit mu-1.
/FTId=PRO_0000193788.
DOMAIN 184 448 MHD. {ECO:0000255|PROSITE-
ProRule:PRU00404}.
SEQUENCE 449 AA; 49509 MW; 579AEAE1F82B5D04 CRC64;
MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGGESPVVMY HGDRHFIHIR
HSGLYLVATT LENVSPFSLL ELLSRLATLL GDYCGSLNEG TISRNVALVY ELLDEVLDYG
YVQTTSTEML RNFIQTEAVV SKPFSLFDLS SVGLFGAETQ QNKVAPSSAA SRPVLSSRSD
QSQKNEVFLD VVERLSVLIA SNGSLLKVDV QGEIRLKSFL PSGSEICIGL TEEFCVGKSE
LRGYGPGIRV DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP
SVQWDQGSGR LQVYLKLRCD LPPKSQALNI HLHLPLPRGV ISLSQELSSP DQKAELGEGA
LHWDLPRVQG GSQLSGLFQM DVPGLQGLPN HGPSPLGLGP ASLSFELPRH TCSGLQVRFL
RLSFSACGNA NPHKWVRHLS HSNAYVIRI


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