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ASNSD1 upstream open reading frame protein (ASNSD1 small/short open reading frame-encoded polypeptide) (ASNSD1-SEP)

 ASURF_HUMAN             Reviewed;          96 AA.
L0R819;
22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
06-MAR-2013, sequence version 1.
23-MAY-2018, entry version 33.
RecName: Full=ASNSD1 upstream open reading frame protein {ECO:0000312|HGNC:HGNC:53619};
AltName: Full=ASNSD1 small/short open reading frame-encoded polypeptide {ECO:0000303|PubMed:23160002, ECO:0000303|PubMed:25857697};
Short=ASNSD1-SEP {ECO:0000303|PubMed:23160002, ECO:0000303|PubMed:25857697};
Name=ASDURF {ECO:0000312|HGNC:HGNC:53619};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000312|EMBL:CCO13681.1};
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE INITIATION (ISOFORM
2).
PubMed=23950983; DOI=10.1371/journal.pone.0070698;
Vanderperre B., Lucier J.-F., Motard J., Tremblay G., Vanderperre S.,
Wisztorski M., Salzet M., Boisvert F.-M., Roucou X.;
"Direct detection of alternative open reading frames translation
products in human significantly expands the proteome.";
PLoS ONE 8:E70698-E70698(2013).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[3]
ALTERNATIVE INITIATION (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORM 2),
AND IDENTIFICATION BY MASS SPECTROMETRY (ISOFORM 2).
PubMed=23160002; DOI=10.1038/nchembio.1120;
Slavoff S.A., Mitchell A.J., Schwaid A.G., Cabili M.N., Ma J.,
Levin J.Z., Karger A.D., Budnik B.A., Rinn J.L., Saghatelian A.;
"Peptidomic discovery of short open reading frame-encoded peptides in
human cells.";
Nat. Chem. Biol. 9:59-64(2013).
[4]
ALTERNATIVE INITIATION (ISOFORM 2).
PubMed=25857697; DOI=10.3109/10409238.2015.1016215;
Chu Q., Ma J., Saghatelian A.;
"Identification and characterization of sORF-encoded polypeptides.";
Crit. Rev. Biochem. Mol. Biol. 50:134-141(2015).
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23160002}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=2;
Name=2; Synonyms=uORF {ECO:0000303|PubMed:23160002};
IsoId=L0R819-1; Sequence=Displayed;
Note=Product of the upstream open reading frame of this
bicistronic gene. {ECO:0000303|PubMed:23160002,
ECO:0000303|PubMed:23950983, ECO:0000303|PubMed:25857697};
Name=1;
IsoId=Q9NWL6-1; Sequence=External;
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EMBL; HF547970; CCO13681.1; -; Genomic_DNA.
EMBL; AC012488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
UniGene; Hs.101364; -.
SMR; L0R819; -.
EPD; L0R819; -.
PeptideAtlas; L0R819; -.
Ensembl; ENST00000607829; ENSP00000475224; ENSG00000138381.
UCSC; uc061qov.1; human. [L0R819-1]
EuPathDB; HostDB:ENSG00000138381.9; -.
GeneCards; ASDURF; -.
HGNC; HGNC:53619; ASDURF.
OpenTargets; ENSG00000138381; -.
GeneTree; ENSGT00390000012446; -.
Proteomes; UP000005640; Chromosome 2.
Bgee; ENSG00000138381; -.
ExpressionAtlas; L0R819; baseline and differential.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
Gene3D; 1.10.287.370; -; 1.
InterPro; IPR009053; Prefoldin.
1: Evidence at protein level;
Alternative initiation; Coiled coil; Complete proteome; Cytoplasm;
Reference proteome.
CHAIN 1 96 ASNSD1 upstream open reading frame
protein.
/FTId=PRO_0000442240.
COILED 23 96 {ECO:0000255}.
SEQUENCE 96 AA; 11250 MW; 87905E0870BB4731 CRC64;
MPSRGTRPED SSVLIPTDNS TPHKEDLSSK IKEQKIVVDE LSNLKKNRKV YRQQQNSNIF
FLADRTEMLS ESKNILDELK KEYQEIENLD KTKIKK


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