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AT-hook motif nuclear-localized protein 16 (Protein TRANSPOSABLE ELEMENT SILENCING VIA AT-HOOK) (Protein TEK)

 AHL16_ARATH             Reviewed;         257 AA.
Q9SJG4;
04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
07-JUN-2017, entry version 103.
RecName: Full=AT-hook motif nuclear-localized protein 16 {ECO:0000312|EMBL:FAA00287.1};
AltName: Full=Protein TRANSPOSABLE ELEMENT SILENCING VIA AT-HOOK {ECO:0000303|PubMed:23394836};
Short=Protein TEK {ECO:0000303|PubMed:23394836};
Name=AHL16 {ECO:0000303|PubMed:15604740};
Synonyms=TEK {ECO:0000303|PubMed:23394836};
OrderedLocusNames=At2g42940 {ECO:0000312|Araport:AT2G42940};
ORFNames=F23E6.8 {ECO:0000312|EMBL:AAM15286.1},
F7D19.6 {ECO:0000312|EMBL:AAD21715.1};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
"Arabidopsis ORF clones.";
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[4]
IDENTIFICATION, GENE FAMILY, AND NOMENCLATURE.
STRAIN=cv. Columbia;
PubMed=15604740; DOI=10.1007/s11103-004-3249-5;
Fujimoto S., Matsunaga S., Yonemura M., Uchiyama S., Azuma T.,
Fukui K.;
"Identification of a novel plant MAR DNA binding protein localized on
chromosomal surfaces.";
Plant Mol. Biol. 56:225-239(2004).
[5]
FUNCTION, TISSUE SPECIFICITY, AND INTERACTION WITH FVE/MSI4 AND MSI5.
STRAIN=cv. Landsberg erecta;
PubMed=23394836; DOI=10.1016/j.cub.2013.01.030;
Xu Y., Wang Y., Stroud H., Gu X., Sun B., Gan E.S., Ng K.H.,
Jacobsen S.E., He Y., Ito T.;
"A matrix protein silences transposons and repeats through interaction
with retinoblastoma-associated proteins.";
Curr. Biol. 23:345-350(2013).
[6]
FUNCTION.
PubMed=23836195; DOI=10.4161/nucl.25612;
Xu Y., Gan E.S., He Y., Ito T.;
"Flowering and genome integrity control by a nuclear matrix protein in
Arabidopsis.";
Nucleus 4:274-276(2013).
[7]
FUNCTION.
PubMed=23733063; DOI=10.4161/psb.25006;
Xu Y., Gan E.S., Ito T.;
"The AT-hook/PPC domain protein TEK negatively regulates floral
repressors including MAF4 and MAF5.";
Plant Signal. Behav. 8:E25006-E25006(2013).
[8]
GENE FAMILY, AND DOMAIN PPC.
PubMed=24218605; DOI=10.1073/pnas.1219277110;
Zhao J., Favero D.S., Peng H., Neff M.M.;
"Arabidopsis thaliana AHL family modulates hypocotyl growth
redundantly by interacting with each other via the PPC/DUF296
domain.";
Proc. Natl. Acad. Sci. U.S.A. 110:E4688-E4697(2013).
[9]
FUNCTION, AND MUTAGENESIS OF 57-GLY--PRO-59.
PubMed=25336567; DOI=10.1093/mp/ssu114;
Jia Q.S., Zhu J., Xu X.F., Lou Y., Zhang Z.L., Zhang Z.P., Yang Z.N.;
"Arabidopsis AT-hook protein TEK positively regulates the expression
of arabinogalactan proteins in controlling nexine layer formation in
the pollen wall.";
Mol. Plant 0:0-0(2014).
[10]
FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=24804694; DOI=10.1038/ncomms4855;
Lou Y., Xu X.F., Zhu J., Gu J.N., Blackmore S., Yang Z.N.;
"The tapetal AHL family protein TEK determines nexine formation in the
pollen wall.";
Nat. Commun. 5:3855-3855(2014).
-!- FUNCTION: Transcription factor that specifically binds AT-rich DNA
sequences related to the nuclear matrix attachment regions (MARs)
(PubMed:25336567). Encodes a nuclear matrix protein that acts in
the maintenance of genomic integrity by silencing TEs and repeat-
containing genes through epigenetic machinery. Acts as a chromatin
remodeling factor that modifies the architecture of FLC and FWA
chromatin by modulating both H3 acetylation and methylation
leading to the regulation of FLC and FWA expression
(PubMed:23394836, PubMed:23836195). Negatively regulates floral
repressors including MAF4 and MAF5 (PubMed:23733063). Plays a
transcription activation role in anther development. Regulates the
expression of arabinogalactan proteins (AGPs) involved in the
formation of the nexine layer of the pollen wall (PubMed:25336567,
PubMed:24804694). Binds AGP6, AGP11, AGP23 and AGP40 promoters
(PubMed:25336567). {ECO:0000250|UniProtKB:Q8VYJ2,
ECO:0000269|PubMed:23394836, ECO:0000269|PubMed:23733063,
ECO:0000269|PubMed:23836195, ECO:0000269|PubMed:24804694,
ECO:0000269|PubMed:25336567}.
-!- SUBUNIT: Interacts with FVE/MSI4 and MSI5 which are components of
HDAC corepressor complexes. {ECO:0000269|PubMed:23394836}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24804694}.
-!- TISSUE SPECIFICITY: Preferentially expressed in the inflorescence
meristem and young floral buds, as well as in seedling-stage
vegetative meristems (PubMed:23394836). Widely expressed in
flowers, roots and stems, with relatively low expression in leaves
(PubMed:24804694). {ECO:0000269|PubMed:23394836,
ECO:0000269|PubMed:24804694}.
-!- DEVELOPMENTAL STAGE: Expressed in tapetum during the tetrad stage.
{ECO:0000269|PubMed:24804694}.
-!- DOMAIN: The PPC domain mediates interactions between AHL proteins.
{ECO:0000269|PubMed:24218605}.
-!- DISRUPTION PHENOTYPE: Abnormal pollen wall with the absence of the
nexine and intine layers causing microspore abortion and male
sterility. {ECO:0000269|PubMed:24804694}.
-!- MISCELLANEOUS: AHL16/TEK knockdown results in late flowering
phenotype. {ECO:0000269|PubMed:23394836}.
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EMBL; AC006580; AAM15286.1; -; Genomic_DNA.
EMBL; AC006931; AAD21715.1; -; Genomic_DNA.
EMBL; CP002685; AEC10189.1; -; Genomic_DNA.
EMBL; BT010721; AAR20778.1; -; mRNA.
EMBL; BT010995; AAR24773.1; -; mRNA.
EMBL; BR000352; FAA00287.1; -; mRNA.
PIR; B84860; B84860.
RefSeq; NP_181822.1; NM_129855.3.
UniGene; At.45674; -.
UniGene; At.73075; -.
ProteinModelPortal; Q9SJG4; -.
SMR; Q9SJG4; -.
IntAct; Q9SJG4; 4.
STRING; 3702.AT2G42940.1; -.
PaxDb; Q9SJG4; -.
PRIDE; Q9SJG4; -.
EnsemblPlants; AT2G42940.1; AT2G42940.1; AT2G42940.
GeneID; 818895; -.
Gramene; AT2G42940.1; AT2G42940.1; AT2G42940.
KEGG; ath:AT2G42940; -.
Araport; AT2G42940; -.
TAIR; locus:2045585; AT2G42940.
eggNOG; ENOG410IEMZ; Eukaryota.
eggNOG; ENOG41119VG; LUCA.
HOGENOM; HOG000239043; -.
OMA; SWAPGRN; -.
OrthoDB; EOG09360PTZ; -.
PhylomeDB; Q9SJG4; -.
PRO; PR:Q9SJG4; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; Q9SJG4; baseline and differential.
Genevisible; Q9SJG4; AT.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0003680; F:AT DNA binding; IBA:GO_Central.
GO; GO:0031490; F:chromatin DNA binding; IDA:TAIR.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0035067; P:negative regulation of histone acetylation; IMP:TAIR.
GO; GO:0010529; P:negative regulation of transposition; IMP:TAIR.
GO; GO:0010208; P:pollen wall assembly; IMP:UniProtKB.
GO; GO:1900111; P:positive regulation of histone H3-K9 dimethylation; IMP:TAIR.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:UniProtKB.
CDD; cd11378; DUF296; 1.
InterPro; IPR014476; AT-hook_nuclear.
InterPro; IPR005175; PPC_dom.
Pfam; PF03479; DUF296; 1.
PIRSF; PIRSF016021; ESCAROLA; 1.
PROSITE; PS51742; PPC; 1.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 257 AT-hook motif nuclear-localized protein
16.
/FTId=PRO_0000432034.
DOMAIN 77 214 PPC. {ECO:0000255|PROSITE-
ProRule:PRU01078}.
DNA_BIND 53 65 A.T hook. {ECO:0000255}.
MUTAGEN 57 59 GRP->AAA: Reduces DNA-binding activity.
{ECO:0000269|PubMed:25336567}.
SEQUENCE 257 AA; 27004 MW; 00DA8F50213F6DE9 CRC64;
MAGGTALTPT SVGSKSVPMR NHEATERGNT NNNLRALPKA VQPVSSIEGE MAKRPRGRPA
GSKNKPKPPI IVTHDSPNSL RANAVEISSG CDICETLSDF ARRKQRGLCI LSANGCVTNV
TLRQPASSGA IVTLHGRYEI LSLLGSILPP PAPLGITGLT IYLAGPQGQV VGGGVVGGLI
ASGPVVLMAA SFMNAVFDRL PMDDDEAASM QNQQYYQNGR SRPLDDIHGL PQNLLTNGNS
ASDIYSWGPA QRVMSKP


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