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ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ)

 ATMIN_MOUSE             Reviewed;         818 AA.
Q6P9S1; Q05CB1; Q80U05; Q8C311;
25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
25-NOV-2008, sequence version 2.
28-MAR-2018, entry version 99.
RecName: Full=ATM interactor {ECO:0000312|EMBL:AAH60631.1};
AltName: Full=ATM/ATR-substrate CHK2-interacting zinc finger protein {ECO:0000250|UniProtKB:O43313};
Short=ASCIZ {ECO:0000250|UniProtKB:O43313};
Name=Atmin {ECO:0000312|MGI:MGI:2682328};
Synonyms=Kiaa0431 {ECO:0000312|EMBL:BAC65563.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain {ECO:0000269|PubMed:17525732};
PubMed=17525732; DOI=10.1038/sj.emboj.7601733;
Kanu N., Behrens A.;
"ATMIN defines an NBS1-independent pathway of ATM signalling.";
EMBO J. 26:2933-2941(2007).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3] {ECO:0000305, ECO:0000312|EMBL:AAH60631.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH60631.1};
TISSUE=Brain {ECO:0000312|EMBL:AAH60631.1}, and
Mammary tumor {ECO:0000312|EMBL:AAH27752.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4] {ECO:0000305, ECO:0000312|EMBL:BAC65563.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-818.
TISSUE=Brain {ECO:0000312|EMBL:BAC65563.1};
PubMed=12693553; DOI=10.1093/dnares/10.1.35;
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
Nakajima D., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene:
II. The complete nucleotide sequences of 400 mouse KIAA-homologous
cDNAs identified by screening of terminal sequences of cDNA clones
randomly sampled from size-fractionated libraries.";
DNA Res. 10:35-48(2003).
[5] {ECO:0000305, ECO:0000312|EMBL:BAC39849.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 220-818.
STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC39849.1};
TISSUE=Lung {ECO:0000312|EMBL:BAC39849.1};
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[6]
FUNCTION.
PubMed=22167198; DOI=10.1074/jbc.M111.306019;
Jurado S., Conlan L.A., Baker E.K., Ng J.L., Tenis N., Hoch N.C.,
Gleeson K., Smeets M., Izon D., Heierhorst J.;
"ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional
transcriptional activator and feedback sensor in the regulation of
dynein light chain (DYNLL1) expression.";
J. Biol. Chem. 287:3156-3164(2012).
-!- FUNCTION: Transcription factor. Plays a crucial role in cell
survival and RAD51 foci formation in response to methylating DNA
damage. Involved in regulating the activity of ATM in the absence
of DNA damage. May play a role in stabilizing ATM (By similarity).
Binds to the DYNLL1 promoter and activates its transcription.
{ECO:0000250, ECO:0000269|PubMed:22167198}.
-!- SUBUNIT: Interacts via its C-terminus with ATM. Interacts with
DYNLL; this interaction inhibits ATMIN transcriptional activity
and hence may play a role in a feedback loop whereby DYNLL1
inhibits transactivation of its own promoter by ATMIN. ATMIN.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43313}.
Note=Nuclear, in discrete foci during G1 phase.
{ECO:0000250|UniProtKB:O43313}.
-!- SEQUENCE CAUTION:
Sequence=AAH27752.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=AAH60631.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=BAC39849.1; Type=Frameshift; Positions=222; Evidence={ECO:0000305};
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EMBL; AC162858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC027752; AAH27752.1; ALT_SEQ; mRNA.
EMBL; BC060631; AAH60631.1; ALT_INIT; mRNA.
EMBL; AK122281; BAC65563.1; -; mRNA.
EMBL; AK087334; BAC39849.1; ALT_FRAME; mRNA.
CCDS; CCDS22694.2; -.
RefSeq; NP_808368.3; NM_177700.4.
UniGene; Mm.259736; -.
ProteinModelPortal; Q6P9S1; -.
SMR; Q6P9S1; -.
STRING; 10090.ENSMUSP00000104727; -.
iPTMnet; Q6P9S1; -.
PhosphoSitePlus; Q6P9S1; -.
PaxDb; Q6P9S1; -.
PRIDE; Q6P9S1; -.
Ensembl; ENSMUST00000109099; ENSMUSP00000104727; ENSMUSG00000047388.
GeneID; 234776; -.
KEGG; mmu:234776; -.
UCSC; uc009nop.2; mouse.
CTD; 23300; -.
MGI; MGI:2682328; Atmin.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00390000013091; -.
HOGENOM; HOG000034178; -.
HOVERGEN; HBG106238; -.
InParanoid; Q6P9S1; -.
OMA; PVMQLAH; -.
OrthoDB; EOG091G0EJB; -.
PhylomeDB; Q6P9S1; -.
TreeFam; TF331171; -.
PRO; PR:Q6P9S1; -.
Proteomes; UP000000589; Chromosome 8.
Bgee; ENSMUSG00000047388; -.
Genevisible; Q6P9S1; MM.
GO; GO:0016604; C:nuclear body; ISO:MGI.
GO; GO:0070840; F:dynein complex binding; ISO:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
GO; GO:0044458; P:motile cilium assembly; IMP:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
GO; GO:1902857; P:positive regulation of non-motile cilium assembly; IMP:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR013087; Znf_C2H2_type.
SMART; SM00355; ZnF_C2H2; 4.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
2: Evidence at transcript level;
Activator; Complete proteome; DNA damage; Metal-binding; Nucleus;
Reference proteome; Repeat; Transcription; Transcription regulation;
Zinc; Zinc-finger.
CHAIN 1 818 ATM interactor.
/FTId=PRO_0000355036.
ZN_FING 80 105 C2H2-type 1. {ECO:0000255}.
ZN_FING 161 181 C2H2-type 2; degenerate. {ECO:0000255}.
REGION 219 437 Required for formation of RAD51 foci.
{ECO:0000250}.
CONFLICT 1 3 MAA -> MGP (in Ref. 1). {ECO:0000305}.
CONFLICT 1 1 M -> TRP (in Ref. 3; AAH27752).
{ECO:0000305}.
SEQUENCE 818 AA; 87424 MW; F083B47FE0621B35 CRC64;
MAATEAAAAD SAGPAPGVPA TPASTRGAAA ASSPWRPPES RLQGSRPRPA RARAAAPVPP
ARELIQPTVS ELSRAVRTNI LCTVRGCGKI LPNSPALNMH LVKSHRLQDG IVNPTIRKDL
TTAPKFYCCP IKGCPRGPDR PFSQFSLVKQ HFMKMHAEKK HKCSKCSNSY GTEWDLKRHE
EDCGKTFQCT CGCPYASRTA LQSHIYRTGH EIPAEHRDPP SKKRKMESYL QNQKLSSKTT
EPLSDQAAPR QDAAEPDAPE VKPAASLEDS CSAHTKKQSV ATPPRCPQKL LLPKPKVALV
KLPVMQFSPV PVFVPTAESS AQPVVLGVDH SSAAGTVHLV PLSVGALILS LDSEACSLKE
SLPLSKIISP VVEPMNTGVQ VNLGKSLCSP LQEVGSVCQR TSISSSNVQT DLTYASANLI
PSAQWLGPDS SVSSCSQTDL SFDSQVSLPV SVHTQTLVPS SKVTSSIAAQ TDAFIDACFQ
PGGVSRETQT SRMQNRTNDS VPVGHTGLCG DIFESVHASY SVPTDTIMSS SLVAETGTHG
LPPQSDPKIL GQVMEKSAPV LNFSTQNGLL PAHTMTDNQT QTIDLLSDLE NILSSNLPGQ
TLDNRSLLSD TNPGPDAQLP AGSAQNSGID FDIEEFLSAS NIQTQTEESE LSSMSTEPVL
ESLDIETQTD VLLSDPSTQP YGFRAGSGFL GLEMFDTQTQ TDLNFFLDSS PHLPLGSILK
HSSFSMSTDS SDTETQTEGA CPARHLPALE SKVQLSSTET QTMSSGFEPL GNLFLTSNET
QTAMDDFLLA DLAWNTMESQ FSSVETQTCA ELHAVSSF


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