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ATP synthase protein 8 (A6L) (F-ATPase subunit 8)

 ATP8_EQUAS              Reviewed;          67 AA.
P92479;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
10-OCT-2018, entry version 88.
RecName: Full=ATP synthase protein 8;
AltName: Full=A6L;
AltName: Full=F-ATPase subunit 8;
Name=MT-ATP8; Synonyms=ATP8, ATPASE8, MTATP8;
Equus asinus (Donkey) (Equus africanus asinus).
Mitochondrion.
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9793;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Kidney;
PubMed=8875857; DOI=10.1007/BF02337515;
Xu X., Gullberg A., Arnason U.;
"The complete mitochondrial DNA (mtDNA) of the donkey and mtDNA
comparisons among four closely related mammalian species-pairs.";
J. Mol. Evol. 43:438-446(1996).
-!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP
synthase or Complex V) produces ATP from ADP in the presence of a
proton gradient across the membrane which is generated by electron
transport complexes of the respiratory chain. F-type ATPases
consist of two structural domains, F(1) - containing the
extramembraneous catalytic core and F(0) - containing the membrane
proton channel, linked together by a central stalk and a
peripheral stalk. During catalysis, ATP synthesis in the catalytic
domain of F(1) is coupled via a rotary mechanism of the central
stalk subunits to proton translocation. Part of the complex F(0)
domain. Minor subunit located with subunit a in the membrane (By
similarity). {ECO:0000250}.
-!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic
core - and CF(0) - the membrane proton channel. Component of an
ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD,
ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B,
ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and MP68 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
protein.
-!- SIMILARITY: Belongs to the ATPase protein 8 family. {ECO:0000305}.
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EMBL; X97337; CAA66018.1; -; Genomic_DNA.
PIR; T11367; T11367.
RefSeq; NP_007385.1; NC_001788.1.
GeneID; 808062; -.
KEGG; eai:808062; -.
CTD; 4509; -.
HOVERGEN; HBG017400; -.
KO; K02125; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; ISS:UniProtKB.
GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
GO; GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro.
InterPro; IPR039017; ATP8_mammal.
InterPro; IPR001421; ATP8_metazoa.
PANTHER; PTHR13722; PTHR13722; 1.
Pfam; PF00895; ATP-synt_8; 1.
3: Inferred from homology;
Acetylation; ATP synthesis; CF(0); Hydrogen ion transport;
Ion transport; Membrane; Mitochondrion; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 67 ATP synthase protein 8.
/FTId=PRO_0000195528.
TRANSMEM 8 24 Helical. {ECO:0000255}.
MOD_RES 54 54 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:P03930}.
MOD_RES 54 54 N6-succinyllysine; alternate.
{ECO:0000250|UniProtKB:P03930}.
MOD_RES 57 57 N6-acetyllysine.
{ECO:0000250|UniProtKB:P03930}.
SEQUENCE 67 AA; 7908 MW; AE77B87483064A70 CRC64;
MPQLDTSTWF INIVSMILTL FIVFQLKISK HSYPMHPEAK TTKMAKRLTP WESKWTKIYS
PLSLPQQ


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