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ATP-binding cassette sub-family C member 11 (Multidrug resistance-associated protein 8)

 ABCCB_HUMAN             Reviewed;        1382 AA.
Q96J66; Q8TDJ0; Q96JA6; Q9BX80;
07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
22-NOV-2017, entry version 136.
RecName: Full=ATP-binding cassette sub-family C member 11;
AltName: Full=Multidrug resistance-associated protein 8;
Name=ABCC11; Synonyms=MRP8;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Testis;
PubMed=11483364; DOI=10.1016/S0378-1119(01)00572-8;
Tammur J., Prades C., Arnould I., Rzhetsky A., Hutchinson A.,
Adachi M., Schuetz J.D., Swoboda K.J., Ptacek L.J., Rosier M.,
Dean M., Allikmets R.;
"Two new genes from the human ATP-binding cassette transporter
superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome
16q12.";
Gene 273:89-96(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Liver;
PubMed=11688999; DOI=10.1006/bbrc.2001.5865;
Yabuuchi H., Shimizu H., Takayanagi S., Ishikawa T.;
"Multiple splicing variants of two new human ATP-binding cassette
transporters, ABCC11 and ABCC12.";
Biochem. Biophys. Res. Commun. 288:933-939(2001).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
VARIANTS GLU-317 AND ARG-1344.
TISSUE=Mammary gland;
PubMed=11591886;
Bera T.K., Lee S., Salvatore G., Lee B.K., Pastan I.H.;
"MRP8, a new member of ABC transporter superfamily, identified by EST
database mining and gene prediction program, is highly expressed in
breast cancer.";
Mol. Med. 7:509-516(2001).
[4]
FUNCTION IN CYCLIC NUCLEOTIDE EFFLUX.
PubMed=12764137; DOI=10.1074/jbc.M304059200;
Guo Y., Kotova E., Chen Z.S., Lee K., Hopper-Borge E., Belinsky M.G.,
Kruh G.D.;
"MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide
efflux pump and a resistance factor for fluoropyrimidines 2',3'-
dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine.";
J. Biol. Chem. 278:29509-29514(2003).
[5]
FUNCTION.
PubMed=15537867; DOI=10.1124/mol.104.007138;
Chen Z.S., Guo Y., Belinsky M.G., Kotova E., Kruh G.D.;
"Transport of bile acids, sulfated steroids, estradiol 17-beta-D-
glucuronide, and leukotriene C4 by human multidrug resistance protein
8 (ABCC11).";
Mol. Pharmacol. 67:545-557(2005).
[6]
POLYMORPHISM, VARIANT ARG-180, CHARACTERIZATION OF VARIANT ARG-180,
AND FUNCTION IN SECRETION OF EARWAX.
PubMed=16444273; DOI=10.1038/ng1733;
Yoshiura K., Kinoshita A., Ishida T., Ninokata A., Ishikawa T.,
Kaname T., Bannai M., Tokunaga K., Sonoda S., Komaki R., Ihara M.,
Saenko V.A., Alipov G.K., Sekine I., Komatsu K., Takahashi H.,
Nakashima M., Sosonkina N., Mapendano C.K., Ghadami M., Nomura M.,
Liang D.-S., Miwa N., Kim D.-K., Garidkhuu A., Natsume N., Ohta T.,
Tomita H., Kaneko A., Kikuchi M., Russomando G., Hirayama K.,
Ishibashi M., Takahashi A., Saitou N., Murray J.C., Saito S.,
Nakamura Y., Niikawa N.;
"A SNP in the ABCC11 gene is the determinant of human earwax type.";
Nat. Genet. 38:324-330(2006).
[7]
VARIANT ARG-180, CHARACTERIZATION OF VARIANTS HIS-19; ARG-180;
GLU-317; MET-546; TRP-630; ILE-648; ILE-687; ARG-735; VAL-970 AND
ARG-1344, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
GLYCOSYLATION AT ASN-838 AND ASN-844, POLYMORPHISM, AND MUTAGENESIS OF
GLY-180; ASN-838 AND ASN-844.
PubMed=19383836; DOI=10.1096/fj.09-129098;
Toyoda Y., Sakurai A., Mitani Y., Nakashima M., Yoshiura K.,
Nakagawa H., Sakai Y., Ota I., Lezhava A., Hayashizaki Y., Niikawa N.,
Ishikawa T.;
"Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in
the human ABC transporter ABCC11 gene determine earwax type?";
FASEB J. 23:2001-2013(2009).
[8]
VARIANT ARG-180, CHARACTERIZATION OF VARIANT ARG-180, FUNCTION, TISSUE
SPECIFICITY, AND POLYMORPHISM.
PubMed=19710689; DOI=10.1038/jid.2009.254;
Martin A., Saathoff M., Kuhn F., Max H., Terstegen L., Natsch A.;
"A functional ABCC11 allele is essential in the biochemical formation
of human axillary odor.";
J. Invest. Dermatol. 130:529-540(2010).
[9]
CHARACTERIZATION OF VARIANTS HIS-19; ARG-180; GLU-317; MET-546;
ILE-648 AND ARG-1344, FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=25896536; DOI=10.1038/tpj.2015.27;
Arlanov R., Lang T., Jedlitschky G., Schaeffeler E., Ishikawa T.,
Schwab M., Nies A.T.;
"Functional characterization of common protein variants in the efflux
transporter ABCC11 and identification of T546M as functionally
damaging variant.";
Pharmacogenomics J. 16:193-201(2016).
-!- FUNCTION: Participates in physiological processes involving bile
acids, conjugated steroids and cyclic nucleotides
(PubMed:12764137, PubMed:15537867). Enhances the cellular
extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867).
Stimulates the ATP-dependent uptake of a range of physiological
and synthetic lipophilic anions, including the glutathione S-
conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid
sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and
estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-
glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate
and taurocholate, and methotrexate (PubMed:15537867,
PubMed:25896536). Probably functions to secrete earwax
(PubMed:16444273, PubMed:19383836). Required for the secretion of
components contributing to axillary odor formation
(PubMed:19710689). {ECO:0000269|PubMed:12764137,
ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273,
ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689,
ECO:0000269|PubMed:25896536}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19383836,
ECO:0000269|PubMed:25896536}; Multi-pass membrane protein
{ECO:0000255}. Vacuole membrane {ECO:0000269|PubMed:19383836}.
Cytoplasmic vesicle membrane {ECO:0000269|PubMed:25896536}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q96J66-1; Sequence=Displayed;
Name=2; Synonyms=Isoform A;
IsoId=Q96J66-2; Sequence=VSP_017351;
-!- TISSUE SPECIFICITY: Expressed in ceruminous apocrine gland (at
protein level) (PubMed:19383836, PubMed:19710689). Expressed in
many tissues. Not expressed in kidney, spleen and colon. Highly
expressed in breast cancer. Expressed at moderate levels in normal
breast and testis and at very low levels in liver, brain and
placenta. {ECO:0000269|PubMed:11483364,
ECO:0000269|PubMed:11591886, ECO:0000269|PubMed:19383836,
ECO:0000269|PubMed:19710689}.
-!- POLYMORPHISM: Polymorphism in ABCC11 is associated with variation
in apocrine gland secretion [MIM:117800]. This determines
different ear wax phenotypes, presence or absence of axillary
odor, and variation in colostrum secretion. Characteristic of
earwax and strength of axillary odor are most likely
interconnected. Human earwax is a Mendelian trait consisting of
wet and dry types. The wet earwax is brownish and sticky, whereas
the dry type lacks cerumen. The wet cerumen phenotype is
completely dominant. The dry type is seen frequently (80-95%)
among East Asians, but uncommon (0-3%) in populations of European
and African origins. Intermediate frequencies (30-50%) of the dry
type are seen in populations of Southern Asia, the Pacific
Islands, Central Asia and Asia Minor, as well as among the Native
North American and Inuit of Asian ancestry. The allele with Arg-
180 is responsible for the dry earwax phenotype and lack of
axillary odor. {ECO:0000269|PubMed:16444273,
ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689}.
-!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC
family. Conjugate transporter (TC 3.A.1.208) subfamily.
{ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=Of earwax and migration
- Issue 67 of February 2006;
URL="https://web.expasy.org/spotlight/back_issues/067";
-!- WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC
proteins;
URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q96J66";
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EMBL; AY040219; AAK76739.1; -; mRNA.
EMBL; AF367202; AAK58869.1; -; mRNA.
EMBL; AF411579; AAL99902.1; -; mRNA.
EMBL; AF352582; AAK19755.1; -; mRNA.
CCDS; CCDS10732.1; -. [Q96J66-1]
CCDS; CCDS10733.1; -. [Q96J66-2]
RefSeq; NP_115972.2; NM_032583.3. [Q96J66-1]
RefSeq; NP_149163.2; NM_033151.3. [Q96J66-1]
RefSeq; NP_660187.1; NM_145186.2. [Q96J66-2]
RefSeq; XP_016879284.1; XM_017023795.1. [Q96J66-1]
RefSeq; XP_016879285.1; XM_017023796.1. [Q96J66-1]
RefSeq; XP_016879286.1; XM_017023797.1. [Q96J66-1]
RefSeq; XP_016879287.1; XM_017023798.1. [Q96J66-1]
RefSeq; XP_016879288.1; XM_017023799.1. [Q96J66-1]
RefSeq; XP_016879289.1; XM_017023800.1. [Q96J66-1]
UniGene; Hs.652267; -.
ProteinModelPortal; Q96J66; -.
SMR; Q96J66; -.
STRING; 9606.ENSP00000349017; -.
ChEMBL; CHEMBL2073702; -.
DrugBank; DB00286; Conjugated Equine Estrogens.
DrugBank; DB02527; Cyclic Adenosine Monophosphate.
DrugBank; DB00158; Folic Acid.
DrugBank; DB00328; Indomethacin.
DrugBank; DB00563; Methotrexate.
DrugBank; DB01032; Probenecid.
DrugBank; DB04348; Taurocholic Acid.
TCDB; 3.A.1.208.13; the atp-binding cassette (abc) superfamily.
iPTMnet; Q96J66; -.
PhosphoSitePlus; Q96J66; -.
BioMuta; ABCC11; -.
DMDM; 74762666; -.
MaxQB; Q96J66; -.
PaxDb; Q96J66; -.
PeptideAtlas; Q96J66; -.
PRIDE; Q96J66; -.
DNASU; 85320; -.
Ensembl; ENST00000353782; ENSP00000311326; ENSG00000121270. [Q96J66-2]
Ensembl; ENST00000356608; ENSP00000349017; ENSG00000121270. [Q96J66-1]
Ensembl; ENST00000394747; ENSP00000378230; ENSG00000121270. [Q96J66-1]
Ensembl; ENST00000394748; ENSP00000378231; ENSG00000121270. [Q96J66-1]
GeneID; 85320; -.
KEGG; hsa:85320; -.
UCSC; uc002eff.1; human. [Q96J66-1]
CTD; 85320; -.
DisGeNET; 85320; -.
EuPathDB; HostDB:ENSG00000121270.15; -.
GeneCards; ABCC11; -.
HGNC; HGNC:14639; ABCC11.
HPA; CAB032513; -.
HPA; HPA031980; -.
HPA; HPA031981; -.
HPA; HPA031982; -.
MIM; 117800; phenotype.
MIM; 607040; gene.
neXtProt; NX_Q96J66; -.
OpenTargets; ENSG00000121270; -.
PharmGKB; PA24393; -.
eggNOG; KOG0054; Eukaryota.
eggNOG; COG1132; LUCA.
GeneTree; ENSGT00900000140905; -.
HOVERGEN; HBG108314; -.
InParanoid; Q96J66; -.
KO; K05671; -.
OMA; KYRDNTP; -.
OrthoDB; EOG091G01TC; -.
PhylomeDB; Q96J66; -.
TreeFam; TF352085; -.
Reactome; R-HSA-382556; ABC-family proteins mediated transport.
GeneWiki; ABCC11; -.
GenomeRNAi; 85320; -.
PRO; PR:Q96J66; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000121270; -.
CleanEx; HS_ABCC11; -.
ExpressionAtlas; Q96J66; baseline and differential.
Genevisible; Q96J66; HS.
GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
GO; GO:0043225; F:ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
GO; GO:0008514; F:organic anion transmembrane transporter activity; IDA:UniProtKB.
GO; GO:0015216; F:purine nucleotide transmembrane transporter activity; IDA:UniProtKB.
GO; GO:0015711; P:organic anion transport; IDA:UniProtKB.
GO; GO:0015865; P:purine nucleotide transport; IDA:UniProtKB.
GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
Gene3D; 1.20.1560.10; -; 2.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR011527; ABC1_TM_dom.
InterPro; IPR036640; ABC1_TM_sf.
InterPro; IPR003439; ABC_transporter-like.
InterPro; IPR017871; ABC_transporter_CS.
InterPro; IPR030251; ABCC11.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR24223:SF168; PTHR24223:SF168; 1.
Pfam; PF00664; ABC_membrane; 2.
Pfam; PF00005; ABC_tran; 2.
SMART; SM00382; AAA; 2.
SUPFAM; SSF52540; SSF52540; 2.
SUPFAM; SSF90123; SSF90123; 2.
PROSITE; PS50929; ABC_TM1F; 2.
PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
1: Evidence at protein level;
Alternative splicing; ATP-binding; Cell membrane; Complete proteome;
Cytoplasmic vesicle; Glycoprotein; Membrane; Nucleotide-binding;
Polymorphism; Reference proteome; Repeat; Transmembrane;
Transmembrane helix; Transport; Vacuole.
CHAIN 1 1382 ATP-binding cassette sub-family C member
11.
/FTId=PRO_0000225594.
TOPO_DOM 1 163 Cytoplasmic. {ECO:0000255}.
TRANSMEM 164 184 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 195 215 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 271 291 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 297 317 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 384 404 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 418 438 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TOPO_DOM 439 806 Cytoplasmic. {ECO:0000255}.
TRANSMEM 807 827 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 864 884 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 931 951 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 1050 1070 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TOPO_DOM 1071 1382 Cytoplasmic. {ECO:0000255}.
DOMAIN 163 443 ABC transmembrane type-1 1.
{ECO:0000255|PROSITE-ProRule:PRU00441}.
DOMAIN 508 732 ABC transporter 1. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
DOMAIN 806 1105 ABC transmembrane type-1 2.
{ECO:0000255|PROSITE-ProRule:PRU00441}.
DOMAIN 1141 1375 ABC transporter 2. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
NP_BIND 544 551 ATP 1. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
NP_BIND 1175 1182 ATP 2. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
CARBOHYD 838 838 N-linked (GlcNAc...) asparagine.
{ECO:0000255,
ECO:0000269|PubMed:19383836}.
CARBOHYD 844 844 N-linked (GlcNAc...) asparagine.
{ECO:0000255,
ECO:0000269|PubMed:19383836}.
CARBOHYD 992 992 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 1261 1298 Missing (in isoform 2).
{ECO:0000303|PubMed:11688999}.
/FTId=VSP_017351.
VARIANT 19 19 R -> H (no effect on glycosylation; no
effect on transport activity; no effect
on plasma membrane localization;
dbSNP:rs16945988).
{ECO:0000269|PubMed:19383836,
ECO:0000269|PubMed:25896536}.
/FTId=VAR_025437.
VARIANT 180 180 G -> R (in dry earwax and lack of
axillary odor phenotype; loss of N-
glycosylation; strongly reduced plasma
membrane localization; reduced transport
activity; decreased protein concentration
in axillary sweat; dbSNP:rs17822931).
{ECO:0000269|PubMed:16444273,
ECO:0000269|PubMed:19383836,
ECO:0000269|PubMed:19710689,
ECO:0000269|PubMed:25896536}.
/FTId=VAR_025438.
VARIANT 317 317 A -> E (no effect on glycoslylation; no
effect on transport activity; no effect
on plasma membrane localization;
dbSNP:rs11863236).
{ECO:0000269|PubMed:11591886,
ECO:0000269|PubMed:19383836,
ECO:0000269|PubMed:25896536}.
/FTId=VAR_048144.
VARIANT 546 546 T -> M (reduced transport activity; no
effect on glycoslylation; no effect on
plasma membrane localization;
dbSNP:rs17822471).
{ECO:0000269|PubMed:19383836,
ECO:0000269|PubMed:25896536}.
/FTId=VAR_048145.
VARIANT 630 630 R -> W (no effect on glycoslylation;
dbSNP:rs41282045).
{ECO:0000269|PubMed:19383836}.
/FTId=VAR_077575.
VARIANT 648 648 V -> I (no effect on glycoslylation; no
effect on transport activity; no effect
on plasma membrane localization;
dbSNP:rs16945930).
{ECO:0000269|PubMed:19383836,
ECO:0000269|PubMed:25896536}.
/FTId=VAR_048146.
VARIANT 687 687 V -> I (no effect on glycoslylation;
dbSNP:rs16945928).
{ECO:0000269|PubMed:19383836}.
/FTId=VAR_048147.
VARIANT 735 735 K -> R (no effect on glycoslylation;
dbSNP:rs16945926).
{ECO:0000269|PubMed:19383836}.
/FTId=VAR_048148.
VARIANT 970 970 M -> V (no effect on glycoslylation;
dbSNP:rs41280943).
{ECO:0000269|PubMed:19383836}.
/FTId=VAR_077576.
VARIANT 1344 1344 H -> R (no effect on glycoslylation; no
effect on transport activity; no effect
on plasma membrane localization;
dbSNP:rs16945916).
{ECO:0000269|PubMed:11591886,
ECO:0000269|PubMed:19383836,
ECO:0000269|PubMed:25896536}.
/FTId=VAR_048149.
MUTAGEN 180 180 G->A,P: Does not affect N-glycosylation.
{ECO:0000269|PubMed:19383836}.
MUTAGEN 180 180 G->L,H,D,E: Loss of N-glycosylation.
{ECO:0000269|PubMed:19383836}.
MUTAGEN 838 838 N->Q: Loss of N-glycosylation.
{ECO:0000269|PubMed:19383836}.
MUTAGEN 844 844 N->Q: Loss of N-glycosylation.
{ECO:0000269|PubMed:19383836}.
CONFLICT 199 199 V -> A (in Ref. 2; AAK58869/AAL99902).
{ECO:0000305}.
CONFLICT 311 311 L -> P (in Ref. 3; AAK19755).
{ECO:0000305}.
CONFLICT 363 363 K -> E (in Ref. 2; AAK58869/AAL99902).
{ECO:0000305}.
CONFLICT 395 395 T -> A (in Ref. 3; AAK19755).
{ECO:0000305}.
CONFLICT 632 632 L -> P (in Ref. 3; AAK19755).
{ECO:0000305}.
CONFLICT 688 688 L -> Q (in Ref. 3; AAK19755).
{ECO:0000305}.
CONFLICT 702 702 I -> V (in Ref. 3; AAK19755).
{ECO:0000305}.
CONFLICT 982 982 K -> E (in Ref. 3; AAK19755).
{ECO:0000305}.
SEQUENCE 1382 AA; 154301 MW; 0F3C17DC69AE97F4 CRC64;
MTRKRTYWVP NSSGGLVNRG IDIGDDMVSG LIYKTYTLQD GPWSQQERNP EAPGRAAVPP
WGKYDAALRT MIPFRPKPRF PAPQPLDNAG LFSYLTVSWL TPLMIQSLRS RLDENTIPPL
SVHDASDKNV QRLHRLWEEE VSRRGIEKAS VLLVMLRFQR TRLIFDALLG ICFCIASVLG
PILIIPKILE YSEEQLGNVV HGVGLCFALF LSECVKSLSF SSSWIINQRT AIRFRAAVSS
FAFEKLIQFK SVIHITSGEA ISFFTGDVNY LFEGVCYGPL VLITCASLVI CSISSYFIIG
YTAFIAILCY LLVFPLAVFM TRMAVKAQHH TSEVSDQRIR VTSEVLTCIK LIKMYTWEKP
FAKIIEDLRR KERKLLEKCG LVQSLTSITL FIIPTVATAV WVLIHTSLKL KLTASMAFSM
LASLNLLRLS VFFVPIAVKG LTNSKSAVMR FKKFFLQESP VFYVQTLQDP SKALVFEEAT
LSWQQTCPGI VNGALELERN GHASEGMTRP RDALGPEEEG NSLGPELHKI NLVVSKGMML
GVCGNTGSGK SSLLSAILEE MHLLEGSVGV QGSLAYVPQQ AWIVSGNIRE NILMGGAYDK
ARYLQVLHCC SLNRDLELLP FGDMTEIGER GLNLSGGQKQ RISLARAVYS DRQIYLLDDP
LSAVDAHVGK HIFEECIKKT LRGKTVVLVT HQLQYLEFCG QIILLENGKI CENGTHSELM
QKKGKYAQLI QKMHKEATSD MLQDTAKIAE KPKVESQALA TSLEESLNGN AVPEHQLTQE
EEMEEGSLSW RVYHHYIQAA GGYMVSCIIF FFVVLIVFLT IFSFWWLSYW LEQGSGTNSS
RESNGTMADL GNIADNPQLS FYQLVYGLNA LLLICVGVCS SGIFTKVTRK ASTALHNKLF
NKVFRCPMSF FDTIPIGRLL NCFAGDLEQL DQLLPIFSEQ FLVLSLMVIA VLLIVSVLSP
YILLMGAIIM VICFIYYMMF KKAIGVFKRL ENYSRSPLFS HILNSLQGLS SIHVYGKTED
FISQFKRLTD AQNNYLLLFL SSTRWMALRL EIMTNLVTLA VALFVAFGIS STPYSFKVMA
VNIVLQLASS FQATARIGLE TEAQFTAVER ILQYMKMCVS EAPLHMEGTS CPQGWPQHGE
IIFQDYHMKY RDNTPTVLHG INLTIRGHEV VGIVGRTGSG KSSLGMALFR LVEPMAGRIL
IDGVDICSIG LEDLRSKLSV IPQDPVLLSG TIRFNLDPFD RHTDQQIWDA LERTFLTKAI
SKFPKKLHTD VVENGGNFSV GERQLLCIAR AVLRNSKIIL IDEATASIDM ETDTLIQRTI
REAFQGCTVL VIAHRVTTVL NCDHILVMGN GKVVEFDRPE VLRKKPGSLF AALMATATSS
LR


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EIAAB25426 Abcc2,ATP-binding cassette sub-family C member 2,Canalicular multidrug resistance protein,Canalicular multispecific organic anion transporter 1,Cmoat,Cmrp,Mrp2,Multidrug resistance-associated protein
EIAAB25437 ABCC6,Anthracycline resistance-associated protein,ARA,ATP-binding cassette sub-family C member 6,Homo sapiens,Human,MOAT-E,MRP6,Multidrug resistance-associated protein 6,Multi-specific organic anion t
EIAAB25444 Abcc12,ATP-binding cassette sub-family C member 12,Mouse,Mrp9,Multidrug resistance-associated protein 9,Mus musculus
EIAAB25439 Abcc6,ATP-binding cassette sub-family C member 6,Mouse,Mrp6,Multidrug resistance-associated protein 6,Mus musculus
EIAAB25440 Abcc10,ATP-binding cassette sub-family C member 10,Mouse,Mrp7,Multidrug resistance-associated protein 7,Mus musculus
EIAAB25442 Abcc12,ATP-binding cassette sub-family C member 12,Mrp9,Multidrug resistance-associated protein 9,Rat,Rattus norvegicus
EIAAB25429 ABCC2,ATP-binding cassette sub-family C member 2,Canalicular multidrug resistance protein,Canalicular multispecific organic anion transporter 1,CMOAT,CMOAT1,CMRP,Homo sapiens,Human,MRP2,Multidrug resi
E0960p ELISA kit ABCG2,ATP-binding cassette sub-family G member 2,BMDP,Brain multidrug resistance protein,Pig,Sus scrofa 96T
EIAAB25436 Abcc5,Abcc5a,ATP-binding cassette sub-family C member 5,Mrp5,Multidrug resistance-associated protein 5,Rat,Rattus norvegicus
EIAAB25443 ABCC12,ATP-binding cassette sub-family C member 12,Homo sapiens,Human,MRP9,Multidrug resistance-associated protein 9
E0960p ELISA ABCG2,ATP-binding cassette sub-family G member 2,BMDP,Brain multidrug resistance protein,Pig,Sus scrofa 96T
U0960p CLIA ABCG2,ATP-binding cassette sub-family G member 2,BMDP,Brain multidrug resistance protein,Pig,Sus scrofa 96T
EIAAB25441 ABCC10,ATP-binding cassette sub-family C member 10,Homo sapiens,Human,MRP7,Multidrug resistance-associated protein 7,SIMRP7
EIAAB25438 Abcc6,ATP-binding cassette sub-family C member 6,Mlp1,MLP-1,Mrp6,MRP-like protein 1,Multidrug resistance-associated protein 6,Rat,Rattus norvegicus
EIAAB25432 Abcc3,ATP-binding cassette sub-family C member 3,Canalicular multispecific organic anion transporter 2,Cmoat2,Mlp2,MLP-2,Mrp3,MRP-like protein 2,Multidrug resistance-associated protein 3,Rat,Rattus no
EIAAB25431 Abcc3,ATP-binding cassette sub-family C member 3,Canalicular multispecific organic anion transporter 2,Cmoat2,Mouse,Mrp3,Multidrug resistance-associated protein 3,Mus musculus
EIAAB25434 Abcc5,Abcc5a,ATP-binding cassette sub-family C member 5,MOAT-C,Mouse,Mrp5,Multidrug resistance-associated protein 5,Multi-specific organic anion transporter C,Mus musculus,SMRP
E1068r ELISA kit Abcc1,ATP-binding cassette sub-family C member 1,Leukotriene C(4) transporter,LTC4 transporter,Mrp1,Multidrug resistance-associated protein 1,Rat,Rattus norvegicus 96T
E1068b ELISA kit ABCC1,ATP-binding cassette sub-family C member 1,Bos taurus,Bovine,Leukotriene C(4) transporter,LTC4 transporter,MRP1,Multidrug resistance-associated protein 1 96T
E1068b ELISA ABCC1,ATP-binding cassette sub-family C member 1,Bos taurus,Bovine,Leukotriene C(4) transporter,LTC4 transporter,MRP1,Multidrug resistance-associated protein 1 96T
E1068r ELISA Abcc1,ATP-binding cassette sub-family C member 1,Leukotriene C(4) transporter,LTC4 transporter,Mrp1,Multidrug resistance-associated protein 1,Rat,Rattus norvegicus 96T
U1068r CLIA Abcc1,ATP-binding cassette sub-family C member 1,Leukotriene C(4) transporter,LTC4 transporter,Mrp1,Multidrug resistance-associated protein 1,Rat,Rattus norvegicus 96T
U1068b CLIA ABCC1,ATP-binding cassette sub-family C member 1,Bos taurus,Bovine,Leukotriene C(4) transporter,LTC4 transporter,MRP1,Multidrug resistance-associated protein 1 96T
EIAAB25435 ABCC5,ATP-binding cassette sub-family C member 5,Homo sapiens,Human,MOAT-C,MRP5,Multidrug resistance-associated protein 5,Multi-specific organic anion transporter C,pABC11,SMRP
U1068h CLIA ABCC1,ATP-binding cassette sub-family C member 1,Homo sapiens,Human,Leukotriene C(4) transporter,LTC4 transporter,MRP,MRP1,Multidrug resistance-associated protein 1 96T


 

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