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ATP-dependent DNA helicase 2 subunit KU70 (OsKU70) (EC 3.6.4.12) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit)

 KU70_ORYSJ              Reviewed;         624 AA.
Q7F1M0; A0A0N7KN15; A3BH97; B9FVV9; Q7F1L9;
18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
05-DEC-2018, entry version 106.
RecName: Full=ATP-dependent DNA helicase 2 subunit KU70;
Short=OsKU70;
EC=3.6.4.12;
AltName: Full=ATP-dependent DNA helicase 2 subunit 1;
AltName: Full=ATP-dependent DNA helicase II 70 kDa subunit;
Name=KU70; OrderedLocusNames=Os07g0184900, LOC_Os07g08729;
ORFNames=OJ1046_F10.128, OsJ_23357, OsJ_23359;
Oryza sativa subsp. japonica (Rice).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
NCBI_TaxID=39947;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
PubMed=16100779; DOI=10.1038/nature03895;
International rice genome sequencing project (IRGSP);
"The map-based sequence of the rice genome.";
Nature 436:793-800(2005).
[2]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=18089549; DOI=10.1093/nar/gkm978;
The rice annotation project (RAP);
"The rice annotation project database (RAP-DB): 2008 update.";
Nucleic Acids Res. 36:D1028-D1033(2008).
[3]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=24280374; DOI=10.1186/1939-8433-6-4;
Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
Buell C.R., Matsumoto T.;
"Improvement of the Oryza sativa Nipponbare reference genome using
next generation sequence and optical map data.";
Rice 6:4-4(2013).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H.,
Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J.,
Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X.,
Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y.,
Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J.,
Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y.,
Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y.,
Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z.,
Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T.,
Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H.,
Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J.,
Samudrala R., Wang J., Wong G.K.-S., Yang H.;
"The genomes of Oryza sativa: a history of duplications.";
PLoS Biol. 3:266-281(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Nipponbare;
PubMed=12869764; DOI=10.1126/science.1081288;
The rice full-length cDNA consortium;
"Collection, mapping, and annotation of over 28,000 cDNA clones from
japonica rice.";
Science 301:376-379(2003).
[6]
TISSUE SPECIFICITY, INTERACTION WITH KU80, AND DISRUPTION PHENOTYPE.
PubMed=19923234; DOI=10.1104/pp.109.150391;
Hong J.P., Byun M.Y., An K., Yang S.J., An G., Kim W.T.;
"OsKu70 is associated with developmental growth and genome stability
in rice.";
Plant Physiol. 152:374-387(2010).
-!- FUNCTION: Single-stranded DNA-dependent ATP-dependent helicase.
Involved in DNA non-homologous end joining (NHEJ) required for
double-strand break repair. When associated with KU70, binds to
double-stranded telomeric and non-telomeric DNA sequences, but not
to single-stranded DNA (By similarity). Required for the
maintenance of chromosome stability and normal developmental
growth. Plays a role in maintaining telomere length. Acts as a
negative regulator in telomere homeostasis. {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
-!- SUBUNIT: Interacts with KU80. {ECO:0000269|PubMed:19923234}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed ubiquitously.
{ECO:0000269|PubMed:19923234}.
-!- DOMAIN: The N-terminal domain (1-265) is necessary for binding to
KU80.
-!- DISRUPTION PHENOTYPE: Severe developmental defects in both
vegetative and reproductive organs resulting in sterile flowers.
Hypersensitivity to methylmethane sulfonate (MMS). Longer
telomeres. {ECO:0000269|PubMed:19923234}.
-!- SIMILARITY: Belongs to the ku70 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAC83190.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=EAZ38936.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=EEE66696.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AP003861; BAC83189.1; -; Genomic_DNA.
EMBL; AP003861; BAC83190.1; ALT_SEQ; Genomic_DNA.
EMBL; AP008213; BAF20975.1; -; Genomic_DNA.
EMBL; AP014963; BAT00354.1; -; Genomic_DNA.
EMBL; CM000144; EAZ38936.1; ALT_SEQ; Genomic_DNA.
EMBL; CM000144; EEE66696.1; ALT_SEQ; Genomic_DNA.
EMBL; AK102066; BAG95371.1; -; mRNA.
RefSeq; XP_015646738.1; XM_015791252.1.
UniGene; Os.51984; -.
ProteinModelPortal; Q7F1M0; -.
SMR; Q7F1M0; -.
STRING; 39947.LOC_Os07g08729.1; -.
PaxDb; Q7F1M0; -.
EnsemblPlants; Os07t0184900-01; Os07t0184900-01; Os07g0184900.
GeneID; 4342584; -.
Gramene; Os07t0184900-01; Os07t0184900-01; Os07g0184900.
KEGG; osa:4342584; -.
eggNOG; KOG2327; Eukaryota.
eggNOG; ENOG410XNXU; LUCA.
HOGENOM; HOG000030793; -.
InParanoid; Q7F1M0; -.
KO; K10884; -.
OMA; DVFTSCN; -.
OrthoDB; EOG0936071J; -.
Reactome; R-OSA-5693571; Nonhomologous End-Joining (NHEJ).
Reactome; R-OSA-6798695; Neutrophil degranulation.
Proteomes; UP000059680; Chromosome 7.
ExpressionAtlas; Q7F1M0; differential.
Genevisible; Q7F1M0; OS.
GO; GO:0043564; C:Ku70:Ku80 complex; IBA:GO_Central.
GO; GO:0000784; C:nuclear chromosome, telomeric region; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
GO; GO:0003690; F:double-stranded DNA binding; IEA:EnsemblPlants.
GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
GO; GO:0071480; P:cellular response to gamma radiation; IBA:GO_Central.
GO; GO:0071481; P:cellular response to X-ray; IBA:GO_Central.
GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
GO; GO:0006281; P:DNA repair; IMP:UniProtKB.
GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IBA:GO_Central.
GO; GO:0009408; P:response to heat; IEA:EnsemblPlants.
GO; GO:0000723; P:telomere maintenance; IMP:UniProtKB.
Gene3D; 1.10.720.30; -; 1.
Gene3D; 2.40.290.10; -; 1.
Gene3D; 3.40.50.410; -; 1.
Gene3D; 4.10.970.10; -; 1.
InterPro; IPR006165; Ku70.
InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
InterPro; IPR005160; Ku_C.
InterPro; IPR005161; Ku_N.
InterPro; IPR003034; SAP_dom.
InterPro; IPR036361; SAP_dom_sf.
InterPro; IPR016194; SPOC-like_C_dom_sf.
InterPro; IPR036465; vWFA_dom_sf.
PANTHER; PTHR12604:SF2; PTHR12604:SF2; 1.
Pfam; PF02735; Ku; 1.
Pfam; PF03730; Ku_C; 1.
Pfam; PF03731; Ku_N; 1.
Pfam; PF02037; SAP; 1.
PIRSF; PIRSF003033; Ku70; 1.
SMART; SM00559; Ku78; 1.
SMART; SM00513; SAP; 1.
SUPFAM; SSF100939; SSF100939; 1.
SUPFAM; SSF53300; SSF53300; 1.
SUPFAM; SSF68906; SSF68906; 1.
TIGRFAMs; TIGR00578; ku70; 1.
PROSITE; PS50800; SAP; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; DNA damage; DNA recombination;
DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding;
Nucleus; Reference proteome.
CHAIN 1 624 ATP-dependent DNA helicase 2 subunit
KU70.
/FTId=PRO_0000394139.
DOMAIN 270 470 Ku.
DOMAIN 588 622 SAP. {ECO:0000255|PROSITE-
ProRule:PRU00186}.
COMPBIAS 550 583 Ala-rich.
SEQUENCE 624 AA; 70056 MW; A3A56D1E1980B65E CRC64;
MDLDPEGLFR DDSDEDDDNV QEREANKEMV VYLIDASPKM FTPATKADEK EETHFHTIVN
CITHALKTQI IGRSYDEVAI CFFNTKEKKN LQELAGVYVY NVTEREPLDR PDARLIKEFS
CIEDSFMSNI GSRYGITSGS RENTLYNALW VAQALLRKGS VKTVSKRIVI FTNEDDPFGG
LTGAVKTDMI RTTIQRARDA QDLGLSIELL PLSRPDEEFN MSLFYADLIG LEGDEIVDYL
PSSGEKLEDM TNQLKKRMMK KRKVKTLAFA ITNDVCIEVN TYALIRSTTP GAITWLDSIS
NLPLKAERSF ICNDTGALIQ DPQKRFQVYN DKIVKFSTRE LSDVKRVSSH HLRLLGFKPL
DYLKDYHNLR PSTFIYPSDE QIFGSTRVFV ALHSSMRRLG RFALAFYGNP TRPQLVALIA
QEEVTSAGGQ IEPPGIHMIY LPYSDDVRYP EEVHLTSDDA PRATDEQIKK ASNLLRRIDL
KNFSVCQFSN PALQRHYGIL EALALGEDEM PDVKDETLPD EEGLARPVVV KAVEEFKASV
YGENYDQEEA EAAAAKAGAS KKRKALTDAA AEKSAAHNWA ELADTGKLKD MTVVDLKSYL
SAHGLPVSGK KEALVSRILT HLGK


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