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 FAL1_AJECN              Reviewed;         450 AA.
 A6QSQ0;
 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
 21-AUG-2007, sequence version 1.
 25-OCT-2017, entry version 50.
 RecName: Full=ATP-dependent RNA helicase FAL1;
          EC=3.6.4.13;
 Name=FAL1; ORFNames=HCAG_00406;
 Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
 (Histoplasma capsulatum).
 Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
 Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
 NCBI_TaxID=339724;
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=NAm1 / WU24;
 PubMed=19717792; DOI=10.1101/gr.087551.108;
 Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J.,
 Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E.,
 Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M.,
 Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J.,
 Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.;
 "Comparative genomic analyses of the human fungal pathogens
 Coccidioides and their relatives.";
 Genome Res. 19:1722-1731(2009).
 -!- FUNCTION: ATP-dependent RNA helicase involved in 40S ribosomal
     subunit biogenesis. Required for the processing and cleavage of
     35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA
     (By similarity). {ECO:0000250}.
 -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
 -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
 -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
     box family of RNA helicases and controls ATP binding and
     hydrolysis.
 -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX48/FAL1
     subfamily. {ECO:0000305}.
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 EMBL; CH476655; EDN02542.1; -; Genomic_DNA.
 RefSeq; XP_001543360.1; XM_001543310.1.
 ProteinModelPortal; A6QSQ0; -.
 SMR; A6QSQ0; -.
 STRING; 339724.XP_001543360.1; -.
 PRIDE; A6QSQ0; -.
 EnsemblFungi; EDN02542; EDN02542; HCAG_00406.
 GeneID; 5450501; -.
 KEGG; aje:HCAG_00406; -.
 EuPathDB; FungiDB:HCAG_00406; -.
 eggNOG; KOG0327; Eukaryota.
 eggNOG; COG0513; LUCA.
 KO; K13025; -.
 OrthoDB; EOG092C2B1L; -.
 Proteomes; UP000009297; Unassembled WGS sequence.
 GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
 GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 CDD; cd00079; HELICc; 1.
 InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
 InterPro; IPR014001; Helicase_ATP-bd.
 InterPro; IPR001650; Helicase_C.
 InterPro; IPR027417; P-loop_NTPase.
 InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
 InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
 Pfam; PF00270; DEAD; 1.
 Pfam; PF00271; Helicase_C; 1.
 SMART; SM00487; DEXDc; 1.
 SMART; SM00490; HELICc; 1.
 SUPFAM; SSF52540; SSF52540; 1.
 PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
 PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
 PROSITE; PS51194; HELICASE_CTER; 1.
 PROSITE; PS51195; Q_MOTIF; 1.
 3: Inferred from homology;
 ATP-binding; Complete proteome; Helicase; Hydrolase;
 Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
 RNA-binding; rRNA processing.
 CHAIN         1    450       ATP-dependent RNA helicase FAL1.
                              /FTId=PRO_0000310175.
 DOMAIN       56    226       Helicase ATP-binding.
                              {ECO:0000255|PROSITE-ProRule:PRU00541}.
 DOMAIN      237    398       Helicase C-terminal.
                              {ECO:0000255|PROSITE-ProRule:PRU00542}.
 NP_BIND      69     76       ATP. {ECO:0000255|PROSITE-
                              ProRule:PRU00541}.
 MOTIF        25     53       Q motif.
 MOTIF       174    177       DEAD box.
 SEQUENCE   450 AA;  51476 MW;  98F43F905E48AB22 CRC64;
 MADGIDRTAE ERMEFTTSKE VTVAPTFEDM HLKENLLRGI YAYGYESPSA VQSRAIVQIC
 KGRDTIAQAQ SGTGKTATFS ISILQVIDTV LRETQALVLS PTRELATQIQ SVVMALGDYM
 NVQCHACIGG TNVGEDIRKL DHGQHVVSGT PGRVADMIRR RHLRTRHIKM LVLDEADELL
 NRGFREQIYD VYRYLPPATQ VVVVSATLPY DVLDMTTKFM TDPVRILVKR DELTLEGLKQ
 YFIAVEKEEW KFDTLCDLYD TLTITQAVIF CNTRRKVDWL TDKMREANFT VSSMHGEMPQ
 KERDSIMQDF RQGNSRVLIS TDVWARGIDV QQVSLVINYD LPSNRENYIH RIGRSGRFGR
 KGVAINFVTS EDVRILRDIE LYYSTQIDEM PMNGTLFYLR YRPMSRLSLW LTQSNSCRPS
 HVTTLSWSTN VEHTFPLLLM NAFSKIQIGI

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