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ATP-sensitive inward rectifier potassium channel 10 (Inward rectifier K( ) channel Kir4.1) (Potassium channel, inwardly rectifying subfamily J member 10)

 KCJ10_MOUSE             Reviewed;         379 AA.
Q9JM63;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
25-OCT-2017, entry version 141.
RecName: Full=ATP-sensitive inward rectifier potassium channel 10;
AltName: Full=Inward rectifier K(+) channel Kir4.1;
AltName: Full=Potassium channel, inwardly rectifying subfamily J member 10;
Name=Kcnj10;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Inanobe A., Takahashi K., Tanemoto M., Fujita A., Kurachi Y.;
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=CD-1, and ICR; TISSUE=Brain;
PubMed=11169792;
DOI=10.1002/1098-1136(20010101)33:1<57::AID-GLIA1006>3.0.CO;2-0;
Li L., Head V., Timpe L.C.;
"Identification of an inward rectifier potassium channel gene
expressed in mouse cortical astrocytes.";
Glia 33:57-71(2001).
[3]
INTERACTION WITH PATJ.
PubMed=9647694; DOI=10.1006/mcne.1998.0679;
Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.;
"CIPP, a novel multivalent PDZ domain protein, selectively interacts
with Kir4.0 family members, NMDA receptor subunits, neurexins, and
neuroligins.";
Mol. Cell. Neurosci. 11:161-172(1998).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, and Kidney;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: May be responsible for potassium buffering action of
glial cells in the brain. Inward rectifier potassium channels are
characterized by a greater tendency to allow potassium to flow
into the cell rather than out of it. Their voltage dependence is
regulated by the concentration of extracellular potassium; as
external potassium is raised, the voltage range of the channel
opening shifts to more positive voltages. The inward rectification
is mainly due to the blockage of outward current by internal
magnesium. Can be blocked by extracellular barium and cesium (By
similarity). In the kidney, together with KCNJ16, mediates
basolateral K(+) recycling in distal tubules; this process is
critical for Na(+) reabsorption at the tubules (By similarity).
{ECO:0000250, ECO:0000250|UniProtKB:P78508}.
-!- SUBUNIT: Heterodimer with Kir5.1/KCNJ16; this interaction is
required for KCNJ16 localization to the basolateral membrane in
kidney cells. Interacts with MAGI1, alone and possibly as a
heterodimer with KCNJ16; this interaction may facilitate
KCNJ10/KCNJ16 potassium channel expression at the basolateral
membrane in kidney cells (By similarity). Interacts with PATJ
(PubMed:9647694). {ECO:0000250|UniProtKB:P78508,
ECO:0000269|PubMed:9647694}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P78508};
Multi-pass membrane protein {ECO:0000250|UniProtKB:P78508}.
Basolateral cell membrane {ECO:0000250|UniProtKB:P78508}. Note=In
kidney distal convoluted tubules, located in the basolateral
membrane where it colocalizes with KCNJ16.
{ECO:0000250|UniProtKB:P78508}.
-!- TISSUE SPECIFICITY: Widely expressed in adult brain, including in
the neocortex, the stratum pyrimadale of the hippocampus and the
piriform cortex. Expressed by cultured astrocytes and also by
cocultured cortical neurons (at protein level).
{ECO:0000269|PubMed:11169792}.
-!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
(TC 1.A.2.1) family. KCNJ10 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB039879; BAA92432.1; -; mRNA.
EMBL; AF322631; AAG42845.1; -; mRNA.
CCDS; CCDS15512.1; -.
RefSeq; NP_001034573.1; NM_001039484.1.
RefSeq; XP_006496740.2; XM_006496677.3.
UniGene; Mm.254563; -.
ProteinModelPortal; Q9JM63; -.
SMR; Q9JM63; -.
BioGrid; 200895; 6.
CORUM; Q9JM63; -.
IntAct; Q9JM63; 3.
MINT; MINT-1891836; -.
STRING; 10090.ENSMUSP00000054356; -.
iPTMnet; Q9JM63; -.
PhosphoSitePlus; Q9JM63; -.
SwissPalm; Q9JM63; -.
MaxQB; Q9JM63; -.
PaxDb; Q9JM63; -.
PRIDE; Q9JM63; -.
Ensembl; ENSMUST00000056136; ENSMUSP00000054356; ENSMUSG00000044708.
GeneID; 16513; -.
KEGG; mmu:16513; -.
UCSC; uc007dqj.1; mouse.
CTD; 3766; -.
MGI; MGI:1194504; Kcnj10.
eggNOG; KOG3827; Eukaryota.
eggNOG; ENOG410XQ62; LUCA.
GeneTree; ENSGT00900000140895; -.
HOVERGEN; HBG006178; -.
InParanoid; Q9JM63; -.
KO; K05003; -.
OMA; PCVMQMQ; -.
OrthoDB; EOG091G08HC; -.
PhylomeDB; Q9JM63; -.
TreeFam; TF313676; -.
Reactome; R-MMU-1296041; Activation of G protein gated Potassium channels.
Reactome; R-MMU-1296067; Potassium transport channels.
Reactome; R-MMU-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
ChiTaRS; Kcnj10; mouse.
PRO; PR:Q9JM63; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000044708; -.
ExpressionAtlas; Q9JM63; baseline and differential.
Genevisible; Q9JM63; MM.
GO; GO:0016323; C:basolateral plasma membrane; IDA:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0098793; C:presynapse; IEA:GOC.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0015272; F:ATP-activated inward rectifier potassium channel activity; IBA:GO_Central.
GO; GO:0005242; F:inward rectifier potassium channel activity; IMP:MGI.
GO; GO:0005267; F:potassium channel activity; IDA:MGI.
GO; GO:0007628; P:adult walking behavior; IMP:MGI.
GO; GO:0022010; P:central nervous system myelination; IMP:MGI.
GO; GO:0051935; P:glutamate reuptake; IMP:MGI.
GO; GO:0014003; P:oligodendrocyte development; IMP:MGI.
GO; GO:0055075; P:potassium ion homeostasis; IMP:MGI.
GO; GO:0010107; P:potassium ion import; IBA:GO_Central.
GO; GO:0071805; P:potassium ion transmembrane transport; IMP:MGI.
GO; GO:0006813; P:potassium ion transport; IDA:MGI.
GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.
GO; GO:0042391; P:regulation of membrane potential; IMP:MGI.
GO; GO:0060075; P:regulation of resting membrane potential; IMP:MGI.
GO; GO:0007601; P:visual perception; IMP:MGI.
Gene3D; 2.60.40.1400; -; 1.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR016449; K_chnl_inward-rec_Kir.
InterPro; IPR003269; K_chnl_inward-rec_Kir1.2.
InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
PANTHER; PTHR11767; PTHR11767; 1.
PANTHER; PTHR11767:SF21; PTHR11767:SF21; 1.
Pfam; PF01007; IRK; 1.
PIRSF; PIRSF005465; GIRK_kir; 1.
PRINTS; PR01322; KIR12CHANNEL.
PRINTS; PR01320; KIRCHANNEL.
SUPFAM; SSF81296; SSF81296; 1.
1: Evidence at protein level;
ATP-binding; Cell membrane; Complete proteome; Ion channel;
Ion transport; Membrane; Nucleotide-binding; Potassium;
Potassium transport; Reference proteome; Transmembrane;
Transmembrane helix; Transport; Voltage-gated channel.
CHAIN 1 379 ATP-sensitive inward rectifier potassium
channel 10.
/FTId=PRO_0000154954.
TOPO_DOM 1 64 Cytoplasmic. {ECO:0000250}.
TRANSMEM 65 89 Helical; Name=M1. {ECO:0000250}.
TOPO_DOM 90 114 Extracellular. {ECO:0000250}.
INTRAMEM 115 126 Helical; Pore-forming; Name=H5.
{ECO:0000250}.
INTRAMEM 127 133 Pore-forming. {ECO:0000250}.
TOPO_DOM 134 142 Extracellular. {ECO:0000250}.
TRANSMEM 143 164 Helical; Name=M2. {ECO:0000250}.
TOPO_DOM 165 379 Cytoplasmic. {ECO:0000250}.
NP_BIND 210 217 ATP. {ECO:0000255}.
MOTIF 128 133 Selectivity filter. {ECO:0000250}.
SITE 158 158 Role in the control of polyamine-mediated
channel gating and in the blocking by
intracellular magnesium. {ECO:0000250}.
SEQUENCE 379 AA; 42432 MW; 7FF08446B7F43453 CRC64;
MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI
DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG PPANHTPCVV QVHTLTGAFL
FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR
FSQHAVVASH NGKPCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV
DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY
LPEEILWGYE FTPAISLSAS GKYIADFSLF DQVVKVASPS GLRDSTVRYG DPEKLKLEES
LREQAEKEGS ALSVRISNV


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