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ATP-sensitive inward rectifier potassium channel 11 (BIR) (Inward rectifier K( ) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)

 KCJ11_RAT               Reviewed;         390 AA.
P70673; Q62906; Q9JM48;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
25-OCT-2017, entry version 141.
RecName: Full=ATP-sensitive inward rectifier potassium channel 11;
AltName: Full=BIR;
AltName: Full=Inward rectifier K(+) channel Kir6.2;
AltName: Full=Potassium channel, inwardly rectifying subfamily J member 11;
Name=Kcnj11;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8798681; DOI=10.1074/jbc.271.40.24321;
Isomoto S., Kondo C., Yamada M., Matsumoto S., Higashiguchi O.,
Horio Y., Matsuzawa Y., Kurachi Y.;
"A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle
type ATP-sensitive K+ channel.";
J. Biol. Chem. 271:24321-24324(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pancreatic islet;
Faure C., Partiseti M., Gouhier C., Graham D.;
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Pancreatic islet;
PubMed=8607800; DOI=10.1006/bbrc.1996.0439;
Tokuyama Y., Fan Z., Furuta H., Makielski J.C., Polonsky K.S.,
Bell G.I., Yano H.;
"Rat inwardly rectifying potassium channel Kir6.2: cloning
electrophysiological characterization, and decreased expression in
pancreatic islets of male Zucker diabetic fatty rats.";
Biochem. Biophys. Res. Commun. 220:532-538(1996).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Heart ventricle;
Wada Y., Takao K., Nishi M., Takeshima H., Imai K., Yamashita T.,
Kokubun S., Yoshii M., Nukada T.;
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Vascular smooth muscle;
Cao K., Wang R.;
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: This receptor is controlled by G proteins. Inward
rectifier potassium channels are characterized by a greater
tendency to allow potassium to flow into the cell rather than out
of it. Their voltage dependence is regulated by the concentration
of extracellular potassium; as external potassium is raised, the
voltage range of the channel opening shifts to more positive
voltages. The inward rectification is mainly due to the blockage
of outward current by internal magnesium. Can be blocked by
extracellular barium. Can form cardiac and smooth muscle-type KATP
channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is
required for activation and regulation (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Interacts with ABCC9/SUR2 (By similarity). Interacts with
ABCC8/SUR. {ECO:0000250}.
-!- INTERACTION:
Q63563:Abcc9; NbExp=2; IntAct=EBI-9560239, EBI-8744493;
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- PTM: Phosphorylation by MAPK1 results in changes in channel gating
that destabilize the closed states and reduce the ATP sensitivity.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
(TC 1.A.2.1) family. KCNJ11 subfamily. {ECO:0000305}.
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EMBL; D86039; BAA12971.1; -; mRNA.
EMBL; X97041; CAA65754.1; -; mRNA.
EMBL; U44897; AAB01810.1; -; mRNA.
EMBL; D61687; BAA23630.1; -; mRNA.
EMBL; AB043638; BAA96239.1; -; mRNA.
PIR; JC4689; JC4689.
RefSeq; NP_112648.2; NM_031358.3.
UniGene; Rn.3985; -.
PDB; 5TWV; EM; 6.30 A; A/C/E/G=1-390.
PDBsum; 5TWV; -.
ProteinModelPortal; P70673; -.
SMR; P70673; -.
CORUM; P70673; -.
DIP; DIP-58641N; -.
IntAct; P70673; 2.
STRING; 10116.ENSRNOP00000028685; -.
ChEMBL; CHEMBL3038487; -.
GuidetoPHARMACOLOGY; 442; -.
TCDB; 1.A.2.1.7; the inward rectifier k(+) channel (irk-c) family.
iPTMnet; P70673; -.
PhosphoSitePlus; P70673; -.
PaxDb; P70673; -.
PRIDE; P70673; -.
Ensembl; ENSRNOT00000028685; ENSRNOP00000028685; ENSRNOG00000021128.
GeneID; 83535; -.
KEGG; rno:83535; -.
UCSC; RGD:69247; rat.
CTD; 3767; -.
RGD; 69247; Kcnj11.
eggNOG; KOG3827; Eukaryota.
eggNOG; ENOG410XQ62; LUCA.
GeneTree; ENSGT00760000118842; -.
HOGENOM; HOG000237325; -.
HOVERGEN; HBG006178; -.
InParanoid; P70673; -.
KO; K05004; -.
OMA; NGNCNVA; -.
OrthoDB; EOG091G08HC; -.
PhylomeDB; P70673; -.
TreeFam; TF313676; -.
Reactome; R-RNO-1296025; ATP sensitive Potassium channels.
Reactome; R-RNO-382556; ABC-family proteins mediated transport.
Reactome; R-RNO-422356; Regulation of insulin secretion.
Reactome; R-RNO-5578775; Ion homeostasis.
PRO; PR:P70673; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000021128; -.
Genevisible; P70673; RN.
GO; GO:0001669; C:acrosomal vesicle; IDA:RGD.
GO; GO:0008282; C:ATP-sensitive potassium channel complex; IDA:RGD.
GO; GO:0030673; C:axolemma; IDA:RGD.
GO; GO:0070852; C:cell body fiber; IDA:RGD.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0005783; C:endoplasmic reticulum; IDA:RGD.
GO; GO:0005768; C:endosome; IDA:RGD.
GO; GO:0014704; C:intercalated disc; IDA:RGD.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0043209; C:myelin sheath; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0005635; C:nuclear envelope; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0042383; C:sarcolemma; IDA:RGD.
GO; GO:0030315; C:T-tubule; IDA:RGD.
GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
GO; GO:0030506; F:ankyrin binding; IPI:BHF-UCL.
GO; GO:0005524; F:ATP binding; IEA:Ensembl.
GO; GO:0015272; F:ATP-activated inward rectifier potassium channel activity; IDA:RGD.
GO; GO:0031072; F:heat shock protein binding; IPI:RGD.
GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
GO; GO:0008022; F:protein C-terminus binding; IPI:RGD.
GO; GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
GO; GO:0071316; P:cellular response to nicotine; IEP:RGD.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO; GO:0050877; P:nervous system process; IEA:Ensembl.
GO; GO:2001259; P:positive regulation of cation channel activity; IMP:RGD.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IMP:RGD.
GO; GO:0010107; P:potassium ion import; IBA:GO_Central.
GO; GO:0006813; P:potassium ion transport; IDA:RGD.
GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
GO; GO:0033198; P:response to ATP; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0002931; P:response to ischemia; IEP:RGD.
GO; GO:0033574; P:response to testosterone; IEP:RGD.
Gene3D; 2.60.40.1400; -; 1.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR016449; K_chnl_inward-rec_Kir.
InterPro; IPR003279; K_chnl_inward-rec_Kir6.2.
InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
PANTHER; PTHR11767; PTHR11767; 1.
PANTHER; PTHR11767:SF44; PTHR11767:SF44; 1.
Pfam; PF01007; IRK; 1.
PIRSF; PIRSF005465; GIRK_kir; 1.
PRINTS; PR01332; KIR62CHANNEL.
PRINTS; PR01320; KIRCHANNEL.
SUPFAM; SSF81296; SSF81296; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Ion channel; Ion transport; Membrane;
Phosphoprotein; Potassium; Potassium transport; Reference proteome;
Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
CHAIN 1 390 ATP-sensitive inward rectifier potassium
channel 11.
/FTId=PRO_0000154960.
TOPO_DOM 1 68 Cytoplasmic. {ECO:0000250}.
TRANSMEM 69 93 Helical; Name=M1. {ECO:0000250}.
TOPO_DOM 94 116 Extracellular. {ECO:0000250}.
INTRAMEM 117 128 Helical; Pore-forming; Name=H5.
{ECO:0000250}.
INTRAMEM 129 135 Pore-forming. {ECO:0000250}.
TOPO_DOM 136 144 Extracellular. {ECO:0000250}.
TRANSMEM 145 166 Helical; Name=M2. {ECO:0000250}.
TOPO_DOM 167 390 Cytoplasmic. {ECO:0000250}.
MOTIF 130 135 Selectivity filter. {ECO:0000250}.
SITE 160 160 Role in the control of polyamine-mediated
channel gating and in the blocking by
intracellular magnesium. {ECO:0000250}.
MOD_RES 341 341 Phosphothreonine; by MAPK1.
{ECO:0000250|UniProtKB:Q14654}.
MOD_RES 385 385 Phosphoserine; by MAPK1.
{ECO:0000250|UniProtKB:Q14654}.
CONFLICT 191 191 L -> P (in Ref. 5; BAA96239).
{ECO:0000305}.
CONFLICT 365 365 R -> Q (in Ref. 3; AAB01810).
{ECO:0000305}.
SEQUENCE 390 AA; 43608 MW; C8E59AD298DE4F13 CRC64;
MLSRKGIIPE EYVLTRLAED PTEPRYRTRE RRARFVSKKG NCNVAHKNIR EQGRFLQDVF
TTLVDLKWPH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL APGEGTNVPC VTSIHSFSSA
FLFSIEVQVT IGFGGRMVTE ECPLAILILI VQNIVGLMIN AIMLGCIFMK TAQAHRRAET
LIFSKHAVIT LRHGRLCFML RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM
ENGVGGNSIF LVAPLIIYHV IDSNSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD EDRSLLDALT
LASSRGPLRK RSVAVAKAKP KFSISPDSLS


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