Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K( ) channel Kir2.2) (IRK-2) (Inward rectifier K( ) channel Kir2.2v) (Potassium channel, inwardly rectifying subfamily J member 12)

 KCJ12_HUMAN             Reviewed;         433 AA.
Q14500; O43401; Q15756; Q8NG63;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
11-OCT-2005, sequence version 2.
23-MAY-2018, entry version 170.
RecName: Full=ATP-sensitive inward rectifier potassium channel 12;
AltName: Full=Inward rectifier K(+) channel Kir2.2;
Short=IRK-2;
AltName: Full=Inward rectifier K(+) channel Kir2.2v;
AltName: Full=Potassium channel, inwardly rectifying subfamily J member 12;
Name=KCNJ12; Synonyms=IRK2, KCNJN1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
TISSUE=Heart atrium;
PubMed=7859381; DOI=10.1161/01.RES.76.3.343;
Wible B.A., de Biasi M., Majumder K., Taglialatela M., Brown A.M.;
"Cloning and functional expression of an inwardly rectifying K+
channel from human atrium.";
Circ. Res. 76:343-350(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
VARIANT VAL-100.
PubMed=8647284; DOI=10.1016/0014-5793(96)00445-0;
Namba N., Inagaki N., Gonoi T., Seino Y., Seino S.;
"Kir2.2v: a possible negative regulator of the inwardly rectifying K+
channel Kir2.2.";
FEBS Lett. 386:211-214(1996).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND SUBCELLULAR
LOCATION.
PubMed=12417321; DOI=10.1016/S0014-5793(02)03512-3;
Kaibara M., Ishihara K., Doi Y., Hayashi H., Ehara T., Taniyama K.;
"Identification of human Kir2.2 (KCNJ12) gene encoding functional
inward rectifier potassium channel in both mammalian cells and Xenopus
oocytes.";
FEBS Lett. 531:250-254(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 161-433.
TISSUE=Skeletal muscle;
PubMed=9430667; DOI=10.1074/jbc.273.3.1339;
Gallagher P.G., Forget B.G.;
"An alternate promoter directs expression of a truncated, muscle-
specific isoform of the human ankyrin 1 gene.";
J. Biol. Chem. 273:1339-1348(1998).
[6]
INTERACTION WITH KCNJ4.
PubMed=12032359; DOI=10.1073/pnas.102609499;
Preisig-Muller R., Schlichthorl G., Goerge T., Heinen S.,
Bruggemann A., Rajan S., Derst C., Veh R.W., Daut J.;
"Heteromerization of Kir2.x potassium channels contributes to the
phenotype of Andersen's syndrome.";
Proc. Natl. Acad. Sci. U.S.A. 99:7774-7779(2002).
[7]
FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
PubMed=20921230; DOI=10.1074/jbc.C110.186692;
D'Avanzo N., Cheng W.W., Doyle D.A., Nichols C.G.;
"Direct and specific activation of human inward rectifier K+ channels
by membrane phosphatidylinositol 4,5-bisphosphate.";
J. Biol. Chem. 285:37129-37132(2010).
-!- FUNCTION: Inward rectifying potassium channel that is activated by
phosphatidylinositol 4,5-bisphosphate and that probably
participates in controlling the resting membrane potential in
electrically excitable cells. Probably participates in
establishing action potential waveform and excitability of
neuronal and muscle tissues. Inward rectifier potassium channels
are characterized by a greater tendency to allow potassium to flow
into the cell rather than out of it. Their voltage dependence is
regulated by the concentration of extracellular potassium; as
external potassium is raised, the voltage range of the channel
opening shifts to more positive voltages. The inward rectification
is mainly due to the blockage of outward current by internal
magnesium. {ECO:0000269|PubMed:12417321,
ECO:0000269|PubMed:20921230, ECO:0000269|PubMed:7859381,
ECO:0000269|PubMed:8647284}.
-!- SUBUNIT: Association, via its PDZ-recognition domain, with LIN7A,
LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its
localization and trafficking (By similarity). Homotetramer. Forms
heteromer with KCNJ4. {ECO:0000250, ECO:0000269|PubMed:20921230}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
membrane; Multi-pass membrane protein.
-!- DOMAIN: Phosphatidylinositol 4,5-bisphosphate binding to the
cytoplasmic side of the channel triggers a conformation change
leading to channel opening. {ECO:0000250}.
-!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
(TC 1.A.2.1) family. KCNJ12 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; L36069; AAA65122.1; -; mRNA.
EMBL; U53143; AAC50615.1; -; Genomic_DNA.
EMBL; AB074970; BAC02718.1; -; Genomic_DNA.
EMBL; AB182123; BAD23901.1; -; mRNA.
EMBL; BC027982; AAH27982.1; -; mRNA.
EMBL; AF005214; AAC01951.1; -; mRNA.
CCDS; CCDS11219.1; -.
PIR; I52864; I52864.
PIR; S71341; S71341.
RefSeq; NP_066292.2; NM_021012.4.
RefSeq; XP_005256682.1; XM_005256625.4.
RefSeq; XP_011522133.1; XM_011523831.2.
UniGene; Hs.200629; -.
ProteinModelPortal; Q14500; -.
SMR; Q14500; -.
BioGrid; 109970; 16.
IntAct; Q14500; 2.
MINT; Q14500; -.
STRING; 9606.ENSP00000328150; -.
DrugBank; DB00204; Dofetilide.
DrugBank; DB01392; Yohimbine.
GuidetoPHARMACOLOGY; 431; -.
TCDB; 1.A.2.1.9; the inward rectifier k(+) channel (irk-c) family.
iPTMnet; Q14500; -.
PhosphoSitePlus; Q14500; -.
BioMuta; KCNJ12; -.
DMDM; 77416868; -.
PaxDb; Q14500; -.
PeptideAtlas; Q14500; -.
PRIDE; Q14500; -.
Ensembl; ENST00000331718; ENSP00000328150; ENSG00000184185.
Ensembl; ENST00000583088; ENSP00000463778; ENSG00000184185.
GeneID; 3768; -.
KEGG; hsa:3768; -.
UCSC; uc002gyv.2; human.
CTD; 3768; -.
DisGeNET; 3768; -.
EuPathDB; HostDB:ENSG00000184185.9; -.
GeneCards; KCNJ12; -.
HGNC; HGNC:6258; KCNJ12.
HPA; HPA027021; -.
MIM; 602323; gene.
neXtProt; NX_Q14500; -.
OpenTargets; ENSG00000184185; -.
PharmGKB; PA218; -.
eggNOG; KOG3827; Eukaryota.
eggNOG; ENOG410XQ62; LUCA.
GeneTree; ENSGT00760000118842; -.
HOGENOM; HOG000237325; -.
HOVERGEN; HBG006178; -.
InParanoid; Q14500; -.
KO; K05005; -.
OMA; TPCVLQV; -.
OrthoDB; EOG091G08HC; -.
PhylomeDB; Q14500; -.
TreeFam; TF313676; -.
Reactome; R-HSA-1296041; Activation of G protein gated Potassium channels.
Reactome; R-HSA-1296053; Classical Kir channels.
Reactome; R-HSA-5576886; Phase 4 - resting membrane potential.
Reactome; R-HSA-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
SIGNOR; Q14500; -.
ChiTaRS; KCNJ12; human.
GeneWiki; KCNJ12; -.
GenomeRNAi; 3768; -.
PRO; PR:Q14500; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000184185; -.
Genevisible; Q14500; HS.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0031224; C:intrinsic component of membrane; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; TAS:Reactome.
GO; GO:0005242; F:inward rectifier potassium channel activity; IDA:UniProtKB.
GO; GO:0006936; P:muscle contraction; TAS:ProtInc.
GO; GO:0010107; P:potassium ion import; IBA:GO_Central.
GO; GO:0006813; P:potassium ion transport; IDA:UniProtKB.
GO; GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
GO; GO:0008016; P:regulation of heart contraction; TAS:ProtInc.
GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
Gene3D; 2.60.40.1400; -; 2.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR016449; K_chnl_inward-rec_Kir.
InterPro; IPR003272; K_chnl_inward-rec_Kir2.2.
InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
PANTHER; PTHR11767; PTHR11767; 1.
PANTHER; PTHR11767:SF14; PTHR11767:SF14; 1.
Pfam; PF01007; IRK; 1.
Pfam; PF08466; IRK_N; 1.
PRINTS; PR01325; KIR22CHANNEL.
PRINTS; PR01320; KIRCHANNEL.
SUPFAM; SSF81296; SSF81296; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond; Ion channel;
Ion transport; Membrane; Polymorphism; Potassium; Potassium transport;
Reference proteome; S-nitrosylation; Transmembrane;
Transmembrane helix; Transport; Voltage-gated channel.
CHAIN 1 433 ATP-sensitive inward rectifier potassium
channel 12.
/FTId=PRO_0000154962.
TOPO_DOM 1 82 Cytoplasmic. {ECO:0000250}.
TRANSMEM 83 107 Helical; Name=M1. {ECO:0000250}.
TOPO_DOM 108 123 Extracellular. {ECO:0000250}.
INTRAMEM 124 128 {ECO:0000250}.
INTRAMEM 129 141 Helical; Pore-forming; Name=H5.
{ECO:0000250}.
INTRAMEM 142 151 Pore-forming. {ECO:0000250}.
TOPO_DOM 152 156 Extracellular. {ECO:0000250}.
TRANSMEM 157 181 Helical; Name=M2. {ECO:0000250}.
TOPO_DOM 182 433 Cytoplasmic. {ECO:0000250}.
MOTIF 79 81 Interaction with phosphatidylinositides.
{ECO:0000250}.
MOTIF 143 148 Selectivity filter. {ECO:0000250}.
MOTIF 183 190 Interaction with phosphatidylinositides.
{ECO:0000250}.
MOTIF 431 433 PDZ-binding. {ECO:0000255}.
SITE 173 173 Role in the control of polyamine-mediated
channel gating and in the blocking by
intracellular magnesium. {ECO:0000250}.
MOD_RES 75 75 S-nitrosocysteine.
{ECO:0000250|UniProtKB:P63252}.
DISULFID 155 155 Interchain. {ECO:0000250}.
VARIANT 6 6 R -> Q (in dbSNP:rs3752032).
/FTId=VAR_024509.
VARIANT 15 15 S -> L (in dbSNP:rs1657738).
/FTId=VAR_049671.
VARIANT 100 100 I -> V (in dbSNP:rs8076599).
{ECO:0000269|PubMed:8647284}.
/FTId=VAR_059365.
VARIANT 118 118 R -> Q (in dbSNP:rs1657740).
/FTId=VAR_059366.
VARIANT 156 156 P -> L (in dbSNP:rs1714864).
/FTId=VAR_049672.
VARIANT 192 192 Q -> H (in dbSNP:rs1657742).
/FTId=VAR_059367.
VARIANT 249 249 I -> V (in dbSNP:rs4985866).
/FTId=VAR_049673.
VARIANT 430 430 E -> G (in dbSNP:rs5021699).
/FTId=VAR_059368.
CONFLICT 43 43 R -> H (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 71 71 M -> I (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 139 139 E -> K (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 142 142 T -> N (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 145 145 G -> S (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 173 173 D -> N (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 184 184 M -> V (in Ref. 5; AAC01951).
{ECO:0000305}.
CONFLICT 185 185 A -> V (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 211 211 L -> F (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 239 239 E -> K (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 261 262 RI -> HS (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 285 285 Missing (in Ref. 1; AAA65122).
{ECO:0000305}.
CONFLICT 289 290 ET -> QM (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 297 297 V -> I (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 302 302 M -> I (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 334 334 Missing (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 335 335 Missing (in Ref. 5; AAC01951).
{ECO:0000305}.
CONFLICT 343 343 S -> L (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 371 371 S -> R (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 378 378 E -> K (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 402 402 D -> E (in Ref. 2; AAC50615).
{ECO:0000305}.
CONFLICT 405 405 S -> I (in Ref. 2; AAC50615).
{ECO:0000305}.
SEQUENCE 433 AA; 49001 MW; 082027A1765B6F4E CRC64;
MTAASRANPY SIVSSEEDGL HLVTMSGANG FGNGKVHTRR RCRNRFVKKN GQCNIEFANM
DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGI IFWVIAVAHG DLEPAEGRGR
TPCVMQVHGF MAAFLFSIET QTTIGYGLRC VTEECPVAVF MVVAQSIVGC IIDSFMIGAI
MAKMARPKKR AQTLLFSHNA VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE
GEYIPLDQID IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE
GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE VPSTPRCSAK
DLVENKFLLP SANSFCYENE LAFLSRDEED EADGDQDGRS RDGLSPQARH DFDRLQAGGG
VLEQRPYRRE SEI


Related products :

Catalog number Product name Quantity
YHB0135Ra Rat ATP-sensitive inward rectifier potassium channel 14,KCNJ14-Kir2.4 ELISA Kit 48T
E1040Ra Rat ATP-sensitive inward rectifier potassium channel 12,KCNJ12-Kir2.2 ELISA Kit 96T
E1042Ra Rat ATP-sensitive inward rectifier potassium channel 14,KCNJ14-Kir2.4 ELISA Kit 96T
E1042Ra Rat ATP-sensitive inward rectifier potassium channel 14,KCNJ14 per Kir2.4 ELISA Kit 96T
YHB0134Ra Rat ATP-sensitive inward rectifier potassium channel 12,KCNJ12-Kir2.2 ELISA Kit 48T
E1040Ra Rat ATP-sensitive inward rectifier potassium channel 12,KCNJ12 per Kir2.2 ELISA Kit 96T
YHB0135Ra Rat ATP-sensitive inward rectifier potassium channel 14,KCNJ14-Kir2.4 ELISA Kit 96T
E1041Ra Rat ATP-sensitive inward rectifier potassium channel 14,KCNJ14-Kir2.4 ELISA Kit 48T
E1040Ra Rat ATP-sensitive inward rectifier potassium channel 12,KCNJ12 per Kir2.2 ELISA Kit 48T
E1039Ra Rat ATP-sensitive inward rectifier potassium channel 12,KCNJ12-Kir2.2 ELISA Kit 48T
E1042Ra Rat ATP-sensitive inward rectifier potassium channel 14,KCNJ14 per Kir2.4 ELISA Kit 48T
YHB0134Ra Rat ATP-sensitive inward rectifier potassium channel 12,KCNJ12-Kir2.2 ELISA Kit 96T
E0171Bo Bovine ATP-sensitive inward rectifier potassium channel 12,KCNJ12 per Kir2.2 ELISA Kit 48T
E1799Hu Human ATP-sensitive inward rectifier potassium channel 12,KCNJ12-Kir2.2 ELISA Kit 96T
E1319Mo Mouse ATP-sensitive inward rectifier potassium channel 14,KCNJ14 per Kir2.4 ELISA Kit 48T
E1810Hu Human ATP-sensitive inward rectifier potassium channel 14,KCNJ14 per Kir2.4 ELISA Kit 96T
E0170Bo Bovine ATP-sensitive inward rectifier potassium channel 12,KCNJ12-Kir2.2 ELISA Kit 48T
E1317Mo Mouse ATP-sensitive inward rectifier potassium channel 12,KCNJ12 per Kir2.2 ELISA Kit 48T
YHB0024BO Bovine ATP-sensitive inward rectifier potassium channel 12,KCNJ12-Kir2.2 ELISA Kit 48T
E1810Hu Human ATP-sensitive inward rectifier potassium channel 14,KCNJ14-Kir2.4 ELISA Kit 96T
E0171Bo Bovine ATP-sensitive inward rectifier potassium channel 12,KCNJ12 per Kir2.2 ELISA Kit 96T
E1799Hu Human ATP-sensitive inward rectifier potassium channel 12,KCNJ12 per Kir2.2 ELISA Kit 96T
E1318Mo Mouse ATP-sensitive inward rectifier potassium channel 14,KCNJ14-Kir2.4 ELISA Kit 48T
E1319Mo Mouse ATP-sensitive inward rectifier potassium channel 14,KCNJ14 per Kir2.4 ELISA Kit 96T
YHB0024BO Bovine ATP-sensitive inward rectifier potassium channel 12,KCNJ12-Kir2.2 ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur