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ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K( ) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1)

 KCNJ8_RAT               Reviewed;         424 AA.
Q63664; Q9JM49; Q9JM50;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
12-SEP-2018, entry version 143.
RecName: Full=ATP-sensitive inward rectifier potassium channel 8;
AltName: Full=Inward rectifier K(+) channel Kir6.1;
AltName: Full=Potassium channel, inwardly rectifying subfamily J member 8;
AltName: Full=uKATP-1;
Name=Kcnj8;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley; TISSUE=Pancreatic islet;
PubMed=7890693; DOI=10.1074/jbc.270.11.5691;
Inagaki N., Tsuura Y., Namba N., Masuda K., Gonoi T., Horie M.,
Seino Y., Mizuta M., Seino S.;
"Cloning and functional characterization of a novel ATP-sensitive
potassium channel ubiquitously expressed in rat tissues, including
pancreatic islets, pituitary, skeletal muscle, and heart.";
J. Biol. Chem. 270:5691-5694(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS.
STRAIN=Sprague-Dawley; TISSUE=Vascular smooth muscle;
Cao K., Wang R.;
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: This potassium channel is controlled by G proteins.
Inward rectifier potassium channels are characterized by a greater
tendency to allow potassium to flow into the cell rather than out
of it. Their voltage dependence is regulated by the concentration
of extracellular potassium; as external potassium is raised, the
voltage range of the channel opening shifts to more positive
voltages. The inward rectification is mainly due to the blockage
of outward current by internal magnesium. Can be blocked by
external barium. {ECO:0000269|PubMed:7890693}.
-!- INTERACTION:
P08050:Gja1; NbExp=4; IntAct=EBI-6991142, EBI-476947;
P23242:Gja1 (xeno); NbExp=4; IntAct=EBI-6991142, EBI-298630;
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
{ECO:0000305}.
-!- TISSUE SPECIFICITY: Widely expressed, including in pancreatic
islets, pituitary, skeletal muscle and heart.
{ECO:0000269|PubMed:7890693}.
-!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
(TC 1.A.2.1) family. KCNJ8 subfamily. {ECO:0000305}.
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EMBL; D42145; BAA07716.1; -; mRNA.
EMBL; AB043636; BAA96237.1; -; mRNA.
EMBL; AB043637; BAA96238.1; -; mRNA.
PIR; I60373; I60373.
RefSeq; NP_058795.3; NM_017099.4.
UniGene; Rn.229203; -.
ProteinModelPortal; Q63664; -.
SMR; Q63664; -.
CORUM; Q63664; -.
IntAct; Q63664; 3.
MINT; Q63664; -.
STRING; 10116.ENSRNOP00000018057; -.
iPTMnet; Q63664; -.
PhosphoSitePlus; Q63664; -.
PaxDb; Q63664; -.
Ensembl; ENSRNOT00000018057; ENSRNOP00000018057; ENSRNOG00000013463.
GeneID; 25472; -.
KEGG; rno:25472; -.
UCSC; RGD:2960; rat.
CTD; 3764; -.
RGD; 2960; Kcnj8.
eggNOG; KOG3827; Eukaryota.
eggNOG; ENOG410XQ62; LUCA.
GeneTree; ENSGT00760000118842; -.
HOGENOM; HOG000237325; -.
HOVERGEN; HBG006178; -.
InParanoid; Q63664; -.
KO; K05001; -.
OMA; AMELQCS; -.
OrthoDB; EOG091G08HC; -.
PhylomeDB; Q63664; -.
TreeFam; TF313676; -.
Reactome; R-RNO-1296025; ATP sensitive Potassium channels.
PRO; PR:Q63664; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000013463; Expressed in 9 organ(s), highest expression level in heart.
Genevisible; Q63664; RN.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
GO; GO:0008282; C:inward rectifying potassium channel; IDA:RGD.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0005739; C:mitochondrion; IDA:RGD.
GO; GO:0030016; C:myofibril; IEA:Ensembl.
GO; GO:0042383; C:sarcolemma; IDA:RGD.
GO; GO:0005524; F:ATP binding; IDA:RGD.
GO; GO:0015272; F:ATP-activated inward rectifier potassium channel activity; IDA:RGD.
GO; GO:0017098; F:sulfonylurea receptor binding; IPI:RGD.
GO; GO:1902282; F:voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEP:RGD.
GO; GO:0010107; P:potassium ion import; IDA:RGD.
GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
GO; GO:0006813; P:potassium ion transport; IDA:RGD.
GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
GO; GO:0043330; P:response to exogenous dsRNA; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
Gene3D; 2.60.40.1400; -; 2.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR016449; K_chnl_inward-rec_Kir.
InterPro; IPR003278; K_chnl_inward-rec_Kir6.1.
InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
PANTHER; PTHR11767; PTHR11767; 1.
PANTHER; PTHR11767:SF11; PTHR11767:SF11; 1.
Pfam; PF01007; IRK; 1.
PIRSF; PIRSF005465; GIRK_kir; 1.
PRINTS; PR01331; KIR61CHANNEL.
PRINTS; PR01320; KIRCHANNEL.
SUPFAM; SSF81296; SSF81296; 1.
1: Evidence at protein level;
Complete proteome; Ion channel; Ion transport; Membrane;
Phosphoprotein; Polymorphism; Potassium; Potassium transport;
Reference proteome; Transmembrane; Transmembrane helix; Transport;
Voltage-gated channel.
CHAIN 1 424 ATP-sensitive inward rectifier potassium
channel 8.
/FTId=PRO_0000154949.
TOPO_DOM 1 69 Cytoplasmic. {ECO:0000250}.
TRANSMEM 70 94 Helical; Name=M1. {ECO:0000250}.
TOPO_DOM 95 126 Extracellular. {ECO:0000250}.
INTRAMEM 127 138 Helical; Pore-forming; Name=H5.
{ECO:0000250}.
INTRAMEM 139 145 Pore-forming. {ECO:0000250}.
TOPO_DOM 146 154 Extracellular. {ECO:0000250}.
TRANSMEM 155 176 Helical; Name=M2. {ECO:0000250}.
TOPO_DOM 177 424 Cytoplasmic. {ECO:0000250}.
MOTIF 140 145 Selectivity filter. {ECO:0000250}.
SITE 170 170 Role in the control of polyamine-mediated
channel gating and in the blocking by
intracellular magnesium. {ECO:0000250}.
MOD_RES 6 6 Phosphoserine.
{ECO:0000250|UniProtKB:P97794}.
VARIANT 23 23 R -> H.
VARIANT 48 48 K -> Q.
VARIANT 150 150 E -> G.
VARIANT 170 170 N -> D.
VARIANT 241 241 V -> A.
VARIANT 379 379 S -> F.
SEQUENCE 424 AA; 47963 MW; 22548313B92FE095 CRC64;
MLARKSIIPE EYVLARIAAE NLRKPRIRDR LPKARFIAKS GACNLAHKNI REQGRFLQDI
FTTLVDLKWR HTLVIFTMSF LCSWLLFAIM WWLVAFAHGD IYAYMEKGIT EKSGLESAVC
VTNVRSFTSA FLFSIEVQVT IGFGGRMMTE ECPLAITVLI LQNIVGLIIN AVMLGCIFMK
TAQAHRRAET LIFSRHAVIA VRNGKLCFMF RVGDLRKSMI ISASVRIQVV KKTTTPEGEV
VPIHQQDIPV DNPIESNNIF LVAPLIICHV IDKRSPLYDI SATDLVNQDL EVIVILEGVV
ETTGITTQAR TSYIAEEIQW GHRFVSIVTE EEGVYSVDYS KFGNTVRVAA PRCSARELDE
KPSILIQTLQ KSELSHQNSL RKRNSMRRNN SMRRSNSIRR NNSSLMVPKV QFMTPEGNQC
PSES


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