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ATPase GET3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Golgi to ER traffic protein 3) (Guided entry of tail-anchored proteins 3)

 A0A0L0NTM3_9ASCO        Unreviewed;       349 AA.
A0A0L0NTM3;
11-NOV-2015, integrated into UniProtKB/TrEMBL.
11-NOV-2015, sequence version 1.
22-NOV-2017, entry version 22.
RecName: Full=ATPase GET3 {ECO:0000256|HAMAP-Rule:MF_03112};
EC=3.6.-.- {ECO:0000256|HAMAP-Rule:MF_03112};
AltName: Full=Arsenical pump-driving ATPase {ECO:0000256|HAMAP-Rule:MF_03112};
AltName: Full=Arsenite-stimulated ATPase {ECO:0000256|HAMAP-Rule:MF_03112};
AltName: Full=Golgi to ER traffic protein 3 {ECO:0000256|HAMAP-Rule:MF_03112};
AltName: Full=Guided entry of tail-anchored proteins 3 {ECO:0000256|HAMAP-Rule:MF_03112};
Name=GET3 {ECO:0000256|HAMAP-Rule:MF_03112};
ORFNames=QG37_05896 {ECO:0000313|EMBL:KND97506.1};
[Candida] auris.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Metschnikowiaceae; Clavispora;
Clavispora/Candida clade.
NCBI_TaxID=498019 {ECO:0000313|EMBL:KND97506.1, ECO:0000313|Proteomes:UP000037122};
[1] {ECO:0000313|Proteomes:UP000037122}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=6684 {ECO:0000313|Proteomes:UP000037122};
PubMed=26346253; DOI=10.1186/s12864-015-1863-z;
Chatterjee S., Alampalli S.V., Nageshan R.K., Chettiar S.T., Joshi S.,
Tatu U.S.;
"Draft genome of a commonly misdiagnosed multidrug resistant pathogen
Candida auris.";
BMC Genomics 16:686-686(2015).
-!- FUNCTION: ATPase required for the post-translational delivery of
tail-anchored (TA) proteins to the endoplasmic reticulum.
Recognizes and selectively binds the transmembrane domain of TA
proteins in the cytosol. This complex then targets to the
endoplasmic reticulum by membrane-bound receptors, where the tail-
anchored protein is released for insertion. This process is
regulated by ATP binding and hydrolysis. ATP binding drives the
homodimer towards the closed dimer state, facilitating recognition
of newly synthesized TA membrane proteins. ATP hydrolysis is
required for insertion. Subsequently, the homodimer reverts
towards the open dimer state, lowering its affinity for the
membrane-bound receptor, and returning it to the cytosol to
initiate a new round of targeting. {ECO:0000256|HAMAP-
Rule:MF_03112}.
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_03112,
ECO:0000256|SAAS:SAAS00846957}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03112}.
Endoplasmic reticulum {ECO:0000256|HAMAP-Rule:MF_03112}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum
{ECO:0000256|SAAS:SAAS00846961}.
-!- SIMILARITY: Belongs to the arsA ATPase family. {ECO:0000256|HAMAP-
Rule:MF_03112, ECO:0000256|SAAS:SAAS00846955}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:KND97506.1}.
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EMBL; LGST01000041; KND97506.1; -; Genomic_DNA.
RefSeq; XP_018167230.1; XM_018314812.1.
EnsemblFungi; KND97506; KND97506; QG37_05896.
GeneID; 28879588; -.
KEGG; caur:QG37_05896; -.
KO; K01551; -.
Proteomes; UP000037122; Unassembled WGS sequence.
GO; GO:0043529; C:GET complex; IEA:EnsemblFungi.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0016887; F:ATPase activity; IEA:EnsemblFungi.
GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0051082; F:unfolded protein binding; IEA:EnsemblFungi.
GO; GO:1990507; P:ATP-independent chaperone mediated protein folding; IEA:EnsemblFungi.
GO; GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IEA:EnsemblFungi.
GO; GO:0006620; P:posttranslational protein targeting to endoplasmic reticulum membrane; IEA:EnsemblFungi.
GO; GO:0045048; P:protein insertion into ER membrane; IEA:UniProtKB-UniRule.
GO; GO:0009408; P:response to heat; IEA:EnsemblFungi.
GO; GO:0010038; P:response to metal ion; IEA:EnsemblFungi.
GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:EnsemblFungi.
CDD; cd02035; ArsA; 1.
HAMAP; MF_03112; Asna1_Get3; 1.
InterPro; IPR025723; Anion-transp_ATPase-like_dom.
InterPro; IPR016300; ATPase_ArsA/GET3.
InterPro; IPR027542; ATPase_ArsA/GET3_euk.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR10803; PTHR10803; 1.
PANTHER; PTHR10803:SF3; PTHR10803:SF3; 1.
Pfam; PF02374; ArsA_ATPase; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00345; GET3_arsA_TRC40; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|HAMAP-Rule:MF_03112,
ECO:0000256|SAAS:SAAS00846966};
Complete proteome {ECO:0000313|Proteomes:UP000037122};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03112,
ECO:0000256|SAAS:SAAS00846962};
Endoplasmic reticulum {ECO:0000256|HAMAP-Rule:MF_03112};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_03112,
ECO:0000256|SAAS:SAAS00846968};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_03112,
ECO:0000256|SAAS:SAAS00846954};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_03112,
ECO:0000256|SAAS:SAAS00846966};
Reference proteome {ECO:0000313|Proteomes:UP000037122};
Transport {ECO:0000256|HAMAP-Rule:MF_03112,
ECO:0000256|SAAS:SAAS00846958};
Zinc {ECO:0000256|HAMAP-Rule:MF_03112, ECO:0000256|SAAS:SAAS00846960}.
DOMAIN 19 330 ArsA_ATPase. {ECO:0000259|Pfam:PF02374}.
NP_BIND 26 33 ATP. {ECO:0000256|HAMAP-Rule:MF_03112}.
ACT_SITE 57 57 {ECO:0000256|HAMAP-Rule:MF_03112}.
METAL 280 280 Zinc; shared with dimeric partner.
{ECO:0000256|HAMAP-Rule:MF_03112}.
METAL 283 283 Zinc; shared with dimeric partner.
{ECO:0000256|HAMAP-Rule:MF_03112}.
BINDING 243 243 ATP. {ECO:0000256|HAMAP-Rule:MF_03112}.
BINDING 270 270 ATP. {ECO:0000256|HAMAP-Rule:MF_03112}.
SEQUENCE 349 AA; 39409 MW; B031FAEA052131B2 CRC64;
MDLELEPTLE SIVHQDTLKW VFVGGKGGVG KTTTSSSIAV QLALAYPDEQ FLLISTDPAH
NLSDAFCQKF GKDARKVEGL SNLSCMEIDP EAAMSDLQNQ AQQYNNDPND PLKSMMKDMT
GSIPGIDEAL SFMEVLKHIK NQKVATEKDN GDTISYKTII FDTAPTGHTL RFLQLPATLE
KLLSKFKDLS GKFGPMLSML GGGAGQQQDI FEKLNEVQRN VSEVNEQFTN PDLTTFVCVC
ISEFLSLYET ERMIQELMSY NMDVNSIVVN QLLFADKDDC RRCQSRWKMQ KKYLDQMGEL
YEDYHLVKMP LLGTEIRGVE NLKKFSKFLL KPYDPKVDSG LIYDLEETK


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