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Acetyl-coenzyme A synthetase (AcCoA synthetase) (Acs) (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme)

 A0A045KET6_MYCTX        Unreviewed;       651 AA.
A0A045KET6;
09-JUL-2014, integrated into UniProtKB/TrEMBL.
09-JUL-2014, sequence version 1.
23-MAY-2018, entry version 42.
RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|HAMAP-Rule:MF_01123};
Short=AcCoA synthetase {ECO:0000256|HAMAP-Rule:MF_01123};
Short=Acs {ECO:0000256|HAMAP-Rule:MF_01123};
EC=6.2.1.1 {ECO:0000256|HAMAP-Rule:MF_01123};
AltName: Full=Acetate--CoA ligase {ECO:0000256|HAMAP-Rule:MF_01123};
AltName: Full=Acyl-activating enzyme {ECO:0000256|HAMAP-Rule:MF_01123};
Name=acs {ECO:0000313|EMBL:CFE38497.1};
Synonyms=acs_1 {ECO:0000313|EMBL:CNH17688.1},
acsA {ECO:0000256|HAMAP-Rule:MF_01123};
ORFNames=ERS007665_00305 {ECO:0000313|EMBL:CNU05478.1},
ERS007670_01215 {ECO:0000313|EMBL:CNU28053.1},
ERS007679_00545 {ECO:0000313|EMBL:COU87313.1},
ERS007681_01022 {ECO:0000313|EMBL:CFE38497.1},
ERS007688_01514 {ECO:0000313|EMBL:CFE49574.1},
ERS007722_02822 {ECO:0000313|EMBL:COW47558.1},
ERS023446_02925 {ECO:0000313|EMBL:CNN31431.1},
ERS027652_01885 {ECO:0000313|EMBL:CKR61942.1},
ERS027659_00063 {ECO:0000313|EMBL:CKQ75109.1},
ERS124361_03038 {ECO:0000313|EMBL:CNH17688.1},
SAMEA2682864_03161 {ECO:0000313|EMBL:SGM78577.1},
SAMEA2683035_00764 {ECO:0000313|EMBL:SGH27675.1};
Mycobacterium tuberculosis.
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
NCBI_TaxID=1773 {ECO:0000313|EMBL:CFE38497.1, ECO:0000313|Proteomes:UP000048289};
[1] {ECO:0000313|Proteomes:UP000039953, ECO:0000313|Proteomes:UP000041288, ECO:0000313|Proteomes:UP000043293}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=200127 {ECO:0000313|EMBL:CNH17688.1,
ECO:0000313|Proteomes:UP000047075},
A70144_2 {ECO:0000313|EMBL:CNN31431.1,
ECO:0000313|Proteomes:UP000039953},
Bir 178 {ECO:0000313|EMBL:CKR61942.1,
ECO:0000313|Proteomes:UP000049299},
Bir 185 {ECO:0000313|EMBL:CKQ75109.1,
ECO:0000313|Proteomes:UP000050164},
D00700688 {ECO:0000313|EMBL:CNU05478.1,
ECO:0000313|Proteomes:UP000045274},
E09701106 {ECO:0000313|EMBL:CNU28053.1,
ECO:0000313|Proteomes:UP000041288},
G09801536 {ECO:0000313|EMBL:COU87313.1,
ECO:0000313|Proteomes:UP000045842},
G09901357 {ECO:0000313|EMBL:CFE38497.1,
ECO:0000313|Proteomes:UP000048289},
H09601792 {ECO:0000313|EMBL:CFE49574.1,
ECO:0000313|Proteomes:UP000046947}, and
M09502139 {ECO:0000313|EMBL:COW47558.1,
ECO:0000313|Proteomes:UP000043293};
Murphy D.;
Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:SGH27675.1, ECO:0000313|Proteomes:UP000182946, ECO:0000313|Proteomes:UP000183655}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2926STDY5723616 {ECO:0000313|EMBL:SGM78577.1,
ECO:0000313|Proteomes:UP000183655}, and
2926STDY5723788 {ECO:0000313|EMBL:SGH27675.1,
ECO:0000313|Proteomes:UP000182946};
Pathogen Informatics;
Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the conversion of acetate into acetyl-CoA
(AcCoA), an essential intermediate at the junction of anabolic and
catabolic pathways. AcsA undergoes a two-step reaction. In the
first half reaction, AcsA combines acetate with ATP to form
acetyl-adenylate (AcAMP) intermediate. In the second half
reaction, it can then transfer the acetyl group from AcAMP to the
sulfhydryl group of CoA, forming the product AcCoA.
{ECO:0000256|HAMAP-Rule:MF_01123, ECO:0000256|SAAS:SAAS00711888}.
-!- CATALYTIC ACTIVITY: ATP + acetate + CoA = AMP + diphosphate +
acetyl-CoA. {ECO:0000256|HAMAP-Rule:MF_01123}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_01123,
ECO:0000256|SAAS:SAAS00711884};
-!- PTM: Acetylated. Deacetylation by the SIR2-homolog deacetylase
activates the enzyme. {ECO:0000256|HAMAP-Rule:MF_01123}.
-!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme
family. {ECO:0000256|HAMAP-Rule:MF_01123}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01123}.
-----------------------------------------------------------------------
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EMBL; CFOE01000089; CFE38497.1; -; Genomic_DNA.
EMBL; CFOH01000198; CFE49574.1; -; Genomic_DNA.
EMBL; CNFT01000007; CKQ75109.1; -; Genomic_DNA.
EMBL; CNFQ01000371; CKR61942.1; -; Genomic_DNA.
EMBL; CHDS01000064; CNH17688.1; -; Genomic_DNA.
EMBL; CQGE01000076; CNN31431.1; -; Genomic_DNA.
EMBL; CQPW01000032; CNU05478.1; -; Genomic_DNA.
EMBL; CQPL01000182; CNU28053.1; -; Genomic_DNA.
EMBL; CSAD01000043; COU87313.1; -; Genomic_DNA.
EMBL; CSAM01000237; COW47558.1; -; Genomic_DNA.
EMBL; FPTZ01000003; SGH27675.1; -; Genomic_DNA.
EMBL; FPXX01000022; SGM78577.1; -; Genomic_DNA.
RefSeq; WP_003899631.1; NZ_PQBT01000061.1.
EnsemblBacteria; AMC48178; AMC48178; RN05_3902.
EnsemblBacteria; CFE38497; CFE38497; ERS007681_01022.
EnsemblBacteria; CFE49574; CFE49574; ERS007688_01514.
EnsemblBacteria; CKQ75109; CKQ75109; ERS027659_00063.
EnsemblBacteria; CKR61942; CKR61942; ERS027652_01885.
EnsemblBacteria; CNH17688; CNH17688; ERS124361_03038.
EnsemblBacteria; CNN31431; CNN31431; ERS023446_02925.
EnsemblBacteria; CNU05478; CNU05478; ERS007665_00305.
EnsemblBacteria; CNU28053; CNU28053; ERS007670_01215.
EnsemblBacteria; CNY17882; CNY17882; ERS013471_00710.
EnsemblBacteria; COU87313; COU87313; ERS007679_00545.
EnsemblBacteria; COW47558; COW47558; ERS007722_02822.
PATRIC; fig|1773.206.peg.2428; -.
Proteomes; UP000039953; Unassembled WGS sequence.
Proteomes; UP000041288; Unassembled WGS sequence.
Proteomes; UP000043293; Unassembled WGS sequence.
Proteomes; UP000045274; Unassembled WGS sequence.
Proteomes; UP000045842; Unassembled WGS sequence.
Proteomes; UP000046947; Unassembled WGS sequence.
Proteomes; UP000047075; Unassembled WGS sequence.
Proteomes; UP000048289; Unassembled WGS sequence.
Proteomes; UP000049299; Unassembled WGS sequence.
Proteomes; UP000050164; Unassembled WGS sequence.
Proteomes; UP000182946; Unassembled WGS sequence.
Proteomes; UP000183655; Unassembled WGS sequence.
GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
GO; GO:0016208; F:AMP binding; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
CDD; cd05966; ACS; 1.
HAMAP; MF_01123; Ac_CoA_synth; 1.
InterPro; IPR011904; Ac_CoA_lig.
InterPro; IPR032387; ACAS_N.
InterPro; IPR025110; AMP-bd_C.
InterPro; IPR020845; AMP-binding_CS.
InterPro; IPR000873; AMP-dep_Synth/Lig.
Pfam; PF16177; ACAS_N; 1.
Pfam; PF00501; AMP-binding; 1.
Pfam; PF13193; AMP-binding_C; 1.
TIGRFAMs; TIGR02188; Ac_CoA_lig_AcsA; 1.
PROSITE; PS00455; AMP_BINDING; 1.
3: Inferred from homology;
Acetylation {ECO:0000256|HAMAP-Rule:MF_01123};
ATP-binding {ECO:0000256|HAMAP-Rule:MF_01123};
Complete proteome {ECO:0000313|Proteomes:UP000039953,
ECO:0000313|Proteomes:UP000041288, ECO:0000313|Proteomes:UP000043293,
ECO:0000313|Proteomes:UP000045274};
Ligase {ECO:0000256|HAMAP-Rule:MF_01123, ECO:0000313|EMBL:CFE38497.1};
Magnesium {ECO:0000256|HAMAP-Rule:MF_01123,
ECO:0000256|SAAS:SAAS00711869};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_01123,
ECO:0000256|SAAS:SAAS00711886};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01123}.
DOMAIN 26 79 ACAS_N. {ECO:0000259|Pfam:PF16177}.
DOMAIN 85 530 AMP-binding. {ECO:0000259|Pfam:PF00501}.
DOMAIN 539 617 AMP-binding_C.
{ECO:0000259|Pfam:PF13193}.
NP_BIND 387 389 ATP. {ECO:0000256|HAMAP-Rule:MF_01123}.
NP_BIND 411 416 ATP. {ECO:0000256|HAMAP-Rule:MF_01123}.
REGION 190 193 Coenzyme A binding. {ECO:0000256|HAMAP-
Rule:MF_01123}.
METAL 545 545 Magnesium; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_01123}.
METAL 547 547 Magnesium; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_01123}.
METAL 550 550 Magnesium; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_01123}.
BINDING 311 311 Coenzyme A. {ECO:0000256|HAMAP-
Rule:MF_01123}.
BINDING 508 508 ATP. {ECO:0000256|HAMAP-Rule:MF_01123}.
BINDING 523 523 ATP. {ECO:0000256|HAMAP-Rule:MF_01123}.
BINDING 531 531 Coenzyme A; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_01123}.
BINDING 534 534 ATP. {ECO:0000256|HAMAP-Rule:MF_01123}.
MOD_RES 617 617 N6-acetyllysine. {ECO:0000256|HAMAP-
Rule:MF_01123}.
SEQUENCE 651 AA; 71476 MW; 94290C0517A0445B CRC64;
MSESTPEVSS SYPPPAHFAE HANARAELYR EAEEDRLAFW AKQANRLSWT TPFTEVLDWS
GAPFAKWFVG GELNVAYNCV DRHVEAGHGD RVAIHWEGEP VGDRRTLTYS DLLAEVSKAA
NALTDLGLVA GDRVAIYLPL IPEAVIAMLA CARLGIMHSV VFGGFTAAAL QARIVDAQAK
LLITADGQFR RGKPSPLKAA ADEALAAIPD CSVEHVLVVR RTGIEMAWSE GRDLWWHHVV
GSASPAHTPE PFDSEHPLFL LYTSGTTGKP KGIMHTSGGY LTQCCYTMRT IFDVKPDSDV
FWCTADIGWV TGHTYGVYGP LCNGVTEVLY EGTPDTPDRH RHFQIIEKYG VTIYYTAPTL
IRMFMKWGRE IPDSHDLSSL RLLGSVGEPI NPEAWRWYRD VIGGGRTPLV DTWWQTETGS
AMISPLPGIA AAKPGSAMTP LPGISAKIVD DHGDPLPPHT EGAQHVTGYL VLDQPWPSML
RGIWGDPARY WHSYWSKFSD KGYYFAGDGA RIDPDGAIWV LGRIDDVMNV SGHRISTAEV
ESALVAHSGV AEAAVVGVTD ETTTQAICAF VVLRANYAPH DRTAEELRTE VARVISPIAR
PRDVHVVPEL PKTRSGKIMR RLLRDVAENR ELGDTSTLLD PTVFDAIRAA K


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