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Acetylcholine receptor subunit beta-like 2 (Nicotinic acetylcholine receptor beta 2)

 ACH4_DROME              Reviewed;         519 AA.
P25162; O18403; Q8IMW6; Q8SXP7; Q9VC71;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 3.
30-AUG-2017, entry version 163.
RecName: Full=Acetylcholine receptor subunit beta-like 2;
AltName: Full=Nicotinic acetylcholine receptor beta 2;
Flags: Precursor;
Name=nAChRbeta2; Synonyms=Acr96Ac, AcrF, nAcRbeta-96, SBD;
ORFNames=CG6798;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [MRNA] OF 20-519 (ISOFORM A), TISSUE SPECIFICITY,
AND DEVELOPMENTAL STAGE.
STRAIN=Canton-S; TISSUE=Embryo;
PubMed=2121539; DOI=10.1016/0014-5793(90)81078-3;
Sawruk E., Udri C., Betz H., Schmitt B.;
"SBD, a novel structural subunit of the Drosophila nicotinic
acetylcholine receptor, shares its genomic localization with two
alpha-subunits.";
FEBS Lett. 273:177-181(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-65.
PubMed=9109505;
Lansdell S.J., Schmitt B., Betz H., Sattelle D.B., Millar N.S.;
"Temperature-sensitive expression of Drosophila neuronal nicotinic
acetylcholine receptors.";
J. Neurochem. 68:1812-1819(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
STRAIN=Berkeley; TISSUE=Head;
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[6]
RNA EDITING OF POSITION 278.
PubMed=12907802; DOI=10.1126/science.1086763;
Hoopengardner B., Bhalla T., Staber C., Reenan R.;
"Nervous system targets of RNA editing identified by comparative
genomics.";
Science 301:832-836(2003).
-!- FUNCTION: After binding acetylcholine, the AChR responds by an
extensive change in conformation that affects all subunits and
leads to opening of an ion-conducting channel across the plasma
membrane. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
membrane; Multi-pass membrane protein. Cell membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=A;
IsoId=P25162-1; Sequence=Displayed;
Name=B;
IsoId=P25162-2; Sequence=VSP_007411, VSP_007412;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: CNS in embryos. {ECO:0000269|PubMed:2121539}.
-!- DEVELOPMENTAL STAGE: Late embryonic and late pupal stages.
{ECO:0000269|PubMed:2121539}.
-!- RNA EDITING: Modified_positions=278 {ECO:0000269|PubMed:12907802};
Note=Partially edited.;
-!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAL90236.1; Type=Frameshift; Positions=237; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; X55676; CAA39211.1; -; mRNA.
EMBL; Y14678; CAA74994.1; -; mRNA.
EMBL; AE014297; AAF56304.1; -; Genomic_DNA.
EMBL; AE014297; AAN13998.1; -; Genomic_DNA.
EMBL; AY089498; AAL90236.1; ALT_FRAME; mRNA.
PIR; S12899; S12899.
RefSeq; NP_524483.1; NM_079759.4. [P25162-1]
RefSeq; NP_733002.1; NM_170147.3. [P25162-2]
UniGene; Dm.4978; -.
ProteinModelPortal; P25162; -.
SMR; P25162; -.
STRING; 7227.FBpp0084061; -.
ChEMBL; CHEMBL2366470; -.
PaxDb; P25162; -.
PRIDE; P25162; -.
EnsemblMetazoa; FBtr0084681; FBpp0084061; FBgn0004118. [P25162-1]
EnsemblMetazoa; FBtr0084682; FBpp0084062; FBgn0004118. [P25162-2]
GeneID; 42920; -.
KEGG; dme:Dmel_CG6798; -.
CTD; 42920; -.
FlyBase; FBgn0004118; nAChRbeta2.
eggNOG; KOG3645; Eukaryota.
eggNOG; ENOG410XQGR; LUCA.
GeneTree; ENSGT00760000118930; -.
InParanoid; P25162; -.
KO; K05312; -.
OMA; ITVCVLN; -.
OrthoDB; EOG091G0R20; -.
PhylomeDB; P25162; -.
Reactome; R-DME-629587; Highly sodium permeable acetylcholine nicotinic receptors.
Reactome; R-DME-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
Reactome; R-DME-629597; Highly calcium permeable nicotinic acetylcholine receptors.
Reactome; R-DME-6798695; Neutrophil degranulation.
GenomeRNAi; 42920; -.
PRO; PR:P25162; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0004118; -.
ExpressionAtlas; P25162; differential.
Genevisible; P25162; DM.
GO; GO:0005892; C:acetylcholine-gated channel complex; ISS:FlyBase.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; ISS:FlyBase.
GO; GO:0017085; P:response to insecticide; IMP:FlyBase.
GO; GO:0007271; P:synaptic transmission, cholinergic; IEP:FlyBase.
Gene3D; 2.70.170.10; -; 1.
InterPro; IPR006202; Neur_chan_lig-bd.
InterPro; IPR006201; Neur_channel.
InterPro; IPR006029; Neurotrans-gated_channel_TM.
InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
PANTHER; PTHR18945; PTHR18945; 1.
Pfam; PF02931; Neur_chan_LBD; 1.
Pfam; PF02932; Neur_chan_memb; 1.
PRINTS; PR00254; NICOTINICR.
PRINTS; PR00252; NRIONCHANNEL.
SUPFAM; SSF63712; SSF63712; 1.
SUPFAM; SSF90112; SSF90112; 1.
TIGRFAMs; TIGR00860; LIC; 1.
PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
2: Evidence at transcript level;
Alternative splicing; Cell junction; Cell membrane; Complete proteome;
Disulfide bond; Glycoprotein; Ion channel; Ion transport;
Ligand-gated ion channel; Membrane; Postsynaptic cell membrane;
Receptor; Reference proteome; RNA editing; Signal; Synapse;
Transmembrane; Transmembrane helix; Transport.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 519 Acetylcholine receptor subunit beta-like
2.
/FTId=PRO_0000000302.
TOPO_DOM 19 244 Extracellular.
TRANSMEM 245 269 Helical. {ECO:0000255}.
TRANSMEM 277 295 Helical. {ECO:0000255}.
TRANSMEM 311 332 Helical. {ECO:0000255}.
TOPO_DOM 333 462 Cytoplasmic.
TRANSMEM 463 481 Helical. {ECO:0000255}.
CARBOHYD 50 50 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 154 168 {ECO:0000250}.
VAR_SEQ 279 304 LCISILVSLTVFFLLLAEIIPPTSLA -> KMDPPNSMIKN
LRVIPSFLWHVACFC (in isoform B).
{ECO:0000303|PubMed:12537569}.
/FTId=VSP_007411.
VAR_SEQ 305 519 Missing (in isoform B).
{ECO:0000303|PubMed:12537569}.
/FTId=VSP_007412.
VARIANT 278 278 T -> A (in RNA edited version).
CONFLICT 344 344 P -> R (in Ref. 1; CAA39211).
{ECO:0000305}.
SEQUENCE 519 AA; 60140 MW; DDE67674529D2FCB CRC64;
MWHWSLLCVF LLVPLANSTA PISFEANPDT KRLYDDLLSN YNRLIRPVVN NTETLTVWLG
LKLSQLIEVN LKNQVMTTNL WVKQRWFDYK LRWDPEEYGG VEQLYVPSEH IWVPDIVLYN
NWDGNYEVTL MTKATLKYTG EVFWEPPAIY KSSCEMNVEY FPYDEQICFM KFGSWTYNGA
QVDLKHLDQI PGSNLVQVGI DLTEFYLSVE WDILEVPATK NEEYYPDTLE PFSDITFKLT
MRRKTLFYTV NLIVPCVALT FLTVLVFYLP SDSGEKVTLC ISILVSLTVF FLLLAEIIPP
TSLAVPLLGK YLLFTMILVS LSVWTTVCVL NIHFRSPSTH NMSPLVRKLF LHFMPKLMMM
RRTQYTLPDY DDSTPSNGYT NEIDVRDSIS DFPSEFKDSQ DGAYDNGMQN SVDSDNVIPR
NLTPEVLQAL RAVRFIAQHI KDADKDNEIV EDWKFVSMVL DRFFLWLFTL SCVFGTLAII
CQSPSLYDTR SPIDRQLSEI PLRKNNFMLP PDIVRQVLT


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