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Achaete-scute family bHLH transcription factor 1

 E1B7V5_BOVIN            Unreviewed;       219 AA.
E1B7V5;
02-NOV-2010, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 2.
12-SEP-2018, entry version 52.
SubName: Full=Achaete-scute family bHLH transcription factor 1 {ECO:0000313|Ensembl:ENSBTAP00000021592};
Name=ASCL1 {ECO:0000313|Ensembl:ENSBTAP00000021592,
ECO:0000313|VGNC:VGNC:26206};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000021592, ECO:0000313|Proteomes:UP000009136};
[1] {ECO:0000313|Ensembl:ENSBTAP00000021592, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000021592,
ECO:0000313|Proteomes:UP000009136};
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[2] {ECO:0000313|Ensembl:ENSBTAP00000021592}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000021592};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
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EMBL; DAAA02013706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_002687686.1; XM_002687640.4.
RefSeq; XP_594382.3; XM_594382.8.
STRING; 9913.ENSBTAP00000021592; -.
PaxDb; E1B7V5; -.
PRIDE; E1B7V5; -.
Ensembl; ENSBTAT00000021592; ENSBTAP00000021592; ENSBTAG00000016227.
GeneID; 540473; -.
KEGG; bta:540473; -.
CTD; 429; -.
VGNC; VGNC:26206; ASCL1.
eggNOG; KOG4029; Eukaryota.
eggNOG; ENOG411227D; LUCA.
GeneTree; ENSGT00530000063321; -.
InParanoid; E1B7V5; -.
KO; K09067; -.
OMA; ELMRCKR; -.
OrthoDB; EOG091G0OB6; -.
TreeFam; TF322889; -.
Proteomes; UP000009136; Chromosome 5.
Bgee; ENSBTAG00000016227; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; IBA:GO_Central.
GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0070888; F:E-box binding; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0061104; P:adrenal chromaffin cell differentiation; IEA:Ensembl.
GO; GO:0061103; P:carotid body glomus cell differentiation; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO; GO:0021892; P:cerebral cortex GABAergic interneuron differentiation; IEA:Ensembl.
GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IEA:Ensembl.
GO; GO:0061100; P:lung neuroendocrine cell differentiation; IEA:Ensembl.
GO; GO:0050883; P:musculoskeletal movement, spinal reflex action; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0007400; P:neuroblast fate determination; IEA:Ensembl.
GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
GO; GO:0048665; P:neuron fate specification; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0003358; P:noradrenergic neuron development; IEA:Ensembl.
GO; GO:0003359; P:noradrenergic neuron fate commitment; IEA:Ensembl.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:0060166; P:olfactory pit development; IEA:Ensembl.
GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0030856; P:regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0007346; P:regulation of mitotic cell cycle; IEA:Ensembl.
GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
GO; GO:0060165; P:regulation of timing of subpallium neuron differentiation; IEA:Ensembl.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO; GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl.
GO; GO:0021530; P:spinal cord oligodendrocyte cell fate specification; IEA:Ensembl.
GO; GO:0061102; P:stomach neuroendocrine cell differentiation; IEA:Ensembl.
GO; GO:0060163; P:subpallium neuron fate commitment; IEA:Ensembl.
GO; GO:0061549; P:sympathetic ganglion development; IEA:Ensembl.
GO; GO:0060579; P:ventral spinal cord interneuron fate commitment; IEA:Ensembl.
GO; GO:0021750; P:vestibular nucleus development; IEA:Ensembl.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR015660; MASH1/Ascl1a-like.
PANTHER; PTHR13935; PTHR13935; 1.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000009136};
Reference proteome {ECO:0000313|Proteomes:UP000009136}.
DOMAIN 101 153 BHLH. {ECO:0000259|PROSITE:PS50888}.
SEQUENCE 219 AA; 23635 MW; 14F0B7CBB4CB9C27 CRC64;
MESSAKMESG GAGPQPQQPF LPPAACFFAT AAAQSAQQPP PPPPPPPQLS PAADGQPSGG
GHKSAPKQVK RQRSSSPELM RCKRRLNFSG FGYSLPQQQP AAVARRNERE RNRVKLVNLG
FATLREHVPN GAANKKMSKV ETLRSAVEYI RALQQLLDEH DAVSAAFQAG VLSPTISPNY
SNDMNSMAGS PVSSYSSDEG SYDPLSPEEQ ELLDFTNWF


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