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Achaete-scute homolog 1a (Zash-1a) (Pituitary-absent protein)

 ASL1A_DANRE             Reviewed;         196 AA.
Q90259;
09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
28-MAR-2018, entry version 110.
RecName: Full=Achaete-scute homolog 1a;
Short=Zash-1a;
AltName: Full=Pituitary-absent protein;
Name=ascl1a {ECO:0000312|ZFIN:ZDB-GENE-980526-90};
Synonyms=ash {ECO:0000312|EMBL:AAA78898.1},
ash1a {ECO:0000303|PubMed:12702659},
asha {ECO:0000312|ZFIN:ZDB-GENE-980526-90},
pia {ECO:0000303|PubMed:16481349};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1] {ECO:0000305, ECO:0000312|EMBL:AAA78898.1}
NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE
SPECIFICITY.
TISSUE=Embryo {ECO:0000269|PubMed:7813774};
PubMed=7813774; DOI=10.1006/dbio.1994.1334;
Allende M.L., Weinberg E.S.;
"The expression pattern of two zebrafish achaete-scute homolog (ash)
genes is altered in the embryonic brain of the cyclops mutant.";
Dev. Biol. 166:509-530(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[3] {ECO:0000312|EMBL:CAI21097.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye {ECO:0000312|EMBL:AAH98521.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000305}
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=12702659; DOI=10.1242/dev.00452;
Cau E., Wilson S.W.;
"Ash1a and neurogenin1 function downstream of floating head to
regulate epiphysial neurogenesis.";
Development 130:2455-2466(2003).
[5] {ECO:0000305}
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=15659486; DOI=10.1242/dev.01616;
Amoyel M., Cheng Y.-C., Jiang Y.-J., Wilkinson D.G.;
"Wnt1 regulates neurogenesis and mediates lateral inhibition of
boundary cell specification in the zebrafish hindbrain.";
Development 132:775-785(2005).
[6] {ECO:0000305}
FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=16481349; DOI=10.1242/dev.02296;
Pogoda H.-M., von der Hardt S., Herzog W., Kramer C., Schwarz H.,
Hammerschmidt M.;
"The proneural gene ascl1a is required for endocrine differentiation
and cell survival in the zebrafish adenohypophysis.";
Development 133:1079-1089(2006).
-!- FUNCTION: Transcriptional regulator. May mediate transcription
activation by binding to the E box-containing promoter (By
similarity). Involved in neurogenesis. Required for the
development of neurons in the epiphysis, acting partially
redundantly with neurog1 and downstream of flh. Involved in
maintaining rhombomere boundaries in the hindbrain, probably via
up-regulation of delta expression. Also involved in pituitary
development; required cell-autonomously in adenohypophyseal cells
for endocrine differentiation and for survival of a subset of
cells. {ECO:0000250, ECO:0000269|PubMed:12702659,
ECO:0000269|PubMed:15659486, ECO:0000269|PubMed:16481349}.
-!- SUBUNIT: Efficient DNA binding requires dimerization with another
bHLH protein. {ECO:0000250|UniProtKB:P50553}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- TISSUE SPECIFICITY: In the 24 hours embryo, expressed in the
dorsal hindbrain in two bilaterally symmetrical lines of cells
marking the boundary between the alar and basal plates, and
ventrally in rhombomere 1 near the floor plate. Also expressed in
embryonic adenohypophysis, telencephalon, diencephalon, epiphysis,
ventral tegmentum, neural retina and spinal cord, in discrete
regions distinct from those expressing ascl1b. In the 30 hours
embryo, hindbrain expression is in stripes adjacent to rhombomere
boundaries. {ECO:0000269|PubMed:12702659,
ECO:0000269|PubMed:15659486, ECO:0000269|PubMed:16481349,
ECO:0000269|PubMed:7813774}.
-!- DEVELOPMENTAL STAGE: First detected at 12 hours post-fertilization
(hpf), increasing over the next 24 hours, then decreasing between
48 and 72 hours. Not detected in adult.
{ECO:0000269|PubMed:7813774}.
-!- DISRUPTION PHENOTYPE: In pituitary absent (pia) mutants,
adenohypophyseal cells fail to express hormone genes and some
become apoptotic. {ECO:0000269|PubMed:16481349}.
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EMBL; U14587; AAA78898.1; -; mRNA.
EMBL; BX510924; CAK04833.1; -; Genomic_DNA.
EMBL; BX511171; CAI21097.1; -; Genomic_DNA.
EMBL; BC098521; AAH98521.1; -; mRNA.
PIR; I50507; I50507.
RefSeq; NP_571294.1; NM_131219.1.
UniGene; Dr.314; -.
ProteinModelPortal; Q90259; -.
SMR; Q90259; -.
STRING; 7955.ENSDARP00000056004; -.
PaxDb; Q90259; -.
Ensembl; ENSDART00000056005; ENSDARP00000056004; ENSDARG00000038386.
GeneID; 30466; -.
KEGG; dre:30466; -.
CTD; 30466; -.
ZFIN; ZDB-GENE-980526-90; ascl1a.
eggNOG; KOG4029; Eukaryota.
eggNOG; ENOG411227D; LUCA.
GeneTree; ENSGT00530000063321; -.
HOGENOM; HOG000013056; -.
HOVERGEN; HBG050590; -.
InParanoid; Q90259; -.
KO; K09067; -.
OMA; ELMRCKR; -.
OrthoDB; EOG091G0OB6; -.
PhylomeDB; Q90259; -.
TreeFam; TF322889; -.
PRO; PR:Q90259; -.
Proteomes; UP000000437; Chromosome 4.
Bgee; ENSDARG00000038386; -.
GO; GO:0005634; C:nucleus; IC:ZFIN.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; IBA:GO_Central.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IPI:ZFIN.
GO; GO:0000989; F:transcription factor activity, transcription factor binding; ISS:UniProtKB.
GO; GO:0021984; P:adenohypophysis development; IMP:UniProtKB.
GO; GO:0031103; P:axon regeneration; IMP:ZFIN.
GO; GO:0043697; P:cell dedifferentiation; IGI:ZFIN.
GO; GO:0048566; P:embryonic digestive tract development; IMP:ZFIN.
GO; GO:0002070; P:epithelial cell maturation; IMP:ZFIN.
GO; GO:0021575; P:hindbrain morphogenesis; IMP:UniProtKB.
GO; GO:0060575; P:intestinal epithelial cell differentiation; IMP:ZFIN.
GO; GO:0010629; P:negative regulation of gene expression; IMP:ZFIN.
GO; GO:0007399; P:nervous system development; IMP:ZFIN.
GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:ZFIN.
GO; GO:0031099; P:regeneration; IMP:ZFIN.
GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0070654; P:sensory epithelium regeneration; IGI:ZFIN.
GO; GO:0061549; P:sympathetic ganglion development; IMP:ZFIN.
GO; GO:0061195; P:taste bud formation; IMP:ZFIN.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR015660; MASH1/Ascl1a-like.
PANTHER; PTHR13935; PTHR13935; 1.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; Differentiation;
DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 196 Achaete-scute homolog 1a.
/FTId=PRO_0000271235.
DOMAIN 78 130 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
SEQUENCE 196 AA; 21928 MW; 462E3A35DCBA183A CRC64;
MDITAKMEIS VNQQQFMPPA CFFASQSIQL SPTDSQCSNK SASKQAKRQR SSSPELLRCK
RRLNFAGFGY SLPQQQPHAV ARRNERERNR VKLVNNGFAT LREHVPNGAA NKKMSKVETL
RSAVEYIRAL QQLLDEHDAV SAAFQSGVLS PTISQNYSND MNSMAGSPVS SYSSDEGSYD
PLSPEEQELL DFTNWF


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