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Achaete-scute homolog 3 (ASH-3) (mASH-3) (mASH3) (bHLH transcriptional regulator Sgn-1)

 ASCL3_MOUSE             Reviewed;         174 AA.
Q9JJR7; Q3SXE3;
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
28-MAR-2018, entry version 118.
RecName: Full=Achaete-scute homolog 3;
Short=ASH-3;
Short=mASH-3;
Short=mASH3;
AltName: Full=bHLH transcriptional regulator Sgn-1;
Name=Ascl3; Synonyms=Mash3, Sgn1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Kemp P.R., Cooper W.N., Metcalfe J.C.;
"MASH3 a novel basic helix-loop-helix protein that inhibits myogenesis
in C2C12 cells.";
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
PubMed=11784080; DOI=10.1006/dbio.2001.0473;
Yoshida S., Ohbo K., Takakura A., Takebayashi H., Okada T., Abe K.,
Nabeshima Y.;
"Sgn1, a basic helix-loop-helix transcription factor delineates the
salivary gland duct cell lineage in mice.";
Dev. Biol. 240:517-530(2001).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11528127;
Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A.,
Zabel B., Hankeln T., Schmidt E.R.;
"Comparative genomic sequencing reveals a strikingly similar
architecture of a conserved syntenic region on human chromosome
11p15.3 (including gene ST5) and mouse chromosome 7.";
Cytogenet. Cell Genet. 93:284-290(2001).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Transcriptional repressor. Inhibits myogenesis.
-!- SUBUNIT: Efficient DNA binding requires dimerization with another
bHLH protein.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Specifically expressed in the salivary duct
cells.
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EMBL; AJ277605; CAC37689.1; -; mRNA.
EMBL; AB046448; BAB83911.1; -; mRNA.
EMBL; AJ400878; CAB92296.1; -; Genomic_DNA.
EMBL; BC104346; AAI04347.1; -; mRNA.
EMBL; BC104347; AAI04348.1; -; mRNA.
CCDS; CCDS21737.1; -.
RefSeq; NP_064435.1; NM_020051.1.
UniGene; Mm.29275; -.
ProteinModelPortal; Q9JJR7; -.
SMR; Q9JJR7; -.
BioGrid; 208173; 5.
STRING; 10090.ENSMUSP00000037702; -.
PhosphoSitePlus; Q9JJR7; -.
PaxDb; Q9JJR7; -.
PRIDE; Q9JJR7; -.
Ensembl; ENSMUST00000035372; ENSMUSP00000037702; ENSMUSG00000035951.
GeneID; 56787; -.
KEGG; mmu:56787; -.
UCSC; uc009jeb.1; mouse.
CTD; 56676; -.
MGI; MGI:1928820; Ascl3.
eggNOG; KOG4029; Eukaryota.
eggNOG; ENOG411227D; LUCA.
GeneTree; ENSGT00530000063321; -.
HOGENOM; HOG000034089; -.
HOVERGEN; HBG050591; -.
InParanoid; Q9JJR7; -.
KO; K09067; -.
OMA; GYAQLRH; -.
OrthoDB; EOG091G0OGL; -.
PhylomeDB; Q9JJR7; -.
TreeFam; TF322889; -.
PRO; PR:Q9JJR7; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000035951; -.
CleanEx; MM_ASCL3; -.
Genevisible; Q9JJR7; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; IBA:GO_Central.
GO; GO:0005667; C:transcription factor complex; IPI:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR015660; MASH1/Ascl1a-like.
PANTHER; PTHR13935; PTHR13935; 1.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
2: Evidence at transcript level;
Complete proteome; DNA-binding; Nucleus; Reference proteome;
Repressor; Transcription; Transcription regulation.
CHAIN 1 174 Achaete-scute homolog 3.
/FTId=PRO_0000127134.
DOMAIN 92 144 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
SEQUENCE 174 AA; 20245 MW; D89E56C8A9D3440B CRC64;
MDTRSYPSPP DRLSVFAESA HLPLSRPFYL DPMVTVHLCP ETPVPASYTD ELPLLPFSSD
TLIMNNYGDP YPFPFPMPYT NYRRCDYTYG PAFIRKRNER ERQRVKCVNE GYARLRRHLP
EDYLEKRLSK VETLRAAIKY ISYLQSLLYP DESETKKNPR TASCGSLDPA LRVI


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