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Acriflavine resistance protein

 J0FW89_HELPX            Unreviewed;      1028 AA.
J0FW89;
03-OCT-2012, integrated into UniProtKB/TrEMBL.
03-OCT-2012, sequence version 1.
27-SEP-2017, entry version 19.
SubName: Full=Acriflavine resistance protein {ECO:0000313|EMBL:EJC16459.1};
Name=acrB {ECO:0000313|EMBL:EJC16459.1};
ORFNames=HPHPP74_1270 {ECO:0000313|EMBL:EJC16459.1};
Helicobacter pylori Hp P-74.
Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
Helicobacteraceae; Helicobacter.
NCBI_TaxID=992091 {ECO:0000313|EMBL:EJC16459.1, ECO:0000313|Proteomes:UP000005724};
[1] {ECO:0000313|EMBL:EJC16459.1, ECO:0000313|Proteomes:UP000005724}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hp P-74 {ECO:0000313|EMBL:EJC16459.1,
ECO:0000313|Proteomes:UP000005724};
PubMed=23661595; DOI=10.1111/2049-632X.12045;
Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
"Genome sequences of 65 Helicobacter pylori strains isolated from
asymptomatic individuals and patients with gastric cancer, peptic
ulcer disease, or gastritis.";
Pathog. Dis. 68:39-43(2013).
-!- SIMILARITY: Belongs to the resistance-nodulation-cell division
(RND) (TC 2.A.6) family. {ECO:0000256|SAAS:SAAS00693190}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:EJC16459.1}.
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EMBL; AKPX01000002; EJC16459.1; -; Genomic_DNA.
RefSeq; WP_000278353.1; NZ_AKPX01000002.1.
EnsemblBacteria; EJC16459; EJC16459; HPHPP74_1270.
PATRIC; fig|992091.3.peg.1232; -.
Proteomes; UP000005724; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005215; F:transporter activity; IEA:InterPro.
Gene3D; 3.30.2090.10; -; 2.
InterPro; IPR027463; AcrB_DN_DC_subdom.
InterPro; IPR001036; Acrflvin-R.
InterPro; IPR000731; SSD.
PANTHER; PTHR32063; PTHR32063; 1.
Pfam; PF00873; ACR_tran; 1.
PRINTS; PR00702; ACRIFLAVINRP.
SUPFAM; SSF82714; SSF82714; 2.
PROSITE; PS50156; SSD; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000005724};
Membrane {ECO:0000256|SAM:Phobius};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 327 344 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 351 371 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 377 401 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 422 442 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 454 481 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 515 537 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 855 874 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 881 901 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 907 932 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 953 972 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 984 1010 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 349 479 SSD. {ECO:0000259|PROSITE:PS50156}.
SEQUENCE 1028 AA; 113689 MW; 9193A1F32D013433 CRC64;
MYKTAINRPI TTLMFALAIV FFGTMGFKKL SVALFPKIDL PTVVVTTTYP GASAEIIESK
VTDKIEEAVM GIDGIKKVTS TSSKNVSIVV IEFELEKPNE EALNDVMNKI SSVRFDDSNI
KKPSINKFDT DSQAIISLFV SSSSVPATTL NDYAKNTIKP MLQKINGVGG VQLNGFRERQ
IRIYADPTLM NKYNLTYADL FSTLKAENVE IDGGRIVNSQ RELSILINAN SYSVADVEKI
QVGNHVRLGD IAKIEIGLEE DNTFASFKDK PGVILEIQKI AGANEIEIVD RVYEALKYIQ
AISPSYEIRP FLDTTGYIRT SIEDVKFDLV LGAILAVLVV FAFLRNGTIT LVSAISIPIS
IMGTFALIQW MGFSLNMLTM VALTLAIGII IDDAIVVIEN IHKKLEMGMS KRKASYEGVR
EIGFALVAIS AMLLSVFVPI GNMKGIIGRF FQSFGITVAL AIALSYVVVV TIIPMVSSVV
VNPRHSRFYV WSEPFFKALE SRYTKLLQWV LNHKLIIFIA VVLVFVGSLF VASKLGMEFM
LKEDRGRFLV WLKAKPGVSI DYMTQKSKIF QKAIEKHAEV EFTTLQVGYG TTQNPFKAKI
FVQLKPLKER KKEHQLGQFE LMSVLRKELR SLPEAKGLDT INLSEVALIG GGGDSSPFQT
FVFSHSQEAV DKSVENLKKF LLESPELKGK VESYHTSTSE SQPQLQLKIL RQNANKYGVS
AQTIGSVVSS AFSGTSQASV FKEDGKEYDM IIRVPDDKRV SVEDIKRLQV RNKYDKLMFL
DALVEITETK SPSSISRYNR QRSVTVLAEP NRNAGVSLGE ILTQVSKNTK EWLVEGANYR
FAGEADNAKE SNGEFLVALA TAFVLIYMIL AALYESILEP FIIMVTMPLS FSGAFFALGL
VHQPLSMFSM IGLILLIGMV GKNATLLIDV ANEERKKGLN IQEAILFAGK TRLRPILMTT
IAMVCGMLPL ALASGDGAAM KSPIGIAMSG GLMISMVLSL LIVPVFYRLL APIDDKIKRF
YQNQKALE


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