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Acrosin (EC 3.4.21.10)

 P79343_BOVIN            Unreviewed;       377 AA.
P79343;
01-MAY-1997, integrated into UniProtKB/TrEMBL.
01-MAY-1997, sequence version 1.
27-SEP-2017, entry version 114.
RecName: Full=Acrosin {ECO:0000256|PIRNR:PIRNR001141};
EC=3.4.21.10 {ECO:0000256|PIRNR:PIRNR001141};
Name=bovine proacrosine {ECO:0000313|EMBL:CAA48294.1};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|EMBL:CAA48294.1};
[1] {ECO:0000313|EMBL:CAA48294.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Liver {ECO:0000313|EMBL:CAA48294.1};
Keime S.;
Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:CAA48294.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Liver {ECO:0000313|EMBL:CAA48294.1};
PubMed=8737992;
Adham I.M., Kremling H., Nieter S., Zimmermann S., Hummel M.,
Schroeter U., Engel W.;
"The structures of the bovine and porcine proacrosin genes and their
conservation during mammals.";
Biol. Chem. Hoppe-Seyler 377:261-265(1996).
-!- FUNCTION: Acrosin is the major protease of mammalian spermatozoa.
It is a serine protease of trypsin-like cleavage specificity, it
is synthesized in a zymogen form, proacrosin and stored in the
acrosome. {ECO:0000256|PIRNR:PIRNR001141}.
-!- CATALYTIC ACTIVITY: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.
{ECO:0000256|PIRNR:PIRNR001141}.
-!- SUBUNIT: Heavy chain (catalytic) and a light chain linked by two
disulfide bonds. {ECO:0000256|PIRNR:PIRNR001141}.
-!- SIMILARITY: Belongs to the peptidase S1 family.
{ECO:0000256|PIRNR:PIRNR001141, ECO:0000256|SAAS:SAAS00559343}.
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EMBL; X68212; CAA48294.1; -; Genomic_DNA.
UniGene; Bt.45050; -.
ProteinModelPortal; P79343; -.
CORUM; P79343; -.
IntAct; P79343; 1.
MINT; MINT-6825120; -.
MEROPS; S01.223; -.
PRIDE; P79343; -.
HOGENOM; HOG000033792; -.
HOVERGEN; HBG013304; -.
BRENDA; 3.4.21.10; 908.
GO; GO:0043159; C:acrosomal matrix; IDA:UniProtKB.
GO; GO:0004040; F:amidase activity; ISS:UniProtKB.
GO; GO:0005507; F:copper ion binding; NAS:UniProtKB.
GO; GO:0008144; F:drug binding; ISS:UniProtKB.
GO; GO:0042806; F:fucose binding; ISS:UniProtKB.
GO; GO:0005537; F:mannose binding; ISS:UniProtKB.
GO; GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO; GO:0007340; P:acrosome reaction; ISS:UniProtKB.
GO; GO:0007190; P:activation of adenylate cyclase activity; IDA:UniProtKB.
GO; GO:0007338; P:single fertilization; ISS:UniProtKB.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR012267; Pept_S1A_acrosin.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
PANTHER; PTHR24252; PTHR24252; 1.
Pfam; PF00089; Trypsin; 1.
PIRSF; PIRSF001141; Acrosin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
3: Inferred from homology;
Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
Hydrolase {ECO:0000256|PIRNR:PIRNR001141,
ECO:0000256|RuleBase:RU363034};
Protease {ECO:0000256|PIRNR:PIRNR001141,
ECO:0000256|RuleBase:RU363034};
Serine protease {ECO:0000256|PIRNR:PIRNR001141,
ECO:0000256|RuleBase:RU363034}.
DOMAIN 3 251 Peptidase S1.
{ECO:0000259|PROSITE:PS50240}.
ACT_SITE 49 49 Charge relay system.
{ECO:0000256|PIRSR:PIRSR001141-1}.
ACT_SITE 103 103 Charge relay system.
{ECO:0000256|PIRSR:PIRSR001141-1}.
ACT_SITE 201 201 Charge relay system.
{ECO:0000256|PIRSR:PIRSR001141-1}.
SEQUENCE 377 AA; 41722 MW; DF0BB014860430CC CRC64;
MRIIGGQDAA HGSWPWMVSL QIFTYHNNRR YHVCWGLLLN AHWLLTAAHC FRIKKKVTDW
RLIFGAKEVE WGSNKPVKPP LQERYVEKII IHEKYSASSE ANDIALIKIT PPVICGHFIG
PGCLPQFRAG PPRVPQTCWV AGWGFLRENA RRTSPVLQEA HVDLIDLDLC NSTRWYNGRI
RSTNVCAGYP EGKIDTCQGD SGGPLMCKDS VENSYVVVGI TSWGVGCSRA KRPGVYTSTW
SYLNWIASKI GSNTVHMIQL PTAPPASTPA AQASPGSVQP SIRPPWFFQH VPQPPPSQQA
IAVAQPSRPS SPRPSVPPAP RPPRPPPPQP STRPPQALSF AKRLQQLIEV LKGKTFLNEK
SNYEMETTGL PGQHASS


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